DK1463487T3 - Liposomal afgivelse af vitamin-E baserede forbindelser - Google Patents

Liposomal afgivelse af vitamin-E baserede forbindelser

Info

Publication number: DK1463487T3
Authority: DK; Denmark
Prior art keywords: vitamin; based compounds; liposomal delivery; hydrogen; vesicle
Prior art date: 2001-12-19

Application number

DK02797447.6T

Other languages

English (en)

Inventor

Bob G Sanders

Kimberly Kline

Karla A Lawson

Marla S Menchaca

J Vernon Knight

Clyde W Wellen

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-19

Filing date

2002-12-19

Publication date

2010-08-23

2002-12-19 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

2010-08-23 Application granted granted Critical

2010-08-23 Publication of DK1463487T3 publication Critical patent/DK1463487T3/da

Links

GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 title abstract 4
229930003427 Vitamin E Natural products 0.000 title abstract 2
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title abstract 2
229940046009 vitamin E Drugs 0.000 title abstract 2
235000019165 vitamin E Nutrition 0.000 title abstract 2
239000011709 vitamin E Substances 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001093 anti-cancer Effects 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurology (AREA)
Dispersion Chemistry (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Dermatology (AREA)
Oncology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Psychiatry (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02797447.6T 2001-12-19 2002-12-19 Liposomal afgivelse af vitamin-E baserede forbindelser DK1463487T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US34215601P	2001-12-19	2001-12-19
US40680702P	2002-08-29	2002-08-29
US41860202P	2002-10-15	2002-10-15
PCT/US2002/040846 WO2003053407A1 (en)	2001-12-19	2002-12-19	Liposomal delivery of vitamin e based compounds

Publications (1)

Publication Number	Publication Date
DK1463487T3 true DK1463487T3 (da)	2010-08-23

Family

ID=27407497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02797447.6T DK1463487T3 (da)	2001-12-19	2002-12-19	Liposomal afgivelse af vitamin-E baserede forbindelser

Country Status (12)

Country	Link
EP (1)	EP1463487B1 (da)
JP (1)	JP2005526705A (da)
KR (1)	KR101013426B1 (da)
CN (1)	CN100515497C (da)
AT (1)	ATE468109T1 (da)
AU (1)	AU2002361812B2 (da)
CA (1)	CA2470920C (da)
DE (1)	DE60236456D1 (da)
DK (1)	DK1463487T3 (da)
IL (2)	IL162614A0 (da)
NZ (1)	NZ533565A (da)
WO (1)	WO2003053407A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002950713A0 (en)	2002-08-09	2002-09-12	Vital Health Sciences Pty Ltd	Carrier
US8101199B2 (en)	2003-10-21	2012-01-24	Celonova Biosciences, Inc.	Des-methyl-tocopherol therapy for restenosis prevention
JP2006151965A (ja) *	2004-10-28	2006-06-15	Mi Tec:Kk	セレン含有組成物及びその製法
CA2599424A1 (en) *	2005-03-03	2006-09-08	Vital Health Sciences Pty Ltd	Compounds having anti-cancer properties
KR100884570B1 (ko) *	2005-03-07	2009-02-18	순천향대학교 산학협력단	미강 내 토코트리에놀의 대량생산방법 및 이를 이용한 고기능성 토코트리에놀 제제
NZ565049A (en)	2005-06-17	2012-02-24	Vital Health Sciences Pty Ltd	A carrier comprising one or more DI and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
MY154376A (en) *	2006-02-13	2015-06-15	Malaysian Palm Oil Board Mpob	A transdermal fluid
US8288369B2 (en) *	2006-06-27	2012-10-16	University Of South Florida	Delta-tocotrienol treatment and prevention of pancreatic cancer
AU2008210207B2 (en) *	2007-02-01	2014-05-15	Med-Life Discoveries Lp	Methods for the diagnosis of ovarian cancer health states and risk of ovarian cancer health states
ES2999020T3 (en)	2010-02-05	2025-02-24	Phosphagenics Ltd	Carrier comprising non-neutralised tocopheryl phosphate
EP2552486B1 (en)	2010-03-30	2020-08-12	Phosphagenics Limited	Transdermal delivery patch
WO2012122586A1 (en)	2011-03-15	2012-09-20	Phosphagenics Limited	New composition
US8816071B2 (en)	2011-12-02	2014-08-26	First Tech International Limited	Tocotrienol derivatives and associated methods
EP3041831B1 (en) *	2013-09-06	2019-10-23	Research Development Foundation	Alpha-tea salt forms: compositions and uses for treating disease
KR101629370B1 (ko) *	2014-05-14	2016-06-14	대한민국	토코트리에놀 생합성 형질전환 벼를 포함하는 전립선암 예방 또는 치료용 조성물
MY197126A (en) *	2015-01-23	2023-05-26	Malaysian Palm Oil Board	Nanocarrier delivery system for hydrophobic substances
CA2991868C (en) *	2015-07-31	2025-05-27	Immunewalk Therapeutics, Inc.	PROTEIN 2 CONTAINING THE MOTILE SPERM DOMAIN AND CANCER
EP3328408B1 (en)	2015-07-31	2020-10-07	Vascular Biogenics Ltd.	Motile sperm domain containing protein 2 and inflammation
CN114712308A (zh)	2015-12-09	2022-07-08	磷肌酸有限公司	药物制剂
CN108175861A (zh) *	2016-12-08	2018-06-19	暨南大学	一种抗肿瘤小核酸药物的递送系统及其应用
EP3558903B1 (en)	2016-12-21	2024-07-03	Avecho Biotechnology Limited	Process for phosphorylating a complex alcohol
WO2022053985A1 (en)	2020-09-10	2022-03-17	Vascular Biogenics Ltd.	Motile sperm domain containing protein 2 antibodies and methods of use thereof
CN112915105B (zh) *	2021-03-12	2024-07-19	上海市第六人民医院	间充质干细胞分泌的小细胞外囊泡在制备治疗cp/cpps的药物上的应用

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US4181725A (en) *	1977-05-02	1980-01-01	The Regents Of The University Of Michigan	Method for alleviating psoriasis
US4873088A (en) *	1983-09-06	1989-10-10	Liposome Technology, Inc.	Liposome drug delivery method and composition
DE3686025T2 (de) *	1985-05-22	1993-01-07	Liposome Technology Inc	Verfahren und system zum einatmen von liposomen.
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PT93772A (pt) *	1989-04-17	1991-01-08	Searle & Co	Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer
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2002
- 2002-12-19 EP EP02797447A patent/EP1463487B1/en not_active Expired - Lifetime
- 2002-12-19 IL IL16261402A patent/IL162614A0/xx unknown
- 2002-12-19 KR KR1020047009724A patent/KR101013426B1/ko not_active Expired - Fee Related
- 2002-12-19 JP JP2003554166A patent/JP2005526705A/ja active Pending
- 2002-12-19 CN CNB02827914XA patent/CN100515497C/zh not_active Expired - Fee Related
- 2002-12-19 WO PCT/US2002/040846 patent/WO2003053407A1/en not_active Ceased
- 2002-12-19 AT AT02797447T patent/ATE468109T1/de not_active IP Right Cessation
- 2002-12-19 DE DE60236456T patent/DE60236456D1/de not_active Expired - Lifetime
- 2002-12-19 DK DK02797447.6T patent/DK1463487T3/da active
- 2002-12-19 NZ NZ533565A patent/NZ533565A/en not_active IP Right Cessation
- 2002-12-19 AU AU2002361812A patent/AU2002361812B2/en not_active Ceased
- 2002-12-19 CA CA2470920A patent/CA2470920C/en not_active Expired - Fee Related
2004
- 2004-06-17 IL IL162614A patent/IL162614A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN100515497C (zh)	2009-07-22
DE60236456D1 (de)	2010-07-01
EP1463487B1 (en)	2010-05-19
CA2470920A1 (en)	2003-07-03
AU2002361812B2 (en)	2007-11-08
KR20040079911A (ko)	2004-09-16
IL162614A (en)	2013-12-31
EP1463487A1 (en)	2004-10-06
EP1463487A4 (en)	2007-01-03
CA2470920C (en)	2013-04-02
WO2003053407A1 (en)	2003-07-03
IL162614A0 (en)	2005-11-20
CN1617711A (zh)	2005-05-18
NZ533565A (en)	2006-11-30
JP2005526705A (ja)	2005-09-08
AU2002361812A1 (en)	2003-07-09
ATE468109T1 (de)	2010-06-15
KR101013426B1 (ko)	2011-02-14

Publication	Publication Date	Title
DK1463487T3 (da)	2010-08-23	Liposomal afgivelse af vitamin-E baserede forbindelser
NZ331457A (en)	2000-01-28	Methoxybenzophenone compounds, a process for their preparation and a method involving them for combating fungal growth
YU31303A (sh)	2006-05-25	Jedinjenja imidazola sa pripojenim arilom ili heteroarilom kao anti-inflamatorni i analgetički agensi
ATE126216T1 (de)	1995-08-15	Pyrazolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellung.
DK0528337T3 (da)	2000-03-27	Thiazolylbenzofuranderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater, der indeholder disse forbin
IS6520A (is)	2002-08-22	Ný efnasambönd
DE69811329D1 (de)	2003-03-20	Imidazolidin-4-on Derivate verwendbar als Antikrebsmittel
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
DE50011034D1 (de)	2005-09-29	N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE359786T1 (de)	2007-05-15	Camptothecin derivate
ATE319680T1 (de)	2006-03-15	Substituierte 2-benzylamino-2-phenyl- acetamidverbindungen
ES2052504T3 (es)	1994-07-16	Derivado de difenilmetano, compuesto farmaceutico y su utilizacion.
EA200100090A2 (ru)	2001-08-27	Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
ATE287886T1 (de)	2005-02-15	Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b) pyridinen als cyclin- abhängige kinase-hemmer
WO2002012188A3 (en)	2002-10-03	Indole compounds useful for the treatment of cancer
DE60134735D1 (de)	2008-08-21	Neue neurokinin-antagonisten zum gebrauch als arzneimittel
DE69623610D1 (de)	2002-10-17	Neue heterozyklische chemie
EA200400523A1 (ru)	2004-08-26	Производные [[2-(амино-3,4-диоксо-1-циклобутен-1-ил)амино]алкил] кислоты, применяемые для лечения боли
AR020294A1 (es)	2002-05-02	COMPUESTOS DERIVADOS DE 1-TRIFLUOROMETIL-4-HIDROXI-7-PIPERIDINIL-AMINOMETILCROMANO, COMPOSICION FARMACEUTICA Y USO EN LA PREPARACIoN DE MEDICAMENTOS.
BR0112957A (pt)	2003-07-08	Composto, método de tratamento, uso de um composto, e, composição farmacêutica
DE60114597D1 (de)	2005-12-08	Naphthamid-neurokinin antagonisten zur verwendung als medikamente
DE60013515D1 (de)	2004-10-14	4-Arylpiperidinderivate zur Behandlung von Pruritus
EA200200379A3 (ru)	2002-12-26	Новые соединения пиримидин-4-она, способ их получения и содержащие их фармацевтические композиции
EA200100155A3 (ru)	2001-10-22	Новые производные 6-амино или 6-гидразиносульфонил-3-хинолинилфосфоновой кислоты, способ их получения и содержащие их фармацевтические композиции
DE69827706D1 (de)	2004-12-30	5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems