DK1463731T3 - Dibenzodiazepinderivater, deres fremstilling og anvendelse - Google Patents

Dibenzodiazepinderivater, deres fremstilling og anvendelse

Info

Publication number: DK1463731T3
Authority: DK; Denmark
Prior art keywords: preparation; sup; dibenzodiazepine derivatives; dibenzodiazepine; derivatives
Prior art date: 2002-01-10

Application number

DK03729243T

Other languages

English (en)

Inventor

Wilfried Lubisch

Wilfried Braje

Thomas Subkowski

Wolfgang Wernet

Karla Drescher

Roland Grandel

Reinhold Muller

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-10

Filing date

2003-01-10

Publication date

2006-02-13

2003-01-10 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2006-02-13 Application granted granted Critical

2006-02-13 Publication of DK1463731T3 publication Critical patent/DK1463731T3/da

Links

150000008533 dibenzodiazepines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Virology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
AIDS & HIV (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)

DK03729243T 2002-01-10 2003-01-10 Dibenzodiazepinderivater, deres fremstilling og anvendelse DK1463731T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/041,556 US7026311B2 (en)	2002-01-10	2002-01-10	Dibenzodiazepine derivatives, their preparation and use

Publications (1)

Publication Number	Publication Date
DK1463731T3 true DK1463731T3 (da)	2006-02-13

Family

ID=21917135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03729243T DK1463731T3 (da)	2002-01-10	2003-01-10	Dibenzodiazepinderivater, deres fremstilling og anvendelse

Country Status (11)

Country	Link
US (1)	US7026311B2 (da)
EP (1)	EP1463731B1 (da)
JP (1)	JP4308017B2 (da)
AT (1)	ATE305472T1 (da)
AU (1)	AU2003235806A1 (da)
CA (1)	CA2472107C (da)
DE (1)	DE60301725T2 (da)
DK (1)	DK1463731T3 (da)
ES (1)	ES2249718T3 (da)
MX (1)	MXPA04006443A (da)
WO (1)	WO2003057699A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2672860C (en) *	2006-12-28	2013-01-29	Abbott Laboratories	Inhibitors of poly(adp-ribose)polymerase
WO2009035997A2 (en)	2007-09-14	2009-03-19	Cara Therapeutics, Inc.	Benzo-fused heterocycles
US9975906B2 (en)	2014-05-16	2018-05-22	Shionogi & Co., Ltd.	Tricyclic heterocycle derivatives having HIV replication inhibitory effect
JP6525422B2 (ja) *	2014-07-03	2019-06-05	セルジーンクオンティセルリサーチ，インク．	リジン特異的なデメチラーゼ−１の阻害剤
TWI700284B (zh) *	2015-05-29	2020-08-01	日商塩野義製藥股份有限公司	具有ｈｉｖ複製抑制作用之含氮３環性衍生物
AU2016296905B2 (en)	2015-07-23	2018-07-05	Centre National De La Recherche Scientifique	Use of a combination of Dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
WO2018162439A1 (en)	2017-03-08	2018-09-13	Onxeo	New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
CA3092779A1 (en)	2018-03-13	2019-09-19	Onxeo	A dbait molecule against acquired resistance in the treatment of cancer
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
CN121398822A (zh)	2023-06-21	2026-01-23	四方生物科学有限公司	用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ECSP003637A (es)	1999-08-31	2002-03-25	Agouron Pharma	Inhibidores triciclicos de poli (adp-ribosa) polimerasas
EP1183259A2 (de)	1999-09-28	2002-03-06	Basf Aktiengesellschaft	Azepinoindol-derivate, deren herstellung und anwendung

2002
- 2002-01-10 US US10/041,556 patent/US7026311B2/en not_active Expired - Fee Related
2003
- 2003-01-10 DE DE60301725T patent/DE60301725T2/de not_active Expired - Lifetime
- 2003-01-10 AU AU2003235806A patent/AU2003235806A1/en not_active Abandoned
- 2003-01-10 EP EP03729243A patent/EP1463731B1/en not_active Expired - Lifetime
- 2003-01-10 AT AT03729243T patent/ATE305472T1/de active
- 2003-01-10 WO PCT/EP2003/000192 patent/WO2003057699A1/en not_active Ceased
- 2003-01-10 ES ES03729243T patent/ES2249718T3/es not_active Expired - Lifetime
- 2003-01-10 JP JP2003558014A patent/JP4308017B2/ja not_active Expired - Fee Related
- 2003-01-10 DK DK03729243T patent/DK1463731T3/da active
- 2003-01-10 MX MXPA04006443A patent/MXPA04006443A/es active IP Right Grant
- 2003-01-10 CA CA002472107A patent/CA2472107C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4308017B2 (ja)	2009-08-05
JP2005516031A (ja)	2005-06-02
US20030139394A1 (en)	2003-07-24
US7026311B2 (en)	2006-04-11
CA2472107A1 (en)	2003-07-17
ES2249718T3 (es)	2006-04-01
EP1463731B1 (en)	2005-09-28
CA2472107C (en)	2008-10-28
EP1463731A1 (en)	2004-10-06
ATE305472T1 (de)	2005-10-15
MXPA04006443A (es)	2004-10-04
DE60301725D1 (de)	2006-02-09
AU2003235806A1 (en)	2003-07-24
WO2003057699A1 (en)	2003-07-17
DE60301725T2 (de)	2006-07-06

Publication	Publication Date	Title
NO20021379L (no)	2002-03-20	Benzodiazepin-derivater, fremstilling og anvendelse derav
BG105650A (en)	2002-02-28	Azepinoindole derivatives, the production and use thereof
DE602004008098D1 (de)	2007-09-20	Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
BR0313330A (pt)	2005-06-14	Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4
EA200501333A1 (ru)	2006-06-30	5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
CY1106969T1 (el)	2012-09-26	Αναστολεις dpp-iv
DE60012188D1 (de)	2004-08-19	Fungizide
SE9900100D0 (sv)	1999-01-15	New compounds
CY1105410T1 (el)	2010-04-28	Υποκατεστημενες 2-φαινυλοβενζιμιδαζολες, η παρασκευη και η εφαρμογη τους
ATE345349T1 (de)	2006-12-15	Purinderivate
PE20030061A1 (es)	2003-02-08	1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4
DK1463731T3 (da)	2006-02-13	Dibenzodiazepinderivater, deres fremstilling og anvendelse
MY141011A (en)	2010-02-25	Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
DK1313740T3 (da)	2006-04-03	Prodrugs af imidazopyridinderivater
SE0203303D0 (sv)	2002-11-07	Novel Compounds
EA200600607A1 (ru)	2006-10-27	Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
ATE359283T1 (de)	2007-05-15	Substituierte pyrazinonverbindungen zur behandlung von entzündungen
EP1667976A4 (en)	2008-02-13	Isoquinolinone POTASSIUM CHANNEL INHIBITORS
UY27587A1 (es)	2003-07-31	Heterociclos terapéuticos
GB0229081D0 (en)	2003-01-15	Multifunctional cationic photoinitiators, their preparation and use
SE0203300D0 (sv)	2002-11-07	Novel Compounds
EA200301101A1 (ru)	2004-04-29	Производные пиперазина и их применение в качестве ингибиторов pde4
EA200600601A1 (ru)	2006-10-27	Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы
DK1644385T3 (da)	2008-01-02	Siliciumforbindelser og deres anvendelse
EA200600608A1 (ru)	2006-10-27	Производные имидазопиридина как ингибиторы индуцируемой no-синтазы