DK1463731T3 - Dibenzodiazepinderivater, deres fremstilling og anvendelse - Google Patents

Dibenzodiazepinderivater, deres fremstilling og anvendelse

Info

Publication number: DK1463731T3
Authority: DK; Denmark
Prior art keywords: preparation; sup; dibenzodiazepine derivatives; dibenzodiazepine; derivatives
Prior art date: 2002-01-10

Application number

DK03729243T

Other languages

English (en)

Inventor

Wilfried Lubisch

Wilfried Braje

Thomas Subkowski

Wolfgang Wernet

Karla Drescher

Roland Grandel

Reinhold Muller

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-10

Filing date

2003-01-10

Publication date

2006-02-13

2003-01-10 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2006-02-13 Application granted granted Critical

2006-02-13 Publication of DK1463731T3 publication Critical patent/DK1463731T3/da

Links

150000008533 dibenzodiazepines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Hematology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)

DK03729243T 2002-01-10 2003-01-10 Dibenzodiazepinderivater, deres fremstilling og anvendelse DK1463731T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/041,556 US7026311B2 (en)	2002-01-10	2002-01-10	Dibenzodiazepine derivatives, their preparation and use

Publications (1)

Publication Number	Publication Date
DK1463731T3 true DK1463731T3 (da)	2006-02-13

Family

ID=21917135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03729243T DK1463731T3 (da)	2002-01-10	2003-01-10	Dibenzodiazepinderivater, deres fremstilling og anvendelse

Country Status (11)

Country	Link
US (1)	US7026311B2 (da)
EP (1)	EP1463731B1 (da)
JP (1)	JP4308017B2 (da)
AT (1)	ATE305472T1 (da)
AU (1)	AU2003235806A1 (da)
CA (1)	CA2472107C (da)
DE (1)	DE60301725T2 (da)
DK (1)	DK1463731T3 (da)
ES (1)	ES2249718T3 (da)
MX (1)	MXPA04006443A (da)
WO (1)	WO2003057699A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2009007053A (es) *	2006-12-28	2009-07-09	Abbott Lab	Inhibidores de poli (adp-ribosa) polimerasa.
US7960376B2 (en)	2007-09-14	2011-06-14	Cara Therapeutics, Inc.	Benzo-fused heterocycles
JP6579549B2 (ja)	2014-05-16	2019-09-25	塩野義製薬株式会社	Ｈｉｖ複製阻害作用を有する３環性複素環誘導体
EA201790082A1 (ru)	2014-07-03	2017-08-31	Селджен Квонтисел Рисёрч, Инк.	Ингибиторы лизин-специфической демитилазы-1
AU2016271762B2 (en) *	2015-05-29	2020-01-23	Shionogi & Co., Ltd.	Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity
WO2017013237A1 (en)	2015-07-23	2017-01-26	Institut Curie	Use of a combination of dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
WO2018162439A1 (en)	2017-03-08	2018-09-13	Onxeo	New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
WO2019175132A1 (en)	2018-03-13	2019-09-19	Onxeo	A dbait molecule against acquired resistance in the treatment of cancer
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
WO2024261243A1 (en)	2023-06-21	2024-12-26	Hemispherian As	Combination comprising a deoxycytidine derivative and a parp inhibitor for use in a method of treating hr proficient cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ECSP003637A (es)	1999-08-31	2002-03-25	Agouron Pharma	Inhibidores triciclicos de poli (adp-ribosa) polimerasas
KR20010087401A (ko)	1999-09-28	2001-09-15	스타르크, 카르크	아제피노인돌 유도체, 그의 제법 및 용도

2002
- 2002-01-10 US US10/041,556 patent/US7026311B2/en not_active Expired - Fee Related
2003
- 2003-01-10 CA CA002472107A patent/CA2472107C/en not_active Expired - Fee Related
- 2003-01-10 ES ES03729243T patent/ES2249718T3/es not_active Expired - Lifetime
- 2003-01-10 DK DK03729243T patent/DK1463731T3/da active
- 2003-01-10 MX MXPA04006443A patent/MXPA04006443A/es active IP Right Grant
- 2003-01-10 JP JP2003558014A patent/JP4308017B2/ja not_active Expired - Fee Related
- 2003-01-10 EP EP03729243A patent/EP1463731B1/en not_active Expired - Lifetime
- 2003-01-10 AT AT03729243T patent/ATE305472T1/de active
- 2003-01-10 WO PCT/EP2003/000192 patent/WO2003057699A1/en not_active Ceased
- 2003-01-10 DE DE60301725T patent/DE60301725T2/de not_active Expired - Lifetime
- 2003-01-10 AU AU2003235806A patent/AU2003235806A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MXPA04006443A (es)	2004-10-04
CA2472107A1 (en)	2003-07-17
EP1463731A1 (en)	2004-10-06
JP4308017B2 (ja)	2009-08-05
ES2249718T3 (es)	2006-04-01
AU2003235806A1 (en)	2003-07-24
US7026311B2 (en)	2006-04-11
EP1463731B1 (en)	2005-09-28
DE60301725T2 (de)	2006-07-06
CA2472107C (en)	2008-10-28
ATE305472T1 (de)	2005-10-15
US20030139394A1 (en)	2003-07-24
WO2003057699A1 (en)	2003-07-17
JP2005516031A (ja)	2005-06-02
DE60301725D1 (de)	2006-02-09

Publication	Publication Date	Title
NO20021379L (no)	2002-03-20	Benzodiazepin-derivater, fremstilling og anvendelse derav
BG105650A (en)	2002-02-28	Azepinoindole derivatives, the production and use thereof
DE602004008098D1 (de)	2007-09-20	Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
BR0313330A (pt)	2005-06-14	Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4
CY1106969T1 (el)	2012-09-26	Αναστολεις dpp-iv
DE60012188D1 (de)	2004-08-19	Fungizide
SE9900100D0 (sv)	1999-01-15	New compounds
CY1105410T1 (el)	2010-04-28	Υποκατεστημενες 2-φαινυλοβενζιμιδαζολες, η παρασκευη και η εφαρμογη τους
NO20070532L (no)	2007-01-29	Substituerte 2-alkyl-kinazolinonderivater som PARP-inhibitorer
NL1027811A1 (nl)	2005-06-21	Heterocyclische aminen als remmers 11- -hydroxy-steroïd-dehydrogenase type 1.
ATE345349T1 (de)	2006-12-15	Purinderivate
PE20030061A1 (es)	2003-02-08	1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4
BR0313385A (pt)	2005-06-14	Derivados de pirimidina-2,4-diona como inibidores de metaloproteinase da matriz
MY141011A (en)	2010-02-25	Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
DK1313740T3 (da)	2006-04-03	Prodrugs af imidazopyridinderivater
SE0203303D0 (sv)	2002-11-07	Novel Compounds
ATE359283T1 (de)	2007-05-15	Substituierte pyrazinonverbindungen zur behandlung von entzündungen
TR200201128T2 (tr)	2002-08-21	PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
EP1667976A4 (en)	2008-02-13	Isoquinolinone POTASSIUM CHANNEL INHIBITORS
ATE305472T1 (de)	2005-10-15	Dibenzodiazepin derivate, deren herstellung und verwendung
UY27587A1 (es)	2003-07-31	Heterociclos terapéuticos
GB0229081D0 (en)	2003-01-15	Multifunctional cationic photoinitiators, their preparation and use
SE0203300D0 (sv)	2002-11-07	Novel Compounds
SE0203302D0 (sv)	2002-11-07	Novel Compounds
EA200600601A1 (ru)	2006-10-27	Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы