DK146444C - Analogifremgangsmaade til fremstilling af 1-oxo-2,3-hydrocarbylen-5-indanyloxy-eddikesyrer eller salte deraf med baser - Google Patents

Analogifremgangsmaade til fremstilling af 1-oxo-2,3-hydrocarbylen-5-indanyloxy-eddikesyrer eller salte deraf med baser

Info

Publication number
DK146444C
DK146444C DK525773A DK525773A DK146444C DK 146444 C DK146444 C DK 146444C DK 525773 A DK525773 A DK 525773A DK 525773 A DK525773 A DK 525773A DK 146444 C DK146444 C DK 146444C
Authority
DK
Denmark
Prior art keywords
hydrocarbylen
indanyloxy
analogy
oxo
bases
Prior art date
Application number
DK525773A
Other languages
English (en)
Other versions
DK146444B (da
Inventor
Jr Edward Jethro Cragoe
Jr Otto William Woltersdorf
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA178,825A external-priority patent/CA1027581A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK146444B publication Critical patent/DK146444B/da
Application granted granted Critical
Publication of DK146444C publication Critical patent/DK146444C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK525773A 1972-10-13 1973-09-26 Analogifremgangsmaade til fremstilling af 1-oxo-2,3-hydrocarbylen-5-indanyloxy-eddikesyrer eller salte deraf med baser DK146444C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA153921 1972-10-13
CA153921 1972-10-13
CA178825 1973-08-28
CA178,825A CA1027581A (en) 1973-08-28 1973-08-28 (1-oxo-2,3-hydrocarbylene-5-indanyloxy (or thio)) alkanoic acids

Publications (2)

Publication Number Publication Date
DK146444B DK146444B (da) 1983-10-10
DK146444C true DK146444C (da) 1984-03-19

Family

ID=25667130

Family Applications (1)

Application Number Title Priority Date Filing Date
DK525773A DK146444C (da) 1972-10-13 1973-09-26 Analogifremgangsmaade til fremstilling af 1-oxo-2,3-hydrocarbylen-5-indanyloxy-eddikesyrer eller salte deraf med baser

Country Status (11)

Country Link
US (1) US3976686A (da)
JP (1) JPS581096B2 (da)
CH (1) CH605555A5 (da)
DE (1) DE2351411C2 (da)
DK (1) DK146444C (da)
ES (1) ES419506A1 (da)
FR (1) FR2202694B1 (da)
GB (1) GB1427090A (da)
HU (1) HU169581B (da)
NL (1) NL7314105A (da)
SE (1) SE412383B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4085219A (en) * 1972-10-13 1978-04-18 Merck & Co., Inc. 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids
DK0655992T3 (da) * 1993-06-18 1999-07-19 Otsuka Pharma Co Ltd Fluorenonderivater, fremgangsmåde til deres fremstilling samt regenererings- og beskyttelsesmiddel mod central eller perife
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
PE20151054A1 (es) 2012-12-17 2015-08-07 Parion Sciences Inc Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales
MX2015007797A (es) 2012-12-17 2015-10-05 Parion Sciences Inc Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
US9206151B2 (en) * 2013-11-20 2015-12-08 Transitions Optical, Inc. Method of preparing fused ring indeno compounds
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344742B (da) * 1968-09-25 1972-05-02 Ciba Geigy Ag
US3668241A (en) * 1968-11-25 1972-06-06 Merck & Co Inc Substituted 1-oxoinden-5-yloxy alkanoic acids
CH517688A (de) * 1969-07-09 1972-01-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Aryloxy-essigsäurederivaten
DE2208893A1 (de) * 1972-02-25 1973-08-30 Boehringer Mannheim Gmbh Tricyclische alpha-oxy-carbonsaeurederivate und verfahren zur herstellung derselben

Also Published As

Publication number Publication date
GB1427090A (en) 1976-03-03
DK146444B (da) 1983-10-10
DE2351411A1 (de) 1974-04-25
DE2351411C2 (de) 1983-04-21
ES419506A1 (es) 1976-12-16
JPS4993352A (da) 1974-09-05
FR2202694B1 (da) 1977-01-28
US3976686A (en) 1976-08-24
JPS581096B2 (ja) 1983-01-10
AU6096773A (en) 1975-04-10
FR2202694A1 (da) 1974-05-10
HU169581B (da) 1976-12-28
SE412383B (sv) 1980-03-03
CH605555A5 (da) 1978-09-29
NL7314105A (da) 1974-04-16

Similar Documents

Publication Publication Date Title
DK140895B (da) Analogifremgangsmåde til fremstilling af derivater af 7-(pyridyl)-1,4-dihydro-4-oxo-3-quinolincarboxylsyrer eller salte deraf.
DK137327B (da) Analogifremgangsmåde til fremstilling af olefiniske 4-substituerede piperidinoderivater eller salte deraf.
DK131725B (da) Analogifremgangsmåde til fremstilling af 2,4-diaminoquinazoliner eller salte deraf.
DK136157B (da) Analogifremgangsmåde til fremstilling af 3alfa-hydroxy-17beta-karboxylsyrederivater af androstanrækken eller salte deraf.
DK140461B (da) Analogifremgangsmåde til fremstilling af 8-azapurin-6-oner eller salte deraf.
DK128420B (da) Analogifremgangsmåde til fremstilling af thiachromon-2-carboxylsyrer eller salte deraf med baser.
DK138020B (da) Analogifremgangsmåde til fremstilling af pyrazolodiazepinforbindelser eller salte deraf.
DK140545B (da) Analogifremgangsmåde til fremstilling af benzoylphenylsmørsyrederivater eller salte deraf.
DK127926B (da) Fremgangsmåde til fremstilling af dibenzo[d,g][1,3]dioxocinsyrer eller salte heraf med baser.
DK123708B (da) Fremgangsmåde til fremstilling af polyencarboxylsyrer eller salte deraf.
DK140841B (da) Analogifremgangsmåde til fremstilling af isoquinolinderivater eller salte deraf.
DK138745B (da) Fremgangsmåde til fremstilling af cephalexin eller salte deraf.
DK131149B (da) Analogifremgangsmåde til fremstilling af 4-hydroxy-cinnolincarboxylsyrer eller salte deraf.
DK135504B (da) Analogifremgangsmåde til fremstilling af 6-substituerede 3-carbethoxyhydrazinopyridaziner eller salte deraf.
DK122809B (da) Analogifremgangsmåde til fremstilling af aminomethyl-bicyclo-carboxylsyrer eller salte heraf med syrer eller baser.
DK138449B (da) Fremgangsmåde til fremstilling af D(-)-penicillamin eller salte deraf.
DK136906B (da) Analogifremgangsmåde til fremstilling af dibenzoxyrenazepinderivater eller salte deraf.
DK131569B (da) Analogifremgangsmåde til fremstilling af 2-carboxy-4-oxo-4H,10H-(2)-benzopyrano-/4,3-g/-(1)-benzopyraner eller salte heraf med baser.
DK131724B (da) Analogifremgangsmåde til fremstilling af bis-(4,7-dihydroxykumarinyl-3)-eddikesyre eller salte heraf med baser.
DK138600B (da) Analogifremgangsmåde til fremstilling af succinimidobenzensulfonamider eller salte deraf med baser.
DK138651B (da) Analogifremgangsmåde til fremstilling af penicilliner eller salte eller estere deraf.
DK128244B (da) Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf med baser.
DK127432B (da) Analogifremgangsmåde til fremstilling af acylaminopenicillansyrer eller salte deraf.
DK136038B (da) Analogifremgangsmåde til fremstilling af substituerede quinoliner eller salte deraf.
DK144560C (da) Analogifremgangsmaade til fremstilling af (1-hydroxy-5-indanyloxy)eddikesyrer eller salte deraf med baser

Legal Events

Date Code Title Description
PBP Patent lapsed