DK146489A - Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider - Google Patents

Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider

Info

Publication number
DK146489A
DK146489A DK146489A DK146489A DK146489A DK 146489 A DK146489 A DK 146489A DK 146489 A DK146489 A DK 146489A DK 146489 A DK146489 A DK 146489A DK 146489 A DK146489 A DK 146489A
Authority
DK
Denmark
Prior art keywords
didehydronucleosides
dideoxy
preparing
Prior art date
Application number
DK146489A
Other languages
English (en)
Other versions
DK146489D0 (da
Inventor
Jr John E Starrett
Muzammil M Mansuri
John C Martin
Carl E Fuller
Henry G Howell
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK146489D0 publication Critical patent/DK146489D0/da
Publication of DK146489A publication Critical patent/DK146489A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK146489A 1988-03-24 1989-03-22 Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider DK146489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/173,473 US4904770A (en) 1988-03-24 1988-03-24 Production of 2',3'-dideoxy-2',3'-didehydronucleosides

Publications (2)

Publication Number Publication Date
DK146489D0 DK146489D0 (da) 1989-03-22
DK146489A true DK146489A (da) 1989-09-25

Family

ID=22632190

Family Applications (1)

Application Number Title Priority Date Filing Date
DK146489A DK146489A (da) 1988-03-24 1989-03-22 Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider

Country Status (14)

Country Link
US (1) US4904770A (da)
EP (1) EP0334368A3 (da)
JP (1) JPH02149595A (da)
KR (2) KR0140889B1 (da)
AU (1) AU622439B2 (da)
CA (1) CA1339448C (da)
DK (1) DK146489A (da)
EG (1) EG18661A (da)
FI (1) FI93111C (da)
IL (2) IL105573A (da)
NO (1) NO171367C (da)
NZ (1) NZ228390A (da)
PT (1) PT90099B (da)
ZA (1) ZA892166B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455339A (en) * 1986-05-01 1995-10-03 University Of Georgia Research Foundation, Inc. Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
JPH02152976A (ja) * 1988-05-06 1990-06-12 Bristol Myers Co ２´，３´―ジデヒドロ―２´，３´―ジデオキシヌクレオシドのプロドラッグ
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
US5200514A (en) * 1990-01-19 1993-04-06 University Of Georgia Research Foundation, Inc. Synthesis of 2'-deoxypyrimidine nucleosides
WO1992002516A1 (en) * 1990-07-27 1992-02-20 Japan Tobacco Inc. Process for producing 2',3'-dideoxy-2',3'-didehydronucleoside
US5166327A (en) * 1990-07-31 1992-11-24 Yuki Gosei Kogyo Co., Ltd. Process for producing 3'-deoxy-3-'-fluorothymidine
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
JP3042073B2 (ja) * 1991-06-19 2000-05-15 味の素株式会社 ヌクレオシド誘導体とその製造方法
HUT63852A (en) * 1991-06-21 1993-10-28 Acic Canada Inc Process for producing antiviral compounds and pharmaceutical compositions comprising same as active ingredient
FR2688003B1 (fr) * 1992-02-28 1995-06-30 Univ Limoges Derives de nucleosides, leur preparation et leurs applications biologiques.
US5506349A (en) * 1992-05-13 1996-04-09 Ribozyme Pharmaceuticals, Inc. Chemical synthesis of 2', 3'-dideoxycytidine
US5539099A (en) * 1993-11-15 1996-07-23 Bristol-Myers Squibb Company Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US6635753B1 (en) 1998-09-30 2003-10-21 Brantford Chemicals Inc. Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
IT1318463B1 (it) * 2000-04-12 2003-08-25 Archimica S P A Ora Clariant L Procedimento per la preparazione di 5'-acetilstavudina.
RU2003129164A (ru) * 2001-03-01 2005-03-20 Фармассет Лтд. (Bb) Способ синтеза 2`,3`-дидезокси-2`,3`-дидегидронуклеозидов
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US20050171126A1 (en) * 2003-12-26 2005-08-04 Ajinomoto Co., Inc. Process for the production of purine nucleoside compounds
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
EP2305696A3 (en) 2005-07-25 2011-10-12 Intermune, Inc. Macrocyclic inhibitors of Hepatitis C virus replication
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
CN101029068B (zh) * 2007-04-09 2010-06-23 陆咏 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法
HUE042327T2 (hu) 2011-08-30 2019-06-28 Astex Pharmaceuticals Inc Decitabin-származék készítmények
WO2014172264A1 (en) * 2013-04-16 2014-10-23 Bristol-Myers Squibb Company Method for producing festinavir using 5-methyluridine as starting material
WO2017004538A1 (en) 2015-07-02 2017-01-05 Otsuka Pharmaceutical Co., Ltd. Lyophilized pharmaceutical compositions
BR112020002280A2 (pt) 2017-08-03 2020-07-28 Otsuka Pharmaceutical Co., Ltd. composto farmacológico e métodos purificação do mesmo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3539550A (en) * 1967-01-23 1970-11-10 Syntex Corp Process for the preparation of 2'-halo-2'-deoxy pyrimidine nucleosides
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing

Also Published As

Publication number Publication date
EP0334368A3 (en) 1991-12-27
IL89693A (en) 1994-08-26
EG18661A (en) 1993-10-30
NO171367B (no) 1992-11-23
KR0142109B1 (en) 1998-07-01
FI93111C (fi) 1995-02-27
NO891208D0 (no) 1989-03-20
ZA892166B (en) 1992-02-26
FI891338A0 (fi) 1989-03-21
IL89693A0 (en) 1989-09-28
FI93111B (fi) 1994-11-15
NO171367C (no) 1993-03-03
CA1339448C (en) 1997-09-09
JPH02149595A (ja) 1990-06-08
NZ228390A (en) 1991-12-23
PT90099B (pt) 1994-07-29
FI891338L (fi) 1989-09-25
KR890014528A (ko) 1989-10-24
AU3167389A (en) 1989-09-28
IL105573A (en) 1994-04-12
EP0334368A2 (en) 1989-09-27
US4904770A (en) 1990-02-27
DK146489D0 (da) 1989-03-22
AU622439B2 (en) 1992-04-09
NO891208L (no) 1989-09-25
KR0140889B1 (en) 1998-06-15
PT90099A (pt) 1989-11-10

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Legal Events

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AHB Application shelved due to non-payment