DK1485345T3 - Urokinaseinhibitorer, deres fremstilling og anvendelse - Google Patents

Urokinaseinhibitorer, deres fremstilling og anvendelse

Info

Publication number
DK1485345T3
DK1485345T3 DK03714803T DK03714803T DK1485345T3 DK 1485345 T3 DK1485345 T3 DK 1485345T3 DK 03714803 T DK03714803 T DK 03714803T DK 03714803 T DK03714803 T DK 03714803T DK 1485345 T3 DK1485345 T3 DK 1485345T3
Authority
DK
Denmark
Prior art keywords
preparation
urokinase inhibitors
urokinase
inhibitors
tumor
Prior art date
Application number
DK03714803T
Other languages
English (en)
Inventor
Torsten Steinmetzer
Joerg Stuerzebecher
Andrea Schweinitz
Original Assignee
Curacyte Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002110592 external-priority patent/DE10210592A1/de
Application filed by Curacyte Ag filed Critical Curacyte Ag
Application granted granted Critical
Publication of DK1485345T3 publication Critical patent/DK1485345T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Epidemiology (AREA)
DK03714803T 2002-03-11 2003-03-11 Urokinaseinhibitorer, deres fremstilling og anvendelse DK1485345T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2002110592 DE10210592A1 (de) 2002-03-11 2002-03-11 Hemmstoffe der Urokinase, ihre Herstellung und Verwendung
DE10245059 2002-09-26
DE10261435 2002-12-28
PCT/EP2003/002489 WO2003076391A2 (de) 2002-03-11 2003-03-11 Hemmstoffe der urokinase, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
DK1485345T3 true DK1485345T3 (da) 2008-11-03

Family

ID=27808239

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03714803T DK1485345T3 (da) 2002-03-11 2003-03-11 Urokinaseinhibitorer, deres fremstilling og anvendelse

Country Status (9)

Country Link
US (2) US7838560B2 (da)
EP (1) EP1485345B1 (da)
JP (1) JP4898091B2 (da)
AT (1) ATE399175T1 (da)
AU (1) AU2003219039A1 (da)
CA (1) CA2478409C (da)
DE (1) DE50310038D1 (da)
DK (1) DK1485345T3 (da)
WO (1) WO2003076391A2 (da)

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DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
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DE102004045720A1 (de) * 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten
MX2007016439A (es) 2005-06-24 2008-03-04 Wilex Ag Uso de inhibidores de urocinasa para el tratamiento y/o prevencion de enfermedades neuropatologicas.
DE102005044319A1 (de) * 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
CN101835449A (zh) * 2007-08-31 2010-09-15 Dsmip资产有限公司 4-脒基苄胺用于美容和/或皮肤病学的用途
DE102009022794A1 (de) * 2009-05-27 2010-12-02 Philipps-Universität Marburg Verwendung von Hemmstoffen der HAT und TMPRSS2 als Arzneimittel
ES2483802T3 (es) 2010-07-07 2014-08-07 The Medicines Company (Leipzig) Gmbh Inhibidores de serina proteasa
EP2655399B1 (en) 2010-12-21 2017-09-27 The Medicines Company (Leipzig) GmbH Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors iia and xa
BR112015000621A2 (pt) 2012-07-12 2017-06-27 Dsm Ip Assets Bv composição cosmética compreendendo benzilsulfonil-d-ser-homophe-(4-amidino-benzilamida) e um poliálcool
RU2015148536A (ru) * 2013-04-12 2017-05-18 Торэй Индастриз, Инк. Антитромботический искусственный кровеносный сосуд
EP2960232A1 (en) 2014-06-25 2015-12-30 DSM IP Assets B.V. Process for the production of a dipeptide derivative

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DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
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Also Published As

Publication number Publication date
US20110065799A1 (en) 2011-03-17
EP1485345A2 (de) 2004-12-15
AU2003219039A1 (en) 2003-09-22
JP4898091B2 (ja) 2012-03-14
WO2003076391A2 (de) 2003-09-18
US8476306B2 (en) 2013-07-02
JP2005526762A (ja) 2005-09-08
CA2478409A1 (en) 2003-09-18
DE50310038D1 (de) 2008-08-07
US7838560B2 (en) 2010-11-23
WO2003076391A3 (de) 2004-01-22
US20050176993A1 (en) 2005-08-11
CA2478409C (en) 2012-07-31
ATE399175T1 (de) 2008-07-15
EP1485345B1 (de) 2008-06-25

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