DK1485345T3 - Urokinaseinhibitorer, deres fremstilling og anvendelse - Google Patents

Urokinaseinhibitorer, deres fremstilling og anvendelse

Info

Publication number
DK1485345T3
DK1485345T3 DK03714803T DK03714803T DK1485345T3 DK 1485345 T3 DK1485345 T3 DK 1485345T3 DK 03714803 T DK03714803 T DK 03714803T DK 03714803 T DK03714803 T DK 03714803T DK 1485345 T3 DK1485345 T3 DK 1485345T3
Authority
DK
Denmark
Prior art keywords
preparation
urokinase inhibitors
urokinase
inhibitors
tumor
Prior art date
Application number
DK03714803T
Other languages
English (en)
Inventor
Torsten Steinmetzer
Joerg Stuerzebecher
Andrea Schweinitz
Original Assignee
Curacyte Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002110592 external-priority patent/DE10210592A1/de
Application filed by Curacyte Ag filed Critical Curacyte Ag
Application granted granted Critical
Publication of DK1485345T3 publication Critical patent/DK1485345T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK03714803T 2002-03-11 2003-03-11 Urokinaseinhibitorer, deres fremstilling og anvendelse DK1485345T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2002110592 DE10210592A1 (de) 2002-03-11 2002-03-11 Hemmstoffe der Urokinase, ihre Herstellung und Verwendung
DE10245059 2002-09-26
DE10261435 2002-12-28
PCT/EP2003/002489 WO2003076391A2 (de) 2002-03-11 2003-03-11 Hemmstoffe der urokinase, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
DK1485345T3 true DK1485345T3 (da) 2008-11-03

Family

ID=27808239

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03714803T DK1485345T3 (da) 2002-03-11 2003-03-11 Urokinaseinhibitorer, deres fremstilling og anvendelse

Country Status (9)

Country Link
US (2) US7838560B2 (da)
EP (1) EP1485345B1 (da)
JP (1) JP4898091B2 (da)
AT (1) ATE399175T1 (da)
AU (1) AU2003219039A1 (da)
CA (1) CA2478409C (da)
DE (1) DE50310038D1 (da)
DK (1) DK1485345T3 (da)
WO (1) WO2003076391A2 (da)

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DE10301300B4 (de) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
AU2005204428A1 (en) * 2004-01-07 2005-07-28 Ambit Biosciences Corporation Conjugated small molecules
DE102004045720A1 (de) * 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten
MX2007016439A (es) 2005-06-24 2008-03-04 Wilex Ag Uso de inhibidores de urocinasa para el tratamiento y/o prevencion de enfermedades neuropatologicas.
DE102005044319A1 (de) * 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
CN101835449A (zh) * 2007-08-31 2010-09-15 Dsmip资产有限公司 4-脒基苄胺用于美容和/或皮肤病学的用途
DE102009022794A1 (de) * 2009-05-27 2010-12-02 Philipps-Universität Marburg Verwendung von Hemmstoffen der HAT und TMPRSS2 als Arzneimittel
WO2012004678A2 (en) 2010-07-07 2012-01-12 The Medicines Company (Leipzig) Gmbh Serine protease inhibitors
ES2654440T3 (es) 2010-12-21 2018-02-13 The Medicines Company (Leipzig) Gmbh Inhibidores de serina proteasa de tipo tripsina, su preparación y uso como inhibidores selectivos de los factores de coagulación IIa y Xa
EP2872110A2 (en) 2012-07-12 2015-05-20 DSM IP Assets B.V. Cosmetic composition comprising benzylsulfonyl-d-ser-homophe-(4-amidino-benzylamide) and a polyalcohol
JPWO2014168197A1 (ja) * 2013-04-12 2017-02-16 東レ株式会社 抗血栓性を有する人工血管
EP2960232A1 (en) 2014-06-25 2015-12-30 DSM IP Assets B.V. Process for the production of a dipeptide derivative

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DE4243858A1 (de) 1992-12-23 1994-06-30 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH07509731A (ja) 1993-02-10 1995-10-26 ペンタファルム　アクチェンゲゼルシャフト トロンビン阻害剤としての置換されたフェニルアラニン誘導体のピペラジド
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DE102005044319A1 (de) * 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
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Also Published As

Publication number Publication date
JP4898091B2 (ja) 2012-03-14
CA2478409C (en) 2012-07-31
WO2003076391A3 (de) 2004-01-22
JP2005526762A (ja) 2005-09-08
ATE399175T1 (de) 2008-07-15
EP1485345A2 (de) 2004-12-15
AU2003219039A1 (en) 2003-09-22
DE50310038D1 (de) 2008-08-07
WO2003076391A2 (de) 2003-09-18
US20110065799A1 (en) 2011-03-17
CA2478409A1 (en) 2003-09-18
US20050176993A1 (en) 2005-08-11
US8476306B2 (en) 2013-07-02
US7838560B2 (en) 2010-11-23
EP1485345B1 (de) 2008-06-25

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