DK1485345T3 - Urokinaseinhibitorer, deres fremstilling og anvendelse - Google Patents

Urokinaseinhibitorer, deres fremstilling og anvendelse

Info

Publication number
DK1485345T3
DK1485345T3 DK03714803T DK03714803T DK1485345T3 DK 1485345 T3 DK1485345 T3 DK 1485345T3 DK 03714803 T DK03714803 T DK 03714803T DK 03714803 T DK03714803 T DK 03714803T DK 1485345 T3 DK1485345 T3 DK 1485345T3
Authority
DK
Denmark
Prior art keywords
preparation
urokinase inhibitors
urokinase
inhibitors
tumor
Prior art date
Application number
DK03714803T
Other languages
English (en)
Inventor
Torsten Steinmetzer
Joerg Stuerzebecher
Andrea Schweinitz
Original Assignee
Curacyte Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002110592 external-priority patent/DE10210592A1/de
Application filed by Curacyte Ag filed Critical Curacyte Ag
Application granted granted Critical
Publication of DK1485345T3 publication Critical patent/DK1485345T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epidemiology (AREA)
DK03714803T 2002-03-11 2003-03-11 Urokinaseinhibitorer, deres fremstilling og anvendelse DK1485345T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2002110592 DE10210592A1 (de) 2002-03-11 2002-03-11 Hemmstoffe der Urokinase, ihre Herstellung und Verwendung
DE10245059 2002-09-26
DE10261435 2002-12-28
PCT/EP2003/002489 WO2003076391A2 (de) 2002-03-11 2003-03-11 Hemmstoffe der urokinase, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
DK1485345T3 true DK1485345T3 (da) 2008-11-03

Family

ID=27808239

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03714803T DK1485345T3 (da) 2002-03-11 2003-03-11 Urokinaseinhibitorer, deres fremstilling og anvendelse

Country Status (9)

Country Link
US (2) US7838560B2 (da)
EP (1) EP1485345B1 (da)
JP (1) JP4898091B2 (da)
AT (1) ATE399175T1 (da)
AU (1) AU2003219039A1 (da)
CA (1) CA2478409C (da)
DE (1) DE50310038D1 (da)
DK (1) DK1485345T3 (da)
WO (1) WO2003076391A2 (da)

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DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
US20050153371A1 (en) * 2004-01-07 2005-07-14 Ambit Biosciences Corporation Conjugated small molecules
DE102004045720A1 (de) * 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten
MX2007016439A (es) 2005-06-24 2008-03-04 Wilex Ag Uso de inhibidores de urocinasa para el tratamiento y/o prevencion de enfermedades neuropatologicas.
DE102005044319A1 (de) * 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
WO2009026949A1 (en) * 2007-08-31 2009-03-05 Dsm Ip Assets B.V. 4-amidino benzylamines for cosmetic and/or dermatological use
DE102009022794A1 (de) * 2009-05-27 2010-12-02 Philipps-Universität Marburg Verwendung von Hemmstoffen der HAT und TMPRSS2 als Arzneimittel
EP2590945B1 (en) 2010-07-07 2014-04-30 The Medicines Company (Leipzig) GmbH Serine protease inhibitors
EP2655399B1 (en) 2010-12-21 2017-09-27 The Medicines Company (Leipzig) GmbH Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors iia and xa
EP2872110A2 (en) 2012-07-12 2015-05-20 DSM IP Assets B.V. Cosmetic composition comprising benzylsulfonyl-d-ser-homophe-(4-amidino-benzylamide) and a polyalcohol
EP2985041B1 (en) * 2013-04-12 2017-07-19 Toray Industries, Inc. Antithrombotic artificial blood vessel
EP2960232A1 (en) 2014-06-25 2015-12-30 DSM IP Assets B.V. Process for the production of a dipeptide derivative

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CA2073776A1 (en) 1990-11-15 1992-05-16 Joerg Stuerzebecher Meta-substituted phenyl alanine derivatives
DE4243858A1 (de) 1992-12-23 1994-06-30 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
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CZ245797A3 (cs) 1995-02-17 1998-06-17 Basf Aktiengesellschaft Derivát amidinu dipeptidu jako inhibitor thrombinu
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CH689611A5 (de) 1995-03-01 1999-07-15 Pentapharm Ag Urokinase-Inhibitoren.
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NZ506507A (en) * 1998-02-09 2003-08-29 Dimensional Pharm Inc Heteroaryl amidine, methylamidine or guanidine derivatives useful as urokinase inhibitors
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ATE517910T1 (de) 2000-08-11 2011-08-15 Wilex Ag NICHT-KOVALENTE INHIBITOREN VON UROKINASE UND BLUTGEFÄßBILDUNG
JP2004516286A (ja) 2000-12-18 2004-06-03 メルク エンド カムパニー インコーポレーテッド ベンジルアミン誘導体およびそれのトロンビン阻害薬としての使用
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DE10322191B4 (de) 2003-05-16 2014-02-27 The Medicines Company (Leipzig) Gmbh N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
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DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
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Also Published As

Publication number Publication date
US20050176993A1 (en) 2005-08-11
CA2478409A1 (en) 2003-09-18
AU2003219039A1 (en) 2003-09-22
JP2005526762A (ja) 2005-09-08
JP4898091B2 (ja) 2012-03-14
CA2478409C (en) 2012-07-31
ATE399175T1 (de) 2008-07-15
DE50310038D1 (de) 2008-08-07
EP1485345A2 (de) 2004-12-15
WO2003076391A2 (de) 2003-09-18
US8476306B2 (en) 2013-07-02
EP1485345B1 (de) 2008-06-25
US20110065799A1 (en) 2011-03-17
US7838560B2 (en) 2010-11-23
WO2003076391A3 (de) 2004-01-22

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