DK149201C - Fremgangsmaade til rensning af insulin, dets analoge og derivater - Google Patents

Fremgangsmaade til rensning af insulin, dets analoge og derivater

Info

Publication number: DK149201C
Authority: DK; Denmark
Prior art keywords: analogue; derivatives; procedure; purifying insulin; insulin
Prior art date: 1976-07-01

Application number

DK293277A

Other languages

Danish (da)

English (en)

Other versions

DK293277A (da

DK149201B (da

Inventor

Manfred Zoltobrocki

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-07-01

Filing date

1977-06-30

Publication date

1986-08-04

1977-06-30 Application filed by Hoechst Ag filed Critical Hoechst Ag

1978-01-02 Publication of DK293277A publication Critical patent/DK293277A/da

1986-03-10 Publication of DK149201B publication Critical patent/DK149201B/da

1986-08-04 Application granted granted Critical

1986-08-04 Publication of DK149201C publication Critical patent/DK149201C/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/32—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from hydrolysates of wood or straw
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/854—Glands

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Polymers & Plastics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Botany (AREA)
Mycology (AREA)
Physiology (AREA)
Animal Husbandry (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK293277A 1976-07-01 1977-06-30 Fremgangsmaade til rensning af insulin, dets analoge og derivater DK149201C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2629568A DE2629568C3 (de)	1976-07-01	1976-07-01	Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
DE2629568		1976-07-01

Publications (3)

Publication Number	Publication Date
DK293277A DK293277A (da)	1978-01-02
DK149201B DK149201B (da)	1986-03-10
DK149201C true DK149201C (da)	1986-08-04

Family

ID=5981950

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK293277A DK149201C (da)	1976-07-01	1977-06-30	Fremgangsmaade til rensning af insulin, dets analoge og derivater

Country Status (22)

Country	Link
US (1)	US4129560A (de)
JP (1)	JPS535101A (de)
AT (1)	AT352922B (de)
AU (1)	AU509110B2 (de)
BE (1)	BE856385A (de)
CA (1)	CA1086308A (de)
CH (1)	CH626051A5 (de)
DE (1)	DE2629568C3 (de)
DK (1)	DK149201C (de)
ES (1)	ES460099A1 (de)
FI (1)	FI61490C (de)
FR (1)	FR2356630A1 (de)
GB (1)	GB1582056A (de)
GR (1)	GR78333B (de)
IE (1)	IE44766B1 (de)
IT (1)	IT1080658B (de)
NL (1)	NL188804C (de)
NO (1)	NO145692C (de)
NZ (1)	NZ184516A (de)
PT (1)	PT66751B (de)
SE (1)	SE440507B (de)
ZA (1)	ZA773964B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4701521A (en) *	1978-07-17	1987-10-20	The Trustees Of Boston University	Method of effecting cellular uptake of molecules
US4783441A (en) *	1979-04-30	1988-11-08	Hoechst Aktiengesellschaft	Aqueous protein solutions stable to denaturation
US4292041A (en) *	1979-11-02	1981-09-29	Merck & Co., Inc.	Surfactant assay
US4459226A (en) *	1982-02-26	1984-07-10	Eli Lilly And Company	Process for recovering insulin
US4839341A (en) *	1984-05-29	1989-06-13	Eli Lilly And Company	Stabilized insulin formulations
DE3511269A1 (de) *	1985-04-12	1986-10-09	Veb Berlin-Chemie, Ddr 1199 Berlin	Verfahren zur reinigung von insulin
JPS6230956A (ja) *	1985-07-31	1987-02-09	Sumitomo Chem Co Ltd	合成ペプチド類に含有されるイオン類の分析法
DE3726655A1 (de) *	1987-08-11	1989-02-23	Hoechst Ag	Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
JPH07119767B2 (ja) *	1989-03-07	1995-12-20	積水化学工業株式会社	梅毒検査用試薬及びその製造法
DE4028120C2 (de) *	1990-09-05	1996-09-19	Hoechst Ag	Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
SG44748A1 (en) *	1991-12-18	1997-12-19	Hoechst Ag	Process for obtaining insulin-containing solutions
US6451987B1 (en)	1999-03-15	2002-09-17	Novo Nordisk A/S	Ion exchange chromatography of proteins and peptides
US6444788B1 (en) *	1999-03-15	2002-09-03	Novo Nordisk A/S	Ion exchange chromatography of GLP-1, analogs and derivatives thereof
AU2004266757A1 (en) *	2003-08-21	2005-03-03	Novo Nordisk A/S	Separation of polypeptides comprising a racemized amino acid
US20080096800A1 (en) *	2004-03-12	2008-04-24	Biodel, Inc.	Rapid mucosal gel or film insulin compositions
US20080090753A1 (en)	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
US20080085298A1 (en) *	2004-03-12	2008-04-10	Biodel, Inc.	Rapid Mucosal Gel or Film Insulin Compositions
US7713929B2 (en) *	2006-04-12	2010-05-11	Biodel Inc.	Rapid acting and long acting insulin combination formulations
US8084420B2 (en)	2005-09-29	2011-12-27	Biodel Inc.	Rapid acting and long acting insulin combination formulations
CA2649109A1 (en)	2006-04-12	2007-10-25	Biodel, Inc.	Rapid acting and long acting insulin combination formulations
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
JP6110312B2 (ja)	2011-02-01	2017-04-05	ノヴォノルディスクアー／エス	インスリンの精製
RU2014108241A (ru)	2011-08-25	2015-09-27	Ф.Хоффманн-Ля Рош Аг	Способ катион- и анионобменной хроматографии
PL2748181T3 (pl) *	2011-09-30	2016-08-31	Ge Healthcare Bioprocess R&D Ab	Sposób oczyszczania rozszczepionej proinsuliny
CN103130868B (zh) *	2013-03-12	2014-09-17	合肥天麦生物科技发展有限公司	一种蛋白质或多肽的纯化方法
EP3171888B1 (de)	2014-07-21	2022-12-28	Merck Sharp & Dohme LLC	Chromatographieverfahren zur reinigung von insulin und insulinanaloga
KR20200080748A (ko) *	2018-12-27	2020-07-07	주식회사 폴루스	음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3616235A (en) *	1968-05-16	1971-10-26	Forsch Die Garungsindustrie En	Process for precipitating enzymes and enzymatic inactive proteins in solution with synthetic tanning materials
US3607858A (en) *	1970-03-31	1971-09-21	American Cyanamid Co	Process for preparing lyophilized human blood proteins such as gamma globulin in the presence of a nonionic surfactant
US3683939A (en) *	1970-05-28	1972-08-15	Wilson Pharm & Chem Corp	Proteinaceous cosmetic material for hair conditioning
US3907676A (en) *	1970-07-28	1975-09-23	Novo Terapeutisk Labor As	Process for purifying insulin
JPS5328989B2 (de) *	1974-05-27	1978-08-17
US4076800A (en) *	1975-01-13	1978-02-28	The Procter & Gamble Company	Protein-containing detergent compositions for protecting keratinous materials

1976
- 1976-07-01 DE DE2629568A patent/DE2629568C3/de not_active Expired
1977
- 1977-06-24 NL NLAANVRAGE7707037,A patent/NL188804C/xx not_active IP Right Cessation
- 1977-06-25 ES ES460099A patent/ES460099A1/es not_active Expired
- 1977-06-28 GR GR53823A patent/GR78333B/el unknown
- 1977-06-28 CH CH792577A patent/CH626051A5/de not_active IP Right Cessation
- 1977-06-29 NZ NZ184516A patent/NZ184516A/xx unknown
- 1977-06-29 US US05/810,979 patent/US4129560A/en not_active Expired - Lifetime
- 1977-06-29 IT IT25221/77A patent/IT1080658B/it active
- 1977-06-29 FI FI772023A patent/FI61490C/fi not_active IP Right Cessation
- 1977-06-30 CA CA000281825A patent/CA1086308A/en not_active Expired
- 1977-06-30 AU AU26604/77A patent/AU509110B2/en not_active Expired
- 1977-06-30 DK DK293277A patent/DK149201C/da not_active IP Right Cessation
- 1977-06-30 NO NO772318A patent/NO145692C/no unknown
- 1977-06-30 ZA ZA00773964A patent/ZA773964B/xx unknown
- 1977-06-30 PT PT66751A patent/PT66751B/de unknown
- 1977-06-30 AT AT466377A patent/AT352922B/de not_active IP Right Cessation
- 1977-06-30 SE SE7707612A patent/SE440507B/xx not_active IP Right Cessation
- 1977-06-30 GB GB27395/77A patent/GB1582056A/en not_active Expired
- 1977-06-30 IE IE1358/77A patent/IE44766B1/en not_active IP Right Cessation
- 1977-07-01 BE BE179012A patent/BE856385A/xx not_active IP Right Cessation
- 1977-07-01 JP JP7797677A patent/JPS535101A/ja active Granted
- 1977-07-01 FR FR7720310A patent/FR2356630A1/fr active Granted

Also Published As

Publication number	Publication date
BE856385A (fr)	1978-01-02
FR2356630A1 (fr)	1978-01-27
DE2629568A1 (de)	1978-01-12
DK293277A (da)	1978-01-02
SE7707612L (sv)	1978-01-02
NL188804C (nl)	1992-10-01
NO772318L (no)	1978-01-03
GB1582056A (en)	1980-12-31
CH626051A5 (de)	1981-10-30
FI61490C (fi)	1982-08-10
AU2660477A (en)	1979-01-04
SE440507B (sv)	1985-08-05
PT66751B (de)	1979-01-22
FI61490B (fi)	1982-04-30
NZ184516A (en)	1979-10-25
ATA466377A (de)	1979-03-15
DE2629568B2 (de)	1980-09-04
GR78333B (de)	1984-09-26
DE2629568C3 (de)	1981-09-10
AT352922B (de)	1979-10-10
NO145692C (no)	1982-05-12
IE44766L (en)	1978-01-01
NL7707037A (nl)	1978-01-03
ES460099A1 (es)	1978-05-01
CA1086308A (en)	1980-09-23
FI772023A7 (de)	1978-01-02
AU509110B2 (en)	1980-04-17
ZA773964B (en)	1978-05-30
IT1080658B (it)	1985-05-16
IE44766B1 (en)	1982-03-24
US4129560A (en)	1978-12-12
NO145692B (no)	1982-02-01
JPS535101A (en)	1978-01-18
FR2356630B1 (de)	1983-10-07
NL188804B (nl)	1992-05-06
JPS6126560B2 (de)	1986-06-20
DK149201B (da)	1986-03-10
PT66751A (de)	1977-07-01

Legal Events

Date	Code	Title	Description
1997-08-04	PUP	Patent expired

Publication	Publication Date	Title
DK149201C (da)	1986-08-04	Fremgangsmaade til rensning af insulin, dets analoge og derivater
DK59677A (da)	1977-08-14	Fremgangsmade til fremstilling af prolinderivater og dermed beslegtede forbindelser
NO760935L (no)	1977-07-06	Tr}dgitter for byggeelement, samt fremgangsm}te og apparat for dets fremstilling.
DK421879A (da)	1980-04-23	Formstofnet og fremgangsmaade til fremstilling af dette
DK101078A (da)	1978-09-09	Falleroer og fremgangsmaade til fremstilling af samme
DK421979A (da)	1980-04-17	Formstofnet og fremgangsmaade til fremstilling af dette
DK334577A (da)	1978-02-07	Prostansyrederivat og fremgangsmade til dets fremstilling
DK301077A (da)	1978-01-07	Fremgangsmade til fremstilling af 6a,10a-transhexahydrodibenzo (b,d) pyran-9-oner
NO152975C (no)	1985-12-27	Glyceroloksydase og fremgangsmaate til fremstilling derav.
DK275178A (da)	1978-12-21	Fremgangsmaade til fremstilling af lipopeptider og anvendelse deraf
DK559977A (da)	1978-06-17	Apparat til levering af afgroede
DK547476A (da)	1977-06-25	Aktivt carbon og fremgangsmade til fremstilling af samme
DK160726C (da)	1991-09-23	Ribberoer og apparat til dets fremstilling.
DK313878A (da)	1979-01-14	Indolderivater og fremgangsmaade til fremstilling deraf
DK263175A (da)	1975-12-13	Fremgangsmade til fremstilling af insulin, insulinanaloge og -derivater
DK191476A (da)	1976-10-31	Fremgangsmade til fremstilling af et termoelement, derefter fremstillet termoelement og dets anvendelse
NL7803734A (nl)	1978-10-10	Kwartsresonator.
DK255577A (da)	1977-12-11	Fremgangsmade til fremstilling af 3,4-dihydro-2-methyl-4-oxo-2h-1,2-benzothiazin-3-carboxylsyre1,1-dioxid og dets anvendelse som mellemprodukt
NO147418C (no)	1983-04-06	Sementblanding, fremgangsmaate ved fremstilling og anvendelse derav.
DK162648C (da)	1992-04-13	3beta,25-dihydroxy-24-oxocholest-5-en-derivater og fremgangsmaade til fremstilling heraf
DK270077A (da)	1977-12-22	6,7-benzomorphanderivater og fremgangsmade til deres fremstillling
DK143907C (da)	1982-05-24	Fremgangsmaade til fremstilling af antibiotikumet lysolipin,dets komponenter i og x og acylderivater deraf
DK478077A (da)	1978-04-29	Fremgangsmaade til fremstilling af fortimicin-faktorerne d og ke
DK248878A (da)	1978-12-07	Deuterede 1,1,-difluor-2,2-dihalogenethyl-difluormethylethere og fremgangsmaade til fremstilling deraf
NL7804907A (nl)	1978-11-13	Nieuwe chromeenderivaten, werkwijze ter bereiding daar- van en therapeutische preparaten.