DK1497250T3 - Hyperforinderivater, anvendelse heraf og sammensætninger indeholdende disse - Google Patents

Hyperforinderivater, anvendelse heraf og sammensætninger indeholdende disse

Info

Publication number
DK1497250T3
DK1497250T3 DK03718778T DK03718778T DK1497250T3 DK 1497250 T3 DK1497250 T3 DK 1497250T3 DK 03718778 T DK03718778 T DK 03718778T DK 03718778 T DK03718778 T DK 03718778T DK 1497250 T3 DK1497250 T3 DK 1497250T3
Authority
DK
Denmark
Prior art keywords
compositions containing
hyperforin
hyperforin derivatives
derivatives
adhyperforin
Prior art date
Application number
DK03718778T
Other languages
English (en)
Inventor
Ezio Bombardelli
Paolo Morazzoni
Antonella Riva
Nicola Fuzzati
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK1497250T3 publication Critical patent/DK1497250T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Lasers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK03718778T 2002-04-23 2003-04-18 Hyperforinderivater, anvendelse heraf og sammensætninger indeholdende disse DK1497250T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000872A ITMI20020872A1 (it) 2002-04-23 2002-04-23 Derivati dell'iperforina loro uso e formulazioni che li contengono
PCT/EP2003/004100 WO2003091194A1 (en) 2002-04-23 2003-04-18 Hyperforin derivatives, the use thereof and formulations containing them

Publications (1)

Publication Number Publication Date
DK1497250T3 true DK1497250T3 (da) 2008-12-01

Family

ID=11449767

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03718778T DK1497250T3 (da) 2002-04-23 2003-04-18 Hyperforinderivater, anvendelse heraf og sammensætninger indeholdende disse

Country Status (18)

Country Link
US (2) USRE43280E1 (da)
EP (1) EP1497250B1 (da)
JP (1) JP4315818B2 (da)
KR (1) KR100944052B1 (da)
CN (1) CN1290816C (da)
AT (1) ATE404519T1 (da)
CA (1) CA2483205C (da)
DE (1) DE60322871D1 (da)
DK (1) DK1497250T3 (da)
ES (1) ES2311697T3 (da)
IL (1) IL164763A (da)
IT (1) ITMI20020872A1 (da)
NO (1) NO329176B1 (da)
PL (1) PL205829B1 (da)
PT (1) PT1497250E (da)
RU (1) RU2320636C2 (da)
SI (1) SI1497250T1 (da)
WO (1) WO2003091194A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102772461B (zh) * 2011-05-11 2014-05-14 成都康弘药业集团股份有限公司 药物组合物在制备预防或治疗老年性痴呆的药物中的应用
KR20140041610A (ko) * 2011-06-03 2014-04-04 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 하이퍼포린 유사체, 합성 방법 및 그의 용도
ITMI20131012A1 (it) * 2013-06-19 2014-12-20 Indena Spa Derivati dell'iperforina e loro uso nella malattia di alzheimer
US20180071269A1 (en) 2015-08-12 2018-03-15 Tianxin Wang Therapeutical methods, formulations and nutraceutical formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041220A1 (de) 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Stabile hyperforin-salze, verfahren zu ihrer herstellung und verwendung zur therapie der alzheimerschen krankheit
CA2320154A1 (en) * 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Use of hyperforin and hyperforin-containing extracts for the treatment and prophylaxis of dementia diseases
IT1301679B1 (it) 1998-06-10 2000-07-07 Indena Spa Derivati dell'iperforina, loro uso e formulazioni che licontengono.

Also Published As

Publication number Publication date
KR100944052B1 (ko) 2010-02-24
IL164763A0 (en) 2005-12-18
HK1075654A1 (en) 2005-12-23
EP1497250B1 (en) 2008-08-13
PL205829B1 (pl) 2010-05-31
CN1290816C (zh) 2006-12-20
SI1497250T1 (sl) 2008-12-31
JP4315818B2 (ja) 2009-08-19
NO329176B1 (no) 2010-09-06
US20050165117A1 (en) 2005-07-28
KR20040111519A (ko) 2004-12-31
USRE43280E1 (en) 2012-03-27
CA2483205C (en) 2011-07-05
PL371347A1 (en) 2005-06-13
AU2003222828A1 (en) 2003-11-10
US7105705B2 (en) 2006-09-12
ES2311697T3 (es) 2009-02-16
ATE404519T1 (de) 2008-08-15
EP1497250A1 (en) 2005-01-19
RU2320636C2 (ru) 2008-03-27
PT1497250E (pt) 2008-11-12
CN1646462A (zh) 2005-07-27
ITMI20020872A0 (it) 2002-04-23
JP2005523917A (ja) 2005-08-11
CA2483205A1 (en) 2003-11-06
WO2003091194A1 (en) 2003-11-06
ITMI20020872A1 (it) 2003-10-23
DE60322871D1 (de) 2008-09-25
NO20044519L (no) 2004-11-02
RU2004131210A (ru) 2005-04-10
IL164763A (en) 2010-02-17

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