NO20044519L - Hyperforinderivater, anvendelse derav samt formuleringer som inneholder dem - Google Patents
Hyperforinderivater, anvendelse derav samt formuleringer som inneholder demInfo
- Publication number
- NO20044519L NO20044519L NO20044519A NO20044519A NO20044519L NO 20044519 L NO20044519 L NO 20044519L NO 20044519 A NO20044519 A NO 20044519A NO 20044519 A NO20044519 A NO 20044519A NO 20044519 L NO20044519 L NO 20044519L
- Authority
- NO
- Norway
- Prior art keywords
- formulations containing
- hyperforin
- hyperforin derivatives
- derivatives
- adhyperforin
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 1
- 150000002448 hyperforins Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- MGKCAFQXBAFOSW-ACJQSPJVSA-N O=C1C(CC=C(C)C)=C(O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)CC)C2=O Chemical compound O=C1C(CC=C(C)C)=C(O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)CC)C2=O MGKCAFQXBAFOSW-ACJQSPJVSA-N 0.000 abstract 1
- RIISSLSXWPTKFE-UHFFFAOYSA-N adhyperforin Natural products CCC(C)C(=O)C12CC(CC=C(C)C)(CC(CC=C(C)C)C1CCC=C(C)C)C(=C(CC=C(C)C)C2=O)O RIISSLSXWPTKFE-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- IWBJJCOKGLUQIZ-HQKKAZOISA-N hyperforin Chemical compound OC1=C(CC=C(C)C)C(=O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)C)C2=O IWBJJCOKGLUQIZ-HQKKAZOISA-N 0.000 abstract 1
- QOVWXXKVLJOKNW-UHFFFAOYSA-N hyperforin Natural products CC(C)C(=O)C12CC(CC=C(C)C)(CC(CC=C(C)C)C1CCC=C(C)C)C(=C(CC=C(C)C)C2=O)O QOVWXXKVLJOKNW-UHFFFAOYSA-N 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
- C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
- C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Semiconductor Lasers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000872A ITMI20020872A1 (it) | 2002-04-23 | 2002-04-23 | Derivati dell'iperforina loro uso e formulazioni che li contengono |
| PCT/EP2003/004100 WO2003091194A1 (en) | 2002-04-23 | 2003-04-18 | Hyperforin derivatives, the use thereof and formulations containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20044519L true NO20044519L (no) | 2004-11-02 |
| NO329176B1 NO329176B1 (no) | 2010-09-06 |
Family
ID=11449767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20044519A NO329176B1 (no) | 2002-04-23 | 2004-10-21 | Hyperforinderivater, anvendelse derav samt formuleringer som inneholder dem |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7105705B2 (no) |
| EP (1) | EP1497250B1 (no) |
| JP (1) | JP4315818B2 (no) |
| KR (1) | KR100944052B1 (no) |
| CN (1) | CN1290816C (no) |
| AT (1) | ATE404519T1 (no) |
| CA (1) | CA2483205C (no) |
| DE (1) | DE60322871D1 (no) |
| DK (1) | DK1497250T3 (no) |
| ES (1) | ES2311697T3 (no) |
| IL (1) | IL164763A (no) |
| IT (1) | ITMI20020872A1 (no) |
| NO (1) | NO329176B1 (no) |
| PL (1) | PL205829B1 (no) |
| PT (1) | PT1497250E (no) |
| RU (1) | RU2320636C2 (no) |
| SI (1) | SI1497250T1 (no) |
| WO (1) | WO2003091194A1 (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772461B (zh) * | 2011-05-11 | 2014-05-14 | 成都康弘药业集团股份有限公司 | 药物组合物在制备预防或治疗老年性痴呆的药物中的应用 |
| BR112013030986A2 (pt) | 2011-06-03 | 2016-12-06 | Harvard College | análogos de hiperforina, métodos de síntese e usos dos mesmos |
| ITMI20131012A1 (it) * | 2013-06-19 | 2014-12-20 | Indena Spa | Derivati dell'iperforina e loro uso nella malattia di alzheimer |
| US20180071269A1 (en) | 2015-08-12 | 2018-03-15 | Tianxin Wang | Therapeutical methods, formulations and nutraceutical formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6322824B1 (en) | 1998-02-13 | 2001-11-27 | Willmar Schwabe Gmbh & Co. | Use of hyperforin and hyperforin-containing extracts in the treatment of dementia diseases |
| CA2320091A1 (en) * | 1998-02-13 | 1999-08-19 | Dr. Willmar Schwabe Gmbh & Co. | Stable hyperforin salts, methods of manufacturing them, and their use for the treatment of alzheimer's disease |
| IT1301679B1 (it) | 1998-06-10 | 2000-07-07 | Indena Spa | Derivati dell'iperforina, loro uso e formulazioni che licontengono. |
-
2002
- 2002-04-23 IT IT2002MI000872A patent/ITMI20020872A1/it unknown
-
2003
- 2003-04-18 US US10/512,067 patent/US7105705B2/en not_active Ceased
- 2003-04-18 PL PL371347A patent/PL205829B1/pl unknown
- 2003-04-18 DE DE60322871T patent/DE60322871D1/de not_active Expired - Lifetime
- 2003-04-18 EP EP03718778A patent/EP1497250B1/en not_active Expired - Lifetime
- 2003-04-18 SI SI200331386T patent/SI1497250T1/sl unknown
- 2003-04-18 US US12/896,158 patent/USRE43280E1/en not_active Expired - Fee Related
- 2003-04-18 PT PT03718778T patent/PT1497250E/pt unknown
- 2003-04-18 ES ES03718778T patent/ES2311697T3/es not_active Expired - Lifetime
- 2003-04-18 AT AT03718778T patent/ATE404519T1/de active
- 2003-04-18 KR KR1020047016491A patent/KR100944052B1/ko not_active Expired - Fee Related
- 2003-04-18 WO PCT/EP2003/004100 patent/WO2003091194A1/en not_active Ceased
- 2003-04-18 DK DK03718778T patent/DK1497250T3/da active
- 2003-04-18 JP JP2003587762A patent/JP4315818B2/ja not_active Expired - Fee Related
- 2003-04-18 CA CA2483205A patent/CA2483205C/en not_active Expired - Fee Related
- 2003-04-18 RU RU2004131210/04A patent/RU2320636C2/ru not_active IP Right Cessation
- 2003-04-18 CN CNB038089319A patent/CN1290816C/zh not_active Expired - Fee Related
-
2004
- 2004-10-21 NO NO20044519A patent/NO329176B1/no not_active IP Right Cessation
- 2004-10-21 IL IL164763A patent/IL164763A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2311697T3 (es) | 2009-02-16 |
| USRE43280E1 (en) | 2012-03-27 |
| US20050165117A1 (en) | 2005-07-28 |
| ITMI20020872A1 (it) | 2003-10-23 |
| SI1497250T1 (sl) | 2008-12-31 |
| EP1497250B1 (en) | 2008-08-13 |
| AU2003222828A1 (en) | 2003-11-10 |
| KR100944052B1 (ko) | 2010-02-24 |
| CA2483205C (en) | 2011-07-05 |
| IL164763A (en) | 2010-02-17 |
| NO329176B1 (no) | 2010-09-06 |
| ATE404519T1 (de) | 2008-08-15 |
| ITMI20020872A0 (it) | 2002-04-23 |
| WO2003091194A1 (en) | 2003-11-06 |
| PT1497250E (pt) | 2008-11-12 |
| EP1497250A1 (en) | 2005-01-19 |
| DE60322871D1 (de) | 2008-09-25 |
| JP2005523917A (ja) | 2005-08-11 |
| CA2483205A1 (en) | 2003-11-06 |
| PL205829B1 (pl) | 2010-05-31 |
| CN1290816C (zh) | 2006-12-20 |
| KR20040111519A (ko) | 2004-12-31 |
| DK1497250T3 (da) | 2008-12-01 |
| RU2004131210A (ru) | 2005-04-10 |
| RU2320636C2 (ru) | 2008-03-27 |
| HK1075654A1 (en) | 2005-12-23 |
| JP4315818B2 (ja) | 2009-08-19 |
| CN1646462A (zh) | 2005-07-27 |
| US7105705B2 (en) | 2006-09-12 |
| IL164763A0 (en) | 2005-12-18 |
| PL371347A1 (en) | 2005-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |