DK151800C - Analogifremgangsmaade til fremstilling af et 2-phenylenmorpholinderivat, herunder dettes optiske isomere, eller et farmaceutisk acceptabelt syreadditionssalt deraf - Google Patents

Analogifremgangsmaade til fremstilling af et 2-phenylenmorpholinderivat, herunder dettes optiske isomere, eller et farmaceutisk acceptabelt syreadditionssalt deraf

Info

Publication number
DK151800C
DK151800C DK441080A DK441080A DK151800C DK 151800 C DK151800 C DK 151800C DK 441080 A DK441080 A DK 441080A DK 441080 A DK441080 A DK 441080A DK 151800 C DK151800 C DK 151800C
Authority
DK
Denmark
Prior art keywords
pharmaceutically acceptable
acid addition
acceptable acid
phenylene
analogue
Prior art date
Application number
DK441080A
Other languages
English (en)
Other versions
DK441080A (da
DK151800B (da
Inventor
Alan Chapman White
Edwin Trevor Edington
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of DK441080A publication Critical patent/DK441080A/da
Publication of DK151800B publication Critical patent/DK151800B/da
Application granted granted Critical
Publication of DK151800C publication Critical patent/DK151800C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Lubricants (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
DK441080A 1979-10-20 1980-10-17 Analogifremgangsmaade til fremstilling af et 2-phenylenmorpholinderivat, herunder dettes optiske isomere, eller et farmaceutisk acceptabelt syreadditionssalt deraf DK151800C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7936502 1979-10-20
GB7936502 1979-10-20

Publications (3)

Publication Number Publication Date
DK441080A DK441080A (da) 1981-04-21
DK151800B DK151800B (da) 1988-01-04
DK151800C true DK151800C (da) 1988-06-06

Family

ID=10508675

Family Applications (1)

Application Number Title Priority Date Filing Date
DK441080A DK151800C (da) 1979-10-20 1980-10-17 Analogifremgangsmaade til fremstilling af et 2-phenylenmorpholinderivat, herunder dettes optiske isomere, eller et farmaceutisk acceptabelt syreadditionssalt deraf

Country Status (17)

Country Link
US (1) US4360519A (da)
EP (1) EP0027695B1 (da)
JP (1) JPS5665880A (da)
KR (2) KR840002427B1 (da)
AT (1) ATE4980T1 (da)
AU (1) AU531586B2 (da)
CA (1) CA1126731A (da)
DE (1) DE3065304D1 (da)
DK (1) DK151800C (da)
ES (1) ES496074A0 (da)
FI (1) FI803277L (da)
GB (1) GB2061272B (da)
GR (1) GR70235B (da)
IE (1) IE50355B1 (da)
MY (1) MY8500468A (da)
PT (1) PT71940B (da)
ZA (1) ZA806017B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2125793B (en) * 1982-08-19 1985-10-02 Wyeth John & Brother Ltd Morpholine derivatives
GB8305638D0 (en) * 1983-03-01 1983-03-30 Wyeth John & Brother Ltd Morpholine derivatives
FR2553412B1 (fr) * 1983-10-17 1986-03-21 Lafon Labor Derives de 4-alkyl-2-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
GB8418657D0 (en) * 1984-07-21 1984-08-22 Beecham Group Plc Compounds
FR2581383A1 (fr) * 1985-05-03 1986-11-07 Cerm Cent Europ Rech Mauvernay 2-alkyl-2-aryl morpholines substituees, leur preparation et les compositions pharmaceutiques les contenant
DE3621775A1 (de) * 1986-03-13 1988-01-07 Thomae Gmbh Dr K Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
DK0821671T3 (da) * 1995-04-20 2001-04-23 Pfizer Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
EP1575901B1 (en) * 2002-12-19 2012-10-10 Merck Sharp & Dohme Corp. Substituted amides
HUE028976T2 (en) 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EP2471779A1 (en) 2006-04-03 2012-07-04 Arena Pharmaceuticals, Inc. Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8299241B2 (en) 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
CN102015591B (zh) 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
ES2546492T3 (es) 2010-05-21 2015-09-24 Research Triangle Institute Derivados de 1-fenilmorfolina como análogos de hidroxibupropion para tratar drogodependencia
AU2011255276B2 (en) 2010-05-21 2016-09-22 Research Triangle Institute Phenylmorpholines and analogues thereof
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
JP2013536859A (ja) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストの非吸湿性塩
KR20140091458A (ko) 2010-09-01 2014-07-21 아레나 파마슈티칼스, 인크. 신장 손상을 갖는 개체에 대한 로카세린의 투여
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
KR20130138770A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 광학적으로 활성 산을 갖는 로르카세린의 염
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
CN121038788A (zh) * 2023-05-16 2025-11-28 斯普林渥克斯治疗有限公司 用于抑制yap/taz-tead的苯并哌嗪及相关类似物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2835669A (en) * 1958-05-20 Process for the production of substi-
US2997469A (en) * 1961-08-22 Preparation of substituted
GB773780A (en) 1953-07-01 1957-05-01 Albert Boehringer Improvements in or relating to the preparation of substituted morpholines
GB791416A (en) 1956-04-09 1958-03-05 Albert Boehringer Improvements in or relating to the production of substituted tetrahydrooxazines
US3112311A (en) * 1957-04-05 1963-11-26 Geigy Chem Corp 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines
ES247829A1 (es) 1958-03-13 1960-03-16 Boehringer Sohn Ingelheim Procedimeinto para la obtencion de tetrahidro-oxazinas sustituidas
US3296076A (en) * 1962-06-11 1967-01-03 Boehringer Sohn Ingelheim Pilomotor shaving compositions and method of using same
GB1336732A (en) * 1970-10-28 1973-11-07 Istituto Gentili Spa Pisa Diethanolamine derivatives
GB1452701A (en) * 1974-05-07 1976-10-13 Ici Ltd Morpholine derivatives

Also Published As

Publication number Publication date
IE801995L (en) 1981-04-20
ES8107201A1 (es) 1981-10-01
KR840002427B1 (ko) 1984-12-27
AU6292280A (en) 1981-04-30
GB2061272B (en) 1983-08-10
PT71940A (en) 1980-11-01
FI803277A7 (fi) 1981-04-21
KR830004277A (ko) 1983-07-09
GR70235B (da) 1982-09-01
ZA806017B (en) 1982-04-28
CA1126731A (en) 1982-06-29
ATE4980T1 (de) 1983-10-15
EP0027695A1 (en) 1981-04-29
EP0027695B1 (en) 1983-10-12
GB2061272A (en) 1981-05-13
KR840002428B1 (ko) 1984-12-27
DK441080A (da) 1981-04-21
AU531586B2 (en) 1983-09-01
DE3065304D1 (en) 1983-11-17
FI803277L (fi) 1981-04-21
DK151800B (da) 1988-01-04
ES496074A0 (es) 1981-10-01
JPS5665880A (en) 1981-06-03
MY8500468A (en) 1985-12-31
IE50355B1 (en) 1986-04-02
US4360519A (en) 1982-11-23
PT71940B (pt) 1981-08-31

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