DK441080A - Fremgangsmaade til fremstilling af morpholinderivater - Google Patents

Fremgangsmaade til fremstilling af morpholinderivater

Info

Publication number
DK441080A
DK441080A DK441080A DK441080A DK441080A DK 441080 A DK441080 A DK 441080A DK 441080 A DK441080 A DK 441080A DK 441080 A DK441080 A DK 441080A DK 441080 A DK441080 A DK 441080A
Authority
DK
Denmark
Prior art keywords
lower alkyl
alkyl
morpholine derivatives
hydrogen
procedure
Prior art date
Application number
DK441080A
Other languages
English (en)
Other versions
DK151800C (da
DK151800B (da
Inventor
A C White
E T Edington
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of DK441080A publication Critical patent/DK441080A/da
Publication of DK151800B publication Critical patent/DK151800B/da
Application granted granted Critical
Publication of DK151800C publication Critical patent/DK151800C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Lubricants (AREA)
DK441080A 1979-10-20 1980-10-17 Analogifremgangsmaade til fremstilling af et 2-phenylenmorpholinderivat, herunder dettes optiske isomere, eller et farmaceutisk acceptabelt syreadditionssalt deraf DK151800C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7936502 1979-10-20
GB7936502 1979-10-20

Publications (3)

Publication Number Publication Date
DK441080A true DK441080A (da) 1981-04-21
DK151800B DK151800B (da) 1988-01-04
DK151800C DK151800C (da) 1988-06-06

Family

ID=10508675

Family Applications (1)

Application Number Title Priority Date Filing Date
DK441080A DK151800C (da) 1979-10-20 1980-10-17 Analogifremgangsmaade til fremstilling af et 2-phenylenmorpholinderivat, herunder dettes optiske isomere, eller et farmaceutisk acceptabelt syreadditionssalt deraf

Country Status (17)

Country Link
US (1) US4360519A (da)
EP (1) EP0027695B1 (da)
JP (1) JPS5665880A (da)
KR (2) KR840002427B1 (da)
AT (1) ATE4980T1 (da)
AU (1) AU531586B2 (da)
CA (1) CA1126731A (da)
DE (1) DE3065304D1 (da)
DK (1) DK151800C (da)
ES (1) ES496074A0 (da)
FI (1) FI803277A7 (da)
GB (1) GB2061272B (da)
GR (1) GR70235B (da)
IE (1) IE50355B1 (da)
MY (1) MY8500468A (da)
PT (1) PT71940B (da)
ZA (1) ZA806017B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2125793B (en) * 1982-08-19 1985-10-02 Wyeth John & Brother Ltd Morpholine derivatives
GB8305638D0 (en) * 1983-03-01 1983-03-30 Wyeth John & Brother Ltd Morpholine derivatives
FR2553412B1 (fr) * 1983-10-17 1986-03-21 Lafon Labor Derives de 4-alkyl-2-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
GB8418657D0 (en) * 1984-07-21 1984-08-22 Beecham Group Plc Compounds
FR2581383A1 (fr) * 1985-05-03 1986-11-07 Cerm Cent Europ Rech Mauvernay 2-alkyl-2-aryl morpholines substituees, leur preparation et les compositions pharmaceutiques les contenant
DE3621775A1 (de) * 1986-03-13 1988-01-07 Thomae Gmbh Dr K Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
JP3053222B2 (ja) * 1995-04-20 2000-06-19 ファイザー・インコーポレーテッド Ｍｍｐおよびｔｎｆ抑制剤としてのアリールスルホニルヒドロキサム酸誘導体
EP1575901B1 (en) * 2002-12-19 2012-10-10 Merck Sharp & Dohme Corp. Substituted amides
MXPA05013364A (es) 2003-06-17 2006-03-17 Arena Pharm Inc Procedimiento para preparar 3-benzazepinas.
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
JP5404414B2 (ja) 2006-12-05 2014-01-29 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンおよびその中間体を調製するための方法
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
EP2571858B1 (en) 2010-05-21 2018-06-20 Research Triangle Institute Phenylmorpholines and analogues thereof
CA2800219C (en) 2010-05-21 2019-03-12 Research Triangle Institute 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
KR20130138770A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 광학적으로 활성 산을 갖는 로르카세린의 염
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
CA2886875A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
KR20260012196A (ko) * 2023-05-16 2026-01-26 스프링웍스 테라퓨틱스, 인크. Yap/taz-tead 억제를 위한 벤조피페라진 및 관련 유사체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997469A (en) * 1961-08-22 Preparation of substituted
US2835669A (en) * 1958-05-20 Process for the production of substi-
GB773780A (en) 1953-07-01 1957-05-01 Albert Boehringer Improvements in or relating to the preparation of substituted morpholines
GB791416A (en) 1956-04-09 1958-03-05 Albert Boehringer Improvements in or relating to the production of substituted tetrahydrooxazines
US3112311A (en) * 1957-04-05 1963-11-26 Geigy Chem Corp 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines
ES247829A1 (es) 1958-03-13 1960-03-16 Boehringer Sohn Ingelheim Procedimeinto para la obtencion de tetrahidro-oxazinas sustituidas
US3296076A (en) * 1962-06-11 1967-01-03 Boehringer Sohn Ingelheim Pilomotor shaving compositions and method of using same
GB1336732A (en) * 1970-10-28 1973-11-07 Istituto Gentili Spa Pisa Diethanolamine derivatives
GB1452701A (en) * 1974-05-07 1976-10-13 Ici Ltd Morpholine derivatives

Also Published As

Publication number Publication date
GB2061272B (en) 1983-08-10
MY8500468A (en) 1985-12-31
DK151800C (da) 1988-06-06
FI803277L (fi) 1981-04-21
ES8107201A1 (es) 1981-10-01
IE801995L (en) 1981-04-20
EP0027695A1 (en) 1981-04-29
AU6292280A (en) 1981-04-30
EP0027695B1 (en) 1983-10-12
US4360519A (en) 1982-11-23
GB2061272A (en) 1981-05-13
AU531586B2 (en) 1983-09-01
KR840002428B1 (ko) 1984-12-27
IE50355B1 (en) 1986-04-02
KR830004277A (ko) 1983-07-09
PT71940A (en) 1980-11-01
KR840002427B1 (ko) 1984-12-27
ES496074A0 (es) 1981-10-01
DE3065304D1 (en) 1983-11-17
ATE4980T1 (de) 1983-10-15
CA1126731A (en) 1982-06-29
GR70235B (da) 1982-09-01
DK151800B (da) 1988-01-04
JPS5665880A (en) 1981-06-03
ZA806017B (en) 1982-04-28
FI803277A7 (fi) 1981-04-21
PT71940B (pt) 1981-08-31

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