DK1539768T3 - Ny fremgangsmåde til fremstilling af epothilonderivater - Google Patents

Ny fremgangsmåde til fremstilling af epothilonderivater

Info

Publication number: DK1539768T3
Authority: DK; Denmark
Prior art keywords: new method; epothilone derivatives; preparing epothilone; preparing; derivatives
Prior art date: 2002-09-13

Application number

DK03748015T

Other languages

English (en)

Inventor

Guido Koch

Olivier Loiseleur

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-13

Filing date

2003-09-12

Publication date

2008-01-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1539768(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-12 Application filed by Novartis Ag filed Critical Novartis Ag

2008-01-07 Application granted granted Critical

2008-01-07 Publication of DK1539768T3 publication Critical patent/DK1539768T3/da

Links

150000003883 epothilone derivatives Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

DK03748015T 2002-09-13 2003-09-12 Ny fremgangsmåde til fremstilling af epothilonderivater DK1539768T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0221312.2A GB0221312D0 (en)	2002-09-13	2002-09-13	Organic compounds
PCT/EP2003/010171 WO2004024735A2 (en)	2002-09-13	2003-09-12	A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Publications (1)

Publication Number	Publication Date
DK1539768T3 true DK1539768T3 (da)	2008-01-07

Family

ID=9944042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03748015T DK1539768T3 (da)	2002-09-13	2003-09-12	Ny fremgangsmåde til fremstilling af epothilonderivater

Country Status (29)

Country	Link
US (1)	US7470792B2 (da)
EP (1)	EP1539768B1 (da)
JP (1)	JP4628102B2 (da)
KR (1)	KR20050042500A (da)
CN (1)	CN100522968C (da)
AR (1)	AR041231A1 (da)
AT (1)	ATE373663T1 (da)
AU (2)	AU2003267349B2 (da)
BR (1)	BR0314263A (da)
CA (1)	CA2497119C (da)
CY (1)	CY1107794T1 (da)
DE (1)	DE60316456T2 (da)
DK (1)	DK1539768T3 (da)
EC (1)	ECSP055652A (da)
ES (1)	ES2290489T3 (da)
GB (1)	GB0221312D0 (da)
IL (1)	IL166829A (da)
MX (1)	MXPA05002785A (da)
MY (1)	MY140442A (da)
NO (1)	NO20051794L (da)
NZ (1)	NZ538612A (da)
PE (1)	PE20050052A1 (da)
PL (1)	PL375039A1 (da)
PT (1)	PT1539768E (da)
RU (2)	RU2343155C2 (da)
SG (1)	SG155770A1 (da)
TW (1)	TWI289563B (da)
WO (1)	WO2004024735A2 (da)
ZA (1)	ZA200501008B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6242469B1 (en)	1996-12-03	2001-06-05	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
WO2004018478A2 (en)	2002-08-23	2004-03-04	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
CN103037903A (zh)	2010-05-18	2013-04-10	天蓝制药公司	用于治疗自身免疫性疾病或其它疾病的组合物和方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU716610B2 (en) *	1996-08-30	2000-03-02	Novartis Ag	Method for producing epothilones, and intermediate products obtained during the production process
US6441186B1 (en)	1996-12-13	2002-08-27	The Scripps Research Institute	Epothilone analogs
US6380394B1 (en) *	1996-12-13	2002-04-30	The Scripps Research Institute	Epothilone analogs
EP1201666A3 (de) *	1997-02-25	2003-03-05	Gesellschaft für biotechnologische Forschung mbH (GBF)	Seitenkettenmodifizierte Epothilone
US6498257B1 (en)	1998-04-21	2002-12-24	Bristol-Myers Squibb Company	2,3-olefinic epothilone derivatives
GB9810659D0 (en) *	1998-05-18	1998-07-15	Ciba Geigy Ag	Organic compounds
AU2795000A (en) *	1998-12-22	2000-07-12	Novartis Ag	Epothilone derivatives and their use as antitumor agents
JP2003505459A (ja) *	1999-07-22	2003-02-12	シエーリングアクチエンゲゼルシャフト	エポチロンｂおよび誘導体製造のための方法、ならびにこの方法のための中間製品
US6593115B2 (en) *	2000-03-24	2003-07-15	Bristol-Myers Squibb Co.	Preparation of epothilone intermediates
AU2002213248A1 (en) *	2000-10-13	2002-04-22	The University Of Mississipi	Synthesis of epothilones and relates analogs
WO2004012735A2 (en) *	2002-07-31	2004-02-12	Schering Ag	New effector conjugates, process for their production and their pharmaceutical use

2002
- 2002-09-13 GB GBGB0221312.2A patent/GB0221312D0/en not_active Ceased
2003
- 2003-09-11 PE PE2003000922A patent/PE20050052A1/es not_active Application Discontinuation
- 2003-09-11 AR ARP030103290A patent/AR041231A1/es active IP Right Grant
- 2003-09-12 SG SG200701814-6A patent/SG155770A1/en unknown
- 2003-09-12 ES ES03748015T patent/ES2290489T3/es not_active Expired - Lifetime
- 2003-09-12 RU RU2005110925/04A patent/RU2343155C2/ru not_active IP Right Cessation
- 2003-09-12 CN CNB038215837A patent/CN100522968C/zh not_active Expired - Fee Related
- 2003-09-12 CA CA2497119A patent/CA2497119C/en not_active Expired - Fee Related
- 2003-09-12 EP EP03748015A patent/EP1539768B1/en not_active Expired - Lifetime
- 2003-09-12 PL PL03375039A patent/PL375039A1/xx not_active Application Discontinuation
- 2003-09-12 WO PCT/EP2003/010171 patent/WO2004024735A2/en not_active Ceased
- 2003-09-12 PT PT03748015T patent/PT1539768E/pt unknown
- 2003-09-12 JP JP2004535499A patent/JP4628102B2/ja not_active Expired - Fee Related
- 2003-09-12 DK DK03748015T patent/DK1539768T3/da active
- 2003-09-12 KR KR1020057004237A patent/KR20050042500A/ko not_active Ceased
- 2003-09-12 AU AU2003267349A patent/AU2003267349B2/en not_active Ceased
- 2003-09-12 MX MXPA05002785A patent/MXPA05002785A/es active IP Right Grant
- 2003-09-12 TW TW092125250A patent/TWI289563B/zh not_active IP Right Cessation
- 2003-09-12 NZ NZ538612A patent/NZ538612A/en not_active IP Right Cessation
- 2003-09-12 US US10/526,283 patent/US7470792B2/en not_active Expired - Fee Related
- 2003-09-12 DE DE60316456T patent/DE60316456T2/de not_active Expired - Lifetime
- 2003-09-12 AT AT03748015T patent/ATE373663T1/de active
- 2003-09-12 BR BR0314263-9A patent/BR0314263A/pt not_active IP Right Cessation
- 2003-09-12 RU RU2008129613/04A patent/RU2404985C2/ru not_active IP Right Cessation
- 2003-09-13 MY MYPI20033494A patent/MY140442A/en unknown
2005
- 2005-02-03 ZA ZA200501008A patent/ZA200501008B/xx unknown
- 2005-02-10 IL IL166829A patent/IL166829A/en not_active IP Right Cessation
- 2005-03-09 EC EC2005005652A patent/ECSP055652A/es unknown
- 2005-04-12 NO NO20051794A patent/NO20051794L/no not_active Application Discontinuation
2007
- 2007-11-08 CY CY20071101447T patent/CY1107794T1/el unknown
2008
- 2008-08-01 AU AU2008203451A patent/AU2008203451A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP4628102B2 (ja)	2011-02-09
CA2497119C (en)	2011-08-02
AR041231A1 (es)	2005-05-11
NO20051794D0 (no)	2005-04-12
TW200413388A (en)	2004-08-01
AU2003267349A1 (en)	2004-04-30
ECSP055652A (es)	2005-05-30
CY1107794T1 (el)	2013-06-19
RU2005110925A (ru)	2006-01-20
AU2003267349B2 (en)	2008-05-01
SG155770A1 (en)	2009-10-29
MXPA05002785A (es)	2005-06-03
ES2290489T3 (es)	2008-02-16
TWI289563B (en)	2007-11-11
JP2006511469A (ja)	2006-04-06
PE20050052A1 (es)	2005-03-28
MY140442A (en)	2009-12-31
NO20051794L (no)	2005-04-12
US7470792B2 (en)	2008-12-30
AU2008203451A1 (en)	2008-08-21
ATE373663T1 (de)	2007-10-15
CA2497119A1 (en)	2004-03-25
WO2004024735A3 (en)	2004-07-22
EP1539768A2 (en)	2005-06-15
RU2343155C2 (ru)	2009-01-10
RU2404985C2 (ru)	2010-11-27
IL166829A (en)	2011-01-31
RU2008129613A (ru)	2010-01-27
BR0314263A (pt)	2005-07-05
GB0221312D0 (en)	2002-10-23
WO2004024735A2 (en)	2004-03-25
DE60316456D1 (de)	2007-10-31
PL375039A1 (en)	2005-11-14
DE60316456T2 (de)	2008-06-19
KR20050042500A (ko)	2005-05-09
CN100522968C (zh)	2009-08-05
NZ538612A (en)	2008-01-31
PT1539768E (pt)	2007-12-17
HK1078853A1 (en)	2006-03-24
CN1681824A (zh)	2005-10-12
US20060106073A1 (en)	2006-05-18
EP1539768B1 (en)	2007-09-19
ZA200501008B (en)	2006-12-27

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