DK155009C - Analogifremgangsmaade til fremstilling af thienooe2,3-eaa-1,2-thiazin-1,1-dioxidderivat eller farmaceutisk tolerable salte heraf samt udgangsmateriale til brug ved fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af thienooe2,3-eaa-1,2-thiazin-1,1-dioxidderivat eller farmaceutisk tolerable salte heraf samt udgangsmateriale til brug ved fremgangsmaaden

Info

Publication number: DK155009C
Authority: DK; Denmark
Prior art keywords: thienooe2; thiazin; eaa; analogue; procedure
Prior art date: 1982-09-09

Application number

DK381283A

Other languages

English (en)

Other versions

DK155009B (da

DK381283A (da

DK381283D0 (da

Inventor

Rudolf Pfister

Paul Zeller

Dieter Binder

Otto Hromatka

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-09

Filing date

1983-08-19

Publication date

1989-06-05

1983-08-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1983-08-19 Publication of DK381283D0 publication Critical patent/DK381283D0/da

1984-03-10 Publication of DK381283A publication Critical patent/DK381283A/da

1989-01-23 Publication of DK155009B publication Critical patent/DK155009B/da

1989-06-05 Application granted granted Critical

1989-06-05 Publication of DK155009C publication Critical patent/DK155009C/da

Links

238000000034 method Methods 0.000 title 2
150000003839 salts Chemical class 0.000 abstract 3
ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 abstract 2
FHZDNBBQTQLLLV-UHFFFAOYSA-N 4-hydroxy-2-methyl-1,1-dioxo-n-pyridin-2-yl-6-(trifluoromethyl)thieno[2,3-e]thiazine-3-carboxamide Chemical compound OC=1C=2SC(C(F)(F)F)=CC=2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 FHZDNBBQTQLLLV-UHFFFAOYSA-N 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000003356 anti-rheumatic effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003285 pharmacodynamic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK381283A 1982-09-09 1983-08-19 Analogifremgangsmaade til fremstilling af thienooe2,3-eaa-1,2-thiazin-1,1-dioxidderivat eller farmaceutisk tolerable salte heraf samt udgangsmateriale til brug ved fremgangsmaaden DK155009C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH537782		1982-09-09
CH537782		1982-09-09

Publications (4)

Publication Number	Publication Date
DK381283D0 DK381283D0 (da)	1983-08-19
DK381283A DK381283A (da)	1984-03-10
DK155009B DK155009B (da)	1989-01-23
DK155009C true DK155009C (da)	1989-06-05

Family

ID=4292544

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK381283A DK155009C (da)	1982-09-09	1983-08-19	Analogifremgangsmaade til fremstilling af thienooe2,3-eaa-1,2-thiazin-1,1-dioxidderivat eller farmaceutisk tolerable salte heraf samt udgangsmateriale til brug ved fremgangsmaaden

Country Status (13)

Country	Link
US (1)	US4544655A (da)
EP (1)	EP0103142B1 (da)
JP (1)	JPS5967292A (da)
AT (1)	ATE26720T1 (da)
AU (1)	AU560973B2 (da)
CA (1)	CA1217187A (da)
DE (1)	DE3371082D1 (da)
DK (1)	DK155009C (da)
IE (1)	IE55942B1 (da)
IL (1)	IL69628A (da)
NZ (1)	NZ205475A (da)
PH (1)	PH19692A (da)
ZA (1)	ZA836546B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL87951A (en) *	1987-10-29	1992-03-29	Chem Pharm Forsch Gmbh	Carbonic acid esters of 6-chloro-4-(1-hydroxyethoxy)-2-methyl-n-(2-pyridyl)-2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide,their preparation and pharmaceutical compositions containing them
ATA39088A (de)	1988-02-18	1990-06-15	Binder Dieter Dr	Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung
AT399880B (de) *	1992-07-03	1995-08-25	Chem Pharm Forsch Gmbh	Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (de) *	1993-12-14	1995-06-21	Chemisch Pharmazeutische Forschungsgesellschaft m.b.H.	Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
CN101624391A (zh) *	2001-06-11	2010-01-13	病毒化学医药公司	用作黄病毒感染抗病毒剂的噻吩衍生物
US8329924B2 (en) *	2001-06-11	2012-12-11	Vertex Pharmaceuticals (Canada) Incorporated	Compounds and methods for the treatment or prevention of Flavivirus infections
AT413944B (de)	2003-05-27	2006-07-15	Binder Eva Dkfm	Verwendung von oxicam-verbindungen
US7109232B2 (en) *	2004-03-08	2006-09-19	Simpson Biotech Co., Ltd.	Compounds from Antrodia camphorata having anti-inflammatory and anti-tumor activity
JP5749176B2 (ja) *	2008-12-16	2015-07-15	スノビオンプハルマセウトイカルスインコーポレイテッド	トリプル再取込み阻害剤及びそれらの使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1066711A (en) *	1974-08-26	1979-11-20	Hoffmann-La Roche Limited	Thiophene derivatives
IL47877A (en) *	1974-08-26	1978-10-31	Sparamedica Ag	Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them
AU518216B2 (en) *	1977-09-06	1981-09-17	Hafslund Nycomed Pharma Aktiengesellschaft	Thienothiazine derivatives

1983
- 1983-08-04 DE DE8383107677T patent/DE3371082D1/de not_active Expired
- 1983-08-04 EP EP83107677A patent/EP0103142B1/de not_active Expired
- 1983-08-04 AT AT83107677T patent/ATE26720T1/de not_active IP Right Cessation
- 1983-08-12 CA CA000434462A patent/CA1217187A/en not_active Expired
- 1983-08-19 DK DK381283A patent/DK155009C/da not_active IP Right Cessation
- 1983-08-31 US US06/528,341 patent/US4544655A/en not_active Expired - Fee Related
- 1983-09-02 ZA ZA836546A patent/ZA836546B/xx unknown
- 1983-09-02 NZ NZ205475A patent/NZ205475A/xx unknown
- 1983-09-02 IL IL69628A patent/IL69628A/xx unknown
- 1983-09-06 JP JP58162711A patent/JPS5967292A/ja active Pending
- 1983-09-08 IE IE2108/83A patent/IE55942B1/xx unknown
- 1983-09-09 AU AU19007/83A patent/AU560973B2/en not_active Ceased
- 1983-09-09 PH PH29520A patent/PH19692A/en unknown

Also Published As

Publication number	Publication date
EP0103142B1 (de)	1987-04-22
IE832108L (en)	1984-03-09
PH19692A (en)	1986-06-13
IL69628A0 (en)	1983-12-30
DK155009B (da)	1989-01-23
DE3371082D1 (de)	1987-05-27
EP0103142A1 (de)	1984-03-21
IL69628A (en)	1986-09-30
ZA836546B (en)	1984-04-25
NZ205475A (en)	1985-08-30
US4544655A (en)	1985-10-01
AU560973B2 (en)	1987-04-30
DK381283A (da)	1984-03-10
ATE26720T1 (de)	1987-05-15
JPS5967292A (ja)	1984-04-16
DK381283D0 (da)	1983-08-19
IE55942B1 (en)	1991-02-27
CA1217187A (en)	1987-01-27
AU1900783A (en)	1984-03-15

Legal Events

Date	Code	Title	Description
1992-04-21	PBP	Patent lapsed

Publication	Publication Date	Title
HK1085A (en)	1985-01-11	3-carbamoyl-4-hydroxy-2h-thieno-1,2-thiazine-1,1-dioxide derivatives
ES2061663T3 (es)	1994-12-16	Derivados de carbamoilpirrolidina, su uso y preparacion.
JPS55136266A (en)	1980-10-23	Derivatives of 2-imidazoline
DK155009C (da)	1989-06-05	Analogifremgangsmaade til fremstilling af thienooe2,3-eaa-1,2-thiazin-1,1-dioxidderivat eller farmaceutisk tolerable salte heraf samt udgangsmateriale til brug ved fremgangsmaaden
ATE135357T1 (de)	1996-03-15	Cephalosporinderivate
ATE3550T1 (de)	1983-06-15	Kristalline salze eines cephalosporins, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DK237483D0 (da)	1983-05-26	Fremgangsmade til fremstilling af propionsyrederivater
ES515895A0 (es)	1984-04-01	"un procedimiento para la preparacion de un compuesto de imidazol".
DK159110C (da)	1991-02-11	4h-benzo(4,5)cyclohepta(1,2-b)thiophenderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende derivaterne
HUT61769A (en)	1993-03-01	Process for producing new spirocyclopropyl-cephalosporin derivatives and pharmaceutical compositions containing them
SE7906681L (sv)	1980-02-12	Ftalazonderivat
SE8503109D0 (sv)	1985-06-20	Cyclic prodrugs of antiinflammatory oxicams
DE2964850D1 (en)	1983-03-24	Thienylbenzoic-acid derivatives, process for their production, and pharmaceutical preparations containing these compounds
DK379581A (da)	1982-04-07	Fremgangsmaade til fremstilling af acylderivater
DE58906759D1 (de)	1994-03-03	Substituierte thienylethylamine und Verfahren zu deren Herstellung.
PT89356A (pt)	1989-12-29	Processo para a preparacao de derivados da 2-amino-tetra-hidro-isoquinolina e de composicoes farmaceuticas contendo os mesmos
JPS53149932A (en)	1978-12-27	2-(3-alkylnitrosoureido)-hexapyranoside derivatives
EP0138223A3 (en)	1986-12-30	Thiazine derivatives, processes for preparation thereof and pharmaceutical conmposition comprising the same