DK1569900T3 - Substituerede 3-carbonyl-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) - Google Patents

Substituerede 3-carbonyl-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)

Info

Publication number: DK1569900T3
Authority: DK; Denmark
Prior art keywords: pai; carbonyl; inhibitors; substituted; acetic acid
Prior art date: 2002-12-10

Application number

DK03796856T

Other languages

English (en)

Inventor

Lee Dalton Jennings

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-10

Filing date

2003-12-09

Publication date

2006-10-23

2003-12-09 Application filed by Wyeth Corp filed Critical Wyeth Corp

2006-10-23 Application granted granted Critical

2006-10-23 Publication of DK1569900T3 publication Critical patent/DK1569900T3/da

Links

102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 title abstract 4
108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 title abstract 4
239000003112 inhibitor Substances 0.000 title abstract 2
150000001242 acetic acid derivatives Chemical class 0.000 title 1
SCQVRKGGFSEOIG-UHFFFAOYSA-N 2-[3-(oxomethylidene)-2h-indol-1-yl]acetic acid Chemical class C1=CC=C2N(CC(=O)O)CC(=C=O)C2=C1 SCQVRKGGFSEOIG-UHFFFAOYSA-N 0.000 abstract 1
206010051055 Deep vein thrombosis Diseases 0.000 abstract 1
206010047249 Venous thrombosis Diseases 0.000 abstract 1
208000029078 coronary artery disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000003527 fibrinolytic agent Substances 0.000 abstract 1
230000003480 fibrinolytic effect Effects 0.000 abstract 1
208000005069 pulmonary fibrosis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)

DK03796856T 2002-12-10 2003-12-09 Substituerede 3-carbonyl-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) DK1569900T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US43210702P	2002-12-10	2002-12-10

Publications (1)

Publication Number	Publication Date
DK1569900T3 true DK1569900T3 (da)	2006-10-23

Family

ID=32507850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03796856T DK1569900T3 (da)	2002-12-10	2003-12-09	Substituerede 3-carbonyl-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)

Country Status (13)

Country	Link
US (2)	US7078429B2 (da)
EP (1)	EP1569900B1 (da)
JP (1)	JP2006514637A (da)
CN (1)	CN1726190A (da)
AT (1)	ATE331709T1 (da)
AU (1)	AU2003297787A1 (da)
BR (1)	BR0316574A (da)
CA (1)	CA2509238A1 (da)
DE (1)	DE60306548T2 (da)
DK (1)	DK1569900T3 (da)
ES (1)	ES2266907T3 (da)
MX (1)	MXPA05006288A (da)
WO (1)	WO2004052855A2 (da)

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US7265148B2 (en) *	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7411083B2 (en) *	2003-09-25	2008-08-12	Wyeth	Substituted acetic acid derivatives
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US7332521B2 (en) *	2003-09-25	2008-02-19	Wyeth	Substituted indoles
US7582773B2 (en) *	2003-09-25	2009-09-01	Wyeth	Substituted phenyl indoles
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US7442805B2 (en) *	2003-09-25	2008-10-28	Wyeth	Substituted sulfonamide-indoles
WO2006023864A1 (en) *	2004-08-23	2006-03-02	Wyeth	Pyrrolo-naphthyl acids as pai-1 inhibitors
WO2006023866A2 (en)	2004-08-23	2006-03-02	Wyeth	Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1
MX2007002178A (es) *	2004-08-23	2007-04-02	Wyeth Corp	Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares.
US7683091B2 (en)	2005-08-17	2010-03-23	Wyeth	Substituted indoles and methods of their use
TW200744585A (en) *	2006-02-27	2007-12-16	Wyeth Corp	Inhibitors of PAI-1 for treatment of muscular conditions

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US7582773B2 (en)	2003-09-25	2009-09-01	Wyeth	Substituted phenyl indoles
US7420083B2 (en)	2003-09-25	2008-09-02	Wyeth	Substituted aryloximes
US7411083B2 (en) *	2003-09-25	2008-08-12	Wyeth	Substituted acetic acid derivatives
US7265148B2 (en)	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7163954B2 (en)	2003-09-25	2007-01-16	Wyeth	Substituted naphthyl benzothiophene acids
US7332521B2 (en)	2003-09-25	2008-02-19	Wyeth	Substituted indoles
US7351726B2 (en)	2003-09-25	2008-04-01	Wyeth	Substituted oxadiazolidinediones
US7141592B2 (en)	2003-09-25	2006-11-28	Wyeth	Substituted oxadiazolidinediones
US7172076B2 (en) *	2003-12-19	2007-02-06	Xerox Corporation	Internal die filters with multiple passageways which are fluidically in parallel
WO2006023864A1 (en) *	2004-08-23	2006-03-02	Wyeth	Pyrrolo-naphthyl acids as pai-1 inhibitors
WO2006023866A2 (en) *	2004-08-23	2006-03-02	Wyeth	Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1
MX2007002178A (es) *	2004-08-23	2007-04-02	Wyeth Corp	Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares.

2003
- 2003-12-09 US US10/731,723 patent/US7078429B2/en not_active Expired - Fee Related
- 2003-12-09 WO PCT/US2003/039126 patent/WO2004052855A2/en not_active Ceased
- 2003-12-09 CA CA002509238A patent/CA2509238A1/en not_active Abandoned
- 2003-12-09 CN CNA2003801057350A patent/CN1726190A/zh active Pending
- 2003-12-09 EP EP03796856A patent/EP1569900B1/en not_active Expired - Lifetime
- 2003-12-09 MX MXPA05006288A patent/MXPA05006288A/es active IP Right Grant
- 2003-12-09 DK DK03796856T patent/DK1569900T3/da active
- 2003-12-09 BR BR0316574-4A patent/BR0316574A/pt not_active IP Right Cessation
- 2003-12-09 AU AU2003297787A patent/AU2003297787A1/en not_active Withdrawn
- 2003-12-09 ES ES03796856T patent/ES2266907T3/es not_active Expired - Lifetime
- 2003-12-09 DE DE60306548T patent/DE60306548T2/de not_active Expired - Lifetime
- 2003-12-09 AT AT03796856T patent/ATE331709T1/de not_active IP Right Cessation
- 2003-12-09 JP JP2004558615A patent/JP2006514637A/ja active Pending
2006
- 2006-03-15 US US11/375,954 patent/US7566791B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2003297787A1 (en)	2004-06-30
US7566791B2 (en)	2009-07-28
BR0316574A (pt)	2005-10-04
EP1569900A2 (en)	2005-09-07
WO2004052855A3 (en)	2004-09-16
WO2004052855A2 (en)	2004-06-24
US20060178412A1 (en)	2006-08-10
US20040122070A1 (en)	2004-06-24
DE60306548T2 (de)	2007-06-21
CA2509238A1 (en)	2004-06-24
DE60306548D1 (de)	2006-08-10
MXPA05006288A (es)	2005-08-19
US7078429B2 (en)	2006-07-18
EP1569900B1 (en)	2006-06-28
JP2006514637A (ja)	2006-05-11
ATE331709T1 (de)	2006-07-15
CN1726190A (zh)	2006-01-25
ES2266907T3 (es)	2007-03-01

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