DK157292C - Fremgangsmaade til fremstilling af 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl-(eller hydrogen)-polyhydronaphthyl-1')-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-oner eller tilsvarende hydroxysyrer eller farmaceutisk acceptable salte af hydroxysyrerne eller c1-4alkylestere deraf eller phenyl-, dimethylamino- eller acetylaminosubstituerede alkylestere deraf - Google Patents

Fremgangsmaade til fremstilling af 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl-(eller hydrogen)-polyhydronaphthyl-1')-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-oner eller tilsvarende hydroxysyrer eller farmaceutisk acceptable salte af hydroxysyrerne eller c1-4alkylestere deraf eller phenyl-, dimethylamino- eller acetylaminosubstituerede alkylestere deraf

Info

Publication number
DK157292C
DK157292C DK046181A DK46181A DK157292C DK 157292 C DK157292 C DK 157292C DK 046181 A DK046181 A DK 046181A DK 46181 A DK46181 A DK 46181A DK 157292 C DK157292 C DK 157292C
Authority
DK
Denmark
Prior art keywords
methyl
hydroxy
hydroxy acid
phenylylethylethylethylethylethylethyl
polyhydronaphthyl
Prior art date
Application number
DK046181A
Other languages
Danish (da)
English (en)
Other versions
DK157292B (da
DK46181A (da
Inventor
Alvin K Willard
Robert L Smith
William F Hoffman
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK157292(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK46181A publication Critical patent/DK46181A/da
Publication of DK157292B publication Critical patent/DK157292B/da
Application granted granted Critical
Publication of DK157292C publication Critical patent/DK157292C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
DK046181A 1980-02-04 1981-02-03 Fremgangsmaade til fremstilling af 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl-(eller hydrogen)-polyhydronaphthyl-1')-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-oner eller tilsvarende hydroxysyrer eller farmaceutisk acceptable salte af hydroxysyrerne eller c1-4alkylestere deraf eller phenyl-, dimethylamino- eller acetylaminosubstituerede alkylestere deraf DK157292C (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11805180A 1980-02-04 1980-02-04
US11804980A 1980-02-04 1980-02-04
US11805180 1980-02-04
US11804980 1980-02-04
US17546080A 1980-08-05 1980-08-05
US17546080 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
US17523280 1980-08-05

Publications (3)

Publication Number Publication Date
DK46181A DK46181A (da) 1981-08-05
DK157292B DK157292B (da) 1989-12-04
DK157292C true DK157292C (da) 1990-05-07

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
DK046181A DK157292C (da) 1980-02-04 1981-02-03 Fremgangsmaade til fremstilling af 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl-(eller hydrogen)-polyhydronaphthyl-1')-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-oner eller tilsvarende hydroxysyrer eller farmaceutisk acceptable salte af hydroxysyrerne eller c1-4alkylestere deraf eller phenyl-, dimethylamino- eller acetylaminosubstituerede alkylestere deraf

Country Status (22)

Country Link
EP (1) EP0033538B1 (de)
AU (1) AU548996B2 (de)
CA (1) CA1199322A (de)
CY (1) CY1404A (de)
DD (1) DD155989A5 (de)
DE (1) DE3173042D1 (de)
DK (1) DK157292C (de)
ES (1) ES499079A0 (de)
FI (1) FI78082C (de)
GR (1) GR74798B (de)
HK (1) HK16488A (de)
IE (1) IE51478B1 (de)
IL (1) IL62044A (de)
MA (1) MA19054A1 (de)
MY (1) MY8700745A (de)
NL (1) NL930009I2 (de)
NO (2) NO154229C (de)
NZ (1) NZ196172A (de)
PT (1) PT72441B (de)
RO (1) RO82367B (de)
SG (1) SG61087G (de)
YU (1) YU28181A (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
US4343814A (en) * 1980-11-17 1982-08-10 Merck & Co., Inc. Hypocholesterolemic fermentation products
US4432996A (en) * 1980-11-17 1984-02-21 Merck & Co., Inc. Hypocholesterolemic fermentation products and process of preparation
EP0094443A1 (de) * 1982-05-17 1983-11-23 Merck & Co. Inc. 6(R)-(2-(8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S))ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-Pyran-2-on, Verfahren zur Herstellung und diese enthaltende pharmazeutische Zusammenstellung
US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
IE840153L (en) * 1983-01-24 1984-07-24 Sandoz Ltd Mevalonolactone analogues and related hydroxy acids for¹control of blood cholesterol levels.
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
DE3481190D1 (de) * 1983-10-11 1990-03-08 Merck & Co Inc Verfahren zur herstellung von 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)-2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)-decahydronaphthyl-1(s))ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-on.
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
GB8915280D0 (en) * 1989-07-04 1989-08-23 British Bio Technology Compounds
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
GB9100174D0 (en) * 1991-01-04 1991-02-20 British Bio Technology Compounds
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US5798375A (en) * 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
EA000954B1 (ru) * 1995-12-06 2000-08-28 Балканфарма - Разград Ад Способ получения ловастатина
CA2185961A1 (en) 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
CA2240983A1 (en) 1998-06-18 1999-12-18 Yong Tao Process to manufacture simvastatin and intermediates
EP1140186B1 (de) 1998-12-23 2003-06-04 G.D. Searle LLC. Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
PT1140190E (pt) 1998-12-23 2003-02-28 Searle Llc Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares
DK1140185T3 (da) 1998-12-23 2003-09-29 Searle Llc Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer
EP1342475A1 (de) 1998-12-23 2003-09-10 G.D. Searle LLC. Kombinationen von Ileumgallensäuretransportinhibitoren und Cholesterylestertransferproteininhibitoren für kardiovaskuläre Indikationen
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
MXPA01006472A (es) 1998-12-23 2004-03-10 Searle Llc Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares.
DK1140184T3 (da) 1998-12-23 2003-09-29 Searle Llc Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer
EP1286984A2 (de) 2000-03-10 2003-03-05 Pharmacia Corporation Verfahren zur herstellung von tetrahydrobenzothiepinen
HUP0302929A3 (en) * 2000-09-07 2004-10-28 Kaneka Corp Methods for crystallization of hydroxycarboxylic acids
US6740663B2 (en) 2001-11-02 2004-05-25 G.D. Searle, Llc Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
AU2003207431A1 (en) 2002-01-17 2003-09-02 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
KR20040092790A (ko) * 2003-04-29 2004-11-04 씨제이 주식회사 심바스타틴 중간체 제조방법
EP1741427A1 (de) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Pharmazeutische Zusammensetzung enthaltend Simvastatin und Ezetimibe
ES2378281T3 (es) 2006-07-05 2012-04-10 Nycomed Gmbh Combinación de atorvastatina con un inhibidor de fosfodiesterasa 4 para el tratamiento de neumopatías inflamatorias
WO2009013764A2 (en) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
ES2330184B1 (es) 2008-06-03 2010-07-05 Neuron Biopharma, S.A. Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores.
ES2343049B1 (es) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. Biosintesis de derivados de monacolina j.
EP2204170A1 (de) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Pharmazeutische Zusammensetzung mit Ezetimibe und Simvastatin
EP2327682A1 (de) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Verwendung von amphiphilen Verbindungen zur gesteuerten Kristallisation von Statinen und Statin Zwischenprodukte.
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2216016A1 (de) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Verfahren zur Herstellung einer pharmazeutischen Zusammensetzung, die Ezetimib umfasst
EP2241561A1 (de) * 2009-04-16 2010-10-20 Neuron Biopharma, S.A. Neuroprotektive, hypercholesterolemische und antiepileptische Verbindung
WO2011002424A2 (en) 2009-07-02 2011-01-06 Bilgic Mahmut Solubility and stability enchancing pharmaceutical formulation
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
EP2368543A1 (de) 2010-03-25 2011-09-28 KRKA, tovarna zdravil, d.d., Novo mesto Verfahren zur Herstellung einer granulierten pharmazeutischen Zusammensetzung mit Simvastatin und/oder Ezetimibe
ES2380473B1 (es) * 2010-10-13 2013-02-19 Neuron Biopharma, S.A. Compuesto neuroprotector, hipocolesterolémico, antiinflamatorio y antiepiléptico.
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
EP2797641B1 (de) 2011-12-29 2019-07-10 Trustees Of Tufts College Funktionalisierung von biomaterialien zur steuerung von regenerations- und entzündungsreaktionen
EA039663B1 (ru) 2012-05-03 2022-02-24 Амген Инк. Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
RU2015101113A (ru) 2012-06-15 2016-08-10 Дженентек, Инк. Антитела против pcsk9, составы, дозы и способы применения

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5612114B2 (de) * 1974-06-07 1981-03-18
US4137322A (en) 1976-11-02 1979-01-30 Sankyo Company Limited ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents
JPS6026094B2 (ja) 1978-07-04 1985-06-21 三共株式会社 テトラヒドロｍｌ↓−２３６ｂおよびその誘導体並びにそれを有効成分とする高脂血症治療剤
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
GR69216B (de) * 1979-06-15 1982-05-07 Merck & Co Inc
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
PT72394B (en) 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics

Also Published As

Publication number Publication date
GR74798B (de) 1984-07-12
CY1404A (en) 1988-04-22
IE810204L (en) 1981-08-04
ES8609296A1 (es) 1985-10-16
EP0033538A2 (de) 1981-08-12
HK16488A (en) 1988-03-11
MY8700745A (en) 1987-12-31
YU28181A (en) 1983-10-31
AU548996B2 (en) 1986-01-09
DE3173042D1 (en) 1986-01-09
IL62044A (en) 1987-03-31
SG61087G (en) 1987-10-23
NO1994001I1 (no) 1994-07-01
NO154229C (no) 1986-08-13
DK157292B (da) 1989-12-04
DK46181A (da) 1981-08-05
PT72441A (pt) 1981-03-01
MA19054A1 (fr) 1981-10-01
RO82367A (ro) 1984-02-21
PT72441B (pt) 1984-08-01
EP0033538B1 (de) 1985-11-27
EP0033538A3 (en) 1982-02-24
NO154229B (no) 1986-05-05
FI78082C (fi) 1989-06-12
CA1199322A (en) 1986-01-14
DD155989A5 (de) 1982-07-21
IE51478B1 (en) 1987-01-07
AU6657381A (en) 1981-08-13
NL930009I1 (nl) 1993-04-01
RO82367B (ro) 1984-02-28
FI78082B (fi) 1989-02-28
FI810287L (fi) 1981-08-05
IL62044A0 (en) 1981-03-31
NZ196172A (en) 1985-01-31
NL930009I2 (nl) 1993-09-16
NO810358L (no) 1981-08-05
ES499079A0 (es) 1985-10-16

Similar Documents

Publication Publication Date Title
IT1212846B (it) Procedimento per la dissoluzione di carbammato di cellulosa.
ES516482A0 (es) "un metodo para preprar una composicion acuosa de humo liquido".
DK148795C (da) Anologifremgangsmaade til fremstilling af 3-(2-morpholino-ethyl-amino)-5-phenyl-pyridazin eller farmaceutisk acceptable syreadditionssalte deraf
DK45081A (da) Fremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl) )--imidazolin eller ikke-toxiske syreadditionssalte deraf
DK341281A (da) Fremgangsmaade til fremstilling af 3,3-dialkyldenzodiazepinderivater eller syreadditionssalte deraf samt ved fremgangsmaaden som mellemprodukter anvendelige forbindelrser
DK413783D0 (da) Fremgangsmade til fremstilling af 20-amino-macrolidderivater eller syreadditionssalte deraf
DK154557C (da) Analogifremgangsmaade til fremstilling af 3,4-dihydro-8-((2-hydroxy-3-alkylamino)-propoxy)-2h-1-benzopyranderivater eller et farmaceutisk acceptabelt syreadditionssalt deraf
DK462183A (da) Fremgangsmaade til fremstilling af 3-(heterocyclyl eller aryl)methylthio-2-phenyl-1-(1h-1,2,4-triazol-1-yl)-2-propanol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
FI853813A7 (fi) Menetelmä optisesti aktiivisten amiinien valmistamiseksi.
DK540283A (da) Fremgangsmaade til fremstilling af thienyleddikesyreamider eller fysiologisk taalelige syreadditionssalte deraf
DK98383A (da) Fremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
FI832036A7 (fi) Menetelmä oksatsolietikkahapon valmistamiseksi.
DK208981A (da) Fremgangsmaade til fremstilling af benzoxazol- eller benzothiazol-2-carboxylsyreestere eller syreadditionssalte eller konjugatsalte deraf
FI810658A7 (fi) Menetelmä 1-kromaanin N- imidatsolyyliderivaattien valmistamiseksi.
ES515057A0 (es) "un metodo para preparar una suspension acuosa estabilizada de oxendolona".
FI810016A7 (fi) (2-aminotiatsol-4-yyli)etikkahapon hydrokloridin valmistusmenetelmä.
DK562181A (da) Fremgangsmaade mikroorganisme og kulturmedium til fremstilling af et a-4696g-glycoppeptid eller et pharmaceutisk acceptablt syreadditionssalt deraf samt glycopeptidets anvendelse som vaekstfremmende middel
DK446882A (da) Substituerede vinylcyclopropancarboxylsyre-(6-phenoxy-2-pyridinyl)-methylestere, fremgangsmaade til fremstilling heraf samt deres anvendelse som midler til bekaempelse af skadelige organismer
DE3366909D1 (en) Method for racemization of optically active 2,2-dimethylcyclopropane-1-carboxylic acid halide
FI852751A7 (fi) Menetelmä nitrovinkamiinihappojohdannaisten valmistamiseksi.
FI830939A7 (fi) Menetelmä indolitsino(8,7-b)indolin uusien johdannaisten valmistamiseksi.
DK151959C (da) Analogifremgangsmaade til fremstilling af 3-methyl-4-halogenisoxazol-5-yl-methylenoxyguanidin eller farmakologisk acceptable syreadditionssalte deraf
DK485683D0 (da) Benzodioxolderivater og syreadditionssalte deraf samt fremgangsmade til fremstilling deraf
ES523684A0 (es) Un procedimiento para preparar derivados de eburnano racemicos u opticamente activos.
FI831838A7 (fi) Menetelmä 2-(Z)- fenyylimetyleenisykloheptaani-johdannaisten valmistamiseksi.