DK1584232T3 - Mutante ikke-humane pattedyr med mangel på sigmareceptor og anvendelser deraf - Google Patents

Mutante ikke-humane pattedyr med mangel på sigmareceptor og anvendelser deraf

Info

Publication number
DK1584232T3
DK1584232T3 DK03778357T DK03778357T DK1584232T3 DK 1584232 T3 DK1584232 T3 DK 1584232T3 DK 03778357 T DK03778357 T DK 03778357T DK 03778357 T DK03778357 T DK 03778357T DK 1584232 T3 DK1584232 T3 DK 1584232T3
Authority
DK
Denmark
Prior art keywords
sigmar
receptor
lack
human mammals
mutant non
Prior art date
Application number
DK03778357T
Other languages
Danish (da)
English (en)
Inventor
Castanedo Daniel Zamanillo
Jose Lluis Montoliu
Vives Francina Langa
Judez Alfonso Javier Lavado
Herrador Victoria Eugeni Tovar
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Application granted granted Critical
Publication of DK1584232T3 publication Critical patent/DK1584232T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK03778357T 2002-12-09 2003-12-09 Mutante ikke-humane pattedyr med mangel på sigmareceptor og anvendelser deraf DK1584232T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200202815A ES2209650B2 (es) 2002-12-09 2002-12-09 Mamiferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones.
PCT/ES2003/000624 WO2004052092A1 (es) 2002-12-09 2003-12-09 Mamíferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones

Publications (1)

Publication Number Publication Date
DK1584232T3 true DK1584232T3 (da) 2007-07-30

Family

ID=32480022

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03778357T DK1584232T3 (da) 2002-12-09 2003-12-09 Mutante ikke-humane pattedyr med mangel på sigmareceptor og anvendelser deraf

Country Status (14)

Country Link
US (1) US8003847B2 (de)
EP (2) EP1752540A3 (de)
JP (1) JP4515915B2 (de)
AR (1) AR042300A1 (de)
AT (1) ATE360362T1 (de)
AU (1) AU2003285369C1 (de)
CA (1) CA2508697A1 (de)
CY (1) CY1106675T1 (de)
DE (1) DE60313499T2 (de)
DK (1) DK1584232T3 (de)
ES (2) ES2209650B2 (de)
NO (1) NO20053367D0 (de)
PT (1) PT1584232E (de)
WO (1) WO2004052092A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1940389A2 (de) 2005-10-21 2008-07-09 Braincells, Inc. Modulation von neurogenese durch pde-hemmung
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2068872A1 (de) 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US6239326B1 (en) 1996-11-07 2001-05-29 The Wistar Institute Of Anatomy And Biology Sparc-deficient transgenic mice
US6194633B1 (en) 1998-01-26 2001-02-27 University Of Iowa Research Foundation Non-human animal having a functionally disrupted SLP-76 gene
US6207876B1 (en) 1998-04-28 2001-03-27 Board Of Regents, The University Of Texas System Adenosine deaminase deficient transgenic mice and methods for the use thereof
US6252132B1 (en) 1998-11-02 2001-06-26 Institut Pasteur Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor
US6245965B1 (en) 1999-01-29 2001-06-12 St. Jude Children's Research Hospital Knockout mice and cells that lack p19INK4d and p27KIP1 activity and methods of use thereof
US6245963B1 (en) 1999-05-28 2001-06-12 Academia Sinica Knockout-transgenic mouse model of spinal muscular atrophy
JP4470077B2 (ja) * 1999-11-16 2010-06-02 和男 鈴木 好中球走化性因子ｌｅｃｔ２遺伝子の機能が欠損したマウス

Also Published As

Publication number Publication date
EP1752540A2 (de) 2007-02-14
DE60313499D1 (de) 2007-06-06
AR042300A1 (es) 2005-06-15
AU2003285369B2 (en) 2009-09-10
PT1584232E (pt) 2007-07-24
US8003847B2 (en) 2011-08-23
US20050132429A1 (en) 2005-06-16
NO20053367L (no) 2005-07-11
ES2286484T3 (es) 2007-12-01
NO20053367D0 (no) 2005-07-11
EP1584232A1 (de) 2005-10-12
ES2209650B2 (es) 2006-11-01
ATE360362T1 (de) 2007-05-15
WO2004052092A1 (es) 2004-06-24
AU2003285369A1 (en) 2004-06-30
AU2003285369C1 (en) 2010-02-18
ES2209650A1 (es) 2004-06-16
EP1752540A3 (de) 2007-11-21
CA2508697A1 (en) 2004-06-24
HK1083987A1 (en) 2006-07-21
JP4515915B2 (ja) 2010-08-04
CY1106675T1 (el) 2012-05-23
DE60313499T2 (de) 2008-01-03
JP2006508673A (ja) 2006-03-16
EP1584232B1 (de) 2007-04-25

Similar Documents

Publication Publication Date Title
NO20052920D0 (no) 2'-forgrenet nukleosider og flaviviridae mutasjon
ZA200502867B (en) Methods of generating and screening for proteases with altered specificity
EP1474445A4 (de) Glykoisoformen vom adiponektin und deren verwendung
GB2425802B (en) Elastic and plastic expansion of downhole tubulars
TW543821U (en) USB multifunction apparatus and assembly of connection and expansion
IL165803A0 (en) Ultrasonic testing of fitting assembly
ITMI20021135A0 (it) Seggiolone per bambini e simili con mezzi di azionamento facilitato
TW577557U (en) Improved fixing structure of heat sink
IL182185A (en) Isolated atpe protein mutant and associated methods
DK1584232T3 (da) Mutante ikke-humane pattedyr med mangel på sigmareceptor og anvendelser deraf
IS7811A (is) Aðferðir og prófefni til að meðhöndla sjúkdóma ogkvilla sem tengjast auknu magni af bólguvaldandi frumuboðum
IS8315A (is) Breytt IL-4 mútein viðtaka mótlyf
EP1672071A4 (de) Verfahren zum nachweis einer mutation und verfahren zur induktion davon
AU2003296725A1 (en) Subsea structure and methods of construction and installation thereof
ITMI20020690A1 (it) Sedia con sedile avanzabile
TW514125U (en) Improved structure of easy change and adjustment gate
TW533806U (en) Structure of improved-type chair
TW510373U (en) Improved structure of frame member of water gate
TW561886U (en) Structure of chair with toilet device
TW556517U (en) Improved structure of sliding-type support fastening seat
GB0227170D0 (en) Methods of fixing seats to furniture and toilets
AU2003218563A8 (en) Enolase polypeptides and structures
TW541925U (en) Structure of pillow
TW556742U (en) Improved structure of bathroom fixing frames
TW524266U (en) Improved structure of flood-resistant gates