DK1584621T3 - Fremgangsmåde til fremstilling af tolterodin samt mellemprodukter deraf - Google Patents

Fremgangsmåde til fremstilling af tolterodin samt mellemprodukter deraf

Info

Publication number: DK1584621T3
Authority: DK; Denmark
Prior art keywords: tolterodine; intermediates; preparation; methyl; chroman
Prior art date: 2004-03-30

Application number

DK05005572T

Other languages

Danish (da)

English (en)

Inventor

Lino Colombo

Roberto Rossi

Pietro Allegrini

Graziano Castaldi

Original Assignee

Dipharma Francis Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-30

Filing date

2005-03-15

Publication date

2007-09-10

2005-03-15 Application filed by Dipharma Francis Srl filed Critical Dipharma Francis Srl

2007-09-10 Application granted granted Critical

2007-09-10 Publication of DK1584621T3 publication Critical patent/DK1584621T3/da

Links

239000000543 intermediate Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 title abstract 2
229960004045 tolterodine Drugs 0.000 title abstract 2
BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 title abstract 2
FXFYOPQLGGEACP-UHFFFAOYSA-N 6-methylcoumarin Chemical compound O1C(=O)C=CC2=CC(C)=CC=C21 FXFYOPQLGGEACP-UHFFFAOYSA-N 0.000 abstract 2
SUHIZPDCJOQZLN-CYBMUJFWSA-N (4r)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one Chemical compound C1([C@H]2CC(=O)OC3=CC=C(C=C32)C)=CC=CC=C1 SUHIZPDCJOQZLN-CYBMUJFWSA-N 0.000 abstract 1
SUHIZPDCJOQZLN-ZDUSSCGKSA-N (4s)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one Chemical compound C1([C@@H]2CC(=O)OC3=CC=C(C=C32)C)=CC=CC=C1 SUHIZPDCJOQZLN-ZDUSSCGKSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical class OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK05005572T 2004-03-30 2005-03-15 Fremgangsmåde til fremstilling af tolterodin samt mellemprodukter deraf DK1584621T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000616A ITMI20040616A1 (it)	2004-03-30	2004-03-30	Processo per la preparazione di tolterodina e suoi intermedi

Publications (1)

Publication Number	Publication Date
DK1584621T3 true DK1584621T3 (da)	2007-09-10

Family

ID=34897788

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05005572T DK1584621T3 (da)	2004-03-30	2005-03-15	Fremgangsmåde til fremstilling af tolterodin samt mellemprodukter deraf

Country Status (10)

Country	Link
US (1)	US7119212B2 (de)
EP (1)	EP1584621B1 (de)
JP (1)	JP2005281311A (de)
AT (1)	ATE364599T1 (de)
CA (1)	CA2502640A1 (de)
DE (1)	DE602005001340T2 (de)
DK (1)	DK1584621T3 (de)
ES (1)	ES2287828T3 (de)
IT (1)	ITMI20040616A1 (de)
PT (1)	PT1584621E (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100686351B1 (ko) *	2006-01-12	2007-02-22	주식회사 카이로제닉스	톨테로딘 라세미체의 제조방법
KR100717361B1 (ko)	2006-08-07	2007-05-11	주식회사 카이로제닉스	톨테로딘 라세미체 및 이의 중간체의 제조방법
EP2476665A1 (de)	2011-01-17	2012-07-18	Cambrex Profarmaco Milano S.r.l.	Verfahren zur Herstellung von N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl-Propylamin und seine Salze aus einem neuartigen Zwischenstoffs
WO2012098044A1 (en)	2011-01-17	2012-07-26	Cambrex Profarmaco Milano S.R.L.	Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9904850D0 (sv) *	1999-12-30	1999-12-30	Pharmacia & Upjohn Ab	Novel process and intermediates

2004
- 2004-03-30 IT IT000616A patent/ITMI20040616A1/it unknown
2005
- 2005-03-15 DK DK05005572T patent/DK1584621T3/da active
- 2005-03-15 AT AT05005572T patent/ATE364599T1/de not_active IP Right Cessation
- 2005-03-15 PT PT05005572T patent/PT1584621E/pt unknown
- 2005-03-15 DE DE602005001340T patent/DE602005001340T2/de not_active Expired - Fee Related
- 2005-03-15 EP EP05005572A patent/EP1584621B1/de not_active Expired - Lifetime
- 2005-03-15 ES ES05005572T patent/ES2287828T3/es not_active Expired - Lifetime
- 2005-03-29 CA CA002502640A patent/CA2502640A1/en not_active Abandoned
- 2005-03-29 JP JP2005093540A patent/JP2005281311A/ja active Pending
- 2005-03-29 US US11/092,553 patent/US7119212B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2287828T3 (es)	2007-12-16
EP1584621A1 (de)	2005-10-12
CA2502640A1 (en)	2005-09-30
ITMI20040616A1 (it)	2004-06-30
DE602005001340T2 (de)	2008-02-21
PT1584621E (pt)	2007-09-04
EP1584621B1 (de)	2007-06-13
ATE364599T1 (de)	2007-07-15
DE602005001340D1 (de)	2007-07-26
JP2005281311A (ja)	2005-10-13
US20050222437A1 (en)	2005-10-06
US7119212B2 (en)	2006-10-10

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