ATE364599T1 - Verfahren zur herstellung von tolterodine und deren zwischenprodukten. - Google Patents
Verfahren zur herstellung von tolterodine und deren zwischenprodukten.Info
- Publication number
- ATE364599T1 ATE364599T1 AT05005572T AT05005572T ATE364599T1 AT E364599 T1 ATE364599 T1 AT E364599T1 AT 05005572 T AT05005572 T AT 05005572T AT 05005572 T AT05005572 T AT 05005572T AT E364599 T1 ATE364599 T1 AT E364599T1
- Authority
- AT
- Austria
- Prior art keywords
- intermediate products
- tolterodine
- methyl
- producing
- producing tolterodine
- Prior art date
Links
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 title abstract 2
- 229960004045 tolterodine Drugs 0.000 title abstract 2
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- FXFYOPQLGGEACP-UHFFFAOYSA-N 6-methylcoumarin Chemical compound O1C(=O)C=CC2=CC(C)=CC=C21 FXFYOPQLGGEACP-UHFFFAOYSA-N 0.000 abstract 2
- SUHIZPDCJOQZLN-CYBMUJFWSA-N (4r)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one Chemical compound C1([C@H]2CC(=O)OC3=CC=C(C=C32)C)=CC=CC=C1 SUHIZPDCJOQZLN-CYBMUJFWSA-N 0.000 abstract 1
- SUHIZPDCJOQZLN-ZDUSSCGKSA-N (4s)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one Chemical compound C1([C@@H]2CC(=O)OC3=CC=C(C=C32)C)=CC=CC=C1 SUHIZPDCJOQZLN-ZDUSSCGKSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical class OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000616A ITMI20040616A1 (it) | 2004-03-30 | 2004-03-30 | Processo per la preparazione di tolterodina e suoi intermedi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE364599T1 true ATE364599T1 (de) | 2007-07-15 |
Family
ID=34897788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05005572T ATE364599T1 (de) | 2004-03-30 | 2005-03-15 | Verfahren zur herstellung von tolterodine und deren zwischenprodukten. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7119212B2 (de) |
| EP (1) | EP1584621B1 (de) |
| JP (1) | JP2005281311A (de) |
| AT (1) | ATE364599T1 (de) |
| CA (1) | CA2502640A1 (de) |
| DE (1) | DE602005001340T2 (de) |
| DK (1) | DK1584621T3 (de) |
| ES (1) | ES2287828T3 (de) |
| IT (1) | ITMI20040616A1 (de) |
| PT (1) | PT1584621E (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100686351B1 (ko) * | 2006-01-12 | 2007-02-22 | 주식회사 카이로제닉스 | 톨테로딘 라세미체의 제조방법 |
| KR100717361B1 (ko) | 2006-08-07 | 2007-05-11 | 주식회사 카이로제닉스 | 톨테로딘 라세미체 및 이의 중간체의 제조방법 |
| EP2476665A1 (de) | 2011-01-17 | 2012-07-18 | Cambrex Profarmaco Milano S.r.l. | Verfahren zur Herstellung von N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl-Propylamin und seine Salze aus einem neuartigen Zwischenstoffs |
| WO2012098044A1 (en) | 2011-01-17 | 2012-07-26 | Cambrex Profarmaco Milano S.R.L. | Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904850D0 (sv) * | 1999-12-30 | 1999-12-30 | Pharmacia & Upjohn Ab | Novel process and intermediates |
-
2004
- 2004-03-30 IT IT000616A patent/ITMI20040616A1/it unknown
-
2005
- 2005-03-15 DK DK05005572T patent/DK1584621T3/da active
- 2005-03-15 DE DE602005001340T patent/DE602005001340T2/de not_active Expired - Fee Related
- 2005-03-15 AT AT05005572T patent/ATE364599T1/de not_active IP Right Cessation
- 2005-03-15 ES ES05005572T patent/ES2287828T3/es not_active Expired - Lifetime
- 2005-03-15 EP EP05005572A patent/EP1584621B1/de not_active Expired - Lifetime
- 2005-03-15 PT PT05005572T patent/PT1584621E/pt unknown
- 2005-03-29 US US11/092,553 patent/US7119212B2/en not_active Expired - Fee Related
- 2005-03-29 JP JP2005093540A patent/JP2005281311A/ja active Pending
- 2005-03-29 CA CA002502640A patent/CA2502640A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2502640A1 (en) | 2005-09-30 |
| ITMI20040616A1 (it) | 2004-06-30 |
| EP1584621B1 (de) | 2007-06-13 |
| DK1584621T3 (da) | 2007-09-10 |
| US7119212B2 (en) | 2006-10-10 |
| PT1584621E (pt) | 2007-09-04 |
| DE602005001340D1 (de) | 2007-07-26 |
| US20050222437A1 (en) | 2005-10-06 |
| JP2005281311A (ja) | 2005-10-13 |
| DE602005001340T2 (de) | 2008-02-21 |
| ES2287828T3 (es) | 2007-12-16 |
| EP1584621A1 (de) | 2005-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1584621 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |