DK158989C - Cholestadienderivat, der kan anvendes som mellemprodukt til brug ved fremstillingen af homovitamin-d3-derivater - Google Patents

Cholestadienderivat, der kan anvendes som mellemprodukt til brug ved fremstillingen af homovitamin-d3-derivater

Info

Publication number
DK158989C
DK158989C DK177489A DK177489A DK158989C DK 158989 C DK158989 C DK 158989C DK 177489 A DK177489 A DK 177489A DK 177489 A DK177489 A DK 177489A DK 158989 C DK158989 C DK 158989C
Authority
DK
Denmark
Prior art keywords
derivatives
homovitamin
cholesta
stage
preparation
Prior art date
Application number
DK177489A
Other languages
English (en)
Other versions
DK177489A (da
DK158989B (da
DK177489D0 (da
Inventor
Hector F Deluca
Nobuo Ikekawa
Yoko Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK177489A publication Critical patent/DK177489A/da
Publication of DK177489D0 publication Critical patent/DK177489D0/da
Publication of DK158989B publication Critical patent/DK158989B/da
Application granted granted Critical
Publication of DK158989C publication Critical patent/DK158989C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK177489A 1984-10-04 1989-04-13 Cholestadienderivat, der kan anvendes som mellemprodukt til brug ved fremstillingen af homovitamin-d3-derivater DK158989C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65754984A 1984-10-04 1984-10-04
US65754984 1984-10-04
PCT/US1985/001571 WO1986002078A1 (en) 1984-10-04 1985-08-19 Vitamin d derivatives and methods for preparing same
US8501571 1985-08-19

Publications (4)

Publication Number Publication Date
DK177489A DK177489A (da) 1989-04-13
DK177489D0 DK177489D0 (da) 1989-04-13
DK158989B DK158989B (da) 1990-08-13
DK158989C true DK158989C (da) 1991-01-21

Family

ID=24637652

Family Applications (5)

Application Number Title Priority Date Filing Date
DK260086A DK154290C (da) 1984-10-04 1986-06-03 Vitamin-d-derivater og farmaceutiske praeparater indeholdende disse
DK111188A DK159389C (da) 1984-10-04 1988-03-02 Cholestadien- eller -trienderivater, der kan anvendes som mellemprodukter til brug ved fremstillingen af 24-homovitamin-d3-derivater
DK177489A DK158989C (da) 1984-10-04 1989-04-13 Cholestadienderivat, der kan anvendes som mellemprodukt til brug ved fremstillingen af homovitamin-d3-derivater
DK015390A DK158991C (da) 1984-10-04 1990-01-19 Cholestadienderivater, der kan anvendes som mellemprodukter til brug ved fremstillingen af homovitamin-d3-derivater
DK015290A DK158990C (da) 1984-10-04 1990-01-19 Cholestadienderivat, der kan anvendes som mellemprodukt til brug ved fremstillingen af homovitamin-d3-derivater

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK260086A DK154290C (da) 1984-10-04 1986-06-03 Vitamin-d-derivater og farmaceutiske praeparater indeholdende disse
DK111188A DK159389C (da) 1984-10-04 1988-03-02 Cholestadien- eller -trienderivater, der kan anvendes som mellemprodukter til brug ved fremstillingen af 24-homovitamin-d3-derivater

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK015390A DK158991C (da) 1984-10-04 1990-01-19 Cholestadienderivater, der kan anvendes som mellemprodukter til brug ved fremstillingen af homovitamin-d3-derivater
DK015290A DK158990C (da) 1984-10-04 1990-01-19 Cholestadienderivat, der kan anvendes som mellemprodukt til brug ved fremstillingen af homovitamin-d3-derivater

Country Status (13)

Country Link
EP (1) EP0197949A1 (da)
JP (3) JPS62500301A (da)
AU (2) AU582789B2 (da)
BE (1) BE903376A (da)
CH (1) CH672920A5 (da)
DE (2) DE3590488C2 (da)
DK (5) DK154290C (da)
FR (1) FR2571369B1 (da)
GB (2) GB2167070B (da)
IE (1) IE58104B1 (da)
IT (1) IT1190401B (da)
NL (1) NL8520265A (da)
WO (1) WO1986002078A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206229A (en) * 1988-04-21 1993-04-27 Leo Pharmaceutical Products Ltd Vitamin d analogues
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
KR940003360B1 (ko) * 1988-04-29 1994-04-21 위스콘신 알럼나이 리써취 파운데이션 불포화 측쇄를 갖는 1α-히드록시비타민 D동족체
GB2229921B (en) * 1989-04-05 1992-12-16 Chugai Pharmaceutical Co Ltd Treatment for hyperparathyroidism with use of vitamin d derivatives
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5891865A (en) * 1996-10-04 1999-04-06 Wisconsin Alumni Research Foundation Treatment of arthritic disease induced by infectious agents
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US4226770A (en) 1978-02-10 1980-10-07 Kaiser Emil T Synthesis of steroids
US4163744A (en) 1978-02-10 1979-08-07 Kaiser Emil T Synthesis of steroids
AU527805B2 (en) * 1978-07-27 1983-03-24 Research Institute For Medicine And Chemistry Inc. 1alpha, 1beta dihydroxy steroid-5-enes
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
WO1984004527A1 (en) * 1983-05-09 1984-11-22 Wisconsin Alumni Res Found PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS

Also Published As

Publication number Publication date
DK260086D0 (da) 1986-06-03
DK15390D0 (da) 1990-01-19
DE3590488C2 (da) 1992-10-01
JPH05222089A (ja) 1993-08-31
DE3590488T (de) 1986-10-09
CH672920A5 (da) 1990-01-15
JPH05178887A (ja) 1993-07-20
AU605007B2 (en) 1991-01-03
DK15290D0 (da) 1990-01-19
JPH0569103B2 (da) 1993-09-30
AU4776185A (en) 1986-04-17
DK111188D0 (da) 1988-03-02
AU2761488A (en) 1989-06-08
DK15390A (da) 1990-01-19
JPH0635475B2 (ja) 1994-05-11
IT8522359A0 (it) 1985-10-04
FR2571369A1 (fr) 1986-04-11
DK159389C (da) 1991-03-11
NL8520265A (nl) 1986-09-01
JPH0689022B2 (ja) 1994-11-09
DK177489A (da) 1989-04-13
DK158991B (da) 1990-08-13
DK158991C (da) 1991-01-21
DK158990B (da) 1990-08-13
DK158989B (da) 1990-08-13
DK154290C (da) 1989-03-28
DK158990C (da) 1991-01-21
WO1986002078A1 (en) 1986-04-10
IT1190401B (it) 1988-02-16
IE58104B1 (en) 1993-06-30
DK159389B (da) 1990-10-08
GB2167070B (en) 1988-09-01
BE903376A (fr) 1986-02-03
DK177489D0 (da) 1989-04-13
DK15290A (da) 1990-01-19
EP0197949A1 (en) 1986-10-22
GB2188932B (en) 1988-09-01
GB2167070A (en) 1986-05-21
GB8524479D0 (en) 1985-11-06
DK260086A (da) 1986-06-03
FR2571369B1 (fr) 1987-12-04
DK154290B (da) 1988-10-31
GB8709579D0 (en) 1987-05-28
GB2188932A (en) 1987-10-14
IE852443L (en) 1986-04-04
DK111188A (da) 1988-03-02
AU582789B2 (en) 1989-04-13
JPS62500301A (ja) 1987-02-05

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