DK1589976T3 - Anvendelse af en kombination af en aromatase-inhibitor, et progestin og et estrogen til behandling af endometriose - Google Patents

Anvendelse af en kombination af en aromatase-inhibitor, et progestin og et estrogen til behandling af endometriose

Info

Publication number: DK1589976T3
Authority: DK; Denmark
Prior art keywords: progestin; endometriosis; estrogen; treatment; combination
Prior art date: 2003-02-05

Application number

DK04707574T

Other languages

Danish (da)

English (en)

Inventor

Stephen Rubin

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-05

Filing date

2004-02-03

Publication date

2007-12-27

2004-02-03 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2007-12-27 Application granted granted Critical

2007-12-27 Publication of DK1589976T3 publication Critical patent/DK1589976T3/da

Links

229940122815 Aromatase inhibitor Drugs 0.000 title 1
201000009273 Endometriosis Diseases 0.000 title 1
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title 1
239000003886 aromatase inhibitor Substances 0.000 title 1
239000000262 estrogen Substances 0.000 title 1
229940011871 estrogen Drugs 0.000 title 1
239000000583 progesterone congener Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Gynecology & Obstetrics (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK04707574T 2003-02-05 2004-02-03 Anvendelse af en kombination af en aromatase-inhibitor, et progestin og et estrogen til behandling af endometriose DK1589976T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0302572.3A GB0302572D0 (en)	2003-02-05	2003-02-05	Method of treatment
PCT/GB2004/000414 WO2004069260A1 (fr)	2003-02-05	2004-02-03	Composition comportant une combinaison d'un inhibiteur de l'aromatase, d'une progestine et d'un oestrogene et son utilisation pour le traitement des endometrioses

Publications (1)

Publication Number	Publication Date
DK1589976T3 true DK1589976T3 (da)	2007-12-27

Family

ID=9952433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04707574T DK1589976T3 (da)	2003-02-05	2004-02-03	Anvendelse af en kombination af en aromatase-inhibitor, et progestin og et estrogen til behandling af endometriose

Country Status (29)

Country	Link
US (2)	US7910570B2 (fr)
EP (2)	EP1589976B1 (fr)
JP (2)	JP4658918B2 (fr)
KR (1)	KR101075929B1 (fr)
CN (1)	CN100393360C (fr)
AR (1)	AR043013A1 (fr)
AT (1)	ATE374612T1 (fr)
AU (1)	AU2004210184B2 (fr)
BR (1)	BRPI0407039A (fr)
CA (1)	CA2513910C (fr)
CO (1)	CO5580789A2 (fr)
CY (1)	CY1107816T1 (fr)
DE (1)	DE602004009288T2 (fr)
DK (1)	DK1589976T3 (fr)
ES (1)	ES2293215T3 (fr)
GB (1)	GB0302572D0 (fr)
IL (1)	IL169583A0 (fr)
IS (1)	IS2547B (fr)
MX (1)	MXPA05008347A (fr)
MY (1)	MY140723A (fr)
NO (1)	NO20053626L (fr)
NZ (1)	NZ541222A (fr)
PL (1)	PL214680B1 (fr)
PT (1)	PT1589976E (fr)
RU (2)	RU2360681C2 (fr)
TW (1)	TWI354556B (fr)
UA (1)	UA80741C2 (fr)
WO (1)	WO2004069260A1 (fr)
ZA (1)	ZA200506221B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0302572D0 (en) *	2003-02-05	2003-03-12	Astrazeneca Ab	Method of treatment
CN101107004A (zh) *	2004-10-04	2008-01-16	韦恩州立大学	芳香酶抑制剂在子宫内膜腔和子宫手术前的子宫薄化中的应用
WO2009075838A2 (fr) *	2007-12-10	2009-06-18	Meditrina Pharmaceuticals, Inc.	Traitement de la ménorragie avec un inhibiteur de l'aromatase
DE102010003494A1 (de) *	2010-03-31	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
EP2476409A1 (fr) *	2011-01-14	2012-07-18	Université Catholique De Louvain	Implant avec un noyau et un tube enrobant le noyau
RU2541089C1 (ru) *	2013-11-22	2015-02-10	Федеральное государственное бюджетное учреждение "Научно-исследовательски институт акушерства и гинекологии им. Д.О. Отта" Северо-Западного отделения Российской академии медицинских наук	Способ комплексного лечения наружного генитального эндометриоза
GB201614179D0 (en) *	2016-08-19	2016-10-05	Mereo Biopharma 2 Ltd	Dosage regimen for the treatment of endometriosis
CN109248166A (zh) *	2017-07-13	2019-01-22	国家卫生计生委科学技术研究所	阿那曲唑储库型阴道环的制备及应用
KR20240076617A (ko)	2022-11-22	2024-05-30	성균관대학교산학협력단	디프레닐로로볼을 유효성분으로 포함하는 자궁내막증 예방 또는 치료용 약제학적 조성물
US20240315958A1 (en) *	2023-03-23	2024-09-26	Chemo Research, S.L.	Method and device for providing effective contraception
WO2024197239A1 (fr) *	2023-03-23	2024-09-26	William Bologna	Compositions bioadhésives et procédé de traitement de l'endométriose avec des inhibiteurs d'aromatase sans augmentation de la production de gonadatropine

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8813353D0 (en) *	1988-06-06	1988-07-13	Ici Plc	Therapeutic product
PH30747A (en) *	1989-03-10	1997-10-17	Endorech Inc	Combination therapy for the treatment of estrogen sensitive disease.
JP2602456B2 (ja)	1990-04-12	1997-04-23	雪印乳業株式会社	子宮内膜症治療剤
DE4344462C2 (de)	1993-12-22	1996-02-01	Schering Ag	Zusammensetzung für die Empfängnisverhütung
US5681817A (en)	1994-02-04	1997-10-28	The Medical College Of Hampton Roads	Treatment of ovarian estrogen dependent conditions
TR200102867T2 (fr)	1998-06-11	2002-06-21	Endorecherchel@Inc
US6265393B1 (en) *	1998-08-07	2001-07-24	Heinrichs William Leroy	Prevention of endometriosis signs or symptons
CA2462081A1 (fr)	2000-10-11	2002-04-18	Laura Kragie	Composition et procede destines a reduire les effets indesirables et/ou ameliorer l'efficacite d'agents inhibant l'aromatase
DE60214355T2 (de)	2001-01-26	2007-08-30	Pfizer Italia S.R.L.	Exemestan zur behandlung von hormonabhängigen störungen
WO2002074315A1 (fr)	2001-03-21	2002-09-26	Schering Aktiengesellschaft	Preparations pharmaceutiques combinees renfermant des inhibiteurs de l'aromatase et des substances a activite oestrogenique et leur utilisation dans la production d'un medicament pour l'oestrogenotherapie de substitution
GB0120147D0 (en)	2001-08-17	2001-10-10	Metris Therapeutics Ltd	Treatment method
WO2003017973A1 (fr)	2001-08-31	2003-03-06	Pantarhei Bioscience B.V.	Traitement de troubles gynecologiques benins et vecteur d'administration a cet effet
IL161630A0 (en)	2001-11-06	2004-09-27	Applied Research Systems	Methods of treating endometreosis
JP2005518412A (ja)	2002-01-22	2005-06-23	アクゾ・ノベル・エヌ・ベー	内因性エストロゲンの合成を阻害する薬物の投与に伴う愁訴の治療におけるチボロン
AU2003213958A1 (en)	2002-04-03	2003-10-13	Jencap Research Ltd.	Female birth control method
AU2003213956A1 (en) *	2002-04-03	2003-10-13	Jencap Research Ltd.	Improved hormone replacement therapy
CA2521305A1 (fr)	2002-04-03	2003-10-09	Jencap Research Ltd.	Composition pharmaceutique comprenant un inhibiteur de l'aromatase et un oestrogene convenant a une hormonotherapie substitutive pour un homme
JP2006516084A (ja) *	2002-06-27	2006-06-22	セントカー・インコーポレーテツド	Ｃｎｇｈ０００４ポリペプチド、抗体、組成物、方法および使用
GB0302572D0 (en) *	2003-02-05	2003-03-12	Astrazeneca Ab	Method of treatment

2003
- 2003-02-05 GB GBGB0302572.3A patent/GB0302572D0/en not_active Ceased
2004
- 2004-01-29 TW TW093101969A patent/TWI354556B/zh not_active IP Right Cessation
- 2004-02-03 EP EP04707574A patent/EP1589976B1/fr not_active Expired - Lifetime
- 2004-02-03 BR BR0407039-9A patent/BRPI0407039A/pt not_active IP Right Cessation
- 2004-02-03 RU RU2005127667/15A patent/RU2360681C2/ru not_active IP Right Cessation
- 2004-02-03 ES ES04707574T patent/ES2293215T3/es not_active Expired - Lifetime
- 2004-02-03 PL PL377939A patent/PL214680B1/pl unknown
- 2004-02-03 AU AU2004210184A patent/AU2004210184B2/en not_active Ceased
- 2004-02-03 PT PT04707574T patent/PT1589976E/pt unknown
- 2004-02-03 EP EP07016253A patent/EP1857111A3/fr not_active Withdrawn
- 2004-02-03 WO PCT/GB2004/000414 patent/WO2004069260A1/fr not_active Ceased
- 2004-02-03 AT AT04707574T patent/ATE374612T1/de active
- 2004-02-03 AR ARP040100329A patent/AR043013A1/es not_active Application Discontinuation
- 2004-02-03 JP JP2006502229A patent/JP4658918B2/ja not_active Expired - Fee Related
- 2004-02-03 DE DE602004009288T patent/DE602004009288T2/de not_active Expired - Lifetime
- 2004-02-03 NZ NZ541222A patent/NZ541222A/en not_active IP Right Cessation
- 2004-02-03 US US10/543,584 patent/US7910570B2/en not_active Expired - Fee Related
- 2004-02-03 CN CNB2004800035630A patent/CN100393360C/zh not_active Expired - Fee Related
- 2004-02-03 MX MXPA05008347A patent/MXPA05008347A/es active IP Right Grant
- 2004-02-03 CA CA2513910A patent/CA2513910C/fr not_active Expired - Fee Related
- 2004-02-03 KR KR1020057014375A patent/KR101075929B1/ko not_active Expired - Fee Related
- 2004-02-03 DK DK04707574T patent/DK1589976T3/da active
- 2004-02-04 MY MYPI20040307A patent/MY140723A/en unknown
- 2004-03-02 UA UAA200508473A patent/UA80741C2/uk unknown
2005
- 2005-07-07 IL IL169583A patent/IL169583A0/en not_active IP Right Cessation
- 2005-07-26 NO NO20053626A patent/NO20053626L/no not_active Application Discontinuation
- 2005-08-01 CO CO05075357A patent/CO5580789A2/es not_active Application Discontinuation
- 2005-08-03 ZA ZA200506221A patent/ZA200506221B/en unknown
- 2005-08-30 IS IS8008A patent/IS2547B/is unknown
2007
- 2007-11-29 CY CY20071101527T patent/CY1107816T1/el unknown
2008
- 2008-09-25 RU RU2008138166/15A patent/RU2008138166A/ru not_active Application Discontinuation
2010
- 2010-09-20 US US12/886,269 patent/US20110009373A1/en not_active Abandoned
- 2010-10-07 JP JP2010227516A patent/JP2011001388A/ja active Pending

Also Published As

Publication number	Publication date
MY140723A (en)	2010-01-15
RU2360681C2 (ru)	2009-07-10
CA2513910A1 (fr)	2004-08-19
ZA200506221B (en)	2006-05-31
EP1857111A2 (fr)	2007-11-21
DE602004009288D1 (de)	2007-11-15
EP1589976B1 (fr)	2007-10-03
CY1107816T1 (el)	2013-06-19
CN1747736A (zh)	2006-03-15
KR20050098296A (ko)	2005-10-11
EP1589976A1 (fr)	2005-11-02
DE602004009288T2 (de)	2008-07-10
CA2513910C (fr)	2012-04-03
ATE374612T1 (de)	2007-10-15
KR101075929B1 (ko)	2011-10-26
IS2547B (is)	2009-10-15
US20110009373A1 (en)	2011-01-13
RU2008138166A (ru)	2010-03-27
CN100393360C (zh)	2008-06-11
TWI354556B (en)	2011-12-21
PL214680B1 (pl)	2013-09-30
TW200503731A (en)	2005-02-01
GB0302572D0 (en)	2003-03-12
NO20053626L (no)	2005-08-26
MXPA05008347A (es)	2005-11-04
CO5580789A2 (es)	2005-11-30
PL377939A1 (pl)	2006-02-20
RU2005127667A (ru)	2006-03-27
UA80741C2 (en)	2007-10-25
JP2011001388A (ja)	2011-01-06
US20060142256A1 (en)	2006-06-29
NZ541222A (en)	2008-12-24
HK1082918A1 (en)	2006-06-23
JP4658918B2 (ja)	2011-03-23
US7910570B2 (en)	2011-03-22
PT1589976E (pt)	2007-11-22
ES2293215T3 (es)	2008-03-16
BRPI0407039A (pt)	2006-01-17
WO2004069260A1 (fr)	2004-08-19
IS8008A (is)	2005-08-30
JP2006516602A (ja)	2006-07-06
EP1857111A3 (fr)	2009-03-04
IL169583A0 (en)	2007-07-04
AU2004210184B2 (en)	2007-01-04
AU2004210184A1 (en)	2004-08-19
AR043013A1 (es)	2005-07-13

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