DK0462189T3 - Kombinationsterapi til behandling af østrogenfølsomme sygdomme - Google Patents

Kombinationsterapi til behandling af østrogenfølsomme sygdomme

Info

Publication number: DK0462189T3
Authority: DK; Denmark
Prior art keywords: inhibitor; treatment; secretion; combination therapy; estrogen
Prior art date: 1989-03-10

Application number

DK90904736.7T

Other languages

English (en)

Inventor

Fernand Labrie

Original Assignee

Endorecherche Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-10

Filing date

1990-03-09

Publication date

1995-11-20

1990-03-09 Application filed by Endorecherche Inc filed Critical Endorecherche Inc

1995-11-20 Application granted granted Critical

1995-11-20 Publication of DK0462189T3 publication Critical patent/DK0462189T3/da

Links

238000002648 combination therapy Methods 0.000 title abstract 2
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
229940011871 estrogen Drugs 0.000 title 1
239000000262 estrogen Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 4
230000028327 secretion Effects 0.000 abstract 4
101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 abstract 2
102100024028 Progonadoliberin-1 Human genes 0.000 abstract 2
101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 abstract 2
XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 abstract 2
108010070743 3(or 17)-beta-hydroxysteroid dehydrogenase Proteins 0.000 abstract 1
JLLYLQLDYORLBB-UHFFFAOYSA-N 5-bromo-n-methylthiophene-2-sulfonamide Chemical compound CNS(=O)(=O)C1=CC=C(Br)S1 JLLYLQLDYORLBB-UHFFFAOYSA-N 0.000 abstract 1
102000014654 Aromatase Human genes 0.000 abstract 1
108010078554 Aromatase Proteins 0.000 abstract 1
206010006187 Breast cancer Diseases 0.000 abstract 1
208000026310 Breast neoplasm Diseases 0.000 abstract 1
101800000414 Corticotropin Proteins 0.000 abstract 1
239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 1
102100034067 Dehydrogenase/reductase SDR family member 11 Human genes 0.000 abstract 1
206010014733 Endometrial cancer Diseases 0.000 abstract 1
206010014759 Endometrial neoplasm Diseases 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 1
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 1
102100024819 Prolactin Human genes 0.000 abstract 1
108010057464 Prolactin Proteins 0.000 abstract 1
102100038803 Somatotropin Human genes 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
229940046836 anti-estrogen Drugs 0.000 abstract 1
230000001833 anti-estrogenic effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
210000000481 breast Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
229960000258 corticotropin Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000328 estrogen antagonist Substances 0.000 abstract 1
239000003163 gonadal steroid hormone Substances 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
230000003054 hormonal effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000009806 oophorectomy Methods 0.000 abstract 1
230000002611 ovarian Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000583 progesterone congener Substances 0.000 abstract 1
229940097325 prolactin Drugs 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK90904736.7T 1989-03-10 1990-03-09 Kombinationsterapi til behandling af østrogenfølsomme sygdomme DK0462189T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US32192689A	1989-03-10	1989-03-10

Publications (1)

Publication Number	Publication Date
DK0462189T3 true DK0462189T3 (da)	1995-11-20

Family

ID=23252650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90904736.7T DK0462189T3 (da)	1989-03-10	1990-03-09	Kombinationsterapi til behandling af østrogenfølsomme sygdomme

Country Status (17)

Country	Link
US (1)	US5550107A (da)
EP (1)	EP0462189B1 (da)
JP (1)	JP2959838B2 (da)
AT (1)	ATE128362T1 (da)
AU (2)	AU5281990A (da)
CA (1)	CA2050291C (da)
DE (1)	DE69022722T2 (da)
DK (1)	DK0462189T3 (da)
ES (1)	ES2077675T3 (da)
HU (1)	HU221589B (da)
IE (1)	IE62715B1 (da)
IL (1)	IL93693A (da)
MY (1)	MY110016A (da)
NZ (2)	NZ232870A (da)
PH (1)	PH30747A (da)
WO (1)	WO1990010462A1 (da)
ZA (1)	ZA901847B (da)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5395842A (en) *	1988-10-31	1995-03-07	Endorecherche Inc.	Anti-estrogenic compounds and compositions
US5393785A (en) *	1988-10-31	1995-02-28	Endorecherche, Inc.	Therapeutic antiestrogens
US5686465A (en) *	1988-10-31	1997-11-11	Endorecherche Inc.	Sex steroid activity inhibitors
US5204337A (en) *	1988-10-31	1993-04-20	Endorecherche Inc.	Estrogen nucleus derivatives for use in inhibition of sex steroid activity
US5595985A (en) *	1989-03-10	1997-01-21	Endorecherche Inc.	Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
DK0595796T3 (da) *	1989-07-07	2003-05-05	Endorech Inc	Fremgangsmåde til behandling af androgen-relaterede sygdomme
NZ241979A (en) *	1991-03-20	1996-01-26	Merck & Co Inc	Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker
US5340586A (en) *	1991-04-12	1994-08-23	University Of Southern California	Methods and formulations for use in treating oophorectomized women
ZA924811B (en) *	1991-06-28	1993-12-29	Endorecherche Inc	Controlled release systems and low dose androgens
HU222501B1 (hu) *	1991-06-28	2003-07-28	Endorecherche Inc.	MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
US6060503A (en) *	1991-12-02	2000-05-09	Endorecherche, Inc.	Benzopyran-containing compounds and method for their use
PT1382340E (pt) *	1993-01-19	2006-07-31	Endorech Inc	Utilizacoes terapeuticas de desidroepiandrosterona para tratar libido diminuida e osteoporose
US5776923A (en) *	1993-01-19	1998-07-07	Endorecherche, Inc.	Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
US5855920A (en) *	1996-12-13	1999-01-05	Chein; Edmund Y. M.	Total hormone replacement therapy
US6653297B1 (en) *	1997-07-03	2003-11-25	Medical College Of Hampton Roads	Control of selective estrogen receptor modulators
US6326392B1 (en)	1997-11-06	2001-12-04	American Home Products Corporation	Anti-estrogen plus progestin containing oral contraceptives
US5879711A (en) *	1997-11-07	1999-03-09	Sequeira; Joel A.	Stable antiandrogenic gel composition
MXPA00008868A (es) *	1998-03-11	2003-04-25	Endorech Inc	Inhibidores de dihidrogenasa de 17 -hidroxiesteroide y metodos para su uso.
US6069153A (en) *	1998-05-12	2000-05-30	American Home Products Corporation	Indenoindoles and benzocarbazoles as estrogenic agents
EP1080073A1 (en) *	1998-05-15	2001-03-07	American Home Products Corporation	Compositions comprising 2-phenyl-indole compounds and estrogen formulations
US6479535B1 (en)	1998-05-15	2002-11-12	Wyeth	2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
US7005428B1 (en)	1998-06-11	2006-02-28	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en)	1998-06-11	2002-10-15	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
AU4701299A (en)	1998-06-23	2000-01-10	Stuart R. Adler	Therapeutic applications of estrogenic carboxylic acids
US8173592B1 (en)	1999-03-31	2012-05-08	Zentaris Ivf Gmbh	Method for a programmed controlled ovarian stimulation protocol
US6159959A (en) *	1999-05-06	2000-12-12	American Home Products Corporation	Combined estrogen and antiestrogen therapy
AU2004222794B2 (en) *	1999-06-11	2007-03-08	Watson Pharmaceuticals, Inc.	Non-oral androgenic steroids for women
JP5184727B2 (ja) *	1999-06-11	2013-04-17	ワトソンファーマシューティカルズ，インコーポレイテッド	女性への非経口アンドロゲンステロイドの投与
US6187750B1 (en)	1999-08-25	2001-02-13	Everyoung Technologies, Inc.	Method of hormone treatment for patients with symptoms consistent with multiple sclerosis
US6562790B2 (en)	2000-02-05	2003-05-13	Chein Edmund Y M	Hormone therapy methods and hormone products for abating coronary artery blockage
HUP0303172A3 (en)	2000-06-28	2006-05-29	Bristol Myers Squibb Co	Selective androgen receptor modulators and methods for their identification, desing and use
US7001911B2 (en)	2000-06-28	2006-02-21	Bristol-Myers Squibb Company	Fused cyclic modulators of nuclear hormone receptor function
US20040077605A1 (en) *	2001-06-20	2004-04-22	Salvati Mark E.	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6503894B1 (en)	2000-08-30	2003-01-07	Unimed Pharmaceuticals, Inc.	Pharmaceutical composition and method for treating hypogonadism
US20040092494A9 (en) *	2000-08-30	2004-05-13	Dudley Robert E.	Method of increasing testosterone and related steroid concentrations in women
US20030139384A1 (en) *	2000-08-30	2003-07-24	Dudley Robert E.	Method for treating erectile dysfunction and increasing libido in men
US6953679B2 (en)	2000-09-19	2005-10-11	Bristol-Myers Squibb Company	Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (en) *	2000-09-19	2007-11-28	Bristol-Myers Squibb Company	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
HUP0301276A2 (hu) *	2000-10-06	2003-11-28	Biomedicines, Inc.	Kombinációs terápia ösztrogénérzékeny betegségek kezelésére
US20040087548A1 (en)	2001-02-27	2004-05-06	Salvati Mark E.	Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
GB2375958B (en) *	2001-04-09	2005-03-02	George Margetts	The use of steroids to lower the levels of cortisol
WO2002089802A2 (en)	2001-05-08	2002-11-14	Schering Corporation	Use of neurokinin receptor antagonists to treat androgen-dependent diseases
DE10141937A1 (de) *	2001-08-28	2003-03-27	Alfred Schmidt	Markierung der Aromatase
MY141661A (en)	2001-09-06	2010-05-31	Schering Corp	17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
ES2347643T3 (es)	2001-10-17	2010-11-03	Schering Corporation	Piperin- y piperazinacetamidas como inhibidores de 17beta hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades dependientes de androgenos.
US20040043938A1 (en) *	2001-11-06	2004-03-04	Dinesh Purandare	Combination therapy for estrogen-dependent disorders
US7087636B2 (en) *	2001-12-19	2006-08-08	Bristol-Myers Squibb Company	Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
WO2003075958A1 (fr) *	2002-03-11	2003-09-18	Takeda Chemical Industries, Ltd.	Medicaments permettant de traiter une maladie dependant d'une hormone sexuelle
JP2004002321A (ja) *	2002-03-11	2004-01-08	Takeda Chem Ind Ltd	性ホルモン依存性疾患治療剤
BR0308584A (pt) *	2002-03-15	2005-02-22	Unimed Pharmaceuticals Inc	Composição farmacêutica androgênica e método para tratamento de depressão
US8569275B2 (en)	2002-08-28	2013-10-29	Harbor Therapeutics, Inc.	Steroids having 7-oxgen and 17-heteroaryl substitution
ES2345146T3 (es)	2002-11-18	2010-09-16	Schering Corporation	Inhibidores de 17beta-hidroxiesteroides deshidrogenasa de tipo 3 para el tratamiento de enfermedades dependientes de androgenos.
AU2003293555A1 (en)	2002-12-17	2004-07-29	Schering Corporation	17 beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
GB0302572D0 (en) *	2003-02-05	2003-03-12	Astrazeneca Ab	Method of treatment
GB2400554B (en) *	2003-04-16	2007-04-18	George Margetts	Treatment of angiotensin II-induced cardiovascular disease
CN106038572A (zh)	2004-10-20	2016-10-26	恩多研究公司	性甾体前体单独或与选择性雌激素受体调节剂联合用于预防和治疗绝经后女性的性功能障碍
GB0513702D0 (en)	2005-07-04	2005-08-10	Sterix Ltd	Compound
RS52671B (sr)	2005-10-12	2013-06-28	Unimed Pharmaceuticals Llc	Poboljšani gel testosterona i postupak korišćenja
CA2626337C (en) *	2005-10-19	2015-12-29	Chavah Pty Ltd	Reduction of side effects from aromatase inhibitors used for treating breast cancer
US20100087407A1 (en) *	2006-08-04	2010-04-08	James Symons	use of aromatase inhibitors
US8268806B2 (en)	2007-08-10	2012-09-18	Endorecherche, Inc.	Pharmaceutical compositions
GB0722779D0 (en)	2007-11-20	2008-01-02	Sterix Ltd	Compound
US20100292150A1 (en) *	2007-12-10	2010-11-18	Meditrina Pharmaceuticals, Inc.	Treatment of Menorrhagia with Aromatase Inhibitor
SG186333A1 (en)	2010-06-16	2013-01-30	Endorech Inc	Methods of treating or preventing estrogen-related diseases
CA2965372C (en)	2014-10-22	2023-09-05	Havah Therapeutics Pty Ltd	Methods of reducing mammographic breast density and/or breast cancer risk
CA3002562A1 (en)	2015-10-22	2017-04-27	Havah Therapeutics Pty Ltd	Methods of reducing mammographic breast density and/or breast cancer risk
CN114599369B (zh)	2019-06-03	2026-02-10	哈瓦赫治疗有限公司	用于递送雄激素剂和芳香酶抑制剂的药物制剂和系统以及使用方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3061616A (en) *	1958-04-24	1962-10-30	Farmaceutici Italia	Steroids, 6-methyl-17-hydroxy-progesterone and esters thereof, and a process for their preparation
US3127427A (en) *	1962-07-17	1964-03-31	Hoffmann La Roche	10-alkenyl-steroids and process therefor
CH507249A (de) *	1968-05-31	1971-05-15	Sandoz Ag	Verfahren zur Herstellung von 2-Brom-a-ergokryptin
DE2438350C3 (de) *	1974-08-09	1979-06-13	Hoechst Ag, 6000 Frankfurt	Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US4071622A (en) *	1976-02-11	1978-01-31	Abbott Laboratories	Treatment of a mammary or DMBA inducible tumor
DE2617646C2 (de) *	1976-04-22	1986-07-31	Hoechst Ag, 6230 Frankfurt	Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
GB1524747A (en) *	1976-05-11	1978-09-13	Ici Ltd	Polypeptide
DE2658307C2 (de) *	1976-12-22	1979-03-15	Klinge Pharma Gmbh & Co, 8000 Muenchen	Di-O'-hydroxyphenyD-alkanverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2465486A1 (fr) *	1979-09-21	1981-03-27	Roussel Uclaf	Nouvelle application utilisant la lh-rh ou des agonistes
IE52535B1 (en) *	1981-02-16	1987-12-09	Ici Plc	Continuous release pharmaceutical compositions
GB2108486B (en) *	1981-10-26	1986-01-29	Farmos Group Ltd	Alkane and alkene derivatives and their preparation and use
US4481190A (en) *	1982-12-21	1984-11-06	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
GB8311678D0 (en) *	1983-04-28	1983-06-02	Ici Plc	Phenol derivatives
US4826831A (en) *	1983-08-05	1989-05-02	Pre Jay Holdings Limited	Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
GB8327256D0 (en) *	1983-10-12	1983-11-16	Ici Plc	Steroid derivatives
FR2558373B1 (fr) *	1984-01-20	1987-07-03	Mauvais Jarvis Pierre	Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
IE58417B1 (en) *	1984-04-27	1993-09-22	Ici Plc	Chemical derivatives
GB8410901D0 (en) *	1984-04-27	1984-06-06	Ici Plc	Phenol derivatives
US4666885A (en) *	1985-02-08	1987-05-19	Fernand Labrie	Combination therapy for treatment of female breast cancer
DE3590389T1 (de) *	1984-08-02	1986-08-28	Schering Corp., Kenilworth, N.J.	Pharmazeutische Zusammensetzung für eine Kombinationstherapie hormon-abhängiger Cancer
US4775660A (en) *	1984-08-02	1988-10-04	Fernand Labrie	Treatment of breast cancer by combination therapy
US4760053A (en) *	1984-08-02	1988-07-26	Fernand Labrie	Combination therapy for selected sex steroid dependent cancers
US4650787A (en) *	1985-04-25	1987-03-17	Schally Andrew Victor	Biologically active octapeptides
CN1021196C (zh) *	1986-12-29	1993-06-16	新泽西州州立大学(鲁杰斯)	透皮雌激素/孕激素药剂单元、系统及方法
US4816258A (en) *	1987-02-26	1989-03-28	Alza Corporation	Transdermal contraceptive formulations

1990
- 1990-03-09 PH PH40166A patent/PH30747A/en unknown
- 1990-03-09 ES ES90904736T patent/ES2077675T3/es not_active Expired - Lifetime
- 1990-03-09 NZ NZ232870A patent/NZ232870A/en unknown
- 1990-03-09 DK DK90904736.7T patent/DK0462189T3/da active
- 1990-03-09 NZ NZ244499A patent/NZ244499A/xx unknown
- 1990-03-09 AT AT90904736T patent/ATE128362T1/de not_active IP Right Cessation
- 1990-03-09 HU HU847/90A patent/HU221589B/hu unknown
- 1990-03-09 IL IL9369390A patent/IL93693A/xx not_active IP Right Cessation
- 1990-03-09 DE DE69022722T patent/DE69022722T2/de not_active Expired - Lifetime
- 1990-03-09 IE IE84690A patent/IE62715B1/en not_active IP Right Cessation
- 1990-03-09 AU AU52819/90A patent/AU5281990A/en not_active Abandoned
- 1990-03-09 EP EP90904736A patent/EP0462189B1/en not_active Expired - Lifetime
- 1990-03-09 ZA ZA901847A patent/ZA901847B/xx unknown
- 1990-03-09 JP JP2504858A patent/JP2959838B2/ja not_active Expired - Lifetime
- 1990-03-09 WO PCT/CA1990/000076 patent/WO1990010462A1/en not_active Ceased
- 1990-03-09 CA CA002050291A patent/CA2050291C/en not_active Expired - Lifetime
- 1990-03-10 MY MYPI90000459A patent/MY110016A/en unknown
1991
- 1991-11-04 US US07/785,890 patent/US5550107A/en not_active Expired - Lifetime
1994
- 1994-01-28 AU AU55131/94A patent/AU669767B2/en not_active Expired

Also Published As

Publication number	Publication date
ATE128362T1 (de)	1995-10-15
MY110016A (en)	1997-11-29
IE900846L (en)	1990-09-10
EP0462189A1 (en)	1991-12-27
HU902847D0 (en)	1991-11-28
AU669767B2 (en)	1996-06-20
JP2959838B2 (ja)	1999-10-06
ES2077675T3 (es)	1995-12-01
EP0462189B1 (en)	1995-09-27
ZA901847B (en)	1991-10-30
JPH04504848A (ja)	1992-08-27
AU5281990A (en)	1990-10-09
US5550107A (en)	1996-08-27
PH30747A (en)	1997-10-17
NZ232870A (en)	1994-01-26
CA2050291A1 (en)	1990-09-11
DE69022722D1 (de)	1995-11-02
IL93693A0 (en)	1990-12-23
HUT59836A (en)	1992-07-28
CA2050291C (en)	2000-12-19
AU5513194A (en)	1994-04-28
DE69022722T2 (de)	1996-05-02
NZ244499A (en)	1999-05-28
IE62715B1 (en)	1995-02-22
HU221589B (hu)	2002-11-28
IL93693A (en)	2000-01-31
WO1990010462A1 (en)	1990-09-20

Publication	Publication Date	Title
ATE128362T1 (de)	1995-10-15	Kombinationstherapie zur behandlung von estrogenempfindlichen erkrankungen.
Singh et al.	2000	Androgen receptor antagonists (antiandrogens) structure-activity relationships
AU643445B2 (en)	1993-11-18	Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
EP1297840A3 (en)	2003-09-10	Methods for treating sex hormone-dependent conditions with LHRH antagonists
BRPI0516243B8 (pt)	2021-02-23	uso de um precursor de esteróide sexual selecionado do grupo que consiste em dehidroepiandrosterona, sulfato de dehidroepiandrosterona, androst-5-eno-3b,17b-diol e 4-androsten-3,17-diona, uso do referido precursor em 5 associação com um modulador de receptor de estrogênio seletivo para proteção uterina e da glândula mamária contra câncer, composição farmacêutica e kit
DK0595796T3 (da)	2003-05-05	Fremgangsmåde til behandling af androgen-relaterede sygdomme
Lundgren	1992	Progestins in Breast Cancer Treatment: A Reveiw
Bogden et al.	1990	Treatment of R-3327 prostate tumors with a somatostatin analogue (somatuline) as adjuvant therapy following surgical castration
Klijn et al.	1984	Anti-tumor and endocrine effects of chronic LHRH agonist treatment (buserelin) with or without tamoxifen in premenopausal metastatic breast cancer
BG101158A (bg)	1997-09-30	Използване на антагонист на gnrh за получаване нафармацевтичен състав за лечение на гонадостероидно зависими заболявания
RU2003112974A (ru)	2004-11-27	Комбинированная терапия для лечения эстрогенчувствительных заболеваний
Labrie et al.	1986	Advantages of the combination therapy in previously untreated and treated patients with advanced prostate cancer
BR0309504A (pt)	2005-02-09	Método de tratamento, prevenção ou retardo de inìcio clìnico de neoplasma, composição, método de reduzir volume ou peso de tumor
Pellegrini et al.	1981	Ethinyl estradiol and medroxyprogesterone treatment in advanced breast cancer: a pilot study
Nicholson	1993	Recent advances in the antihormonal therapy of breast cancer
Bhatnagar et al.	1988	Aromatase inhibitors in cancer treatment
UA85190C2 (en)	2009-01-12	PROCESS FOR THE SYNTHESIS OF PURE D-(17α)-13-ETHYL-17-HYDROXY-18,19-DINORPREGN-4-ENE-20-YNE-3-ONE-3E- AND -3Z-OXIME ISOMERS AND THE MIXTURE OF ISOMERS, AND USE OF THOSE ISOMERS
DK1090028T3 (da)	2002-04-29	Umættede 14,15-cyclopropano-androstaner, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende disse forbindelser
Geller	1991	Review of assessment of total androgen blockade as treatment of metastatic prostate cancer
Attar et al.	2006	Aromatase inhibitors: The next wave in treatment of endometriosis?
Faure et al.	1985	Clinical experience (up to 40 months) with the LH-RH agonist Buserelin in the therapeutic approach