DK1590360T3 - Fremgangsmåde til fremstilling af inhibitorer af nukleosidphosphorylaser og nukleosidaser - Google Patents

Fremgangsmåde til fremstilling af inhibitorer af nukleosidphosphorylaser og nukleosidaser

Info

Publication number
DK1590360T3
DK1590360T3 DK04706902.6T DK04706902T DK1590360T3 DK 1590360 T3 DK1590360 T3 DK 1590360T3 DK 04706902 T DK04706902 T DK 04706902T DK 1590360 T3 DK1590360 T3 DK 1590360T3
Authority
DK
Denmark
Prior art keywords
nucleosidases
inhibitors
preparation
nucleoside phosphorylases
phosphorylases
Prior art date
Application number
DK04706902.6T
Other languages
English (en)
Inventor
Gary Brian Evans
Peter Charles Tyler
Original Assignee
Ind Res Ltd
Einstein Coll Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Res Ltd, Einstein Coll Med filed Critical Ind Res Ltd
Application granted granted Critical
Publication of DK1590360T3 publication Critical patent/DK1590360T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK04706902.6T 2003-02-04 2004-01-30 Fremgangsmåde til fremstilling af inhibitorer af nukleosidphosphorylaser og nukleosidaser DK1590360T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ523970A NZ523970A (en) 2003-02-04 2003-02-04 Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
PCT/NZ2004/000017 WO2004069856A1 (en) 2003-02-04 2004-01-30 Process for preparing inhibitors of nucleoside phosphorylases and nucleosidases

Publications (1)

Publication Number Publication Date
DK1590360T3 true DK1590360T3 (da) 2012-08-27

Family

ID=32844996

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04706902.6T DK1590360T3 (da) 2003-02-04 2004-01-30 Fremgangsmåde til fremstilling af inhibitorer af nukleosidphosphorylaser og nukleosidaser

Country Status (15)

Country Link
US (2) US7655795B2 (da)
EP (1) EP1590360B1 (da)
JP (1) JP4806746B2 (da)
KR (1) KR101185120B1 (da)
CN (1) CN100357308C (da)
BR (1) BRPI0407210A (da)
CA (1) CA2514992C (da)
CY (1) CY1113297T1 (da)
DK (1) DK1590360T3 (da)
ES (1) ES2391043T3 (da)
NZ (1) NZ523970A (da)
PT (1) PT1590360E (da)
RU (1) RU2334757C2 (da)
SI (1) SI1590360T1 (da)
WO (1) WO2004069856A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
CA2696826C (en) * 1999-04-08 2013-01-08 Industrial Research Limited Process for preparing inhibitors of nucleoside metabolism
ES2363766T3 (es) 2002-08-21 2011-08-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibidores de nucleosidasas y fosforilasas de nucleosidos.
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
CA2615549A1 (en) * 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097643A1 (en) * 2006-02-22 2007-08-30 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
EP1991231A4 (en) * 2006-02-24 2010-01-06 Ind Res Ltd METHOD FOR THE TREATMENT OF DISEASES WITH NUCLEOSIDE PHOSPHORUSLASES AND NUCLEOSIDASES INHIBITORS
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
CN101528749B (zh) 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
AU2007293773B2 (en) * 2006-09-07 2013-01-31 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
ES2385759T3 (es) * 2006-12-22 2012-07-31 Industrial Research Limited Análogos azetidina de inhibidores de nucleosidasa y fosforilasa
US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
PL2411394T3 (pl) * 2009-03-24 2015-01-30 Biocryst Pharm Inc Użyteczne sole farmaceutyczne 7-[(3r, 4r)-3-hydroksy-4-hydroksymetylopirolidyn-1-ylometylo]-3,5-dihydropirolo[3,2-d]pirymidyno-4-nu
US9493465B2 (en) 2009-07-17 2016-11-15 Victoria Link Limited 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
CL2011000716A1 (es) 2010-03-31 2012-04-20 Gilead Pharmasset Llc Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c.
WO2012074912A1 (en) 2010-11-29 2012-06-07 Albert Einstein College Of Medicine Of Yeshiva University Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
JP6063571B2 (ja) * 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
EP2920179A4 (en) * 2012-11-12 2016-03-30 Victoria Link Ltd SALT AND POLYMORPHIC FORMS OF (3R, 4S) -L - ((4-AMINO-5H-PYRROLO [3,2-D] PYRIMIDIN-7-YL) METHYL) -4 (METHYLTHIOMETHYL) PYRODIN-3-OL (MTDIA)
CN111499639B (zh) * 2019-01-31 2022-03-04 四川大学华西医院 嘧啶酮衍生物及其在制药中的应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5101030A (en) * 1986-08-26 1992-03-31 Warner-Lambert Company 9-deazaguanines
CA1293727C (en) * 1986-08-26 1991-12-31 Catherine Rose Kostlan 9-deazaguanines
US5102879A (en) * 1986-08-26 1992-04-07 Warner-Lambert Company Method of treating gout with novel 9-deazaguanines
US4923872A (en) * 1986-08-26 1990-05-08 Warner-Lambert Co. Analogues of pyrrolo[3,2d]pyrimidin-4-ones
US4988702A (en) * 1986-08-26 1991-01-29 Warner-Lambert Company Novel 9-deazaguanines
US5061707A (en) * 1986-08-26 1991-10-29 Warner-Lambert Company 9-deazaguanines to treat psoriasis
US5008265A (en) * 1989-10-31 1991-04-16 Biocryst, Inc. 2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US4985434A (en) * 1989-10-31 1991-01-15 Biocryst, Inc. 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same
US5008270A (en) * 1989-10-31 1991-04-16 Biocryst, Inc. 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US4985433A (en) * 1989-10-31 1991-01-15 Biocryst, Inc. 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
AU654264B2 (en) * 1989-10-31 1994-11-03 Biocryst Pharmaceuticals, Inc. Inhibitors of purine nucleoside phosphorylase
US5189039A (en) * 1989-11-29 1993-02-23 Biocryst, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2d]pyrimidine and pharmaceutical uses and compositions containing the same
US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
AU1739097A (en) 1996-02-23 1997-09-10 Albert Einstein College Of Medicine Of Yeshiva University Enzyme detection/assay method and substrates
US6255314B1 (en) * 1996-09-24 2001-07-03 Taiho Charmaceutical Co., Ltd. Cancerous metastasis inhibitors containing uracil derivatives
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
CA2696826C (en) 1999-04-08 2013-01-08 Industrial Research Limited Process for preparing inhibitors of nucleoside metabolism
AU2001284564A1 (en) 2000-08-29 2002-03-13 Albert Einstein College Of Medicine Of Yeshiva University Nucleoside metabolism inhibitors
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ES2363766T3 (es) * 2002-08-21 2011-08-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibidores de nucleosidasas y fosforilasas de nucleosidos.
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
JP2008508287A (ja) 2004-07-27 2008-03-21 バイオクリスト・フアーマシユーテイカルズ・インコーポレイテツド ５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
EP1991231A4 (en) 2006-02-24 2010-01-06 Ind Res Ltd METHOD FOR THE TREATMENT OF DISEASES WITH NUCLEOSIDE PHOSPHORUSLASES AND NUCLEOSIDASES INHIBITORS
AU2007293773B2 (en) * 2006-09-07 2013-01-31 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
EP2066671A1 (en) * 2006-09-26 2009-06-10 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of human 5'-methylthioadenosine phosphorylase
ES2385759T3 (es) * 2006-12-22 2012-07-31 Industrial Research Limited Análogos azetidina de inhibidores de nucleosidasa y fosforilasa

Also Published As

Publication number Publication date
SI1590360T1 (sl) 2012-11-30
CA2514992A1 (en) 2004-08-19
PT1590360E (pt) 2012-08-27
HK1089448A1 (zh) 2006-12-01
CA2514992C (en) 2012-08-07
US7655795B2 (en) 2010-02-02
AU2004208968A1 (en) 2004-08-19
EP1590360B1 (en) 2012-07-11
NZ523970A (en) 2005-02-25
CN100357308C (zh) 2007-12-26
BRPI0407210A (pt) 2006-01-24
RU2334757C2 (ru) 2008-09-27
US20060217551A1 (en) 2006-09-28
JP4806746B2 (ja) 2011-11-02
JP2006516615A (ja) 2006-07-06
CN1771254A (zh) 2006-05-10
ES2391043T3 (es) 2012-11-20
EP1590360A4 (en) 2009-06-24
KR101185120B1 (ko) 2012-09-21
EP1590360A1 (en) 2005-11-02
US20100094003A1 (en) 2010-04-15
KR20050114614A (ko) 2005-12-06
RU2005127630A (ru) 2006-06-27
WO2004069856A1 (en) 2004-08-19
CY1113297T1 (el) 2016-04-13

Similar Documents

Publication Publication Date Title
DK1667986T3 (da) Acetonesolvat af dimethoxydocetaxel og fremgangsmåde til fremstilling heraf
EP1490373A4 (en) Inhibitors of nucleoside phosphorylases and nucleosideases
DK1791852T3 (da) C-aryl glucosid -SGLT2-inhibitorer og metode til deres fremstilling
DK2578685T3 (da) Rna indeholende modificerede nukleosider og fremgangsmåder til anvendelse deraf
DK1312922T3 (da) Nitritstabiliserende sammensætninger af tetrazoliumreagens og fremgangsmåder til deres anvendelse
DK1440908T3 (da) Indsats og fremgangsmåde til fremstilling af drikkevarer
DK1922307T3 (da) Heterocykliske inhibitorer af MEK og fremgangsmåder til anvendelse heraf
DK2089361T3 (da) Inhibitorer af natriumglucose-cotransportør 2 og fremgangsmåder til deres anvendelse
DK1532138T3 (da) Inhibitorer af tyrosinkinaser
DK1509525T3 (da) Fremgangsmåde til fremstilling af xanthin-phosphodiesterase V-inhibitorer og præcursorer derfor
DK1730146T3 (da) Azaindoler anvendelige som inhibitorer af JAK og andre proteinkinaser
DK1562589T3 (da) Diaminotriazoler der er nyttige som inhibitorer af proteinkinaser
DK1656370T3 (da) Heterocykliske biarylforbindelser og fremgangsmåder til fremstilling og anvendelse af samme
DK2508521T4 (da) Dimaleat af en aminocrotonylforbindelse og fremgangsmåde til fremstilling deraf
DK1824475T3 (da) Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol
EP1704145A4 (en) SELECTIVE KINASEINHIBITORS
DK1606283T3 (da) P38-inhibitorer og fremgangsmåder til anvendelse deraf
IS2675B (is) P38-hindrar og aðferðir til notkunar þeirra
DK1532079T3 (da) Skimmelresistent gipsplade og fremgangsmåde til fremstilling af denne
NO20055211D0 (no) Anti-fungale forbindelser og fremgangsmater for anvendelse
DK2183263T3 (da) Fremgangsmåder og forbindelser anvendelige til fremstilling af natriumglucose-cotransportør-2-inhibitorer
IS7606A (is) Aðferð til þess að búa til pyrimídín og pyrimídínafleiður sem eru tálmar prótín kínasa
DK2322517T3 (da) Fremgangsmåder til kemisk syntese og oprensning af diaminophenothiaziniumforbindelser med methylthioniniumchlorid (mtc)
DK1628530T3 (da) Fremgangsmåder og sammensætninger til forebyggelse og behandling af sepsis
DK1620551T3 (da) Phospholipase og fremgangsmåde til fremstilling deraf