DK159786A - Fremgangsmaade til fremstilling af en krystallinsk form af natriumsalatet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre - Google Patents

Fremgangsmaade til fremstilling af en krystallinsk form af natriumsalatet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre Download PDF

Info

Publication number: DK159786A
Authority: DK; Denmark
Prior art keywords: solvate; acid; preparing; salad; oxime derivative
Prior art date: 1977-08-17

Application number

DK159786A

Other languages

English (en)

Other versions

DK163514B (da

DK163514C (da

DK159786D0 (da

Inventor

Gaston Amiard

Dieter Bormann

Walter Duerchheimer

Jean Jolly

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-08-17

Filing date

1986-04-09

Publication date

1986-04-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9194564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK159786(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1986-04-09 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1986-04-09 Publication of DK159786D0 publication Critical patent/DK159786D0/da

1986-04-09 Publication of DK159786A publication Critical patent/DK159786A/da

1992-03-09 Publication of DK163514B publication Critical patent/DK163514B/da

1992-07-27 Application granted granted Critical

1992-07-27 Publication of DK163514C publication Critical patent/DK163514C/da

Links

239000002253 acid Substances 0.000 title abstract 4
150000002923 oximes Chemical class 0.000 title abstract 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
229910052708 sodium Inorganic materials 0.000 title 1
239000011734 sodium Substances 0.000 title 1
239000012453 solvate Substances 0.000 abstract 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 4
159000000000 sodium salts Chemical class 0.000 abstract 3
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 2
235000019253 formic acid Nutrition 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
230000000887 hydrating effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK159786A 1977-08-17 1986-04-09 Fremgangsmaade til fremstilling af en krystallinsk form af natriumsaltet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre DK163514C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR7725142A FR2400519A1 (fr)	1977-08-17	1977-08-17	Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament
FR7725142		1977-08-17
DK361078A DK152213C (da)	1977-08-17	1978-08-16	Fremgangsmaade til fremstilling af en krystallinsk form af natriumsaltet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre
DK361078		1978-08-16

Publications (4)

Publication Number	Publication Date
DK159786D0 DK159786D0 (da)	1986-04-09
DK159786A true DK159786A (da)	1986-04-09
DK163514B DK163514B (da)	1992-03-09
DK163514C DK163514C (da)	1992-07-27

Family

ID=9194564

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK361078A DK152213C (da)	1977-08-17	1978-08-16	Fremgangsmaade til fremstilling af en krystallinsk form af natriumsaltet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre
DK159786A DK163514C (da)	1977-08-17	1986-04-09	Fremgangsmaade til fremstilling af en krystallinsk form af natriumsaltet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK361078A DK152213C (da)	1977-08-17	1978-08-16	Fremgangsmaade til fremstilling af en krystallinsk form af natriumsaltet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre

Country Status (34)

Country	Link
US (1)	US4224371A (da)
EP (1)	EP0001024B1 (da)
JP (1)	JPS5441890A (da)
AT (2)	AT366049B (da)
AU (1)	AU520898B2 (da)
BG (2)	BG33887A3 (da)
CA (1)	CA1121343A (da)
CS (2)	CS207646B2 (da)
DD (1)	DD137588A5 (da)
DE (1)	DE2860358D1 (da)
DK (2)	DK152213C (da)
EG (1)	EG13520A (da)
ES (1)	ES472381A1 (da)
FI (1)	FI65433C (da)
FR (1)	FR2400519A1 (da)
GE (2)	GEP19960476B (da)
GR (1)	GR73661B (da)
HR (1)	HRP931395B1 (da)
HU (1)	HU181497B (da)
IE (1)	IE47230B1 (da)
IL (1)	IL55186A (da)
IT (1)	IT1107961B (da)
MD (2)	MD247C2 (da)
MX (2)	MX5448E (da)
NO (1)	NO156168C (da)
NZ (1)	NZ188163A (da)
OA (1)	OA06016A (da)
PL (1)	PL126619B1 (da)
PT (1)	PT68431A (da)
RO (1)	RO79999A (da)
SI (1)	SI7811917A8 (da)
SU (2)	SU799666A3 (da)
YU (1)	YU42166B (da)
ZA (1)	ZA784187B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60120886A (ja) *	1983-12-02	1985-06-28	Takeda Chem Ind Ltd	セフェムカルボン酸のナトリウム塩の結晶
JPS60142987A (ja) *	1983-12-29	1985-07-29	Mochida Pharmaceut Co Ltd	セフアロスポリン誘導体
DE3485860T2 (de) *	1983-12-29	1993-01-14	Mochida Pharm Co Ltd	Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) *	1985-04-01	1989-06-20	Mochida Pharmaceutical Co., Ltd.	Cephalosporin derivatives
EP0233255B1 (en) *	1985-08-12	1996-05-29	The Upjohn Company	Conversion of cephalosporin hydrohalide salt to alkali metal salt
US4880798A (en) *	1986-11-25	1989-11-14	Mochida Pharmaceutical Co., Ltd.	Cephalosporin derivatives
JPS63132893A (ja) *	1986-11-25	1988-06-04	Mochida Pharmaceut Co Ltd	新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
RU2021274C1 (ru)	1991-05-17	1994-10-15	Польска Акадэмия Наук Институт Хэмии Органичнэй	Способ получения аминотиазолильных производных цефалоспорина
US5318781A (en) *	1993-04-06	1994-06-07	Hoffmann-La Roche Inc.	Absorption enhancement of antibiotics
US5574154A (en) *	1994-09-29	1996-11-12	Alnejma Bulk Pharmaceutical Co. A.B.P.C.	Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) *	1994-11-21	1995-01-11	Biochemie Gmbh	Silylation process
AT402928B (de) *	1994-12-23	1997-09-25	Biochemie Gmbh	Neues verfahren zur herstellung von cefotaxim
AU690482B2 (en) *	1996-03-18	1998-04-23	Ranbaxy Laboratories Limited	Process for producing cephalosporin antibiotics
GB9717629D0 (en) *	1997-08-21	1997-10-22	Johnson Matthey Plc	Removal of residual organic solvents
WO2001092254A1 (en) *	2000-05-30	2001-12-06	Fujisawa Pharmaceutical Co., Ltd.	Method for replacing organic solvents contained in clathrate crystals
WO2004063203A1 (en) *	2003-01-10	2004-07-29	Orchid Chemicals & Pharmaceuticals Ltd	Process for the preparation of cefotaxime sodium
CN100361995C (zh) *	2004-10-27	2008-01-16	山东瑞阳制药有限公司	注射级无菌头孢噻肟钠的一步法制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3970651A (en) *	1974-01-07	1976-07-20	Bristol-Myers Company	Crystalline cephalosporin derivative
US3985747A (en) *	1974-05-24	1976-10-12	Bristol-Myers Company	Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
DK154939C (da) *	1974-12-19	1989-06-12	Takeda Chemical Industries Ltd	Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4006138A (en) *	1975-04-11	1977-02-01	Eli Lilly And Company	Crystalline form of sodium O-formylcefamandole
DE2760123C2 (de) *	1976-01-23	1986-04-30	Roussel-Uclaf, Paris	7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) *	1976-01-23	1985-08-12	Roussel Uclaf	Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra

1977
- 1977-08-17 FR FR7725142A patent/FR2400519A1/fr active Granted
1978
- 1978-07-20 IL IL55186A patent/IL55186A/xx active IP Right Grant
- 1978-07-22 OA OA56566A patent/OA06016A/xx unknown
- 1978-07-24 ZA ZA00784187A patent/ZA784187B/xx unknown
- 1978-08-02 DD DD78207090A patent/DD137588A5/xx unknown
- 1978-08-03 EP EP78400072A patent/EP0001024B1/fr not_active Expired
- 1978-08-03 DE DE7878400072T patent/DE2860358D1/de not_active Expired
- 1978-08-03 AT AT0563578A patent/AT366049B/de not_active IP Right Cessation
- 1978-08-04 ES ES472381A patent/ES472381A1/es not_active Expired
- 1978-08-08 IT IT50648/78A patent/IT1107961B/it active Protection Beyond IP Right Term
- 1978-08-08 CS CS785183A patent/CS207646B2/cs unknown
- 1978-08-09 SU SU782645701A patent/SU799666A3/ru active
- 1978-08-10 US US05/932,437 patent/US4224371A/en not_active Expired - Lifetime
- 1978-08-10 YU YU1917/78A patent/YU42166B/xx unknown
- 1978-08-10 SI SI7811917A patent/SI7811917A8/sl unknown
- 1978-08-11 GR GR56985A patent/GR73661B/el unknown
- 1978-08-11 MX MX787309U patent/MX5448E/es unknown
- 1978-08-11 MX MX7926A patent/MX155976A/es unknown
- 1978-08-15 BG BG040671A patent/BG33887A3/xx unknown
- 1978-08-15 BG BG042035A patent/BG33888A3/xx unknown
- 1978-08-16 PL PL1978209080A patent/PL126619B1/pl unknown
- 1978-08-16 RO RO78101982A patent/RO79999A/ro unknown
- 1978-08-16 EG EG510/78A patent/EG13520A/xx active
- 1978-08-16 DK DK361078A patent/DK152213C/da not_active IP Right Cessation
- 1978-08-16 FI FI782494A patent/FI65433C/fi not_active IP Right Cessation
- 1978-08-16 PT PT68431A patent/PT68431A/pt unknown
- 1978-08-16 AU AU38965/78A patent/AU520898B2/en not_active Expired
- 1978-08-16 NZ NZ188163A patent/NZ188163A/xx unknown
- 1978-08-16 CA CA000309454A patent/CA1121343A/fr not_active Expired
- 1978-08-16 NO NO782782A patent/NO156168C/no unknown
- 1978-08-16 HU HU78RO993A patent/HU181497B/hu unknown
- 1978-08-17 IE IE1669/78A patent/IE47230B1/en not_active IP Right Cessation
- 1978-08-17 JP JP9958078A patent/JPS5441890A/ja active Granted
1979
- 1979-06-27 CS CS794439A patent/CS207647B2/cs unknown
1980
- 1980-01-31 AT AT0052280A patent/AT366050B/de not_active IP Right Cessation
- 1980-03-12 SU SU802891755A patent/SU852175A3/ru active
1986
- 1986-04-09 DK DK159786A patent/DK163514C/da not_active IP Right Cessation
1993
- 1993-07-31 GE GEAP19931355A patent/GEP19960476B/en unknown
- 1993-07-31 GE GEAP19931371A patent/GEP19960475B/en unknown
- 1993-11-11 HR HRP-1917/78A patent/HRP931395B1/xx not_active IP Right Cessation
1994
- 1994-09-08 MD MD94-0275A patent/MD247C2/ro unknown
- 1994-09-08 MD MD94-0267A patent/MD225C2/ro unknown

Also Published As

Publication number	Publication date
CA1121343A (fr)	1982-04-06
ES472381A1 (es)	1979-03-16
AU3896578A (en)	1980-02-21
DK361078A (da)	1979-02-18
JPS6145626B2 (da)	1986-10-08
DD137588A5 (de)	1979-09-12
HU181497B (en)	1983-07-28
EG13520A (en)	1982-03-31
MX5448E (es)	1983-08-09
DK163514B (da)	1992-03-09
IE781669L (en)	1979-02-17
ATA563578A (de)	1981-07-15
IE47230B1 (en)	1984-01-25
MD247C2 (ro)	1995-12-31
AT366050B (de)	1982-03-10
YU191778A (en)	1983-02-28
FR2400519B1 (da)	1980-05-16
HRP931395B1 (en)	1996-04-30
GEP19960476B (en)	1996-07-22
NO782782L (no)	1979-02-20
FR2400519A1 (fr)	1979-03-16
MD225B1 (ro)	1995-06-30
IT1107961B (it)	1985-12-02
DK152213B (da)	1988-02-08
EP0001024A1 (fr)	1979-03-07
NZ188163A (en)	1981-10-19
EP0001024B1 (fr)	1981-01-21
AT366049B (de)	1982-03-10
PL126619B1 (en)	1983-08-31
SU799666A3 (ru)	1981-01-23
SU852175A3 (ru)	1981-07-30
US4224371A (en)	1980-09-23
DK152213C (da)	1988-07-11
DK163514C (da)	1992-07-27
DK159786D0 (da)	1986-04-09
MX155976A (es)	1988-06-06
FI65433C (fi)	1984-05-10
PL209080A1 (pl)	1979-06-04
OA06016A (fr)	1981-06-30
BG33888A3 (bg)	1983-05-16
PT68431A (fr)	1978-09-01
GR73661B (da)	1984-03-28
FI65433B (fi)	1984-01-31
DE2860358D1 (en)	1981-03-12
AU520898B2 (en)	1982-03-04
SI7811917A8 (en)	1997-12-31
CS207647B2 (en)	1981-08-31
JPS5441890A (en)	1979-04-03
NO156168C (no)	1987-08-19
IL55186A0 (en)	1978-09-29
GEP19960475B (en)	1996-07-22
ATA52280A (de)	1981-07-15
ZA784187B (en)	1979-09-26
CS207646B2 (en)	1981-08-31
NO156168B (no)	1987-04-27
RO79999A (ro)	1982-10-11
MD247B1 (ro)	1995-07-31
MD225C2 (ro)	1995-12-31
BG33887A3 (bg)	1983-05-16
IT7850648A0 (it)	1978-08-08
FI782494A7 (fi)	1979-02-18
IL55186A (en)	1981-07-31
YU42166B (en)	1988-06-30

Legal Events

Date	Code	Title	Description
1998-09-28	PUP	Patent expired
2000-05-29	PUP	Patent expired

Publication	Publication Date	Title
DK155048C (da)	1989-06-26	Analogifremgangsmaade til fremstilling af 1,8-naphthyridinforbindelser
NL7703969A (nl)	1977-10-14	Werkwijze ter bereiding van syn-isomeren van 3,7-di-gesubstitueerde 3-cefem-4-carbonzuur- verbindingen.
IT1064324B (it)	1985-02-18	Procedimento di separazione con membrana di composti organici da soluzioni acquose
DK159786D0 (da)	1986-04-09	Fremgangsmaade til fremstilling af en krystallinsk form af natriumsalatet af et oximderivat af 7-aminothiazolylacetamidocephalosporansyre
EA200201016A1 (ru)	2003-02-27	Способ получения кристаллической формы i каберголина
DK155944C (da)	1989-12-04	Analogifremgangsmaade til fremstilling af 7-omega-substitueretethylen(cis)-thio-acetamido)-3-cephem-4-carboxylsyrederivater.
IT1094275B (it)	1985-07-26	Processo per la preparazione di nitrili organici
ES413267A1 (es)	1976-05-01	Un procedimiento para la preparacion de un derivado de aci-do indenilacetico.
DK418781A (da)	1982-03-24	Fremgangsmaade til fremstilling af ergolinderivater
JPS5259111A (en)	1977-05-16	Process for preparation of acid-fluoride-containing fluoride having an ester group
DK157539C (da)	1990-06-11	Fremgangsmaade til fremstilling af acemetacin
JPS5692854A (en)	1981-07-27	Novel imine derived from 33formylcyclopropanee11carboxylic acid ester* its manufacture* its use in corresponding 33vinyl substituted ester manufacture and novel intermediate
ES468417A1 (es)	1978-12-16	Procedimiento para la obtencion de derivados de azucar-teo- filina no glicosidicos.
IT1055785B (it)	1982-01-11	Procedimento per la produzione di dispersioni acquose di copoli meri comprendenti un composto epossidico
ES8203015A1 (es)	1982-02-16	Procedimiento para preparar un solvato de amoxicilina sodicacon n-metil-2-metil-pirrolidona
EP0092185A3 (en)	1985-07-03	Mefloquine-hydrochloride and process for its high purity preparation
KR950000702A (ko)	1995-01-03	결정성 β- 락탐 일수화물의 제조방법
JPS528050A (en)	1977-01-21	Deterioration inhibitor for rubbers
LU78336A1 (fr)	1979-06-01	Procede de transformation du trans-n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thioxanthene-2-sulfamide en son isomere cis et de separation de cet isomere
JPS51130583A (en)	1976-11-12	Process for producing scp or alcohol from organic wastes, espectially kitchen wastes
JPS54971A (en)	1979-01-06	Growing method of ion beam crystal
JPS5618958A (en)	1981-02-23	Preparation of n- d-alpha-methyl-beta-mercaptopropionyl -l- proline derivative
JPS5223086A (en)	1977-02-21	Novel method of preparing 2,3- dioxopiperazine
JPS51115912A (en)	1976-10-13	Method for producing novel plaster
JPS51138698A (en)	1976-11-30	Process preparing 2-cycloalkylthioadenine s