DK1601349T3 - Anvendelse af enantiomeren (1S, 2R) af milnacipran til fremstilling af et lægemiddel - Google Patents

Anvendelse af enantiomeren (1S, 2R) af milnacipran til fremstilling af et lægemiddel

Info

Publication number: DK1601349T3
Authority: DK; Denmark
Prior art keywords: active; serotonin; noradrenaline; capture; enantiomer
Prior art date: 2003-02-14

Application number

DK04711387T

Other languages

English (en)

Inventor

Jean Deregnaucourt

Richard Grosse

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-14

Filing date

2004-02-16

Publication date

2008-10-27

2003-02-14 Priority claimed from FR0301849A external-priority patent/FR2851163B1/fr

2004-02-16 Application filed by Pf Medicament filed Critical Pf Medicament

2008-10-27 Application granted granted Critical

2008-10-27 Publication of DK1601349T3 publication Critical patent/DK1601349T3/da

Links

GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 title abstract 8
229940079593 drug Drugs 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
229960000600 milnacipran Drugs 0.000 title abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 8
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 4
229960002748 norepinephrine Drugs 0.000 abstract 4
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 4
229940076279 serotonin Drugs 0.000 abstract 4
AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 abstract 2
AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229960002296 paroxetine Drugs 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
241000700159 Rattus Species 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000002955 immunomodulating agent Substances 0.000 abstract 1
229940121354 immunomodulator Drugs 0.000 abstract 1
230000002584 immunomodulator Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000002207 metabolite Substances 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Obesity (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

DK04711387T 2003-02-14 2004-02-16 Anvendelse af enantiomeren (1S, 2R) af milnacipran til fremstilling af et lægemiddel DK1601349T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0301849A FR2851163B1 (fr)	2003-02-14	2003-02-14	Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament
US10/453,574 US7005452B2 (en)	2003-02-14	2003-06-03	Use of the dextrogyral enantiomer of milnacipran for the preparation of a drug
PCT/FR2004/000347 WO2004075886A1 (fr)	2003-02-14	2004-02-16	Utilisation de l’enantiomere (1s, 2r) du milnacipran pour la preparation d’un medicament

Publications (1)

Publication Number	Publication Date
DK1601349T3 true DK1601349T3 (da)	2008-10-27

Family

ID=32929266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04711387T DK1601349T3 (da)	2003-02-14	2004-02-16	Anvendelse af enantiomeren (1S, 2R) af milnacipran til fremstilling af et lægemiddel

Country Status (19)

Country	Link
US (2)	US7074833B2 (da)
EP (2)	EP1908461B9 (da)
KR (1)	KR101185322B1 (da)
AT (1)	ATE401872T1 (da)
AU (1)	AU2004216452B2 (da)
BR (1)	BRPI0407256A (da)
CA (1)	CA2514948C (da)
DE (1)	DE602004015257D1 (da)
DK (1)	DK1601349T3 (da)
ES (1)	ES2310715T3 (da)
MA (1)	MA27655A1 (da)
MX (1)	MXPA05008652A (da)
NO (1)	NO333987B1 (da)
NZ (1)	NZ541733A (da)
PL (1)	PL219671B1 (da)
PT (1)	PT1601349E (da)
RU (1)	RU2317817C2 (da)
SI (1)	SI1601349T1 (da)
WO (1)	WO2004075886A1 (da)

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2004
- 2004-02-16 ES ES04711387T patent/ES2310715T3/es not_active Expired - Lifetime
- 2004-02-16 NZ NZ541733A patent/NZ541733A/en not_active IP Right Cessation
- 2004-02-16 WO PCT/FR2004/000347 patent/WO2004075886A1/fr not_active Ceased
- 2004-02-16 PL PL378057A patent/PL219671B1/pl unknown
- 2004-02-16 MX MXPA05008652A patent/MXPA05008652A/es active IP Right Grant
- 2004-02-16 DE DE602004015257T patent/DE602004015257D1/de not_active Expired - Lifetime
- 2004-02-16 KR KR1020057015077A patent/KR101185322B1/ko not_active Expired - Lifetime
- 2004-02-16 AU AU2004216452A patent/AU2004216452B2/en not_active Expired
- 2004-02-16 RU RU2005128548/15A patent/RU2317817C2/ru active
- 2004-02-16 SI SI200430810T patent/SI1601349T1/sl unknown
- 2004-02-16 AT AT04711387T patent/ATE401872T1/de active
- 2004-02-16 EP EP07123564A patent/EP1908461B9/fr not_active Expired - Lifetime
- 2004-02-16 CA CA2514948A patent/CA2514948C/fr not_active Expired - Lifetime
- 2004-02-16 EP EP04711387A patent/EP1601349B1/fr not_active Expired - Lifetime
- 2004-02-16 DK DK04711387T patent/DK1601349T3/da active
- 2004-02-16 BR BR0407256-1A patent/BRPI0407256A/pt not_active Application Discontinuation
- 2004-02-16 PT PT04711387T patent/PT1601349E/pt unknown
- 2004-03-22 US US10/805,940 patent/US7074833B2/en not_active Expired - Lifetime
2005
- 2005-08-12 MA MA28435A patent/MA27655A1/fr unknown
- 2005-09-12 NO NO20054228A patent/NO333987B1/no unknown
- 2005-09-20 US US11/231,236 patent/US20060014837A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR20050096190A (ko)	2005-10-05
DE602004015257D1 (de)	2008-09-04
EP1908461A1 (fr)	2008-04-09
US20040259953A1 (en)	2004-12-23
MA27655A1 (fr)	2005-12-01
EP1601349A1 (fr)	2005-12-07
HK1079117A1 (zh)	2006-03-31
EP1601349B1 (fr)	2008-07-23
RU2317817C2 (ru)	2008-02-27
EP1908461B1 (fr)	2011-03-16
US7074833B2 (en)	2006-07-11
US20060014837A1 (en)	2006-01-19
NO333987B1 (no)	2013-11-04
WO2004075886A1 (fr)	2004-09-10
RU2005128548A (ru)	2006-01-20
PL378057A1 (pl)	2006-02-20
NO20054228L (no)	2005-09-12
PL219671B1 (pl)	2015-06-30
NZ541733A (en)	2009-03-31
SI1601349T1 (sl)	2008-10-31
AU2004216452B2 (en)	2008-10-16
BRPI0407256A (pt)	2006-01-31
CA2514948C (fr)	2013-04-02
AU2004216452A1 (en)	2004-09-10
ATE401872T1 (de)	2008-08-15
KR101185322B1 (ko)	2012-09-21
PT1601349E (pt)	2008-10-27
EP1908461B9 (fr)	2011-08-31
MXPA05008652A (es)	2005-10-18
CA2514948A1 (fr)	2004-09-10
ES2310715T3 (es)	2009-01-16

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DK1601349T3 (da)	2008-10-27	Anvendelse af enantiomeren (1S, 2R) af milnacipran til fremstilling af et lægemiddel
CY1108287T1 (el)	2014-02-12	Χρηση του εναντιομερους (1s, 2r) της μιλνακιπρανης για την παρασκευη ενος φαρμακου
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EA200501865A1 (ru)	2006-08-25	Аналоги тиовольфраматов и их применение
TW200507853A (en)	2005-03-01	Use of s-10-hydroxy-10,11-dihydro-carbamazepine for the treatment of anxiety and bipolar disorders
DK1455770T3 (da)	2007-10-08	Anvendelse af norepinephringenoptagelsesinhibitorer til behandling af tic lidelser
ATE506348T1 (de)	2011-05-15	Neue benzoylpiperidinverbindungen
SE9803155D0 (sv)	1998-09-16	A new composition
BRPI0416691A (pt)	2007-01-30	forma de preparação farmacêutica sólida
TW200504016A (en)	2005-02-01	Inhibitors of monoamine uptake
EA200800125A1 (ru)	2008-04-28	Фармацевтическая композиция, включающая 1-(3-хлорфенил)-3-алкилпиперазин, для лечения расстройств аппетита