DK1606248T3 - Sulfonsyrer, deres derivater og farmaceutiske sammensætninger indeholdende dem - Google Patents

Sulfonsyrer, deres derivater og farmaceutiske sammensætninger indeholdende dem

Info

Publication number: DK1606248T3
Authority: DK; Denmark
Prior art keywords: treatment; derivatives; pharmaceutical compositions; compositions containing; prevention
Prior art date: 2003-03-14

Application number

DK04719463.4T

Other languages

English (en)

Inventor

Marcello Allegretti

Andrea Aramini

Maria Candida Cesta

Riccardo Bertini

Cinzia Bizzarri

Francesco Colotta

Original Assignee

Dompe Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-14

Filing date

2004-03-11

Publication date

2012-06-18

2004-03-11 Application filed by Dompe Spa filed Critical Dompe Spa

2012-06-18 Application granted granted Critical

2012-06-18 Publication of DK1606248T3 publication Critical patent/DK1606248T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
102000004890 Interleukin-8 Human genes 0.000 abstract 2
108090001007 Interleukin-8 Proteins 0.000 abstract 2
230000004913 activation Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 2
229940096397 interleukin-8 Drugs 0.000 abstract 2
230000007170 pathology Effects 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
150000003460 sulfonic acids Chemical class 0.000 abstract 2
102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 abstract 1
102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 abstract 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
206010009900 Colitis ulcerative Diseases 0.000 abstract 1
206010016654 Fibrosis Diseases 0.000 abstract 1
206010018364 Glomerulonephritis Diseases 0.000 abstract 1
101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 abstract 1
108010018951 Interleukin-8B Receptors Proteins 0.000 abstract 1
206010034277 Pemphigoid Diseases 0.000 abstract 1
102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
208000000594 bullous pemphigoid Diseases 0.000 abstract 1
230000003399 chemotactic effect Effects 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000004761 fibrosis Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
201000001441 melanoma Diseases 0.000 abstract 1
210000000440 neutrophil Anatomy 0.000 abstract 1
230000010410 reperfusion Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/35—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)

DK04719463.4T 2003-03-14 2004-03-11 Sulfonsyrer, deres derivater og farmaceutiske sammensætninger indeholdende dem DK1606248T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03005783A EP1457485A1 (en)	2003-03-14	2003-03-14	Sulfonic acids, their derivatives and pharmaceutical compositions containing them
PCT/EP2004/050293 WO2004080951A2 (en)	2003-03-14	2004-03-11	Sulfonic acids, their derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
DK1606248T3 true DK1606248T3 (da)	2012-06-18

Family

ID=32748883

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04719463.4T DK1606248T3 (da)	2003-03-14	2004-03-11	Sulfonsyrer, deres derivater og farmaceutiske sammensætninger indeholdende dem

Country Status (13)

Country	Link
US (1)	US7737139B2 (da)
EP (2)	EP1457485A1 (da)
JP (1)	JP4578466B2 (da)
CN (1)	CN100372831C (da)
AT (1)	ATE547397T1 (da)
AU (1)	AU2004220360B2 (da)
CA (1)	CA2514988C (da)
DK (1)	DK1606248T3 (da)
ES (1)	ES2386811T3 (da)
NO (1)	NO332782B1 (da)
PT (1)	PT1606248E (da)
RU (1)	RU2345063C2 (da)
WO (1)	WO2004080951A2 (da)

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US7504401B2 (en)	2003-08-29	2009-03-17	Locus Pharmaceuticals, Inc.	Anti-cancer agents and uses thereof
ES2238924B1 (es) *	2004-02-17	2006-12-01	Investread Europa, S.L.	Uso del acido 2,5-dihidroxibencenosulfonico, en la fabricacion de medicamentos de aplicacion en el tratamiento de enfermedades angiodependientes.
US20070149618A1 (en)	2004-02-17	2007-06-28	Action Medicines, S.L.	Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis
US20080125485A1 (en)	2004-02-17	2008-05-29	Action Medicines	Use of 2,5-Dihydroxybenzene Derivatives for Treating Actinic Keratosis
US7772271B2 (en)	2004-07-14	2010-08-10	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7868037B2 (en)	2004-07-14	2011-01-11	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
EA200700243A1 (ru)	2004-07-14	2007-08-31	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Способы лечения гепатита с
US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
EP1781289A1 (en)	2004-07-22	2007-05-09	PTC Therapeutics, Inc.	Thienopyridines for treating hepatitis c
TWI331523B (en) *	2005-12-08	2010-10-11	Nat Health Research Institutes	Vinylsulfonate compounds
RS53007B (sr) *	2006-05-18	2014-04-30	Dompe' S.P.A.	(2r)-2-[(4-sulfonil)aminofenil]propanamidi i farmaceutske kompozicije koje ih sadrže
US20080114075A1 (en)	2006-08-16	2008-05-15	Action Medicines	Use of 2,5-Dihydroxybenzene Derivatives for Treating Dermatitis
ES2430204T3 (es)	2006-08-16	2013-11-19	AmDerma Pharmaceuticals, LLC	Uso de compuestos de 2,5-dihidroxibenceno y sus derivados para el tratamiento de la rosácea
US20110257163A1 (en) *	2007-08-07	2011-10-20	Schering Corporation	Gamma secretase modulators
CN103159674A (zh) *	2013-04-03	2013-06-19	苏州安诺生物医药技术有限公司	2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
RU2699034C1 (ru) *	2016-02-16	2019-09-03	ЗОИТИС СЕРВИСЕЗ ЭлЭлСи	Способ получения соединений 7H-пирроло[2,3-d]пиримидина
CN111747838B (zh) *	2020-07-29	2023-04-07	深圳大学	一种电催化合成氘代布洛芬的方法

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IL33051A (en)	1968-10-11	1974-05-16	Ciba Geigy Ag	Alpha-cycloalkenyl-phenyl-fatty acid derivatives and process for their manufacture
JPS4918875A (da)	1972-06-17	1974-02-19
NL7407668A (da) *	1973-06-11	1974-12-13
JPS5277030A (en) *	1975-12-23	1977-06-29	Toyo Pharma Kk	Production of novel benzyl sulphonic acid derivatives
IT1193955B (it)	1980-07-22	1988-08-31	Real Di Alberto Reiner S A S	Derivati ammidici dell'acido p-isobutilfenilpropionico, procedimento per la loro preparazione e relative composizioni farmaceutici
US5216026A (en) *	1990-07-17	1993-06-01	Eli Lilly And Company	Antitumor compositions and methods of treatment
MX9702734A (es) *	1994-10-13	1997-06-28	Pfizer	Benzopirano y compuestos benzocondensados, su preparacion y su uso como antagonistas de leucotrieno b4 (ltb4).
JPH11503110A (ja) *	1995-02-17	1999-03-23	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体拮抗剤
US6262113B1 (en) *	1996-03-20	2001-07-17	Smithkline Beecham Corporation	IL-8 receptor antagonists
US6410584B1 (en) *	1998-01-14	2002-06-25	Cell Pathways, Inc.	Method for inhibiting neoplastic cells with indole derivatives
IT1298214B1 (it) *	1998-01-28	1999-12-20	Dompe Spa	Sali dell'acido (r) 2-(3-benzoilfenil) propionico e loro composizioni farmaceutiche.
IT1303249B1 (it) *	1998-10-23	2000-11-06	Dompe Spa	Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
US6348032B1 (en) *	1998-11-23	2002-02-19	Cell Pathways, Inc.	Method of inhibiting neoplastic cells with benzimidazole derivatives
PE20001566A1 (es) *	1999-03-26	2001-02-05	Ucb Sa	Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
AU2055301A (en) *	1999-12-03	2001-06-12	Bristol-Myers Squibb Pharma Company	Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease
IT1317826B1 (it) *	2000-02-11	2003-07-15	Dompe Spa	Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
IT1318466B1 (it)	2000-04-14	2003-08-25	Dompe Spa	Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria.
ITMI20010395A1 (it) *	2001-02-27	2002-08-27	Dompe Spa	Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
ITMI20012025A1 (it) *	2001-09-28	2003-03-28	Dompe Spa	Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
ITMI20012434A1 (it) *	2001-11-20	2003-05-20	Dompe Spa	Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono

2003
- 2003-03-14 EP EP03005783A patent/EP1457485A1/en not_active Withdrawn
2004
- 2004-03-11 US US10/544,396 patent/US7737139B2/en not_active Expired - Fee Related
- 2004-03-11 DK DK04719463.4T patent/DK1606248T3/da active
- 2004-03-11 WO PCT/EP2004/050293 patent/WO2004080951A2/en not_active Ceased
- 2004-03-11 EP EP04719463A patent/EP1606248B1/en not_active Expired - Lifetime
- 2004-03-11 CN CNB2004800068672A patent/CN100372831C/zh not_active Expired - Fee Related
- 2004-03-11 ES ES04719463T patent/ES2386811T3/es not_active Expired - Lifetime
- 2004-03-11 JP JP2006505463A patent/JP4578466B2/ja not_active Expired - Fee Related
- 2004-03-11 RU RU2005131846/04A patent/RU2345063C2/ru not_active IP Right Cessation
- 2004-03-11 AU AU2004220360A patent/AU2004220360B2/en not_active Ceased
- 2004-03-11 AT AT04719463T patent/ATE547397T1/de active
- 2004-03-11 CA CA2514988A patent/CA2514988C/en not_active Expired - Fee Related
- 2004-03-11 PT PT04719463T patent/PT1606248E/pt unknown
2005
- 2005-10-11 NO NO20054672A patent/NO332782B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2005131846A (ru)	2006-03-27
WO2004080951A2 (en)	2004-09-23
NO332782B1 (no)	2013-01-14
CA2514988A1 (en)	2004-09-23
CA2514988C (en)	2013-07-16
ATE547397T1 (de)	2012-03-15
RU2345063C2 (ru)	2009-01-27
CN100372831C (zh)	2008-03-05
EP1606248B1 (en)	2012-02-29
NO20054672L (no)	2005-12-13
JP4578466B2 (ja)	2010-11-10
AU2004220360A1 (en)	2004-09-23
AU2004220360B2 (en)	2010-10-28
ES2386811T3 (es)	2012-08-31
EP1606248A2 (en)	2005-12-21
US7737139B2 (en)	2010-06-15
JP2006520367A (ja)	2006-09-07
CN1761645A (zh)	2006-04-19
NO20054672D0 (no)	2005-10-11
PT1606248E (pt)	2012-06-01
HK1089431A1 (zh)	2006-12-01
WO2004080951A3 (en)	2004-11-04
EP1457485A1 (en)	2004-09-15
US20060258730A1 (en)	2006-11-16

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ATE464226T1 (de)	2010-04-15	Halb-absenkbar schwimmende fachwerkstruktur
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CO6170405A2 (es)	2010-06-18	Composicion plaguicida que comprende fluopicolida y un compuesto insecticida
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Porter et al.	2014	The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists
NO20080165L (no)	2008-03-14	Alfa-(aryl-OR heteroaryl-metyl)-beta piperidinopropanamidforbindelser som ORL1-receptorantagonister
Parlow et al.	2003	Synthesis and X-ray crystal structures of substituted fluorobenzene and benzoquinone inhibitors of the tissue factor VIIa complex
DE602006007210D1 (de)	2009-07-23	Metaboliten aus 2-arylpropionsäure-derivaten und pharmazeutische zusammensetzungen damit
YU62801A (sh)	2004-07-15	Derivati 4-heterociklilsulfonamidil-6-metoksi-5-(2-metoksi- fenoksi)-2-piridil- piridimina, njihovo dobivanje i primena kao antagonisti endotelinskih receptora
NO20061721L (no)	2006-04-19	Amidiner og derivater derav og farmasoytiske sammensetninger som inneholder disse
CY1110691T1 (el)	2015-06-10	2-αρυλ-προπιονικα οξεα και φαρμακευτικες συνθεσεις που τα περιεχουν
ATE286878T1 (de)	2005-01-15	3,4-dihydro-1h-naphthalin-derivate als hoch selektive cyclooxygenase-2-inhibitoren
TH87151B (th)	2007-10-19	สารประกอบเคมี