NO20080165L - Alfa-(aryl-OR heteroaryl-metyl)-beta piperidinopropanamidforbindelser som ORL1-receptorantagonister - Google Patents

Alfa-(aryl-OR heteroaryl-metyl)-beta piperidinopropanamidforbindelser som ORL1-receptorantagonister

Info

Publication number
NO20080165L
NO20080165L NO20080165A NO20080165A NO20080165L NO 20080165 L NO20080165 L NO 20080165L NO 20080165 A NO20080165 A NO 20080165A NO 20080165 A NO20080165 A NO 20080165A NO 20080165 L NO20080165 L NO 20080165L
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NO
Norway
Prior art keywords
compounds
aryl
piperidinopropanamide
heteroaryl
beta
Prior art date
Application number
NO20080165A
Other languages
English (en)
Inventor
Hiroki Koike
Yukari Matsumoto
Yoshinobu Hashizume
Masako Hirota
Sachiko Mihara
Hiroshi Nakamura
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO20080165L publication Critical patent/NO20080165L/no

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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
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  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
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Abstract

Det er beskrevet forbindelser av formel (I) eller et farmasøytisk akseptabelt salt derav, hvori R1 og R2 uavhengig av hverandre betyr hydrogen eller lignende; R3 og R4 betyr uavhengig av hverandre hydrogen eller lignende; R5 betyr aryl eller lignende; -X-Y betyr -CH20- eller lignende; og n betyr 0, 1 eller 2. Disse forbindelsene har ORLI reseptorantagonistaktivitet og er derfor nyttige for å behandle sykdommer eller tilstander så som smerte, forskjellige CNS sykdommer osv.
NO20080165A 2005-06-17 2008-01-09 Alfa-(aryl-OR heteroaryl-metyl)-beta piperidinopropanamidforbindelser som ORL1-receptorantagonister NO20080165L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69193905P 2005-06-17 2005-06-17
PCT/IB2006/001642 WO2006134486A2 (en) 2005-06-17 2006-06-09 Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists

Publications (1)

Publication Number Publication Date
NO20080165L true NO20080165L (no) 2008-03-14

Family

ID=37416182

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080165A NO20080165L (no) 2005-06-17 2008-01-09 Alfa-(aryl-OR heteroaryl-metyl)-beta piperidinopropanamidforbindelser som ORL1-receptorantagonister

Country Status (12)

Country Link
US (1) US20080200490A1 (no)
EP (1) EP1893610A2 (no)
JP (1) JP2008543827A (no)
KR (1) KR20080012976A (no)
CN (1) CN101198606A (no)
AU (1) AU2006257274A1 (no)
CA (1) CA2612299A1 (no)
IL (1) IL187831A0 (no)
MX (1) MX2007016217A (no)
NO (1) NO20080165L (no)
WO (1) WO2006134486A2 (no)
ZA (1) ZA200710511B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20120841T4 (hr) * 2008-07-21 2015-07-03 Purdue Pharma L.P. Premošteni piperidinski spojevi substituiranog kinoksalin-tipa i njihova uporaba
US9308196B2 (en) 2012-05-18 2016-04-12 Gruenenthal Gmbh Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam
US20130310385A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
US8912226B2 (en) * 2012-05-18 2014-12-16 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r) -6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a NSAR
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
US20130310435A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US9855286B2 (en) 2012-05-18 2018-01-02 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
CN114436996B (zh) * 2021-12-31 2024-05-10 华中科技大学 一种β2-氨基酸衍生物的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030078278A1 (en) * 2001-06-26 2003-04-24 Pfizer Inc. Spiropiperidine compounds as ligands for ORL-1 receptor
CA2466915A1 (en) * 2002-01-28 2003-08-07 Pfizer Inc. N-substituted spiropiperidine compounds as ligands for orl-1 receptor

Also Published As

Publication number Publication date
MX2007016217A (es) 2008-03-07
KR20080012976A (ko) 2008-02-12
WO2006134486A2 (en) 2006-12-21
IL187831A0 (en) 2008-03-20
US20080200490A1 (en) 2008-08-21
WO2006134486A3 (en) 2007-02-22
EP1893610A2 (en) 2008-03-05
JP2008543827A (ja) 2008-12-04
CN101198606A (zh) 2008-06-11
ZA200710511B (en) 2008-10-29
CA2612299A1 (en) 2006-12-21
AU2006257274A1 (en) 2006-12-21

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