DK1606269T3 - Biaryl-substituerede triazoler som natriumkanalblokkere - Google Patents

Biaryl-substituerede triazoler som natriumkanalblokkere

Info

Publication number: DK1606269T3
Authority: DK; Denmark
Prior art keywords: biaryl; sodium channel; channel blockers; substituted triazoles; triazoles
Prior art date: 2003-03-18

Application number

DK04720360T

Other languages

English (en)

Inventor

Prasun K Chakravarty

Michael H Fisher

Brenda Palucki

Min K Park

William H Parsons

Bishan Zhou

James P Carey

Douglas E Frantz

Michael H Kress

Damian Weaver

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-18

Filing date

2004-03-12

Publication date

2009-02-09

2004-03-12 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2009-02-09 Application granted granted Critical

2009-02-09 Publication of DK1606269T3 publication Critical patent/DK1606269T3/da

Links

239000003195 sodium channel blocking agent Substances 0.000 title 1
150000003852 triazoles Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK04720360T 2003-03-18 2004-03-12 Biaryl-substituerede triazoler som natriumkanalblokkere DK1606269T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45595203P	2003-03-18	2003-03-18
PCT/US2004/007597 WO2004083189A1 (en)	2003-03-18	2004-03-12	Biaryl substituted triazoles as sodium channel blockers

Publications (1)

Publication Number	Publication Date
DK1606269T3 true DK1606269T3 (da)	2009-02-09

Family

ID=33030073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04720360T DK1606269T3 (da)	2003-03-18	2004-03-12	Biaryl-substituerede triazoler som natriumkanalblokkere

Country Status (34)

Country	Link
US (2)	US7326726B2 (da)
EP (1)	EP1606269B1 (da)
JP (1)	JP4482554B2 (da)
KR (1)	KR100737721B1 (da)
CN (2)	CN1788002A (da)
AR (1)	AR044503A1 (da)
AT (1)	ATE412639T1 (da)
AU (1)	AU2004221885C1 (da)
BR (1)	BRPI0408407A (da)
CA (1)	CA2519252C (da)
CL (1)	CL2004000551A1 (da)
CY (1)	CY1108720T1 (da)
DE (1)	DE602004017438D1 (da)
DK (1)	DK1606269T3 (da)
EC (1)	ECSP056018A (da)
EG (1)	EG25994A (da)
ES (1)	ES2314387T3 (da)
HR (1)	HRP20050816A2 (da)
IS (1)	IS8001A (da)
JO (1)	JO2480B1 (da)
MA (1)	MA27665A1 (da)
MX (1)	MXPA05009847A (da)
MY (1)	MY142651A (da)
NO (1)	NO20054775L (da)
NZ (1)	NZ542205A (da)
PE (1)	PE20041066A1 (da)
PL (1)	PL1606269T3 (da)
PT (1)	PT1606269E (da)
RU (1)	RU2356897C2 (da)
SI (1)	SI1606269T1 (da)
TW (1)	TWI337605B (da)
UA (1)	UA81660C2 (da)
WO (2)	WO2004083190A1 (da)
ZA (1)	ZA200506906B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE405840T1 (de)	2002-12-19	2008-09-15	Scripps Research Inst	Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung
MY142651A (en) *	2003-03-18	2010-12-15	Merck Sharp & Dohme	Biaryl substituted triazoles as sodium channel blockers
ATE500234T1 (de) *	2003-11-10	2011-03-15	Merck Sharp & Dohme	Substituierte trialzole als blocker des natriumkanals
KR20070032700A (ko)	2004-05-20	2007-03-22	폴드알엑스 파마슈티칼스, 인크.	트랜스티레틴을 안정화하고 트랜스티레틴 미스폴딩을억제하기 위한, ２-((헤테로)아릴)-벤즈옥사졸 화합물 및유도체, 그리고 조성물 및 방법
ATE472529T1 (de)	2005-10-10	2010-07-15	Glaxo Group Ltd	Prolinamidderivate als natriumkanalmodulatoren
TW200728258A (en)	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
TW200730494A (en)	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
WO2008090114A1 (en)	2007-01-24	2008-07-31	Glaxo Group Limited	Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
US8299107B2 (en) *	2007-02-08	2012-10-30	Synta Pharmaceuticals Corporation	Triazole compounds that modulate HSP90 activity
EP2520561B1 (en)	2007-06-08	2016-02-10	MannKind Corporation	IRE-1A Inhibitors
US8952034B2 (en)	2009-07-27	2015-02-10	Gilead Sciences, Inc.	Fused heterocyclic compounds as ion channel modulators
BR112012033402A2 (pt)	2010-07-02	2017-01-24	Gilead Sciences Inc	moduladores de canais de íons conforme os compostos heterocíclicos fundidos
CA2834164A1 (en)	2011-05-10	2012-11-15	Gilead Sciences, Inc.	Fused benzoxazinones as ion channel modulators
TW201837023A (zh)	2011-07-01	2018-10-16	美商基利科學股份有限公司	作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (da)	2011-07-01	2018-04-28
RU2586330C2 (ru)	2011-09-16	2016-06-10	Пфайзер Инк.	Твердые формы ингибитора диссоциации транстиретина
WO2013131018A1 (en) *	2012-03-02	2013-09-06	Zalicus Pharmaceuticals Ltd.	Biaryl inhibitors of the sodium channel
TWI568722B (zh)	2012-06-15	2017-02-01	葛蘭馬克製藥公司	作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
JP6456909B2 (ja)	2013-03-15	2019-01-23	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｌｘｒ調節因子
ES2912881T3 (es)	2014-12-23	2022-05-30	Convergence Pharmaceuticals	Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
JP6616244B2 (ja) *	2015-05-29	2019-12-04	北興化学工業株式会社	新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法
CA3076823A1 (en)	2017-10-05	2019-04-11	Biogen Inc.	Process for preparing alpha-carboxamide pyrrolidine derivatives
KR102512548B1 (ko)	2017-12-22	2023-03-22	삼성디스플레이 주식회사	유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
US20210002232A1 (en) *	2018-03-09	2021-01-07	Pi Industries Ltd.	Heterocyclic compounds as fungicides
CN108863965A (zh) *	2018-06-25	2018-11-23	青岛科技大学	一锅法制备1,2,4-三氮唑-3-甲酰胺的方法
CN108794413A (zh) *	2018-06-25	2018-11-13	青岛科技大学	一种1,2,4-三氮唑-3-甲酰胺的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US875782A (en) *	1907-04-29	1908-01-07	Walter H Cook	Fast-nut.
TW226993B (da) *	1992-05-29	1994-07-21	Kumiai Chemical Industry Co
US5455252A (en) *	1993-03-31	1995-10-03	Syntex (U.S.A.) Inc.	Optionally substituted 6,8-quinolines
JP3682075B2 (ja) *	1993-04-16	2005-08-10	クミアイ化学工業株式会社	トリアゾール誘導体及び殺虫、殺ダニ剤
TW533205B (en) *	1996-06-25	2003-05-21	Novartis Ag	Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition
IT1292091B1 (it) *	1997-06-05	1999-01-25	Geange Ltd	Derivati eterociclici aromatici azotati,procedimento per la loro preparazione e loro impiego come antigestativi,immunosoppressori e
GB9726987D0 (en)	1997-12-22	1998-02-18	Glaxo Group Ltd	Compounds
CA2368631A1 (en)	1999-03-26	2000-10-05	Euro-Celtique S.A.	Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
AR029489A1 (es)	2000-03-10	2003-07-02	Euro Celtique Sa	Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
JP2004532234A (ja) *	2001-04-27	2004-10-21	バーテックス　ファーマシューティカルズ　インコーポレイテッド	トリアゾール由来キナーゼインヒビターおよびその使用
US6797722B2 (en) *	2002-05-03	2004-09-28	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
BR0312503A (pt) *	2002-07-09	2007-06-26	Bristol Myers Squibb Co	derivados heterocìclicos substituìdos úteis como agentes antidiabéticos e antiobesidade, composição farmacêutica, uso e combinação dos mesmos
KR100467668B1 (ko) *	2002-08-07	2005-01-24	씨제이 주식회사	1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) *	2002-11-21	2005-02-05	씨제이 주식회사	1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
JO2397B1 (en) *	2002-12-20	2007-06-17	ميرك شارب اند دوم كوربوريشن	Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
MY142651A (en) *	2003-03-18	2010-12-15	Merck Sharp & Dohme	Biaryl substituted triazoles as sodium channel blockers
ATE500234T1 (de) *	2003-11-10	2011-03-15	Merck Sharp & Dohme	Substituierte trialzole als blocker des natriumkanals

2004
- 2004-03-11 MY MYPI20040842A patent/MY142651A/en unknown
- 2004-03-11 AR ARP040100789A patent/AR044503A1/es unknown
- 2004-03-12 ES ES04720360T patent/ES2314387T3/es not_active Expired - Lifetime
- 2004-03-12 CN CNA200480013089XA patent/CN1788002A/zh active Pending
- 2004-03-12 AT AT04720360T patent/ATE412639T1/de active
- 2004-03-12 SI SI200430959T patent/SI1606269T1/sl unknown
- 2004-03-12 NZ NZ542205A patent/NZ542205A/en not_active IP Right Cessation
- 2004-03-12 CN CNA2008101000997A patent/CN101289428A/zh active Pending
- 2004-03-12 DE DE602004017438T patent/DE602004017438D1/de not_active Expired - Lifetime
- 2004-03-12 HR HR20050816A patent/HRP20050816A2/hr not_active Application Discontinuation
- 2004-03-12 BR BRPI0408407-1A patent/BRPI0408407A/pt not_active IP Right Cessation
- 2004-03-12 EP EP04720360A patent/EP1606269B1/en not_active Expired - Lifetime
- 2004-03-12 AU AU2004221885A patent/AU2004221885C1/en not_active Ceased
- 2004-03-12 DK DK04720360T patent/DK1606269T3/da active
- 2004-03-12 WO PCT/US2004/007830 patent/WO2004083190A1/en not_active Ceased
- 2004-03-12 US US10/799,230 patent/US7326726B2/en not_active Expired - Lifetime
- 2004-03-12 CA CA002519252A patent/CA2519252C/en not_active Expired - Fee Related
- 2004-03-12 PL PL04720360T patent/PL1606269T3/pl unknown
- 2004-03-12 UA UAA200509759A patent/UA81660C2/ru unknown
- 2004-03-12 KR KR1020057017327A patent/KR100737721B1/ko not_active Expired - Fee Related
- 2004-03-12 RU RU2005132168/04A patent/RU2356897C2/ru not_active IP Right Cessation
- 2004-03-12 MX MXPA05009847A patent/MXPA05009847A/es active IP Right Grant
- 2004-03-12 JP JP2006507122A patent/JP4482554B2/ja not_active Expired - Fee Related
- 2004-03-12 WO PCT/US2004/007597 patent/WO2004083189A1/en not_active Ceased
- 2004-03-12 PT PT04720360T patent/PT1606269E/pt unknown
- 2004-03-14 JO JO200430A patent/JO2480B1/en active
- 2004-03-16 PE PE2004000280A patent/PE20041066A1/es not_active Application Discontinuation
- 2004-03-17 TW TW093107083A patent/TWI337605B/zh not_active IP Right Cessation
- 2004-03-17 CL CL200400551A patent/CL2004000551A1/es unknown
2005
- 2005-08-29 IS IS8001A patent/IS8001A/is unknown
- 2005-08-29 ZA ZA200506906A patent/ZA200506906B/xx unknown
- 2005-09-06 MA MA28481A patent/MA27665A1/fr unknown
- 2005-09-14 EC EC2005006018A patent/ECSP056018A/es unknown
- 2005-09-18 EG EGNA2005000548 patent/EG25994A/xx active
- 2005-10-17 NO NO20054775A patent/NO20054775L/no not_active Application Discontinuation
2008
- 2008-01-30 US US12/011,967 patent/US7572822B2/en not_active Expired - Lifetime
2009
- 2009-01-15 CY CY20091100054T patent/CY1108720T1/el unknown

Also Published As

Publication number	Publication date
CA2519252C (en)	2008-11-18
RU2005132168A (ru)	2006-04-27
UA81660C2 (ru)	2008-01-25
PT1606269E (pt)	2008-12-16
KR100737721B1 (ko)	2007-07-11
NO20054775D0 (no)	2005-10-17
ATE412639T1 (de)	2008-11-15
US20050119261A1 (en)	2005-06-02
NZ542205A (en)	2008-11-28
TWI337605B (en)	2011-02-21
JO2480B1 (en)	2009-01-20
KR20050109583A (ko)	2005-11-21
ECSP056018A (es)	2006-01-27
DE602004017438D1 (de)	2008-12-11
AU2004221885A1 (en)	2004-09-30
PE20041066A1 (es)	2005-01-22
EP1606269A1 (en)	2005-12-21
WO2004083189A1 (en)	2004-09-30
US7326726B2 (en)	2008-02-05
NO20054775L (no)	2005-12-16
MY142651A (en)	2010-12-15
CA2519252A1 (en)	2004-09-30
ES2314387T3 (es)	2009-03-16
EG25994A (en)	2012-11-28
TW200505876A (en)	2005-02-16
ZA200506906B (en)	2007-02-28
AU2004221885C1 (en)	2010-09-23
MXPA05009847A (es)	2005-12-05
CN101289428A (zh)	2008-10-22
HRP20050816A2 (hr)	2006-04-30
SI1606269T1 (sl)	2009-02-28
BRPI0408407A (pt)	2006-03-21
JP4482554B2 (ja)	2010-06-16
EP1606269B1 (en)	2008-10-29
AU2004221885B2 (en)	2010-04-22
PL1606269T3 (pl)	2009-04-30
CN1788002A (zh)	2006-06-14
JP2006520782A (ja)	2006-09-14
MA27665A1 (fr)	2005-12-01
WO2004083190A1 (en)	2004-09-30
IS8001A (is)	2005-08-29
US7572822B2 (en)	2009-08-11
CY1108720T1 (el)	2013-09-04
US20080171777A1 (en)	2008-07-17
CL2004000551A1 (es)	2005-01-21
AR044503A1 (es)	2005-09-14
RU2356897C2 (ru)	2009-05-27

Publication	Publication Date	Title
DK1606269T3 (da)	2009-02-09	Biaryl-substituerede triazoler som natriumkanalblokkere
DK1663235T3 (da)	2013-10-28	Beskyttede pyrazinoylguanidin-natriumkanal-blokkere
NO20044654L (no)	2004-10-28	Piperidinoylpiperidiner som 5-HTIF-agonister
DK1605897T3 (da)	2012-08-20	Polyethelen-glycol-link-glp-1-forbindelser
IS8108A (is)	2005-10-31	Ný efnasambönd
EP1670474A4 (en)	2008-08-06	CYCLIC PYRAZINOYLGUANIDINE AS SODIUM CHANNEL BLOCKER
DK1603570T3 (da)	2013-05-21	Aminoheteroarylforbindelser som proteinkinaseinhibitorer
DE602004018654D1 (de)	2009-02-05	Se
SE0302305D0 (sv)	2003-08-27	Novel Compounds
FI6928U1 (fi)	2005-12-30	Peliautomaatti
IS8228A (is)	2006-01-11	Ný asetídínefnasambönd
DK1556377T3 (da)	2006-10-23	Cyclopropylthienylcarboxamider som fungicider
IS8292A (is)	2006-02-09	Ný efnasambönd
EP1681700A4 (en)	2009-04-29	BREAKER SWITCH
EP1501790A4 (en)	2006-03-29	NEW SODIUM CHANNEL BLOCKERS
ATE342335T1 (de)	2006-11-15	Bleichmittelzusammensetzungen
NO20031736D0 (no)	2003-04-15	Forbindelser
ATE360676T1 (de)	2007-05-15	Bleichmittel
SE0303452D0 (sv)	2003-12-18	New compounds
NO20044302L (no)	2004-10-11	Krystallinsk parecoxibnatrium
DE602004007515D1 (de)	2007-08-23	Bleichmittel
SI1485359T1 (sl)	2008-04-30	Blokatorji natrijevega kanala
FI20030693A0 (fi)	2003-05-08	Viestinvälitysmekanismi
SE0300011D0 (sv)	2003-01-08	Blandninganordning
SE0301120D0 (sv)	2003-04-15	New compounds