IS8001A - Bíarýl setin tríasól sem natríum ganga tálmar - Google Patents

Bíarýl setin tríasól sem natríum ganga tálmar

Info

Publication number: IS8001A
Authority: IS; Iceland
Prior art keywords: baryl; substituted triazole; sodium inhibits; inhibits; sodium
Prior art date: 2003-03-18

Application number

IS8001A

Other languages

English (en)

Inventor

K. Chakravarty Prasun

H. Fisher Michael

Palucki Brenda

K. Park Min

H. Parsons William

Zhou Bishan

P. Carey James

E. Frantz Douglas

H. Kress Michael

Weaver Damian

Original Assignee

Merck & Co. Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-18

Filing date

2005-08-29

Publication date

2005-08-29

2005-08-29 Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.

2005-08-29 Publication of IS8001A publication Critical patent/IS8001A/is

Links

DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
BEWFIPLBFJGWSR-AONZOJHOSA-N butyl (z,12r)-12-acetyloxyoctadec-9-enoate Chemical group CCCCCC[C@@H](OC(C)=O)C\C=C/CCCCCCCC(=O)OCCCC BEWFIPLBFJGWSR-AONZOJHOSA-N 0.000 title 1
229910052708 sodium Inorganic materials 0.000 title 1
239000011734 sodium Substances 0.000 title 1
150000003852 triazoles Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IS8001A 2003-03-18 2005-08-29 Bíarýl setin tríasól sem natríum ganga tálmar IS8001A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45595203P	2003-03-18	2003-03-18
PCT/US2004/007830 WO2004083190A1 (en)	2003-03-18	2004-03-12	Biaryl substituted triazoles as sodium channel blockers

Publications (1)

Publication Number	Publication Date
IS8001A true IS8001A (is)	2005-08-29

Family

ID=33030073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS8001A IS8001A (is)	2003-03-18	2005-08-29	Bíarýl setin tríasól sem natríum ganga tálmar

Country Status (34)

Country	Link
US (2)	US7326726B2 (is)
EP (1)	EP1606269B1 (is)
JP (1)	JP4482554B2 (is)
KR (1)	KR100737721B1 (is)
CN (2)	CN1788002A (is)
AR (1)	AR044503A1 (is)
AT (1)	ATE412639T1 (is)
AU (1)	AU2004221885C1 (is)
BR (1)	BRPI0408407A (is)
CA (1)	CA2519252C (is)
CL (1)	CL2004000551A1 (is)
CY (1)	CY1108720T1 (is)
DE (1)	DE602004017438D1 (is)
DK (1)	DK1606269T3 (is)
EC (1)	ECSP056018A (is)
EG (1)	EG25994A (is)
ES (1)	ES2314387T3 (is)
HR (1)	HRP20050816A2 (is)
IS (1)	IS8001A (is)
JO (1)	JO2480B1 (is)
MA (1)	MA27665A1 (is)
MX (1)	MXPA05009847A (is)
MY (1)	MY142651A (is)
NO (1)	NO20054775L (is)
NZ (1)	NZ542205A (is)
PE (1)	PE20041066A1 (is)
PL (1)	PL1606269T3 (is)
PT (1)	PT1606269E (is)
RU (1)	RU2356897C2 (is)
SI (1)	SI1606269T1 (is)
TW (1)	TWI337605B (is)
UA (1)	UA81660C2 (is)
WO (2)	WO2004083189A1 (is)
ZA (1)	ZA200506906B (is)

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CN101413143B (zh)	2002-12-19	2013-09-18	斯克里普斯研究学院	稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错折叠的组合物和方法
AR044503A1 (es) *	2003-03-18	2005-09-14	Merck & Co Inc	Triazoles sustituidos con biarilo como bloqueantes del canal de sodio
RU2372339C2 (ru) *	2003-11-10	2009-11-10	Мерк Энд Ко., Инк.	Замещенные триазолы в качестве блокаторов натриевых каналов
AU2005245470A1 (en)	2004-05-20	2005-12-01	Foldrx Pharmaceuticals, Inc.	2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
TW200730494A (en)	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
EP1943216B1 (en)	2005-10-10	2010-06-30	Glaxo Group Limited	Prolinamide derivatives as sodium channel modulators
TW200728258A (en)	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
JP2010516734A (ja) *	2007-01-24	2010-05-20	グラクソグループリミテッド	３，５−ジアミノ−６−（２，３−ジクロロフェニル）−１，２，４−トリアジンまたはｒ（−）−２，４−ジアミノ−５−（２，３−ジクロロフェニル）−６−フルオロメチルピリミジンを含む医薬組成物
NZ579403A (en) *	2007-02-08	2012-03-30	Synta Pharmaceuticals Corp	Triazole compounds that are useful in the treatment of proliferative disorders, such as cancer
EP2520561B1 (en)	2007-06-08	2016-02-10	MannKind Corporation	IRE-1A Inhibitors
ME02847B (me)	2009-07-27	2018-01-20	Gilead Sciences Inc	Fuzionisana heterociklična jedinjenja kao modulatori jonskih kanala
BR112012033402A2 (pt)	2010-07-02	2017-01-24	Gilead Sciences Inc	moduladores de canais de íons conforme os compostos heterocíclicos fundidos
ES2648820T3 (es)	2011-05-10	2018-01-08	Gilead Sciences, Inc.	Compuestos heterocíclicos condensados como moduladores de los canales de sodio
TWI478908B (zh)	2011-07-01	2015-04-01	Gilead Sciences Inc	作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (is)	2011-07-01	2018-04-28
WO2013038351A1 (en)	2011-09-16	2013-03-21	Pfizer Inc.	Solid forms of a transthyretin dissociation inhibitor
WO2013131018A1 (en) *	2012-03-02	2013-09-06	Zalicus Pharmaceuticals Ltd.	Biaryl inhibitors of the sodium channel
TWI568722B (zh)	2012-06-15	2017-02-01	葛蘭馬克製藥公司	作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
ES2694001T3 (es)	2013-03-15	2018-12-17	Bristol-Myers Squibb Company	Moduladores de LXR
ES2912881T3 (es)	2014-12-23	2022-05-30	Convergence Pharmaceuticals	Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
JP6616244B2 (ja) *	2015-05-29	2019-12-04	北興化学工業株式会社	新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法
JP2020536870A (ja)	2017-10-05	2020-12-17	バイオジェンインコーポレイテッド	アルファカルボキサミドピロリジン誘導体の調製方法
KR102512548B1 (ko)	2017-12-22	2023-03-22	삼성디스플레이 주식회사	유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
US20210002232A1 (en) *	2018-03-09	2021-01-07	Pi Industries Ltd.	Heterocyclic compounds as fungicides
CN108794413A (zh) *	2018-06-25	2018-11-13	青岛科技大学	一种1,2,4-三氮唑-3-甲酰胺的合成方法
CN108863965A (zh) *	2018-06-25	2018-11-23	青岛科技大学	一锅法制备1,2,4-三氮唑-3-甲酰胺的方法

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MY129541A (en) *	1996-06-25	2007-04-30	Novartis Ag	Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
IT1292091B1 (it) *	1997-06-05	1999-01-25	Geange Ltd	Derivati eterociclici aromatici azotati,procedimento per la loro preparazione e loro impiego come antigestativi,immunosoppressori e
GB9726987D0 (en)	1997-12-22	1998-02-18	Glaxo Group Ltd	Compounds
UA72244C2 (en) *	1999-03-26	2005-02-15		Aryl-substituted pyrazols, imidazols, oxazols, thiazols, pyrrols and their use
AR029489A1 (es)	2000-03-10	2003-07-02	Euro Celtique Sa	Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
CA2445568A1 (en) *	2001-04-27	2002-11-07	Vertex Pharmaceuticals Incorporated	Triazole-derived kinase inhibitors and uses thereof
US6797722B2 (en) *	2002-05-03	2004-09-28	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
MXPA05000279A (es) *	2002-07-09	2005-03-31	Squibb Bristol Myers Co	Derivados heterociclicos sustituidos utiles como agentes antidiabeticos y antiobesidad y metodo.
KR100467668B1 (ko) *	2002-08-07	2005-01-24	씨제이 주식회사	1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) *	2002-11-21	2005-02-05	씨제이 주식회사	1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
JO2397B1 (en) *	2002-12-20	2007-06-17	ميرك شارب اند دوم كوربوريشن	Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
AR044503A1 (es) *	2003-03-18	2005-09-14	Merck & Co Inc	Triazoles sustituidos con biarilo como bloqueantes del canal de sodio
RU2372339C2 (ru) *	2003-11-10	2009-11-10	Мерк Энд Ко., Инк.	Замещенные триазолы в качестве блокаторов натриевых каналов

2004
- 2004-03-11 AR ARP040100789A patent/AR044503A1/es unknown
- 2004-03-11 MY MYPI20040842A patent/MY142651A/en unknown
- 2004-03-12 ES ES04720360T patent/ES2314387T3/es not_active Expired - Lifetime
- 2004-03-12 CN CNA200480013089XA patent/CN1788002A/zh active Pending
- 2004-03-12 WO PCT/US2004/007597 patent/WO2004083189A1/en not_active Ceased
- 2004-03-12 CA CA002519252A patent/CA2519252C/en not_active Expired - Fee Related
- 2004-03-12 AT AT04720360T patent/ATE412639T1/de active
- 2004-03-12 PT PT04720360T patent/PT1606269E/pt unknown
- 2004-03-12 BR BRPI0408407-1A patent/BRPI0408407A/pt not_active IP Right Cessation
- 2004-03-12 JP JP2006507122A patent/JP4482554B2/ja not_active Expired - Fee Related
- 2004-03-12 DE DE602004017438T patent/DE602004017438D1/de not_active Expired - Lifetime
- 2004-03-12 NZ NZ542205A patent/NZ542205A/en not_active IP Right Cessation
- 2004-03-12 US US10/799,230 patent/US7326726B2/en not_active Expired - Lifetime
- 2004-03-12 MX MXPA05009847A patent/MXPA05009847A/es active IP Right Grant
- 2004-03-12 CN CNA2008101000997A patent/CN101289428A/zh active Pending
- 2004-03-12 DK DK04720360T patent/DK1606269T3/da active
- 2004-03-12 RU RU2005132168/04A patent/RU2356897C2/ru not_active IP Right Cessation
- 2004-03-12 SI SI200430959T patent/SI1606269T1/sl unknown
- 2004-03-12 WO PCT/US2004/007830 patent/WO2004083190A1/en not_active Ceased
- 2004-03-12 KR KR1020057017327A patent/KR100737721B1/ko not_active Expired - Fee Related
- 2004-03-12 HR HR20050816A patent/HRP20050816A2/hr not_active Application Discontinuation
- 2004-03-12 EP EP04720360A patent/EP1606269B1/en not_active Expired - Lifetime
- 2004-03-12 UA UAA200509759A patent/UA81660C2/ru unknown
- 2004-03-12 PL PL04720360T patent/PL1606269T3/pl unknown
- 2004-03-12 AU AU2004221885A patent/AU2004221885C1/en not_active Ceased
- 2004-03-14 JO JO200430A patent/JO2480B1/en active
- 2004-03-16 PE PE2004000280A patent/PE20041066A1/es not_active Application Discontinuation
- 2004-03-17 TW TW093107083A patent/TWI337605B/zh not_active IP Right Cessation
- 2004-03-17 CL CL200400551A patent/CL2004000551A1/es unknown
2005
- 2005-08-29 IS IS8001A patent/IS8001A/is unknown
- 2005-08-29 ZA ZA200506906A patent/ZA200506906B/xx unknown
- 2005-09-06 MA MA28481A patent/MA27665A1/fr unknown
- 2005-09-14 EC EC2005006018A patent/ECSP056018A/es unknown
- 2005-09-18 EG EGNA2005000548 patent/EG25994A/xx active
- 2005-10-17 NO NO20054775A patent/NO20054775L/no not_active Application Discontinuation
2008
- 2008-01-30 US US12/011,967 patent/US7572822B2/en not_active Expired - Lifetime
2009
- 2009-01-15 CY CY20091100054T patent/CY1108720T1/el unknown

Also Published As

Publication number	Publication date
US7572822B2 (en)	2009-08-11
PT1606269E (pt)	2008-12-16
PL1606269T3 (pl)	2009-04-30
WO2004083189A1 (en)	2004-09-30
AR044503A1 (es)	2005-09-14
MXPA05009847A (es)	2005-12-05
KR20050109583A (ko)	2005-11-21
NO20054775L (no)	2005-12-16
UA81660C2 (ru)	2008-01-25
ES2314387T3 (es)	2009-03-16
TW200505876A (en)	2005-02-16
ZA200506906B (en)	2007-02-28
TWI337605B (en)	2011-02-21
US7326726B2 (en)	2008-02-05
CL2004000551A1 (es)	2005-01-21
RU2356897C2 (ru)	2009-05-27
AU2004221885A1 (en)	2004-09-30
AU2004221885B2 (en)	2010-04-22
MY142651A (en)	2010-12-15
EP1606269B1 (en)	2008-10-29
WO2004083190A1 (en)	2004-09-30
NO20054775D0 (no)	2005-10-17
DE602004017438D1 (de)	2008-12-11
ATE412639T1 (de)	2008-11-15
PE20041066A1 (es)	2005-01-22
CN101289428A (zh)	2008-10-22
EP1606269A1 (en)	2005-12-21
JP2006520782A (ja)	2006-09-14
US20080171777A1 (en)	2008-07-17
DK1606269T3 (da)	2009-02-09
RU2005132168A (ru)	2006-04-27
JP4482554B2 (ja)	2010-06-16
EG25994A (en)	2012-11-28
HRP20050816A2 (hr)	2006-04-30
CA2519252C (en)	2008-11-18
CN1788002A (zh)	2006-06-14
SI1606269T1 (sl)	2009-02-28
US20050119261A1 (en)	2005-06-02
NZ542205A (en)	2008-11-28
KR100737721B1 (ko)	2007-07-11
CA2519252A1 (en)	2004-09-30
MA27665A1 (fr)	2005-12-01
BRPI0408407A (pt)	2006-03-21
JO2480B1 (en)	2009-01-20
AU2004221885C1 (en)	2010-09-23
ECSP056018A (es)	2006-01-27
CY1108720T1 (el)	2013-09-04

Publication	Publication Date	Title
IS8001A (is)	2005-08-29	Bíarýl setin tríasól sem natríum ganga tálmar
IS8345A (is)	2006-03-09	6-útskipt anilínópúrín sem RTK-tálmar
IS8238A (is)	2006-01-18	Pýrrólótvíhýdróísókínólín sem PDE10 tálmar
IS7884A (is)	2005-06-09	Díasepínóindól afleiður sem kínasa hindrar
IS8384A (is)	2006-03-29	Alkýleraðar bensímídasólafleiður sem MEK-hindrar
IS7717A (is)	2005-02-28	Pýrídasínónafleiður sem PDF4-hemlar
EP1575487A4 (en)	2012-12-05	MICROCRYSTALLINE CELLULOSIC COMPOSITIONS
IL176451A0 (en)	2006-10-05	Novel 2-heteroaryl-substituted benzimidazole derivative
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