DK160824C - Benzodioxanderivater - Google Patents

Benzodioxanderivater

Info

Publication number: DK160824C
Authority: DK; Denmark
Prior art keywords: sup; alkyl; compounds; sub; general formula
Prior art date: 1984-04-24

Application number

DK141590A

Other languages

English (en)

Other versions

DK141590A (da

DK160824B (da

DK141590D0 (da

Inventor

John Kitchin

Peter Clive Cherry

Adrian John Pipe

Andrew James Crame

Alan David Borthwick

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-24

Filing date

1990-06-08

Publication date

1991-10-07

1984-04-24 Priority claimed from GB848410456A external-priority patent/GB8410456D0/en

1985-02-15 Priority claimed from GB858503975A external-priority patent/GB8503975D0/en

1990-06-08 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1990-06-08 Publication of DK141590A publication Critical patent/DK141590A/da

1990-06-08 Publication of DK141590D0 publication Critical patent/DK141590D0/da

1991-04-22 Publication of DK160824B publication Critical patent/DK160824B/da

1991-10-07 Application granted granted Critical

1991-10-07 Publication of DK160824C publication Critical patent/DK160824C/da

Links

BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
229940082496 Adrenoreceptor antagonist Drugs 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
238000005576 amination reaction Methods 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Light Receiving Elements (AREA)
Compositions Of Macromolecular Compounds (AREA)
Pyrrole Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyesters Or Polycarbonates (AREA)
Luminescent Compositions (AREA)

DK141590A 1984-04-24 1990-06-08 Benzodioxanderivater DK160824C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB848410456A GB8410456D0 (en)	1984-04-24	1984-04-24	Chemical compounds
GB8410456		1984-04-24
GB858503975A GB8503975D0 (en)	1985-02-15	1985-02-15	Chemical compounds
GB8503975		1985-02-15

Publications (4)

Publication Number	Publication Date
DK141590A DK141590A (da)	1990-06-08
DK141590D0 DK141590D0 (da)	1990-06-08
DK160824B DK160824B (da)	1991-04-22
DK160824C true DK160824C (da)	1991-10-07

Family

ID=26287645

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK184085A DK160556C (da)	1984-04-24	1985-04-24	Benzodioxinpyrrolderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK141590A DK160824C (da)	1984-04-24	1990-06-08	Benzodioxanderivater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK184085A DK160556C (da)	1984-04-24	1985-04-24	Benzodioxinpyrrolderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Country Status (21)

Country	Link
US (1)	US4880801A (da)
EP (2)	EP0162593B1 (da)
JP (2)	JPH02270878A (da)
KR (1)	KR920003065B1 (da)
AT (1)	ATE55605T1 (da)
AU (1)	AU577367B2 (da)
CA (1)	CA1256111A (da)
CS (1)	CS402491A3 (da)
CY (2)	CY1532A (da)
DE (2)	DE3579189D1 (da)
DK (2)	DK160556C (da)
ES (2)	ES8607311A1 (da)
FI (1)	FI84069C (da)
GB (3)	GB2201414B (da)
GR (1)	GR850993B (da)
HK (2)	HK42890A (da)
IL (1)	IL75011A (da)
MX (1)	MX9203233A (da)
NZ (1)	NZ211885A (da)
PT (1)	PT80344B (da)
SG (2)	SG23590G (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8526210D0 (en) *	1985-10-23	1985-11-27	Glaxo Group Ltd	Chemical compounds
GB8526209D0 (en) *	1985-10-23	1985-11-27	Glaxo Group Ltd	Chemical process
US5225431A (en) *	1987-10-23	1993-07-06	Burroughs Wellcome Co.	Therapeutic substituted indole compounds and compositions thereof
GB8828032D0 (en) *	1988-12-01	1989-01-05	Glaxo Group Ltd	Medicaments
GB9012469D0 (en) *	1990-06-05	1990-07-25	Glaxo Group Ltd	Medicaments
GB9119466D0 (en) *	1991-09-12	1991-10-23	Glaxo Group Ltd	Chemical compounds
US6451806B2 (en)	1999-09-29	2002-09-17	Adolor Corporation	Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en)	1999-11-29	2002-10-22	Adolor Corporation	Methods for the treatment and prevention of ileus
BRPI0409492A (pt) *	2003-04-18	2006-05-02	Pharmacia & Up John Company Ll	terapias de combinação
GB2503187A (en) *	2011-09-15	2013-12-25	Univ Sussex	Composition for use in the treatment of neurodevelopmental disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2485539A1 (fr) *	1980-06-26	1981-12-31	Sori Soc Rech Ind	Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique
IL70034A0 (en) *	1982-10-25	1984-01-31	Glaxo Group Ltd	Heterocyclic amino compounds,their preparation and pharmaceutical compositions containing them

1985
- 1985-04-24 GB GB08802949A patent/GB2201414B/en not_active Expired
- 1985-04-24 AU AU41667/85A patent/AU577367B2/en not_active Ceased
- 1985-04-24 DE DE8585302854T patent/DE3579189D1/de not_active Expired - Fee Related
- 1985-04-24 ES ES542516A patent/ES8607311A1/es not_active Expired
- 1985-04-24 AT AT85302854T patent/ATE55605T1/de not_active IP Right Cessation
- 1985-04-24 PT PT80344A patent/PT80344B/pt not_active IP Right Cessation
- 1985-04-24 DE DE89117732T patent/DE3587511T2/de not_active Expired - Fee Related
- 1985-04-24 NZ NZ211885A patent/NZ211885A/xx unknown
- 1985-04-24 GB GB8510449A patent/GB2157691B/en not_active Expired
- 1985-04-24 IL IL75011A patent/IL75011A/xx not_active IP Right Cessation
- 1985-04-24 KR KR1019850002771A patent/KR920003065B1/ko not_active Expired
- 1985-04-24 GR GR850993A patent/GR850993B/el unknown
- 1985-04-24 EP EP85302854A patent/EP0162593B1/en not_active Expired - Lifetime
- 1985-04-24 EP EP89117732A patent/EP0359290B1/en not_active Expired - Lifetime
- 1985-04-24 FI FI851611A patent/FI84069C/fi not_active IP Right Cessation
- 1985-04-24 DK DK184085A patent/DK160556C/da not_active IP Right Cessation
- 1985-04-24 CA CA000479944A patent/CA1256111A/en not_active Expired
1986
- 1986-01-31 ES ES551509A patent/ES8801545A1/es not_active Expired
1987
- 1987-12-11 GB GB878728949A patent/GB8728949D0/en active Pending
1988
- 1988-05-26 US US07/198,971 patent/US4880801A/en not_active Expired - Fee Related
1990
- 1990-03-22 JP JP2073144A patent/JPH02270878A/ja active Pending
- 1990-03-22 JP JP2073145A patent/JPH02270819A/ja active Pending
- 1990-03-24 SG SG235/90A patent/SG23590G/en unknown
- 1990-05-31 HK HK428/90A patent/HK42890A/xx unknown
- 1990-06-08 DK DK141590A patent/DK160824C/da not_active IP Right Cessation
- 1990-11-16 CY CY1532A patent/CY1532A/en unknown
1991
- 1991-12-23 CS CS914024A patent/CS402491A3/cs unknown
1992
- 1992-06-24 MX MX9203233A patent/MX9203233A/es unknown
1993
- 1993-02-05 SG SG122/93A patent/SG12293G/en unknown
- 1993-10-21 HK HK1120/93A patent/HK112093A/en not_active IP Right Cessation
1994
- 1994-01-14 CY CY169594A patent/CY1695A/xx unknown

Also Published As

Publication number	Publication date
FI851611A0 (fi)	1985-04-24
PT80344B (pt)	1987-09-30
ES8801545A1 (es)	1988-02-01
FI84069B (fi)	1991-06-28
DK160556B (da)	1991-03-25
DK184085D0 (da)	1985-04-24
DK184085A (da)	1985-10-25
DK160556C (da)	1991-09-02
GB2157691A (en)	1985-10-30
DK141590A (da)	1990-06-08
FI851611L (fi)	1985-10-25
IL75011A (en)	1990-02-09
CY1695A (en)	1994-01-14
CS402491A3 (en)	1992-10-14
CY1532A (en)	1990-11-16
PT80344A (en)	1985-05-01
NZ211885A (en)	1988-09-29
EP0162593B1 (en)	1990-08-16
GB8728949D0 (en)	1988-01-27
ATE55605T1 (de)	1990-09-15
GB8510449D0 (en)	1985-05-30
DK160824B (da)	1991-04-22
JPH02270819A (ja)	1990-11-05
DE3587511T2 (de)	1993-11-18
EP0359290B1 (en)	1993-08-04
GB2157691B (en)	1989-07-05
AU577367B2 (en)	1988-09-22
SG23590G (en)	1990-07-13
CA1256111A (en)	1989-06-20
EP0162593A1 (en)	1985-11-27
MX9203233A (es)	1992-07-01
DE3579189D1 (de)	1990-09-20
SG12293G (en)	1993-04-16
GR850993B (da)	1985-11-25
ES8607311A1 (es)	1986-06-16
GB8802949D0 (en)	1988-03-09
GB2201414A (en)	1988-09-01
ES542516A0 (es)	1986-06-16
HK112093A (en)	1993-10-29
US4880801A (en)	1989-11-14
AU4166785A (en)	1985-10-31
EP0359290A1 (en)	1990-03-21
DK141590D0 (da)	1990-06-08
KR920003065B1 (ko)	1992-04-13
FI84069C (fi)	1991-10-10
GB2201414B (en)	1988-12-29
KR850007259A (ko)	1985-12-02
DE3587511D1 (de)	1993-09-09
ES551509A0 (es)	1988-02-01
HK42890A (en)	1990-06-08
JPH02270878A (ja)	1990-11-05

Legal Events

Date	Code	Title	Description
1994-12-27	PBP	Patent lapsed

Publication	Publication Date	Title
ES8308311A1 (es)	1983-08-16	Procedimiento para la preparacion de derivados de benzazepina.
AR240909A2 (es)	1991-03-27	Derivados de 2-(2'-alquilbenzoil) -1,3-ciclohexanodiona, composicion que los comprende y procedimiento para prepararlo"
DK141590D0 (da)	1990-06-08	Benzodioxanderivater
ES8609204A1 (es)	1986-09-01	Procedimiento de preparar derivados aminicos
ES546602A0 (es)	1986-11-16	Un procedimiento para producir un derivado de 2-(3,5-dial- quil-4-hidroxifenil)indol
ES541573A0 (es)	1986-04-01	Un procedimiento para preparar un derivado de 2-hidroxi-3- (4-fenilpiperazimil)propoxi-benzofurano
ATE27275T1 (de)	1987-06-15	Imidazolin-derivate.
DE3688128D1 (de)	1993-04-29	Isoindolinderivate und verfahren zu ihrer herstellung.
ATE53388T1 (de)	1990-06-15	3,5-dialkyl-4,6-diaryl-tetrahydro-2h-1,3,5thiadiazin-2-thion-derivate, verfahren zu ihrer herstellung und sie enthaltende antihyperlipidemische mittel.
DK135285D0 (da)	1985-03-26	1,4-dihydropyridinderivater samt laegemiddel indeholdende saadanne forbindelser
JPS543064A (en)	1979-01-11	Benzothiazolylthiocarboxylic acid derivatives
SU1690242A1 (ru)	1999-08-10	Антифидант
RU982328C (ru)	2016-09-10	Соли 9-алкил-2-трет-бутилимидазо[1,2-a]бензимидазолов, обладающие антиаритмической активностью