DK161077C - Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrol oe3,4-eaa-oe1,4aadiazepin-2(3h)-on-derivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrol oe3,4-eaa-oe1,4aadiazepin-2(3h)-on-derivater eller farmaceutisk acceptable syreadditionssalte deraf

Info

Publication number: DK161077C
Authority: DK; Denmark
Prior art keywords: derivatives; dihydropyrole; eaa; analogue; preparation
Prior art date: 1982-09-08

Application number

DK394483A

Other languages

Danish (da)

English (en)

Other versions

DK394483D0 (da

DK394483A (da

DK161077B (da

Inventor

Luigi Mariani

Giorgio Tarzia

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-08

Filing date

1983-08-30

Publication date

1991-11-18

1983-08-30 Application filed by Lepetit Spa filed Critical Lepetit Spa

1983-08-30 Publication of DK394483D0 publication Critical patent/DK394483D0/da

1984-03-09 Publication of DK394483A publication Critical patent/DK394483A/da

1991-05-27 Publication of DK161077B publication Critical patent/DK161077B/da

1991-11-18 Application granted granted Critical

1991-11-18 Publication of DK161077C publication Critical patent/DK161077C/da

Links

239000002253 acid Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000001246 bromo group Chemical group Br* 0.000 abstract 2
125000001309 chloro group Chemical group Cl* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
NCCPPLQKOSIGFQ-UHFFFAOYSA-N 3,7-dihydro-1h-pyrrolo[3,4-e][1,4]diazepin-2-one Chemical class N1C(=O)CN=CC2=CNC=C21 NCCPPLQKOSIGFQ-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
ZDJJKOOESFJHGL-UHFFFAOYSA-N pyrrolo[3,2-c]diazepine Chemical class N1=CC=CC2=NC=CC2=N1 ZDJJKOOESFJHGL-UHFFFAOYSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK394483A 1982-09-08 1983-08-30 Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrol oe3,4-eaa-oe1,4aadiazepin-2(3h)-on-derivater eller farmaceutisk acceptable syreadditionssalte deraf DK161077C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8225582		1982-09-08
GB8225582		1982-09-08

Publications (4)

Publication Number	Publication Date
DK394483D0 DK394483D0 (da)	1983-08-30
DK394483A DK394483A (da)	1984-03-09
DK161077B DK161077B (da)	1991-05-27
DK161077C true DK161077C (da)	1991-11-18

Family

ID=10532762

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK394483A DK161077C (da)	1982-09-08	1983-08-30	Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrol oe3,4-eaa-oe1,4aadiazepin-2(3h)-on-derivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (14)

Country	Link
US (1)	US4508730A (2)
EP (1)	EP0102602B1 (2)
JP (1)	JPS5965093A (2)
KR (1)	KR910000417B1 (2)
AT (1)	ATE51230T1 (2)
AU (1)	AU566404B2 (2)
CA (1)	CA1199633A (2)
DE (1)	DE3381355D1 (2)
DK (1)	DK161077C (2)
ES (2)	ES8503000A1 (2)
GR (1)	GR79626B (2)
IE (1)	IE56043B1 (2)
IL (1)	IL69473A (2)
ZA (1)	ZA835899B (2)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60208488A (ja) *	1984-04-03	1985-10-21	Nippon Mining Co Ltd	スラグからの有価金属の回収法
US20160009725A1 (en)	2013-02-22	2016-01-14	Bayer Pharma Aktiengesellschaft	Pyrrolo- and pyrazolo-triazolodiazepines as bet-protein inhibitors for treating hyperproliferative diseases
EP2958923A1 (de)	2013-02-22	2015-12-30	Bayer Pharma Aktiengesellschaft	4-substituierte pyrrolo- und pyrazolo-diazepine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3553210A (en) *	1968-12-16	1971-01-05	Parke Davis & Co	3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5(1h)-one, 7-oxide compounds
US3553207A (en) *	1968-12-16	1971-01-05	Parke Davis & Co	Phenylpyrazolodiazepinone compounds
GB1433103A (en) *	1974-03-20	1976-04-22	Lepetit Spa	Pharmacologically active pyrrolodiazepines
GR76455B (2) *	1981-06-04	1984-08-10	Lepetit Spa
IT1167788B (it) *	1981-06-08	1987-05-13	Lepetit Spa	Derivati pirrolo-diazepinici

1983
- 1983-08-09 US US06/521,774 patent/US4508730A/en not_active Expired - Fee Related
- 1983-08-11 ZA ZA835899A patent/ZA835899B/xx unknown
- 1983-08-11 AU AU17900/83A patent/AU566404B2/en not_active Ceased
- 1983-08-12 IL IL69473A patent/IL69473A/xx unknown
- 1983-08-27 DE DE8383108446T patent/DE3381355D1/de not_active Expired - Lifetime
- 1983-08-27 EP EP83108446A patent/EP0102602B1/en not_active Expired - Lifetime
- 1983-08-27 AT AT83108446T patent/ATE51230T1/de not_active IP Right Cessation
- 1983-08-29 GR GR72324A patent/GR79626B/el unknown
- 1983-08-30 DK DK394483A patent/DK161077C/da active
- 1983-09-07 JP JP58163392A patent/JPS5965093A/ja active Granted
- 1983-09-07 ES ES525442A patent/ES8503000A1/es not_active Expired
- 1983-09-07 CA CA000436167A patent/CA1199633A/en not_active Expired
- 1983-09-07 IE IE2098/83A patent/IE56043B1/en not_active IP Right Cessation
- 1983-09-08 KR KR1019830004230A patent/KR910000417B1/ko not_active Expired
1984
- 1984-05-14 ES ES532487A patent/ES8507551A1/es not_active Expired

Also Published As

Publication number	Publication date
DK394483D0 (da)	1983-08-30
ES525442A0 (es)	1985-02-01
ZA835899B (en)	1984-07-25
AU1790083A (en)	1984-03-15
EP0102602A1 (en)	1984-03-14
EP0102602B1 (en)	1990-03-21
ES532487A0 (es)	1985-09-01
DK394483A (da)	1984-03-09
DE3381355D1 (de)	1990-04-26
CA1199633A (en)	1986-01-21
ES8507551A1 (es)	1985-09-01
ATE51230T1 (de)	1990-04-15
AU566404B2 (en)	1987-10-22
JPH0447672B2 (2)	1992-08-04
IE832098L (en)	1984-03-08
JPS5965093A (ja)	1984-04-13
US4508730A (en)	1985-04-02
IL69473A (en)	1985-12-31
GR79626B (2)	1984-10-31
DK161077B (da)	1991-05-27
KR840006248A (ko)	1984-11-22
ES8503000A1 (es)	1985-02-01
KR910000417B1 (ko)	1991-01-25
IL69473A0 (en)	1983-11-30
IE56043B1 (en)	1991-03-27

Publication	Publication Date	Title
EA200000334A1 (ru)	2000-10-30	Производные карбоксамидотиазолов, их получение, содержащие их фармацевтические композиции
DK159148C (da)	1991-02-11	Analogifremgangsmaade til fremstilling af tranexamsyrederivater
DK161077C (da)	1991-11-18	Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrol oe3,4-eaa-oe1,4aadiazepin-2(3h)-on-derivater eller farmaceutisk acceptable syreadditionssalte deraf
ATE42292T1 (de)	1989-05-15	Imidazo(1,2-c)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
ES2016017A6 (es)	1990-10-01	Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
DE3069173D1 (en)	1984-10-18	Substituted phenylamino-2-imidazoline-2 derivatives, their acid addition salts, medicaments containing them and process for their preparation
ES8500742A1 (es)	1984-11-01	Procedimiento para la preparacion de derivados de acido fenilacetico
ES8300701A1 (es)	1982-11-01	Procedimiento para preparar derivados de genantreno
IT1150955B (it)	1986-12-17	Derivati 3h-naft(1.2-d)-imidazolici il procedimento per la loro preparazione, il loro uso come agenti antiinfiammatori e le composizioni farmaceutiche che li contengono
IT1207255B (it)	1989-05-17	Derivati 1,2,4-triazolici, un procedimento per la loro produzione, il loro uso come agenti antiriproduttivi e le composizioni farmaceutiche che li contengono.
ATE49601T1 (de)	1990-02-15	Neue 11-piperazinyl-5h-imidazo(2,1c>(1,4>benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel.
ZA793108B (en)	1981-02-25	Imidazo (1,2-a) imidazole derivatives,processes for their preparation,compositions thereof
DK160307C (da)	1991-07-29	Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrolooe3,4-eaaoe1,4aadiazepin-2(1h)-on-derivater
EG16489A (en)	1988-01-31	Process for the preparation of accridanone derivatives
HUT44502A (en)	1988-03-28	Process for producing 3-amino-dihydropyridine derivatives and pharmaceutical compositions containing them
FI883456A7 (fi)	1988-07-21	Azabicykloalkankarboxylsyraderivat och foerfarande foer deras framstaellning.