DK161081C - Syn-isomere 7-(4-halogen-2-hydroxy-imino-3-oxobutyrylamino)-3-(substitueret methyl)-3-cephem-4-carboxylsyrederivater til anvendelse som mellemprodukter samt salte og estere deraf - Google Patents

Syn-isomere 7-(4-halogen-2-hydroxy-imino-3-oxobutyrylamino)-3-(substitueret methyl)-3-cephem-4-carboxylsyrederivater til anvendelse som mellemprodukter samt salte og estere deraf

Info

Publication number
DK161081C
DK161081C DK621189A DK621189A DK161081C DK 161081 C DK161081 C DK 161081C DK 621189 A DK621189 A DK 621189A DK 621189 A DK621189 A DK 621189A DK 161081 C DK161081 C DK 161081C
Authority
DK
Denmark
Prior art keywords
oxobutyrylamino
cephem
syn
imino
isomer
Prior art date
Application number
DK621189A
Other languages
English (en)
Other versions
DK621189D0 (da
DK621189A (da
DK161081B (da
Inventor
Mitsuo Numata
Isao Minamida
Susumu Tsushima
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK621189D0 publication Critical patent/DK621189D0/da
Publication of DK621189A publication Critical patent/DK621189A/da
Publication of DK161081B publication Critical patent/DK161081B/da
Application granted granted Critical
Publication of DK161081C publication Critical patent/DK161081C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK621189A 1976-09-08 1989-12-08 Syn-isomere 7-(4-halogen-2-hydroxy-imino-3-oxobutyrylamino)-3-(substitueret methyl)-3-cephem-4-carboxylsyrederivater til anvendelse som mellemprodukter samt salte og estere deraf DK161081C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10810176 1976-09-08
JP51108101A JPS6011713B2 (ja) 1976-09-08 1976-09-08 セフアロスポリン誘導体およびその製造法

Publications (4)

Publication Number Publication Date
DK621189D0 DK621189D0 (da) 1989-12-08
DK621189A DK621189A (da) 1989-12-08
DK161081B DK161081B (da) 1991-05-27
DK161081C true DK161081C (da) 1991-11-11

Family

ID=14475887

Family Applications (2)

Application Number Title Priority Date Filing Date
DK270377A DK159783C (da) 1976-09-08 1977-06-17 Analogifremgangsmaade til fremstilling af 7-oe2-(2-imino-4-thiazolin-4-yl)-2-hydroxy-iminoacetamidoaa-3-(substitueret methyl)-3-cephem-4-carboxylsyre-(syn)-isomere eller farmaceutisk acceptable salte eller estere deraf samt syn-isomere 2-(4-thiazolin-4-yl)-eddikesyrederivater
DK621189A DK161081C (da) 1976-09-08 1989-12-08 Syn-isomere 7-(4-halogen-2-hydroxy-imino-3-oxobutyrylamino)-3-(substitueret methyl)-3-cephem-4-carboxylsyrederivater til anvendelse som mellemprodukter samt salte og estere deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK270377A DK159783C (da) 1976-09-08 1977-06-17 Analogifremgangsmaade til fremstilling af 7-oe2-(2-imino-4-thiazolin-4-yl)-2-hydroxy-iminoacetamidoaa-3-(substitueret methyl)-3-cephem-4-carboxylsyre-(syn)-isomere eller farmaceutisk acceptable salte eller estere deraf samt syn-isomere 2-(4-thiazolin-4-yl)-eddikesyrederivater

Country Status (22)

Country Link
US (1) US4264595A (da)
JP (1) JPS6011713B2 (da)
AT (1) AT352277B (da)
AU (1) AU508551B2 (da)
BE (1) BE856045A (da)
CA (1) CA1316171C (da)
CH (4) CH629813A5 (da)
DE (3) DE2727753A1 (da)
DK (2) DK159783C (da)
ES (2) ES460124A1 (da)
FI (1) FI67384C (da)
FR (1) FR2408612A1 (da)
GB (1) GB1587941A (da)
GR (1) GR63635B (da)
HU (1) HU182053B (da)
MX (1) MX5198E (da)
NL (1) NL189354C (da)
NO (1) NO772170L (da)
PH (2) PH15144A (da)
PT (1) PT66735B (da)
SE (1) SE464581B (da)
ZA (1) ZA773775B (da)

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JPS5760345B2 (da) * 1974-12-19 1982-12-18 Takeda Chemical Industries Ltd
SE440655B (sv) 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
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SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
US5089490A (en) * 1977-04-02 1992-02-18 Hoechst Aktiengesellschaft Cephem derivatives
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
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FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
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IT1141286B (it) * 1980-04-17 1986-10-01 Dob Far Spa Esteri delle desacetossi cefalosporine loro sali e procedimenti per il loro ottenimento
JPS5759894A (en) * 1980-09-30 1982-04-10 Sankyo Co Ltd Cephalosporin for oral administration
DK379581A (da) * 1980-10-06 1982-04-07 Hoffmann La Roche Fremgangsmaade til fremstilling af acylderivater
US4431642A (en) * 1980-12-01 1984-02-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0061234A3 (en) * 1981-03-05 1983-11-16 Beecham Group Plc Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
FR2508458A1 (fr) * 1981-06-29 1982-12-31 Sandoz Sa Nouveaux derives de l'acide cephalosporanique, leur preparation et leur application comme medicaments
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
US4396619A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
US4396620A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin quinolinium betaines
EP0081971A3 (en) * 1981-12-08 1984-09-26 Tanabe Seiyaku Co., Ltd. Novel cephalosporin compound and process for preparing the same
GB8323034D0 (en) * 1983-08-26 1983-09-28 Fujisawo Pharmaceutical Co Ltd 7-substituted-3-vinyl-3-cephem compounds
US4761409A (en) * 1984-08-16 1988-08-02 Sumitomo Pharmaceuticals Company, Limited Cephem derivatives
DE3585434D1 (de) * 1984-12-27 1992-04-02 Banyu Pharma Co Ltd Cephalosporinverbindungen.
NO862910L (no) * 1985-08-05 1987-02-06 Fujisawa Pharmaceutical Co Fremgangsmaate for fremstilling av 3,7-disubstituerte-3-cefemforbindelser.
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
JPS6417892A (en) * 1987-07-14 1989-01-20 Totoku Electric Iron coated composite material and production thereof
JPH01230547A (ja) * 1988-01-14 1989-09-14 Takeda Chem Ind Ltd ３−オキソ酪酸第三ブチルの製造法及びその用途
DE3804841A1 (de) * 1988-02-17 1989-08-31 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
EP0333082A3 (en) * 1988-03-15 1991-05-02 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
JPH0347187A (ja) * 1989-04-12 1991-02-28 Yamanouchi Pharmaceut Co Ltd 新規なセファロスポリン誘導体
DE3919259A1 (de) * 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
CA2054126A1 (en) * 1990-10-26 1992-04-27 Michiyuki Sendai Cephem compounds, their production and use
IL99898A (en) 1990-11-09 1996-10-31 Eisai Co Ltd 7-Acyl-3-substituted carbamoyloxy cephem compounds their preparation and antibacterial compositions containing them
YU48484B (sh) * 1991-05-24 1998-09-18 Hoechst Aktiengesellschaft Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
PT531875E (pt) * 1991-09-07 2004-08-31 Aventis Pharma Gmbh Diastereomeros do ester 1-(isopropoxicarboniloxi)-etilico do acido 3-cefem-4-carboxilico e processo para a sua preparacao
TW212181B (da) * 1992-02-14 1993-09-01 Hoechst Ag
ES2117066T3 (es) * 1992-05-21 1998-08-01 Hoechst Ag Procedimiento para la disociacion de esteres profarmacos de cefalosporina para dar acido 7-amino-3-metoximetil-cef-3-em-4-carboxilico.
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
US8802387B2 (en) 2008-04-30 2014-08-12 Nanyang Technological University Methods and compounds for detecting beta-lactamase activity
WO2010118361A1 (en) * 2009-04-09 2010-10-14 Sopharmia, Inc. Beta lactamase inhibitors
JP6403289B2 (ja) 2013-03-12 2018-10-10 グラディウス ファーマシューティカルズ コーポレーションＧｌａｄｉｕｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 誘導体化３−スチリル−セファロスポリン

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US4024134A (en) * 1971-01-29 1977-05-17 Glaxo Laboratories Limited Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
US4092477A (en) * 1971-05-14 1978-05-30 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
US4093803A (en) * 1971-05-14 1978-06-06 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
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DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
FR2346014A1 (fr) * 1976-01-23 1977-10-28 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2361894A2 (fr) * 1976-01-23 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
FR2383188A2 (fr) * 1976-01-23 1978-10-06 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2361893A2 (fr) * 1976-01-23 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
AU2627177A (en) 1979-01-04
HU182053B (en) 1983-12-28
GR63635B (en) 1979-11-27
PT66735A (en) 1977-07-01
ES460124A1 (es) 1978-10-01
ES470782A1 (es) 1979-01-16
BE856045A (fr) 1977-12-23
US4264595A (en) 1981-04-28
MX5198E (es) 1983-04-25
DK621189D0 (da) 1989-12-08
FI771951A7 (fi) 1978-03-09
DE2727753A1 (de) 1978-03-16
NL189354C (nl) 1993-03-16
DE2727753C2 (da) 1987-11-05
CH629813A5 (de) 1982-05-14
SE7707176L (sv) 1978-03-09
PH15144A (en) 1982-08-24
DK621189A (da) 1989-12-08
AT352277B (de) 1979-09-10
CA1316171C (en) 1993-04-13
FI67384B (fi) 1984-11-30
DE2760448C2 (da) 1989-06-22
ATA442477A (de) 1979-02-15
CH634578A5 (de) 1983-02-15
JPS6011713B2 (ja) 1985-03-27
DK270377A (da) 1978-03-09
NL189354B (nl) 1992-10-16
CH630923A5 (de) 1982-07-15
FR2408612A1 (fr) 1979-06-08
DK159783C (da) 1991-04-22
NO772170L (no) 1978-03-09
SE464581B (sv) 1991-05-13
NL7707129A (nl) 1978-03-10
PT66735B (en) 1978-11-24
JPS5334794A (en) 1978-03-31
FI67384C (fi) 1985-03-11
DK161081B (da) 1991-05-27
PH19543A (en) 1986-05-20
FR2408612B1 (da) 1982-10-15
ZA773775B (en) 1978-05-30
CH630386A5 (de) 1982-06-15
DE2760271C2 (da) 1988-08-18
DK159783B (da) 1990-12-03
AU508551B2 (en) 1980-03-27
GB1587941A (en) 1981-04-15

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