DK1610878T3 - Fremgangsmåde til fremstilling af partikler - Google Patents

Fremgangsmåde til fremstilling af partikler

Info

Publication number
DK1610878T3
DK1610878T3 DK04712610.7T DK04712610T DK1610878T3 DK 1610878 T3 DK1610878 T3 DK 1610878T3 DK 04712610 T DK04712610 T DK 04712610T DK 1610878 T3 DK1610878 T3 DK 1610878T3
Authority
DK
Denmark
Prior art keywords
manufacturing particles
particles
manufacturing
Prior art date
Application number
DK04712610.7T
Other languages
English (en)
Inventor
Robert Price
Joerg Sebastian Kaerger
Original Assignee
Univ Bath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32910470&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1610878(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0304037A external-priority patent/GB0304037D0/en
Priority claimed from GB0313129A external-priority patent/GB0313129D0/en
Application filed by Univ Bath filed Critical Univ Bath
Application granted granted Critical
Publication of DK1610878T3 publication Critical patent/DK1610878T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
DK04712610.7T 2003-02-21 2004-02-19 Fremgangsmåde til fremstilling af partikler DK1610878T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0304037A GB0304037D0 (en) 2003-02-21 2003-02-21 Process for the production of particles for use in pharmaceutical formulations
GB0313129A GB0313129D0 (en) 2003-06-06 2003-06-06 Process for the production of particles
PCT/GB2004/000654 WO2004073827A1 (en) 2003-02-21 2004-02-19 Process for the production of particles

Publications (1)

Publication Number Publication Date
DK1610878T3 true DK1610878T3 (da) 2014-12-01

Family

ID=32910470

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04712610.7T DK1610878T3 (da) 2003-02-21 2004-02-19 Fremgangsmåde til fremstilling af partikler

Country Status (11)

Country Link
US (2) US20070065372A1 (da)
EP (1) EP1610878B1 (da)
JP (1) JP5154078B2 (da)
CA (1) CA2516733C (da)
DK (1) DK1610878T3 (da)
ES (1) ES2520841T3 (da)
NO (1) NO20053796L (da)
PL (1) PL224720B1 (da)
PT (1) PT1610878E (da)
SI (1) SI1610878T1 (da)
WO (1) WO2004073827A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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US20080259519A1 (en) * 2004-09-14 2008-10-23 Battelle Memorial Institute Highly-Aqueous, Non-Respirable Aerosols Containing Biologically-Active Ingredients, Method of Making, and Device Therefor
AU2006275320B2 (en) 2005-08-04 2012-03-08 Saban Ventures Pty Limited Apparatus for concentrating a nebulant
GB0525852D0 (en) * 2005-12-20 2006-02-01 Accentus Plc Crystallisation apparatus and process
FR2897281B1 (fr) * 2006-02-14 2009-01-23 Saint Louis Inst Procede de fabrication par nanocristallisation de composes energetiques ou inertes
JP4597107B2 (ja) * 2006-03-02 2010-12-15 三井金属鉱業株式会社 砒素含有体からの砒素除去方法及び砒素除去装置
GB0610090D0 (en) * 2006-05-20 2006-06-28 Price Robert Particulate drug compositions and their uses
AU2008210270B8 (en) 2007-02-02 2012-04-26 Saban Ventures Pty Limited Membrane vapour concentrator
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
ES2310131B1 (es) * 2007-06-04 2009-12-04 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" Procedimiento de cristalizacion a partir de solucion.
GB0711680D0 (en) * 2007-06-18 2007-07-25 Prosonix Ltd Process
GB0806873D0 (en) * 2008-04-16 2008-05-21 Breath Ltd Steroid nebuliser formulation
WO2010007447A1 (en) * 2008-07-18 2010-01-21 Prosonix Limited Process for improving crystallinity
WO2010097188A1 (en) 2009-02-25 2010-09-02 Chiesi Farmaceutici S.P.A. Inhalation particles comprising a salt of carmoterol and a corticosteroid
GB0914240D0 (en) 2009-08-14 2009-09-30 Breath Ltd Steroid solvates
GB0914231D0 (en) * 2009-08-14 2009-09-30 Breath Ltd Dry powder inhaler formulations
GB0918431D0 (en) * 2009-10-21 2009-12-09 Prosonix Ltd Process for improving crystallinity
WO2011120779A1 (en) 2010-04-01 2011-10-06 Chiesi Farmaceutici S.P.A. Process for preparing carrier particles for dry powders for inhalation
EP2500072A1 (en) 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. A novel process of residual solvent removal
CN102166504B (zh) * 2011-03-22 2013-03-06 中国人民解放军第三0九医院 一种凝胶微球快速成型装置及方法
CN102350280B (zh) * 2011-06-23 2013-06-05 中国人民解放军第三0九医院 具有超声波振动装置的静电液滴发生装置及应用其制备载药凝胶微球的方法
US9643996B2 (en) 2011-11-04 2017-05-09 Battelle Memorial Institute Processes for producing protein microparticles
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
PL3517541T3 (pl) 2012-05-08 2020-12-28 Nicox Ophthalmics, Inc. Postać polimorficzna propionianu flutykazonu
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
CN104721052A (zh) * 2015-02-10 2015-06-24 武汉工程大学 一种纳米药物制备装置
GB2551944B (en) * 2015-12-18 2021-09-01 Midatech Pharma Wales Ltd Microparticle production process and apparatus
US10583085B2 (en) 2017-05-17 2020-03-10 Chiesi Farmaceutici S.P.A. Carrier particles for dry powder formulations for inhalation
KR102092068B1 (ko) * 2018-03-26 2020-03-23 중앙대학교 산학협력단 약물 결정의 제조를 위한 비용매를 이용한 결정화 장치 및 이를 이용한 약물 결정의 제조 방법
WO2020020957A1 (en) 2018-07-27 2020-01-30 Chiesi Farmaceutici S.P.A. Novel carrier particles for dry powder formulations for inhalation

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE99546T1 (de) * 1989-05-01 1994-01-15 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen.
US5376386A (en) * 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
GB9501841D0 (en) * 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
DE19617085A1 (de) * 1996-04-29 1997-10-30 Bayer Ag Verfahren zur Herstellung von feinstteiligen Kristallisationsprodukten
JP3447042B2 (ja) * 1997-07-23 2003-09-16 フロイント産業株式会社 単一物質球形粒の製造方法
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
US6522582B1 (en) * 1999-03-05 2003-02-18 Xilinx, Inc. Non-volatile memory array using gate breakdown structures
JP3490015B2 (ja) * 1999-03-11 2004-01-26 関西ティー・エル・オー株式会社 化学的耐久性に優れた放射性微小球及びその製造方法
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
GB9925934D0 (en) * 1999-11-03 1999-12-29 Glaxo Group Ltd Novel apparatus and process
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GB0219815D0 (en) * 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals

Also Published As

Publication number Publication date
WO2004073827A1 (en) 2004-09-02
JP2006519780A (ja) 2006-08-31
CA2516733C (en) 2011-09-27
PT1610878E (pt) 2014-12-03
JP5154078B2 (ja) 2013-02-27
SI1610878T1 (sl) 2015-02-27
ES2520841T3 (es) 2014-11-11
US20070065372A1 (en) 2007-03-22
EP1610878A1 (en) 2006-01-04
CA2516733A1 (en) 2004-09-02
EP1610878B1 (en) 2014-09-03
PL224720B1 (pl) 2017-01-31
NO20053796D0 (no) 2005-08-11
PL378127A1 (pl) 2006-03-06
NO20053796L (no) 2005-11-03
US20170143632A1 (en) 2017-05-25

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