DK1624868T3 - (2-Hydroxy-2(4-hydroxy-3-hydroxymethylphenyl)ethylamino)-propyl]phenyl-derivater som beta-2-agonister - Google Patents

(2-Hydroxy-2(4-hydroxy-3-hydroxymethylphenyl)ethylamino)-propyl]phenyl-derivater som beta-2-agonister

Info

Publication number: DK1624868T3
Authority: DK; Denmark
Prior art keywords: hydroxy; hydroxymethylphenyl; ethylamino; agonists; beta
Prior art date: 2003-05-15

Application number

DK04730338T

Other languages

Danish (da)

English (en)

Inventor

Mark Edward Bunnage

Paul Alan Glossop

Charlotte Alice Louise Lane

Russell Andrew Lewthwaite

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-15

Filing date

2004-04-29

Publication date

2009-02-23

2004-04-29 Application filed by Pfizer filed Critical Pfizer

2009-02-23 Application granted granted Critical

2009-02-23 Publication of DK1624868T3 publication Critical patent/DK1624868T3/da

Links

-1 2-Hydroxy-2 (4-hydroxy-3-hydroxymethylphenyl) ethylamino Chemical group 0.000 title 1
229940124748 beta 2 agonist Drugs 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Indole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK04730338T 2003-05-15 2004-04-29 (2-Hydroxy-2(4-hydroxy-3-hydroxymethylphenyl)ethylamino)-propyl]phenyl-derivater som beta-2-agonister DK1624868T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP03010944A EP1477167A1 (de)	2003-05-15	2003-05-15	[(2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethylamino)-propyl] phenyl derivative als beta2 agonist
GBGB0329874.2A GB0329874D0 (en)	2003-05-15	2003-12-23	Compounds useful for the treatment of diseases
PCT/IB2004/001519 WO2004100950A1 (en)	2003-05-15	2004-04-29	‘(2-hydroxy-2-(4-hydroxy-3-hydoxymethylphenyl)-ethylamino)-propyl!phenyl derivatives as beta2 agonists

Publications (1)

Publication Number	Publication Date
DK1624868T3 true DK1624868T3 (da)	2009-02-23

Family

ID=33454327

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04730338T DK1624868T3 (da)	2003-05-15	2004-04-29	(2-Hydroxy-2(4-hydroxy-3-hydroxymethylphenyl)ethylamino)-propyl]phenyl-derivater som beta-2-agonister

Country Status (29)

Country	Link
EP (2)	EP1477167A1 (de)
JP (1)	JP3966897B2 (de)
KR (1)	KR100749990B1 (de)
CN (1)	CN1791407A (de)
AP (1)	AP2005003443A0 (de)
AR (1)	AR044335A1 (de)
AT (1)	ATE413879T1 (de)
AU (1)	AU2004237952A1 (de)
BR (1)	BRPI0410391A (de)
CA (1)	CA2525006A1 (de)
CL (1)	CL2004000963A1 (de)
CO (1)	CO5700776A2 (de)
DE (1)	DE602004017710D1 (de)
DK (1)	DK1624868T3 (de)
EA (1)	EA200501615A1 (de)
EC (1)	ECSP056164A (de)
ES (1)	ES2314395T3 (de)
GB (1)	GB0329874D0 (de)
IS (1)	IS8080A (de)
MA (1)	MA27840A1 (de)
MX (1)	MXPA05012329A (de)
NL (1)	NL1026203C2 (de)
NO (1)	NO20055854L (de)
OA (1)	OA13165A (de)
PA (1)	PA8603001A1 (de)
PE (1)	PE20060095A1 (de)
TW (1)	TW200505865A (de)
UY (1)	UY28317A1 (de)
WO (1)	WO2004100950A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2289691T3 (es) *	2004-01-22	2008-02-01	Pfizer, Inc.	Derivados de sulfonamida para el tratamiento de enfermedades.
GEP20094781B (en)	2004-01-22	2009-09-25	Pfizer	Sulfonamide derivatives for the treatment of diseases
AU2005223488A1 (en) *	2004-03-17	2005-09-29	Pfizer Inc.	Phenylethanolamine derivatives as Beta-2 agonists
WO2005092860A1 (en) *	2004-03-23	2005-10-06	Pfizer Limited	Compounds for the treatment of diseases
CA2560368A1 (en) *	2004-03-23	2005-10-06	Pfizer Inc.	Compounds for the treatment of diseases
PE20060272A1 (es)	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
GB0424284D0 (en)	2004-11-02	2004-12-01	Novartis Ag	Organic compounds
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
GB0516313D0 (en)	2005-08-08	2005-09-14	Argenta Discovery Ltd	Azole derivatives and their uses
EP1924553A1 (de)	2005-08-08	2008-05-28	Argenta Discovery Limited	Bicyclo[2.2.]hept-7-ylaminderivate und anwendungen davon
GB0601951D0 (en)	2006-01-31	2006-03-15	Novartis Ag	Organic compounds
KR20090075714A (ko)	2006-10-30	2009-07-08	노파르티스 아게	소염제로서의 헤테로시클릭 화합물
EP2231642B1 (de)	2008-01-11	2013-10-23	Novartis AG	Pyrimidine als kinasehemmer
US8236786B2 (en)	2008-08-07	2012-08-07	Pulmagen Therapeutics (Inflammation) Limited	Respiratory disease treatment
SI2379507T1 (sl)	2008-12-30	2014-02-28	Pulmagen Therapeutics (Inflammation) Limited	Spojine sulfonamida za zdravljenje respiratornih motenj
WO2010150014A1 (en)	2009-06-24	2010-12-29	Pulmagen Therapeutics (Inflammation) Limited	5r- 5 -deuterated glitazones for respiratory disease treatment
GB201002224D0 (en)	2010-02-10	2010-03-31	Argenta Therapeutics Ltd	Respiratory disease treatment
WO2012034095A1 (en)	2010-09-09	2012-03-15	Irm Llc	Compounds and compositions as trk inhibitors
US8637516B2 (en)	2010-09-09	2014-01-28	Irm Llc	Compounds and compositions as TRK inhibitors
AU2012220572A1 (en)	2011-02-25	2013-08-29	Irm Llc	Compounds and compositions as trk inhibitors
GB201601301D0 (en) *	2016-01-25	2016-03-09	Takeda Pharmaceutical	Novel compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8528633D0 (en) *	1985-11-21	1985-12-24	Beecham Group Plc	Compounds
US5629200A (en) *	1993-11-18	1997-05-13	Daicel Chemical Industries, Ltd.	Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation
US5561142A (en) *	1994-04-26	1996-10-01	Merck & Co., Inc.	Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
EP0824519A1 (de) *	1995-05-10	1998-02-25	Pfizer Inc.	Beta-adrenergische agonisten
US6090942A (en) *	1998-10-15	2000-07-18	Pfizer Inc.	Process and intermediates for a β3 -adrenergic receptor agonist

2003
- 2003-05-15 EP EP03010944A patent/EP1477167A1/de not_active Withdrawn
- 2003-12-23 GB GBGB0329874.2A patent/GB0329874D0/en not_active Ceased
2004
- 2004-04-29 OA OA1200500317A patent/OA13165A/en unknown
- 2004-04-29 CN CNA2004800132433A patent/CN1791407A/zh active Pending
- 2004-04-29 ES ES04730338T patent/ES2314395T3/es not_active Expired - Lifetime
- 2004-04-29 JP JP2006530636A patent/JP3966897B2/ja not_active Expired - Fee Related
- 2004-04-29 EP EP04730338A patent/EP1624868B9/de not_active Expired - Lifetime
- 2004-04-29 AT AT04730338T patent/ATE413879T1/de not_active IP Right Cessation
- 2004-04-29 AU AU2004237952A patent/AU2004237952A1/en not_active Abandoned
- 2004-04-29 WO PCT/IB2004/001519 patent/WO2004100950A1/en not_active Ceased
- 2004-04-29 CA CA002525006A patent/CA2525006A1/en not_active Abandoned
- 2004-04-29 DE DE602004017710T patent/DE602004017710D1/de not_active Expired - Fee Related
- 2004-04-29 EA EA200501615A patent/EA200501615A1/ru unknown
- 2004-04-29 BR BRPI0410391-2A patent/BRPI0410391A/pt not_active IP Right Cessation
- 2004-04-29 DK DK04730338T patent/DK1624868T3/da active
- 2004-04-29 AP AP2005003443A patent/AP2005003443A0/xx unknown
- 2004-04-29 KR KR1020057021707A patent/KR100749990B1/ko not_active Expired - Fee Related
- 2004-04-29 MX MXPA05012329A patent/MXPA05012329A/es unknown
- 2004-05-05 CL CL200400963A patent/CL2004000963A1/es unknown
- 2004-05-11 PE PE2004000483A patent/PE20060095A1/es not_active Application Discontinuation
- 2004-05-12 UY UY28317A patent/UY28317A1/es not_active Application Discontinuation
- 2004-05-13 PA PA20048603001A patent/PA8603001A1/es unknown
- 2004-05-14 TW TW093113677A patent/TW200505865A/zh unknown
- 2004-05-14 AR ARP040101650A patent/AR044335A1/es not_active Application Discontinuation
- 2004-05-14 NL NL1026203A patent/NL1026203C2/nl active Search and Examination
2005
- 2005-10-20 IS IS8080A patent/IS8080A/is unknown
- 2005-11-09 CO CO05113616A patent/CO5700776A2/es not_active Application Discontinuation
- 2005-11-15 EC EC2005006164A patent/ECSP056164A/es unknown
- 2005-11-15 MA MA28609A patent/MA27840A1/fr unknown
- 2005-12-09 NO NO20055854A patent/NO20055854L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP3966897B2 (ja)	2007-08-29
CN1791407A (zh)	2006-06-21
CL2004000963A1 (es)	2005-03-18
GB0329874D0 (en)	2004-01-28
KR20060017607A (ko)	2006-02-24
PA8603001A1 (es)	2004-12-16
WO2004100950A1 (en)	2004-11-25
EA200501615A1 (ru)	2006-06-30
EP1477167A1 (de)	2004-11-17
EP1624868A1 (de)	2006-02-15
EP1624868B9 (de)	2009-08-12
KR100749990B1 (ko)	2007-08-16
NL1026203C2 (nl)	2005-07-26
NO20055854L (no)	2006-02-10
PE20060095A1 (es)	2006-02-18
MXPA05012329A (es)	2006-01-30
NL1026203A1 (nl)	2004-11-16
ES2314395T3 (es)	2009-03-16
CA2525006A1 (en)	2004-11-25
TW200505865A (en)	2005-02-16
EP1624868B1 (de)	2008-11-12
IS8080A (is)	2005-10-20
JP2007503458A (ja)	2007-02-22
BRPI0410391A (pt)	2006-07-18
ATE413879T1 (de)	2008-11-15
AP2005003443A0 (en)	2005-12-31
UY28317A1 (es)	2004-12-31
AU2004237952A1 (en)	2004-11-25
MA27840A1 (fr)	2006-04-03
CO5700776A2 (es)	2006-11-30
OA13165A (en)	2006-12-13
AR044335A1 (es)	2005-09-07
DE602004017710D1 (de)	2008-12-24
ECSP056164A (es)	2006-04-19

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