DK164704C - 3,6-disubstituerede triazolo-oe3,4-aaa-ftalazinderivater, fremgangsmaade til fremstilling deraf, udgangsforbindelse til anvendelse i fremgangsmaaden samt anvendelse af og farmaceutisk praeparat indeholdende forbindelserne - Google Patents

3,6-disubstituerede triazolo-oe3,4-aaa-ftalazinderivater, fremgangsmaade til fremstilling deraf, udgangsforbindelse til anvendelse i fremgangsmaaden samt anvendelse af og farmaceutisk praeparat indeholdende forbindelserne

Info

Publication number: DK164704C
Authority: DK; Denmark
Prior art keywords: preparation; pharmaceutical preparation; triazolo; disubstituted; derivatives
Prior art date: 1983-07-12

Application number

DK331884A

Other languages

Danish (da)

English (en)

Other versions

DK331884A (da

DK164704B (da

DK331884D0 (da

Inventor

Emilio Occelli

Giorgio Tarzia

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-12

Filing date

1984-07-06

Publication date

1992-12-21

1984-07-06 Application filed by Lepetit Spa filed Critical Lepetit Spa

1984-07-06 Publication of DK331884D0 publication Critical patent/DK331884D0/da

1985-01-13 Publication of DK331884A publication Critical patent/DK331884A/da

1992-08-03 Publication of DK164704B publication Critical patent/DK164704B/da

1992-12-21 Application granted granted Critical

1992-12-21 Publication of DK164704C publication Critical patent/DK164704C/da

Links

238000000034 method Methods 0.000 title abstract 3
239000000825 pharmaceutical preparation Substances 0.000 title 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
-1 3,6-disubstituted-1,2,4-triazolo[3,4-a]phthalazine Chemical class 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000000049 anti-anxiety effect Effects 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Anesthesiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK331884A 1983-07-12 1984-07-06 3,6-disubstituerede triazolo-oe3,4-aaa-ftalazinderivater, fremgangsmaade til fremstilling deraf, udgangsforbindelse til anvendelse i fremgangsmaaden samt anvendelse af og farmaceutisk praeparat indeholdende forbindelserne DK164704C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2201483		1983-07-12
IT22014/83A IT1194310B (it)	1983-07-12	1983-07-12	Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti

Publications (4)

Publication Number	Publication Date
DK331884D0 DK331884D0 (da)	1984-07-06
DK331884A DK331884A (da)	1985-01-13
DK164704B DK164704B (da)	1992-08-03
DK164704C true DK164704C (da)	1992-12-21

Family

ID=11190206

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK331884A DK164704C (da)	1983-07-12	1984-07-06	3,6-disubstituerede triazolo-oe3,4-aaa-ftalazinderivater, fremgangsmaade til fremstilling deraf, udgangsforbindelse til anvendelse i fremgangsmaaden samt anvendelse af og farmaceutisk praeparat indeholdende forbindelserne

Country Status (9)

Country	Link
US (1)	US4783461A (it)
EP (1)	EP0134946B1 (it)
JP (1)	JPS6056982A (it)
AT (1)	ATE28874T1 (it)
AU (1)	AU560726B2 (it)
CA (1)	CA1234114A (it)
DE (1)	DE3465309D1 (it)
DK (1)	DK164704C (it)
IT (1)	IT1194310B (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0915875B1 (en)	1996-07-25	2003-04-09	MERCK SHARP & DOHME LTD.	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
EP0915877A1 (en) *	1996-07-25	1999-05-19	MERCK SHARP & DOHME LTD.	SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABA A?$g(a)5 RECEPTOR SUBTYPE
WO1998050385A1 (en)	1997-05-08	1998-11-12	Merck Sharp & Dohme Limited	SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
AU746866B2 (en) *	1998-01-14	2002-05-02	Merck Sharp & Dohme Limited	Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801210D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
MXPA00007135A (es)	1998-01-21	2002-11-07	Merck Sharp & Dohme	Derivados de triazolo-piridazina como ligandos para receptores gaba.
GB9801202D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801234D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801208D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en)	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
US6448249B1 (en)	1998-02-25	2002-09-10	Merck Sharp & Dohme Ltd.	Substituted 1,2,4-triazolo[3,4-A]phthalazine derivatives as GABAα5 ligands
IT1303272B1 (it) *	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en)	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
CA2349700A1 (en)	1998-11-12	2000-05-18	Merck & Co., Inc.	Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
AU1481701A (en) *	1999-11-12	2001-06-06	Neurogen Corporation	Bicyclic and tricyclic heteroaromatic compounds
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
JP5130053B2 (ja) *	2005-01-05	2013-01-30	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	トリアゾロフタラジン
MX2007008137A (es) *	2005-01-05	2007-07-19	Altana Pharma Ag	Triazoloftalazinas como inhibidores de pde2.
CN102292139B (zh)	2009-01-29	2014-09-03	巴斯夫欧洲公司	用于除去酸性气体的包含氨基酸和酸性促进剂的吸收剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2484029A (en) *	1945-12-21	1949-10-11	Ciba Pharm Prod Inc	Hydrazine derivatives of pyridazine compounds
GB629177A (en) *	1945-12-21	1949-09-14	Ciba Ltd	Manufacture of new hydrazine compounds and derivatives thereof
US3711481A (en) *	1970-04-24	1973-01-16	G Hardtmann	6-aryl-imidazo(2,1-a)phthalazines
US3694442A (en) *	1970-07-28	1972-09-26	William J Houlihan	SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO{8 1,2-b{9 PHTHALAZINES
US3704300A (en) *	1971-04-09	1972-11-28	Sandoz Ag	Imidazo(2,1-a)phthalazines
JPS603080B2 (ja) *	1976-08-10	1985-01-25	三菱化学株式会社	Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロフタラジン類
GR70309B (it) *	1979-10-29	1982-09-08	Dow Chemical Co
PH21834A (en) *	1982-01-18	1988-03-17	Lepetit Spa	New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US4391807A (en) *	1982-07-12	1983-07-05	The Dow Chemical Company	6-Substituted tetrahydroimidazo[2,1-a]phthalazines and use as bronchodilators
US4485106A (en) *	1982-07-12	1984-11-27	The Dow Chemical Company	Substituted tetrahydrotetrazolo[5,1-a]phthalazines
US4487930A (en) *	1982-09-07	1984-12-11	The Dow Chemical Company	6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines

1983
- 1983-07-12 IT IT22014/83A patent/IT1194310B/it active
1984
- 1984-06-29 AT AT84107562T patent/ATE28874T1/de not_active IP Right Cessation
- 1984-06-29 EP EP84107562A patent/EP0134946B1/en not_active Expired
- 1984-06-29 DE DE8484107562T patent/DE3465309D1/de not_active Expired
- 1984-07-03 AU AU30224/84A patent/AU560726B2/en not_active Ceased
- 1984-07-06 DK DK331884A patent/DK164704C/da not_active IP Right Cessation
- 1984-07-10 JP JP59141573A patent/JPS6056982A/ja active Granted
- 1984-07-11 CA CA000458575A patent/CA1234114A/en not_active Expired
- 1984-07-11 US US06/629,658 patent/US4783461A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPS6056982A (ja)	1985-04-02
US4783461A (en)	1988-11-08
DK331884A (da)	1985-01-13
EP0134946A1 (en)	1985-03-27
CA1234114A (en)	1988-03-15
IT8322014A0 (it)	1983-07-12
AU560726B2 (en)	1987-04-16
DK164704B (da)	1992-08-03
AU3022484A (en)	1985-01-17
DE3465309D1 (de)	1987-09-17
EP0134946B1 (en)	1987-08-12
DK331884D0 (da)	1984-07-06
IT1194310B (it)	1988-09-14
JPH051267B2 (it)	1993-01-07
ATE28874T1 (de)	1987-08-15

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Legal Events

Date	Code	Title	Description
1994-03-28	PBP	Patent lapsed