IT8322014A0 - Derivati triazolo [3,4-a] ftalazini ci 3,6-disostituiti - Google Patents

Derivati triazolo [3,4-a] ftalazini ci 3,6-disostituiti

Info

Publication number
IT8322014A0
IT8322014A0 IT8322014A IT2201483A IT8322014A0 IT 8322014 A0 IT8322014 A0 IT 8322014A0 IT 8322014 A IT8322014 A IT 8322014A IT 2201483 A IT2201483 A IT 2201483A IT 8322014 A0 IT8322014 A0 IT 8322014A0
Authority
IT
Italy
Prior art keywords
disustituted
phthalazines
triazole derivatives
triazole
derivatives
Prior art date
Application number
IT8322014A
Other languages
English (en)
Other versions
IT1194310B (it
Inventor
Occelli Emilio
Tarzia Giorgio
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Publication of IT8322014A0 publication Critical patent/IT8322014A0/it
Priority to IT22014/83A priority Critical patent/IT1194310B/it
Priority to AT84107562T priority patent/ATE28874T1/de
Priority to DE8484107562T priority patent/DE3465309D1/de
Priority to EP84107562A priority patent/EP0134946B1/en
Priority to AU30224/84A priority patent/AU560726B2/en
Priority to DK331884A priority patent/DK164704C/da
Priority to JP59141573A priority patent/JPS6056982A/ja
Priority to CA000458575A priority patent/CA1234114A/en
Priority to US06/629,658 priority patent/US4783461A/en
Application granted granted Critical
Publication of IT1194310B publication Critical patent/IT1194310B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT22014/83A 1983-07-12 1983-07-12 Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti IT1194310B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT22014/83A IT1194310B (it) 1983-07-12 1983-07-12 Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
AT84107562T ATE28874T1 (de) 1983-07-12 1984-06-29 3,6-disubstituierte triazolo(3,4a>phthalazinderivate.
DE8484107562T DE3465309D1 (de) 1983-07-12 1984-06-29 3,6-disubstituted-triazoloû3,4-a¨phthalazine derivatives
EP84107562A EP0134946B1 (en) 1983-07-12 1984-06-29 3,6-Disubstituted-triazolo[3,4-a]phthalazine derivatives
AU30224/84A AU560726B2 (en) 1983-07-12 1984-07-03 Triazolo(3,4-a)phthalazine and their use as anti-anxiety agents
DK331884A DK164704C (da) 1983-07-12 1984-07-06 3,6-disubstituerede triazolo-oe3,4-aaa-ftalazinderivater, fremgangsmaade til fremstilling deraf, udgangsforbindelse til anvendelse i fremgangsmaaden samt anvendelse af og farmaceutisk praeparat indeholdende forbindelserne
JP59141573A JPS6056982A (ja) 1983-07-12 1984-07-10 ３，６−ジ置換トリアゾロ〔３，４−ａ〕フタラジン誘導体、その製法および製薬学的組成物
CA000458575A CA1234114A (en) 1983-07-12 1984-07-11 3,6-disubstituted triazolo¬3,4-a|phthalazine derivatives
US06/629,658 US4783461A (en) 1983-07-12 1984-07-11 3,6-disubstituted triazolo [3,4-A]phthalazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22014/83A IT1194310B (it) 1983-07-12 1983-07-12 Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti

Publications (2)

Publication Number Publication Date
IT8322014A0 true IT8322014A0 (it) 1983-07-12
IT1194310B IT1194310B (it) 1988-09-14

Family

ID=11190206

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22014/83A IT1194310B (it) 1983-07-12 1983-07-12 Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti

Country Status (9)

Country Link
US (1) US4783461A (it)
EP (1) EP0134946B1 (it)
JP (1) JPS6056982A (it)
AT (1) ATE28874T1 (it)
AU (1) AU560726B2 (it)
CA (1) CA1234114A (it)
DE (1) DE3465309D1 (it)
DK (1) DK164704C (it)
IT (1) IT1194310B (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0915877A1 (en) * 1996-07-25 1999-05-19 MERCK SHARP & DOHME LTD. SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABA A?$g(a)5 RECEPTOR SUBTYPE
ATE236904T1 (de) 1996-07-25 2003-04-15 Merck Sharp & Dohme Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren
CA2288789C (en) * 1997-05-08 2009-07-21 Merck Sharp & Dohme Limited Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands
GB9715977D0 (en) 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
EP1047697A1 (en) * 1998-01-14 2000-11-02 MERCK SHARP & DOHME LTD. Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
US6579875B1 (en) * 1998-01-21 2003-06-17 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801397D0 (en) 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
CZ291302B6 (cs) 1998-02-25 2003-01-15 Merck Sharp & Dohme Limited Substituovaný 1,2,4-triazolo[3,4-a]ftalazinový derivát
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
AU1816900A (en) 1998-11-12 2000-05-29 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
GB9824897D0 (en) 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
ES2195943T3 (es) * 1999-11-12 2003-12-16 Neurogen Corp Compuestos heteroaromaticos biciclicos y triciclicos.
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
ES2397082T3 (es) * 2005-01-05 2013-03-04 Nycomed Gmbh Triazoloftalazinas como inhibidores de PDE2
WO2006072615A2 (en) * 2005-01-05 2006-07-13 Nycomed Gmbh Triazolophthalazines as pde2-inhibitors
ES2428236T3 (es) 2009-01-29 2013-11-06 Basf Se Agente absorbente que contiene aminoácido y promotor ácido para la eliminación de gases ácidos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB629177A (en) * 1945-12-21 1949-09-14 Ciba Ltd Manufacture of new hydrazine compounds and derivatives thereof
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
US3711481A (en) * 1970-04-24 1973-01-16 G Hardtmann 6-aryl-imidazo(2,1-a)phthalazines
US3694442A (en) * 1970-07-28 1972-09-26 William J Houlihan SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO{8 1,2-b{9 PHTHALAZINES
US3704300A (en) * 1971-04-09 1972-11-28 Sandoz Ag Imidazo(2,1-a)phthalazines
JPS603080B2 (ja) * 1976-08-10 1985-01-25 三菱化学株式会社 Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類
GR70309B (it) * 1979-10-29 1982-09-08 Dow Chemical Co
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US4485106A (en) * 1982-07-12 1984-11-27 The Dow Chemical Company Substituted tetrahydrotetrazolo[5,1-a]phthalazines
US4391807A (en) * 1982-07-12 1983-07-05 The Dow Chemical Company 6-Substituted tetrahydroimidazo[2,1-a]phthalazines and use as bronchodilators
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines

Also Published As

Publication number Publication date
EP0134946B1 (en) 1987-08-12
ATE28874T1 (de) 1987-08-15
AU560726B2 (en) 1987-04-16
US4783461A (en) 1988-11-08
DE3465309D1 (de) 1987-09-17
CA1234114A (en) 1988-03-15
IT1194310B (it) 1988-09-14
JPS6056982A (ja) 1985-04-02
DK164704B (da) 1992-08-03
JPH051267B2 (it) 1993-01-07
DK331884D0 (da) 1984-07-06
DK331884A (da) 1985-01-13
AU3022484A (en) 1985-01-17
DK164704C (da) 1992-12-21
EP0134946A1 (en) 1985-03-27

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