DK164801B - Apparat til brug ved anbringelse af vaevsklaebestof paa basis af menneskelige eller dyriske proteiner - Google Patents

Apparat til brug ved anbringelse af vaevsklaebestof paa basis af menneskelige eller dyriske proteiner Download PDF

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DK164801B
DK164801B DK149981A DK149981A DK164801B DK 164801 B DK164801 B DK 164801B DK 149981 A DK149981 A DK 149981A DK 149981 A DK149981 A DK 149981A DK 164801 B DK164801 B DK 164801B
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DK164801C (da
DK149981A (da
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Heinz Redl
Gert Kriwetz
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Immuno Ag
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

i
DK 164801 B
Opfindelsen angår et apparat til brug ved anbringelse af et vævsklæbestof på basis af menneskelige eller dyriske proteiner til sømløs eller sømunderstøttende forbinding af menneskelige eller dyriske vævs- eller organdele, til sårforsegling, blod-5 stilning eller lignende processer, hvilket vævsklæbestof bliver dannet på stedet ved sammenbringning af opløsninger af proteinet og af blodkoaguleringsfremmende koaguleringsmidler, hvilket apparat har en holdeindretning for et flertal af i konusser udmundende sprøjtelegemer, især standardiserede én-10 gangssprøjtelegemer af plast, hvor konussen for det enkelte sprøjtelegeme gennem et samlehoved er forbundet med en transportkanal for den fra konussen udtrædende komponent af vævsklæbestoffet, hvilken transportkanal er adskilt fra transportkanalerne, som de øvrige konusser er forbundet med.
15
Ved anvendelsen af et vævsklæbestof af den nævnte art bliver en opløsning, der indeholder "Faktor-XIII" og fibrinogen blandet med en opløsning, der indeholder et thrombin og anbragt på det sårsted, der skal klæbes sammen eller beskyttes. Kendte 20 påføringsmåder består i at anbringe den ene opløsning på klæbestedet og den anden opløsning i et lag oven på eller først at blande begge opløsninger i et blandekar eller på en lille plade, trække det op i en sprøjte og så påføre det på det sted, der skal klæbes.
25
Begge metoder har ulemper: Ved den første metode indtræffer der på grund af forskellig viskositet i de to opløsninger en for tidlig størkning på overfladen, før en tilstrækkelig intensiv gennemblanding har fundet sted. Anvendelsen af den an-30 den metode kræver stor behændighed hos det medicinske personale, fordi størkning af klæbemidlet sker allerede kort tid efter sammenbringningen af de to opløsninger. Sammenbringningen af komponenterne, deres blanding, optrækning i en sprøjte og påføring på det sted, der skal klæbes, må ske indenfor få se-35 kunder. Denne metode er derfor begrænset til kun få anvendelsesområder .
2
DK 164801B
En indretning af den i indledningen beskrevne art kendes fra US patentskrift 3.223.083. Sprøjtelegemet bliver omsluttet af en klemmeagtig holdeindretning, og sprøjtelegemets konus er indsat i en Y-formet del. I denne Y-formede del bliver vævs-5 klæbestoffets' to komponenter sammenblandet, hvorved der ved en kortvarig afbrydelse af udsprøjtningen sker en uundgåelig størkning af vævsklæbestoffet i den Y-formede del. Oer må derfor efter en sådan afbrydelse også foretages en udskiftning af den Y-formede del, hvad der er omstændeligt. Formålet med op-10 findelsen er at undgå de nævnte ulemper og vanskeligheder og at anvise et apparat af den i indledningen nævnte art, med hvilket påføringen af vævsklæbestofkomponenterne kan ske samtidigt ved betjening af apparatet med én hånd, hvorved der opnås en tilstrækkelig blanding og undgås en for tidlig størknen 15 af komponenterne, før de når sårstedet.
Dette formål opnås ved hjælp af apparatet ifølge opfindelsen, som er ejendommeligt ved, at transportkanalerne er adskilt fra hinanden helt frem til mundingerne, og at der til stemplerne 20 for alle sprøjtel egernerne findes en fælles betjeningsindret ning. Til apparatet kan anvendes standardiserede, i handelen værende éngangsapparatdele, f.eks. éngangssprøjtelegemer og -stempler såvel som standardiserede kanyler, som kan fås i sterile pakninger i forretninger, hvor man forhandler lægein-25 strumenter.
Fordelagtigt kan der på samlehovedet påsættes en blandingskanyle.
30 Med henblik på at opnå en bedre håndtering af apparatet er den fælles betjeningsindretning for sprøjtestemplerne monteret på en føringsstang, der går gennem holdeindretningen.
Formålstjenligt er mundingerne for transportkanalerne anbragt 35 tæt ved siden af hinanden på endefladen af en påsætningskonus for samlehovedet.
DK 164801 B
3
Fordelagtigt kan mundingerne for transportkanalerne til samle-hovedet ligge i området ved udløbsåbninger for under en vinkel med hinanden fremførte tiIføringskanaler for sterile luftarter.
5
Ved en yderligere fordelagtig udførelsesform er akserne for udløbsåbningerne for tiIføringskanalerne rettet i en spids vinkel i forhold til hinanden, hvor vinkelspidsen ligger i en afstand, fortrinsvis i en afstand på 10-20 cm foran mundinger-10 ne for transportkanalerne.
Opfindelsen bliver i det følgende forklaret nærmere ved hjælp af to udførelsesformer under henvisning til tegningen, hvor 15 fig. 1 viser et billede af en delvist gennemskåret første udførelsesform for apparatet ifølge opfindelsen set fra siden, fig. 2 et snit langs linien 11-11 i fig. 1, 20 fig. 3 et snit langs linien 111-111 i fig. 1, fig. 4 en anden udførelsesform for opfindelsen delvist i snit langs linien IV-IV i fig. 5, og 25 fig. 5 et snit langs linien V-V i fig. 4.
Af de to sprøjtelegemer, der er betegnet med 1 og 2, tjener det ene til optagelse af en thrombin-indeholdende opløsning, 30 og det andet til optagelse af en "Faktor-XIII"- og fibrinogen-indeholdende opløsning. Sprøjtelegemerne 1, 2 er formålstjenligt udformet som standardiserede éngangssprøjtelegemer af plast. De er begge indsat i en holdeindretning 3. Holdeindretningen 3 har to U-formede render 4, 5, som begge i deres ender 35 med det største tværsnit er udformet med overgribende nopper 6, så at sprøjtelegemerne 1, 2, som bliver anbragt i renderne ovenfra, kommer i indgreb og ved hjælp af nopperne 6 bliver
DK 164801 B
4 fastholdt i renderne. Ved den ende af holdeindretningen, der har to ved siderne anbragte fingergreb 7, 8 findes der U-for-mede udvidelser 9, 10 i renderne, som sprøjtelegemernes flangeender 11, 12 er ført ind i, så sprøjtelegemerne 1, 2 også 5 bliver fikseret i retning af deres respektive længdeakser 13 i holdeindretningen 3.
Midt imellem de to U-formede render 4, 5 findes der en udtagning 14 for en føringsstang 15, hvilken udtagning ved den ende 10 af holdeindretningen, hvor fingergrebene 7, 8 sidder, går over i et gennemgående borehul 16 i holdeindretningen. Føringsstangen 15 er fast forbundet med en betjeningsindretning 17, hvori knastopsatse 18, 29 hørende til stemplerne 20, 21 i sprøjtelegemerne 1, 2 er indsat. Knastopsatsene 18, 19 hørende til 15 stemplerne 20, 21 er begge indsat i en U-formet udtagning 22, 23 i betjeningsindretningen 17. Føringsstangen har i sin forreste ende en fortykkelse 24, så at den ikke kan glide ud af hullet 16 i holdeindretningen 3.
20 De to konusser 25, 26 på sprøjtelegemerne er ført ind i ind-stikskonusser 27, 28 i et samlehoved 29 og er via dette samle-hoved forbundet med hinanden. Inden i samlehovedet 29 fører der fra hver indstikskonus 27, 28 en særskilt transportkanal 30, 31 ind i et på samlehovedet anbragt påsætningskonushoved 25 32. Mundingerne 33, 34 hørende til transportkanalerne 30, 31 er anbragt tæt ved siden af hinanden på endefladen 35 af dette påsætningskonushoved. En blandingskanyle 36, som ved sin bageste ende er forsynet med en standardiseret indstikningskonus 37 kan skydes ind over påsætningskonushovedet 32.
30
Ved et tryk med tommelfingeren på betjeningsindretningen 17 træder der samtidigt ud af de to sprøjtelegemer 1, 2 forudbestemte mængder. Som følge af de ringe afstande mellem mundingerne 33, 34 hørende til transportkanalerne 30, 31 kommer op-35 løsningerne straks i berøring med hinanden, hvorved blandingseffekten er optimal. Påføringen med én sprøjtefyldning kan ske såvel intermitterende som også kontinuerligt. Brugte sprøjte-
DK 164801 B
5 legemer 1, 2 og blandingskanylen 36 kan hurtigt udskiftes, og hele apparatet kan i givet fald steriliseres uden problemer. Enhåndsbetjeningen og den automatiske dosering af de to opløsninger i et ønsket blandingsforhold udgør en væsentlig ar-5 bejdslettelse. Bliver der anvendt en blandingskanyle 36, så at blandingen er særlig intensiv, hvorved klæbninger af højeste styrke kan opnås. Bliver påføringen af vævsklæbestoffet afbrudt, så må blandingskanylen 36 aftages og erstattes af en ny. Samlehovedet 29 kan derimod anvendes igen. Det beskrevne 10 apparat muliggør en anvendelse af vævsklæbestoffer på næsten alle områder.
Den i fig. 4 og 5 viste udførelsesform muliggør påsprøjning af vævsklæbestoffet på en overflade, der skal klæbes eller for-15 segles. Ved denne udførelsesform er samlehovedet udformet som et sprøjtehoved 38. Det har med udgangspunkt i indstikningskonusserne 39, 40 to fra hinanden adskilte transportkanaler 41, 42, hvis mundinger 43, 44 er anbragt i en afstand, der svarer til afstanden 45 mellem sprøjtelegemerne 1, 2. Opløsningernes 20 udtrædningsretning 46 fra mundingerne 43, 44 er ca. vinkelret på længderetningen 13 for sprøjtelegemerne 1, 2.
Foruden transportkanalerne 41, 42 har samle- eller sprøjtehovedet 38 en ti 1før ingskanal 47 for en steril luftart, f.eks.
25 trykluft, som inden for samlehovedet deler sig i to grene 48, 49. Udtrædningsåbningerne 50, 51 for disse to ti 1 føringskanaler 48, 49 findes i nærheden af mundingerne 43, 44 hørende til transportkanalerne 41, 42. Akserne 52, 53 for udtrædningsåb- ningerne 50, 51 er rettet ca. vinkelret på udtrædningsretnin-30 gen 46 for opløsningerne, hvortil kommer, at akserne 52, 53 for udtræningsåbningerne er rettet i en spids vinkel 54 i forhold til hinanden, og at vi nkel spidsen 55 ligger i en afstand 56 fra ca. 10-20 cm foran mundingen af transportkanalerne.
35 Ved denne udførelsesform sker doseringen af opløsningerne ligeledes ved hjælp af betjeningsindretningen, som er udformet ligesom ved betjeningsindretningen i den i fig. 1 viste udfø-

Claims (6)

1. Apparat til brug ved anbringelse af et vævsklæbestof på basis af menneskelige eller dyriske proteiner til sømløs eller sømunderstøttende forbinding af menneskelige eller dyriske 25 vævs- eller organdele, til sårforsegling, blodstilning eller lignende processer, hvilket vævsklæbestof bliver dannet på stedet ved sammenbringning af opløsninger af proteinet og af blodkoaguleringsfremmende koaguleringsmidler, hvilket apparat har en holdeindretning (3) for et flertal af i konusser (25, 30 26) udmundende sprøjtelegemer (1, 2), især standardiserede én- gangssprøjtelegemer af plast, hvor konussen (25, 26) for det enkelte sprøjtelegeme (1, 2) gennem et samlehoved (29, 38) er forbundet med en transportkanal (30, 31, 41, 42) for den fra konussen udtrædende komponent af vævsklæbestoffet, hvilken .35 transportkanal (30, 31, 41, 42) er adskilt fra transportkanalerne (31, 30, 42, 41), som de øvrige konusser (26, 25) er forbundet med, kendetegnet ved, at transportkana- 7 DK 164801 B lerne (30, 31, 41, 42) er adskilt fra hinanden helt frem til mundingerne (33, 34, 43, 44), og at der til stemplerne (20, 21. for alle sprøjtelegemerne (1, 2) findes en fmiles betjeningsindretning (17). 5
2. Apparat ifølge krav 1, kendetegnet ved, at en blandingskanyle (36) kan påsættes samlehovedet (29).
3. Apparat ifølge krav 1, kendetegnet ved, at den 10 fælles betjeningsindretning (17) for sprøjtestemplerne er monteret på en fælles føringsstang (15), der går gennem holdeindretningen (3).
4. Apparat ifølge krav l, kendetegnet ved, at mun-15 di ngerne (33, 34) for transportkanalerne (30, 31) er anbragt tæt ved siden af hinanden på endefladen (35) af en påsætningskonus (32) for samlehovedet (29).
5. Apparat ifølge et eller flere af kravene 1-4, kende- 20 tegnet ved, at mundingerne (43, 44) for transportkana lerne (41, 42) til samlehovedet (29, 38) ligger i området ved udløbsåbninger (50, 51) for under en vinkel med hinanden anbragte til førse 1 skanal er (48, 49) for sterile luftarter (f ig. 4 og 5). 25
6. Apparat ifølge krav 5, kendetegnet ved, at ak serne (52, 53) for udløbsåbningerne (50, 51) for tilførselskanalerne (48, 49) er rettet i en’ spids vinkel (54) i forhold til hinanden, og at vinkelspidsen (55) ligger i en afstand 30 (56), fortrinsvis i en afstand på 10-20 cm foran mundingerne (43, 44) af transportkanalerne (41, 42). 35
DK149981A 1980-04-02 1981-04-02 Apparat til brug ved anbringelse af vaevsklaebestof paa basis af menneskelige eller dyriske proteiner DK164801C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT179280 1980-04-02
AT0179280A AT366916B (de) 1980-04-02 1980-04-02 Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen

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DK149981A DK149981A (da) 1981-10-03
DK164801B true DK164801B (da) 1992-08-24
DK164801C DK164801C (da) 1993-01-11

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DK149981A DK164801C (da) 1980-04-02 1981-04-02 Apparat til brug ved anbringelse af vaevsklaebestof paa basis af menneskelige eller dyriske proteiner

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US (1) US4359049A (da)
EP (1) EP0037393B1 (da)
JP (3) JPS56152641A (da)
AT (1) AT366916B (da)
DE (1) DE3160381D1 (da)
DK (1) DK164801C (da)
ES (1) ES501017A0 (da)

Families Citing this family (308)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT379311B (de) * 1984-03-29 1985-12-27 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
DE3417182A1 (de) * 1984-05-09 1985-11-14 Gerald Dr. 8000 München Hauer Spritzen-set
WO1985005275A1 (fr) * 1984-05-12 1985-12-05 Dieter Lucas Seringue d'injection
DE3417757C2 (de) * 1984-05-12 1994-11-10 Lucas Dieter Dr Injektionsspritze
AT382783B (de) * 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US4609371A (en) * 1985-06-24 1986-09-02 Pizzino Joanne L Dual syringe for either simultaneous or sequential injection of liquids
JPH0630168Y2 (ja) * 1986-04-23 1994-08-17 ヘキストジャパン株式会社 生体組織接着剤用ノズル
DE3763941D1 (de) * 1986-09-14 1990-08-30 Wilhelm A Keller Doppel-austragkartusche fuer zweikomponentenmassen.
US4743229A (en) * 1986-09-29 1988-05-10 Collagen Corporation Collagen/mineral mixing device and method
AT388503B (de) * 1987-05-21 1989-07-25 Immuno Ag Set zur bereitstellung und applikation eines gewebeklebstoffes
JPH0642890B2 (ja) * 1987-07-21 1994-06-08 株式会社ニッショ− 生体接着剤塗布装置
JPH05169Y2 (da) * 1987-07-28 1993-01-06
DE3725553A1 (de) * 1987-08-01 1989-02-09 Hoechst Ag Spruehkopf zum applizieren eines mehrkomponentenmaterials
DE3725552A1 (de) * 1987-08-01 1989-02-09 Hoechst Ag Spruehkopf zum applizieren eines mehrkomponentenmaterials mittels gas
US4978336A (en) * 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
US4874368A (en) * 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US4902281A (en) * 1988-08-16 1990-02-20 Corus Medical Corporation Fibrinogen dispensing kit
US5226877A (en) * 1989-06-23 1993-07-13 Epstein Gordon H Method and apparatus for preparing fibrinogen adhesive from whole blood
US5116315A (en) * 1989-10-03 1992-05-26 Hemaedics, Inc. Biological syringe system
US4979942A (en) * 1989-10-16 1990-12-25 Johnson & Johnson Medical, Inc. Two component syringe delivery system
US5104375A (en) * 1989-10-16 1992-04-14 Johnson & Johnson Medical, Inc. Locking holder for a pair of syringes and method of use
ATE106758T1 (de) * 1989-11-21 1994-06-15 Andreas Lindner Injektionsvorrichtung.
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5185001A (en) * 1990-01-18 1993-02-09 The Research Foundation Of State University Of New York Method of preparing autologous plasma fibrin and application apparatus therefor
DK119490D0 (da) * 1990-05-14 1990-05-14 Unes As Apparat til fremstilling af et koncentrat af koagulationsfaktorer, saasom fibrinogen, fra en blodportion
US5420250A (en) * 1990-08-06 1995-05-30 Fibrin Corporation Phase transfer process for producing native plasma protein concentrates
US5644032A (en) * 1990-08-06 1997-07-01 Fibrin Corporation Process for producing fibrinogen concentrates
FR2668060B1 (fr) * 1990-10-17 1993-01-29 Fondation Nale Transfusion San Dispositif d'application d'un melange extemporane de plusieurs composants.
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
DK166691D0 (da) * 1991-09-30 1991-09-30 Unes As Flerkomponentsproejte
DK167517B1 (da) * 1991-11-11 1993-11-15 Squibb & Sons Inc Beholder til optagelse og adskillelse af en vaeske, fortrinsvis blodplasma, i dennes bestanddele
US5368563A (en) * 1991-12-18 1994-11-29 Micromedics, Inc. Sprayer assembly for physiologic glue
US5385606A (en) 1992-07-06 1995-01-31 Kowanko; Nicholas Adhesive composition and method
ES2130412T5 (es) * 1992-09-26 2005-03-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Aplicador de adhesivo destinado para tejidos.
US5290259A (en) * 1993-02-18 1994-03-01 Ultradent Products, Inc. Double syringe delivery system
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
ZA941881B (en) * 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
US5584815A (en) * 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
USD351466S (en) 1993-04-02 1994-10-11 Eli Lilly And Company Medication injector
USD351465S (en) 1993-04-02 1994-10-11 Eli Lilly And Company Medication injector
US5478323A (en) * 1993-04-02 1995-12-26 Eli Lilly And Company Manifold for injection apparatus
US5665066A (en) * 1993-09-03 1997-09-09 Ultradent Products, Inc. Methods and apparatus for mixing and dispensing multi-part compositions
AT400675B (de) * 1993-10-18 1996-02-26 Immuno Ag Spritzengarnitur zur aufbewahrung und applikation eines mehrkomponentenmaterials, spritzenvorrichtung und betätigungseinrichtung hiefür sowie verfahren zum herstellen einer befüllten, sterilen spritzenvorrichtung
ZA948564B (en) * 1993-11-19 1995-07-26 Bristol Myers Squibb Co Liquid separation apparatus and method
AT400304B (de) * 1994-02-28 1995-12-27 Immuno Ag Vorrichtung zur applikation eines mehrkomponenten-gewebeklebstoffes
US5474540A (en) * 1994-03-25 1995-12-12 Micromedics, Inc. Fluid separation control attachment for physiologic glue applicator
PT689874E (pt) * 1994-06-28 2002-03-28 Aventis Behring Gmbh Dispositivo para a pulverizacao de uma mistura de dois componentes
PL320512A1 (en) * 1994-12-02 1997-10-13 Bristol Myers Squibb Co System for feeding a reagent into a centrifuge
NZ298284A (en) * 1994-12-02 1999-02-25 Bristol Myers Squibb Co Separating fibrin monomer from plasma comprising the step of converting to non-crosslinked fibrin polymer during centrifugation
US5733446A (en) * 1994-12-02 1998-03-31 Bristol-Myers Squibb Company Centrifuge with annular filter
US5605541A (en) 1994-12-07 1997-02-25 E. R. Squibb And Sons, Inc. Fibrin sealant applicatoor
ATE244584T1 (de) * 1995-01-16 2003-07-15 Baxter Int Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen
US20020131933A1 (en) * 1996-01-16 2002-09-19 Yves Delmotte Biopolymer membrane and methods for its preparation
US5733545A (en) * 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
US5656035A (en) * 1995-04-25 1997-08-12 Avoy; Donald R. Refillable fibrinogen dispensing kit
JPH11508813A (ja) 1995-06-06 1999-08-03 クウォンティック バイオメディカル パートナーズ 血漿を濃縮するための装置及び方法
EP0957772A2 (en) * 1995-06-06 1999-11-24 Quantic Biomedical Partners Wound sealant preparation and application device and method
US5702715A (en) * 1995-10-27 1997-12-30 Drying Technology Reinforced biological sealants
IL124672A0 (en) 1995-12-07 1998-12-06 Bristol Myers Squibb Co A device and method for applying a mixture of two liquid components
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
US5759169A (en) * 1996-03-13 1998-06-02 New York Blood Center Inc. Fibrin sealant glue-gun
DE19781869T1 (de) * 1996-04-30 2000-03-16 Medtronic Inc Verfahren zur Herstellung eines autologen Fibrin-Blutstillungsmittels
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
AR013829A1 (es) * 1996-07-12 2001-01-31 Baxter Int Un dispositivo medico para suministrar cantidades volumetricas de un primer y un segundo fluido, bioquimicamente reactivos, y metodo para suministrarfibrina a una superficie con dicho dispositivo
DE19636622C1 (de) 1996-09-10 1998-06-10 Omrix Biopharm Sa Auftragvorrichtung zum Auftragen eines Mehrkomponenten-Gewebeklebstoffs und Halterung für eine solche Auftragvorrichtung
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
WO1998012274A1 (en) * 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US5759171A (en) * 1996-09-27 1998-06-02 Thermogenesis Corp. Sprayer for fibrin glue
US5975367A (en) * 1996-09-27 1999-11-02 Thermogenesis Corp. Fibrin glue line and dot dispenser
US5968018A (en) * 1996-10-30 1999-10-19 Cohesion Corporation Cell separation device and in-line orifice mixer system
US5844087A (en) * 1996-11-05 1998-12-01 Bayer Corporation Method and device for delivering fibrin glue
CA2583144C (en) 1996-11-15 2009-03-10 Bristol Myers Squibb Company Devices and methods for applying a mixture of two or more liquid components to form a biomaterial
US6613020B1 (en) 1996-12-06 2003-09-02 Bristol-Myers Squibb Company Method of applying a mixture of two liquid components as well as a device for carrying out the method
US6783514B2 (en) 1997-01-31 2004-08-31 United States Surgical Corporation Fibrin sealant applicator
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
US5971956A (en) * 1997-04-15 1999-10-26 Biosurgical Corporation Medical suctioning apparatus and methods of use
CA2306513C (en) 1997-04-14 2008-06-17 Biosurgical Corporation Medical suctioning apparatus and methods of use
US6733472B1 (en) 1997-04-14 2004-05-11 Baxter International Inc. Sealant applicator tip and application method
US6331172B1 (en) * 1997-04-14 2001-12-18 Baxter International Inc. Applicator for dispensing measured quantities with use of controlled suction
WO1998057678A2 (en) * 1997-06-18 1998-12-23 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen
DE29711075U1 (de) * 1997-06-25 1997-08-21 Wenzler Medizintechnik GmbH, 78665 Frittlingen Vorrichtung zum Injizieren von Sklerusierungsmitteln
DE69827132T8 (de) 1997-07-11 2006-06-08 United States Surgical Corp., Norwalk Anordnung zur anwendung von fibrin-kleber
AT406120B (de) 1997-08-28 2000-02-25 Immuno Ag Gewebekleber
JP3401779B2 (ja) * 1997-09-09 2003-04-28 ニプロ株式会社 生体組織接着剤投与具
US6458095B1 (en) 1997-10-22 2002-10-01 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a housing with multiple cavities
US6478808B2 (en) 1997-12-17 2002-11-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6159232A (en) 1997-12-16 2000-12-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6079868A (en) * 1997-12-18 2000-06-27 Advanced Bio Surfaces, Inc. Static mixer
WO1999032173A1 (en) 1997-12-19 1999-07-01 United States Surgical Corporation Two component dispenser system
ES2362502T3 (es) 1997-12-19 2011-07-06 Tyco Healthcare Group Lp Conjunto dispensador para una mezcla de fibrina.
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
USD408527S (en) * 1998-02-02 1999-04-20 Thermogenesis Corp. Medical dispensing gun
US6568434B2 (en) 1998-02-04 2003-05-27 Omrix Biopharmaceuticals S.A. Receiver cup for a vessel housing a medicinal substance
AU2723399A (en) 1998-02-04 1999-08-23 Omrix Biopharmaceuticals S.A. Device for storing a liquid medicinal substance
US6884230B1 (en) 1998-03-09 2005-04-26 Baxter International Inc. Dispensing head for a tissue sealant applicator and process of use
US6461361B1 (en) 1998-05-01 2002-10-08 Baxter International Inc. Gas-driven spraying of mixed sealant agents
AU4198999A (en) * 1998-05-21 1999-12-06 Baxter International Inc. Sealant applicator and method employing impulse clearing
US6475183B1 (en) * 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
JP4860817B2 (ja) * 1998-08-26 2012-01-25 ネオメンド、インク． 化学的に架橋した機械的障壁または被覆構造体をインサイチュ作成するための組成物、システムおよび方法
US6994686B2 (en) * 1998-08-26 2006-02-07 Neomend, Inc. Systems for applying cross-linked mechanical barriers
AU6151799A (en) 1998-09-17 2000-04-03 Focal, Inc. Self-cleaning fluid delivery device for medical applications
US6921380B1 (en) 1998-10-01 2005-07-26 Baxter International Inc. Component mixing catheter
US6471670B1 (en) 1998-10-05 2002-10-29 Karl Enrenfels Fibrin sealant applicator system
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
US7351249B2 (en) * 1998-11-06 2008-04-01 Neomend, Inc. Systems, methods, and compositions for achieving closure of suture sites
US7279001B2 (en) * 1998-11-06 2007-10-09 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
JP2002531217A (ja) 1998-12-04 2002-09-24 チャンドラシェカー ピー． パサック， 生体適合性架橋ポリマー
US20030069601A1 (en) * 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
DE19910972C1 (de) 1999-03-09 2000-10-26 Omrix Biopharm Sa Vorrichtung zum Auftragen eines fließfähigen Mediums, insbesondere eines Gewebeklebstoffs
ATA49899A (de) * 1999-03-19 2002-06-15 Immuno Ag Verfahren und vorrichtung zum mischen von komponenten
US20030007954A1 (en) 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US6432084B1 (en) 1999-05-07 2002-08-13 Baxter International Inc. Non-newtonian fluid spray applicator and method
WO2000074575A1 (en) 1999-06-01 2000-12-14 Closys Corporation Clotting cascade initiating apparatus and methods of use
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
KR100349797B1 (ko) 1999-09-13 2002-08-22 주)녹십자 피브린 실란트 송출 장치
DE29919291U1 (de) * 1999-11-03 2000-12-21 Dentaco Gmbh Mehrkammer-Ampulle zum Ausgeben eines aus mehreren Substanzen bestehenden Gemisches
DE50009788D1 (de) 1999-11-03 2005-04-21 Dentaco Gmbh Mehrkammer-ampulle zum ausgeben eines aus mehreren substanzen bestehenden gemisches
KR20030005232A (ko) 2000-03-23 2003-01-17 덴츠플라이 인터내셔널 인코포레이티드 치아 미백재료와 미백방법
US6802822B1 (en) * 2000-03-31 2004-10-12 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a flexible link
US6921532B1 (en) * 2000-06-22 2005-07-26 Spinal Restoration, Inc. Biological Bioadhesive composition and methods of preparation and use
WO2002005898A1 (en) * 2000-07-17 2002-01-24 Haemacure Corporation Spray head for applying a multi-component mixture
US6506365B1 (en) * 2000-09-25 2003-01-14 Baxter Aktiengesellschaft Fibrin/fibrinogen binding conjugate
AU2002213194A1 (en) * 2000-10-13 2002-04-22 Baxter Healthcare S.A. Fibrinogen plus a non-plasmin-acting fibrinolysis inhibitor for the reduction or prevention of adhesion formation
CA2325842C (en) * 2000-11-02 2007-08-07 Lisa Mckerracher Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US6585696B2 (en) 2000-12-22 2003-07-01 Baxter International, Inc. Method and apparatus for applying a medically useful multiple component material
US6685923B2 (en) 2001-01-25 2004-02-03 Dentsply Research & Development Corp. Tooth whitening material and method of whitening teeth
US7175336B2 (en) 2001-01-26 2007-02-13 Depuy Acromed, Inc. Graft delivery system
US7008433B2 (en) 2001-02-15 2006-03-07 Depuy Acromed, Inc. Vertebroplasty injection device
CA2766682A1 (en) 2001-02-27 2002-09-06 Tyco Healthcare Group Lp External mixer assembly
EP1917914B1 (en) 2001-02-27 2009-07-08 Tyco Healthcare Group Lp External mixer assembly
US6723067B2 (en) 2001-07-26 2004-04-20 David H. Nielson Apparatus for delivering aerosolized fibrin endoscopically to a wound
WO2003071986A2 (en) * 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
US6863660B2 (en) 2002-03-27 2005-03-08 Hapio Biotech, Inc. Fibrin applicator pistol
US6644365B1 (en) 2002-04-19 2003-11-11 Baxter International, Inc. Tilting direct dual filling device
US6936033B2 (en) 2002-06-14 2005-08-30 Medtronic, Inc. Multiple ratio fluid dispenser
US9101536B2 (en) * 2002-08-06 2015-08-11 Matrix Medical Llc Biocompatible phase invertable proteinaceous compositions and methods for making and using the same
US10098981B2 (en) 2002-08-06 2018-10-16 Baxter International Inc. Biocompatible phase invertable proteinaceous compositions and methods for making and using the same
US20060155234A1 (en) * 2002-09-10 2006-07-13 American National Red Cross Hemostatic dressing
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
US7077339B2 (en) * 2003-02-03 2006-07-18 Biomet, Inc. Spray applicator
EP2314259B1 (en) 2003-03-14 2015-07-29 Depuy Spine, Inc. Hydraulic device for injection of bone cement in percutaneous vertebroplasty
US8066713B2 (en) 2003-03-31 2011-11-29 Depuy Spine, Inc. Remotely-activated vertebroplasty injection device
US8415407B2 (en) 2004-03-21 2013-04-09 Depuy Spine, Inc. Methods, materials, and apparatus for treating bone and other tissue
CN100459944C (zh) * 2003-08-21 2009-02-11 药物混合系统股份公司 用于传送、混合和配给组分的装置和方法
US8579908B2 (en) 2003-09-26 2013-11-12 DePuy Synthes Products, LLC. Device for delivering viscous material
EP1753860B1 (en) * 2004-02-20 2012-04-11 Isto Technologies Inc. Intervertebral disc repair and methods therefor
US20050255091A1 (en) * 2004-05-14 2005-11-17 Loomis Gary L Hydrogels for biomedical applications
US8124075B2 (en) * 2004-07-16 2012-02-28 Spinal Restoration, Inc. Enhanced biological autologous tissue adhesive composition and methods of preparation and use
US8419722B2 (en) * 2004-10-29 2013-04-16 Spinal Restoration, Inc. Apparatus and method for injection of fibrin sealant in spinal applications
US20070213660A1 (en) * 2004-10-29 2007-09-13 Mark Richards Fibrin sealant delivery device including pressure monitoring, and method and kits thereof
US8403923B2 (en) * 2004-10-29 2013-03-26 Spinal Restoration, Inc. Injection of fibrin sealant in the absence of corticosteroids in spinal applications
US8206448B2 (en) * 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US7597687B2 (en) 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
CN101065080B (zh) 2004-07-30 2021-10-29 德普伊新特斯产品有限责任公司 用于处理骨和其他组织的材料和器械
AU2005279934A1 (en) * 2004-08-30 2006-03-09 Theregen, Inc. Compositions and methods of promoting hair growth
US20080226604A9 (en) * 2005-06-17 2008-09-18 Theregen Company Methods for treating ischemic tissue
US7490738B2 (en) * 2004-10-01 2009-02-17 Angiotech Pharmaceuticals (Us), Inc. Mixing and dispensing fluid components of a multicomponent composition
US9707252B2 (en) 2005-02-09 2017-07-18 Covidien Lp Synthetic sealants
US7766900B2 (en) 2005-02-21 2010-08-03 Biomet Manufacturing Corp. Method and apparatus for application of a fluid
US9581942B1 (en) 2005-03-23 2017-02-28 Shippert Enterprises, Llc Tissue transfer method and apparatus
US7789872B2 (en) * 2005-03-23 2010-09-07 Shippert Ronald D Tissue transplantation method and apparatus
US7780649B2 (en) * 2005-03-23 2010-08-24 Shippert Ronald D Tissue transplantation method and apparatus
US8622997B2 (en) * 2005-03-23 2014-01-07 Ronald D. Shippert Tissue transfer method and apparatus
US8062286B2 (en) * 2005-03-23 2011-11-22 Shippert Ronald D Tissue transplantation method and apparatus
US7794449B2 (en) * 2005-03-23 2010-09-14 Shippert Ronald D Tissue transplantation method and apparatus
US7635343B2 (en) * 2005-04-21 2009-12-22 Arteriocyte Medical Systems, Inc. Fluid dispenser
US7682336B2 (en) * 2005-05-13 2010-03-23 Micromedics, Inc. Gas assisted endoscopic applicator system
US7468049B2 (en) * 2005-06-14 2008-12-23 Rieke Corporation Dual syringe adapter
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US8360629B2 (en) 2005-11-22 2013-01-29 Depuy Spine, Inc. Mixing apparatus having central and planetary mixing elements
US8403882B2 (en) * 2005-11-22 2013-03-26 Omrix Biopharmaceuticals, S.A. Applicator device for applying a multi-component fluid
JP2009518519A (ja) 2005-12-06 2009-05-07 タイコ ヘルスケア グループ リミテッド パートナーシップ 官能化ポリエチレングリコールのカルボジイミド架橋
EP2633834A1 (en) 2005-12-06 2013-09-04 Covidien LP Bioabsorbable Surgical Composition
BRPI0708152A2 (pt) 2006-02-24 2011-05-17 Sulzer Mixpac Ag dispositivo de administração para uma seringa dupla
US8349349B2 (en) 2006-02-28 2013-01-08 Covidien Lp Tissue adhesives and sealants and method for their use
US8835513B2 (en) 2006-02-28 2014-09-16 Covidien Lp Drug delivery devices
WO2007100882A2 (en) 2006-02-28 2007-09-07 Tyco Healthcare Group Lp Tissue adhesives and sealants and methods for their use
AU2007243483B2 (en) * 2006-04-24 2012-07-26 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
CA2652813A1 (en) * 2006-05-22 2007-12-06 Orthovita, Inc. Delivery of multicomponent compositions
NZ574653A (en) * 2006-08-04 2012-11-30 Stb Lifesaving Technologies Inc Solid dressing for treating wounded tissue
EP2068898A4 (en) 2006-09-14 2011-07-20 Depuy Spine Inc BONE CEMENT AND APPLICATION METHOD THEREFOR
WO2008047371A2 (en) 2006-10-19 2008-04-24 Depuy Spine, Inc. Fluid delivery system
US7806612B1 (en) * 2006-12-05 2010-10-05 Wangler William D Device for applying fluids to convex surfaces
US20080272209A1 (en) * 2007-02-09 2008-11-06 Terumo Kabushiki Kaisha Sprayer
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US20090227981A1 (en) 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20080293910A1 (en) 2007-05-24 2008-11-27 Tyco Healthcare Group Lp Adhesive formulatiions
JP5138683B2 (ja) * 2007-06-15 2013-02-06 一般財団法人化学及血清療法研究所 スプレーヘッド、生体組織接着剤塗布器具、および接着剤の塗布方法
US7858835B2 (en) * 2007-06-27 2010-12-28 Tyco Healthcare Group Lp Foam control for synthetic adhesive/sealant
WO2009020612A1 (en) * 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
US8067028B2 (en) 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8500947B2 (en) * 2007-11-15 2013-08-06 Covidien Lp Speeding cure rate of bioadhesives
US8753670B2 (en) * 2008-03-26 2014-06-17 Baxter International Inc. Fibrin foam and process
JP5306685B2 (ja) * 2008-03-28 2013-10-02 テルモ株式会社 塗布具
US8034396B2 (en) 2008-04-01 2011-10-11 Tyco Healthcare Group Lp Bioadhesive composition formed using click chemistry
US8182769B2 (en) 2008-04-04 2012-05-22 Biomet Biologics, Llc Clean transportation system
US8518272B2 (en) 2008-04-04 2013-08-27 Biomet Biologics, Llc Sterile blood separating system
US8263704B2 (en) * 2008-04-23 2012-09-11 Tyco Healthcare Group Lp Bioabsorbable surgical composition
US8033483B2 (en) 2008-04-25 2011-10-11 Confluent Surgical Inc. Silicone spray tip
US8408480B2 (en) * 2008-04-25 2013-04-02 Confluent Surgical, Inc. Self-cleaning spray tip
CA2721462C (en) * 2008-04-25 2019-02-05 Zymogenetics, Inc. Medical devices for delivering fluids during surgery and methods for their use
WO2009137438A2 (en) 2008-05-06 2009-11-12 Wilson-Cook Medical Inc. Apparatus and methods for delivering therapeutic agents
CH699191A1 (de) * 2008-07-21 2010-01-29 Medmix Systems Ag Austraganordnung mit Einzelspritzen und Spritzenhalter.
US8210453B2 (en) 2008-09-12 2012-07-03 Confluent Surgical, Inc. Spray applicator
ITPR20080063A1 (it) 2008-10-10 2010-04-11 Gem S R L Erogatore di fluido adesivo newtoniano e relativo procedimento di erogazione
US20100092533A1 (en) 2008-10-15 2010-04-15 Joshua Stopek Bioabsorbable Surgical Composition
EP2337502B1 (en) * 2008-10-20 2014-08-06 Covidien LP A device for attaching a patch to a biological tissue
US8523805B2 (en) 2008-10-29 2013-09-03 Biomet Biologics, Llc Method and apparatus for containing, transporting, and providing a material
US20100111919A1 (en) 2008-10-31 2010-05-06 Tyco Healthcare Group Lp Delayed gelation compositions and methods of use
AU2009330505A1 (en) 2008-12-23 2011-06-30 Cook Medical Technologies Llc Apparatus and methods for containing and delivering therapeutic agents
US8349987B2 (en) * 2009-02-19 2013-01-08 Covidien Lp Adhesive formulations
US8877170B2 (en) 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
US8512728B2 (en) 2009-02-21 2013-08-20 Sofradim Production Method of forming a medical device on biological tissue
US8535477B2 (en) 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
EP2398584A2 (en) 2009-02-21 2011-12-28 Sofradim Production Apparatus and method of reaching polymers by exposure to uv radiation to produce injectable medical devices
US8663689B2 (en) 2009-02-21 2014-03-04 Sofradim Production Functionalized adhesive medical gel
WO2010095047A2 (en) 2009-02-21 2010-08-26 Sofradim Production Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices
US8969473B2 (en) 2009-02-21 2015-03-03 Sofradim Production Compounds and medical devices activated with solvophobic linkers
AU2010215931A1 (en) 2009-02-21 2011-10-13 Covidien Lp Medical devices having activated surfaces
US8968733B2 (en) 2009-02-21 2015-03-03 Sofradim Production Functionalized surgical adhesives
CA2753162A1 (en) 2009-02-21 2010-08-26 Sofradim Production Amphiphilic compounds and self-assembling compositions made therefrom
CA2753171A1 (en) 2009-02-21 2010-08-26 Sofradim Production Crosslinked fibers and method of making same using uv radiation
WO2010096654A1 (en) 2009-02-21 2010-08-26 Tyco Healthcare Group Lp Medical devices having activated surfaces
EP2398850B1 (en) 2009-02-21 2018-08-22 Sofradim Production Medical devices with an activated coating
AU2010215196B2 (en) 2009-02-21 2015-04-16 Covidien Lp Crosslinked fibers and method of making same by extrusion
AU2010233169A1 (en) 2009-04-09 2011-11-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Cellular seeding and co-culture of a three dimensional fibroblast construct
US8118777B2 (en) 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
ES2332032B1 (es) * 2009-06-09 2010-06-07 Grifols, S.A. Dispositivo de aplicacion de adhesivo de fibrina.
US20110081398A1 (en) 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
US8968785B2 (en) * 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
US20110081701A1 (en) 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
US20110091549A1 (en) * 2009-10-16 2011-04-21 Confluent Surgical, Inc. Modulating Drug Release Rate By Controlling The Kinetics Of The pH Transition In Hydrogels
US9445795B2 (en) * 2009-10-16 2016-09-20 Confluent Surgical, Inc. Prevention of premature gelling of delivery devices for pH dependent forming materials
AU2011220834B2 (en) * 2010-02-23 2013-06-13 Cryolife, Inc. Applicator delivery tip extension
CA2730598C (en) 2010-03-16 2018-03-13 Confluent Surgical, Inc. Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels
EP2389969A1 (en) 2010-05-26 2011-11-30 Omrix Biopharmaceuticals Ltd. A device for injecting a substance
US9272074B2 (en) 2010-03-25 2016-03-01 Sofradim Production Surgical fasteners and methods for sealing wounds
US8795331B2 (en) 2010-03-25 2014-08-05 Covidien Lp Medical devices incorporating functional adhesives
US8697111B2 (en) 2010-05-12 2014-04-15 Covidien Lp Osteochondral implant comprising osseous phase and chondral phase
US8591929B2 (en) 2010-05-27 2013-11-26 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8754564B2 (en) 2010-05-27 2014-06-17 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8968783B2 (en) 2010-05-27 2015-03-03 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8734824B2 (en) 2010-05-27 2014-05-27 Covidien LLP Hydrogel implants with varying degrees of crosslinking
US8591950B2 (en) 2010-05-27 2013-11-26 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8883185B2 (en) 2010-05-27 2014-11-11 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US10231721B2 (en) 2010-06-24 2019-03-19 St. Croix Surgical Systems, Llc Failsafe percutaneous wound barrier
US9125633B2 (en) * 2010-06-25 2015-09-08 Baxter International Inc. Device for mixing and dispensing of two-component reactive surgical sealant
US8672237B2 (en) 2010-06-25 2014-03-18 Baxter International Inc. Device for mixing and dispensing of two-component reactive surgical sealant
AU2011276443A1 (en) 2010-06-29 2013-01-31 Covidien Lp Microwave-powered reactor and method for in situ forming implants
US9211554B2 (en) 2010-06-30 2015-12-15 Actamax Surgical Materials, Llc Self-contained hand-held direct drive device for dispensing a two-part adhesive aerosol
US8678238B2 (en) 2010-06-30 2014-03-25 Actamax Surgical Materials, Llc Self-contained hand-held yoke-connected device for dispensing a two-part adhesive aerosol
WO2012001532A2 (en) 2010-07-01 2012-01-05 Sofradim Production Medical device with predefined activated cellular integration
WO2012014080A2 (en) 2010-07-27 2012-02-02 Sofradim Production Polymeric fibers having tissue reactive members
US20120065592A1 (en) * 2010-09-10 2012-03-15 E.I. Du Pont De Nemours And Company Device for dispensing microliter quantities of a material into a puncture wound site
US8518440B2 (en) 2010-12-21 2013-08-27 Confluent Surgical, Inc. Biodegradable osmotic pump implant for drug delivery
US8440309B2 (en) 2011-01-31 2013-05-14 Confluent Surgical, Inc. Crosslinked polymers with the crosslinker as therapeutic for sustained release
US8887770B1 (en) 2011-03-17 2014-11-18 Ronald D. Shippert Vessel fill control method and apparatus
EP2688940B1 (en) 2011-03-24 2017-07-12 Sofradim Production Enzymatically degradable compositions
AR086245A1 (es) 2011-05-02 2013-11-27 Baxter Int Peptidos de union a fibrina en base a fgf
US10849931B2 (en) 2011-09-30 2020-12-01 Depuy Synthes Products, Inc Compositions and methods for platelet enriched fibrin constructs
CA2793349A1 (en) 2011-11-18 2013-05-18 Covidien Lp Novel drug delivery devices
CA3078563A1 (en) * 2011-12-29 2013-07-04 Omrix Biopharmaceuticals Ltd. Method and device for fast dissolution of solid protein composition
US9161756B2 (en) 2012-03-16 2015-10-20 Covidien Lp Closure tape dispenser
US9572580B2 (en) 2012-03-16 2017-02-21 Covidien Lp Closure tape dispenser
WO2014018617A1 (en) * 2012-07-26 2014-01-30 Cook Medical Technologies, LLC Multi-barrel syringe injection system
US10309430B2 (en) 2012-08-10 2019-06-04 Confluent Surgical, Inc. Pneumatic actuation assembly
US9468709B2 (en) 2012-11-12 2016-10-18 Shippert Enterprises, Llc Syringe fill method and apparatus
WO2014110624A1 (en) 2013-01-15 2014-07-24 Heriot Wilson J Method and device for treating retinal detachment
US11224538B2 (en) 2013-01-15 2022-01-18 Heriot Eyecare Pty. Ltd. Method and device for treating retinal detachment
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
US9586005B2 (en) * 2013-09-30 2017-03-07 Dennis L Steffen Dual syringe delivery device and method of use
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
EP3125774B1 (en) 2014-04-04 2020-05-27 HyperBranch Medical Technology, Inc. Extended tip spray applicator for two-component surgical selant, and methods of use thereof
US10772997B2 (en) 2014-05-15 2020-09-15 Ronald D. Shippert Tissue parcelization method and apparatus
JP6960333B2 (ja) * 2014-09-09 2021-11-05 ミメディクス グループ インコーポレイテッド 任意にシーラントを含む微粒子化胎盤組織の組成物、ならびにその組成物の作製方法および使用方法
US11382731B2 (en) 2015-02-27 2022-07-12 Covidien Lp Medical devices with sealing properties
CH711347A1 (de) 2015-07-22 2017-01-31 Medmix Systems Ag Austragvorrichtung für zwei Spritzen.
WO2018018042A1 (en) * 2016-07-22 2018-01-25 Isto Technologies, Inc. Multi-component injection system and methods for tissue repair
US10912859B2 (en) 2017-03-08 2021-02-09 Baxter International Inc. Additive able to provide underwater adhesion
US11202848B2 (en) 2017-03-08 2021-12-21 Baxter International Inc. Surgical adhesive able to glue in wet conditions
US10959714B2 (en) * 2018-04-19 2021-03-30 Ethicon, Inc. Dual syringe cartridge and housing
US11357542B2 (en) 2019-06-21 2022-06-14 Covidien Lp Valve assembly and retainer for surgical access assembly
CN110464977B (zh) * 2019-08-27 2024-05-24 郑州大学第一附属医院 一种应用富含血小板血浆填充人体组织窦道的装置
US20210121639A1 (en) * 2019-10-28 2021-04-29 Rowan University Handheld printer for controlled mixing and delivery of multi-component polymers/biomaterials
EP3912709B1 (de) 2020-05-19 2024-02-14 Heraeus Medical GmbH Vorrichtung und verfahren zum mischen von flüssigkeiten
CN115697176A (zh) 2020-06-05 2023-02-03 库克医学技术有限责任公司 用于递送治疗剂的医疗窥镜
US11957325B2 (en) 2021-03-22 2024-04-16 Km Biologics Co., Ltd. Biological tissue adhesive nebulizer and clogging prevention container
WO2023287654A1 (en) 2021-07-14 2023-01-19 Cook Medical Technologies, LLC Systems and methods for preventing clogging of a delivery system
US12496429B2 (en) 2022-10-18 2025-12-16 Cook Medical Technologies Llc Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents
US12329367B2 (en) 2022-12-02 2025-06-17 Kenneth W Wright Fluid mixing and delivery injector system

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE137660C (da) *
FR440425A (fr) 1911-02-20 1912-07-10 Otto Rathke Appareil de lavage vaginal
FR429811A (fr) 1911-04-07 1911-10-02 John Frank Kellogg Seringues
DE562328C (de) 1931-01-20 1932-10-24 Koch Ernst Fuellvorrichtung fuer Spritzen
US2112160A (en) * 1933-04-04 1938-03-22 Kenneth Fredericks Method of and apparatus for effecting medicinal treatment
FR1054173A (fr) 1951-11-30 1954-02-09 Seringue perfectionnée pour injections
FR1051010A (fr) 1952-02-21 1954-01-12 Nouvelle seringue pour injection
FR63467E (fr) * 1952-10-31 1955-09-28 Nouvelle seringue pour injection
US3016897A (en) * 1959-01-13 1962-01-16 John W Kendrick Injection means for injecting serum, vaccine, virus and the like into animals, and method
US3223083A (en) * 1960-09-09 1965-12-14 President And Directors Of Geo Method for adhesively securing together skin and other soft tissue and bone
DE1491877A1 (de) 1965-09-25 1969-05-29 Zeiser Manfred P Spritzampulle fuer zwei oder mehrere verschiedene,getrennt gelagerte Medien
US3467096A (en) * 1966-04-12 1969-09-16 Ferrell S Horn Multiple hypodermic syringe arrangement
US3572336A (en) * 1968-04-30 1971-03-23 Daniel R Hershberg Syringe
CH539551A (de) * 1971-06-29 1973-07-31 Dubach Hans Vorrichtung an Behältern zur dosierten Abgabe eines flüssigen bis pastenförmigen Inhaltes
US3746216A (en) * 1971-09-10 1973-07-17 Us Navy Fluid mixer-dispenser
US4040420A (en) * 1976-04-22 1977-08-09 General Dynamics Packaging and dispensing kit
JPS5615453Y2 (da) * 1976-07-20 1981-04-10
US4109653A (en) * 1977-02-22 1978-08-29 George Kozam Successive delivery multiple barrel syringe

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US4359049A (en) 1982-11-16
EP0037393A1 (de) 1981-10-07
ES8203227A1 (es) 1982-04-01
EP0037393B1 (de) 1983-06-01
JPH0347609Y2 (da) 1991-10-11
AT366916B (de) 1982-05-25
ATA179280A (de) 1981-10-15
ES501017A0 (es) 1982-04-01
DK164801C (da) 1993-01-11
DK149981A (da) 1981-10-03
JPS64948U (da) 1989-01-06
JPS6274837U (da) 1987-05-13
DE3160381D1 (en) 1983-07-07
JPS56152641A (en) 1981-11-26

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