DK164801B - Apparat til brug ved anbringelse af vaevsklaebestof paa basis af menneskelige eller dyriske proteiner - Google Patents

Apparat til brug ved anbringelse af vaevsklaebestof paa basis af menneskelige eller dyriske proteiner Download PDF

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DK164801B
DK164801B DK149981A DK149981A DK164801B DK 164801 B DK164801 B DK 164801B DK 149981 A DK149981 A DK 149981A DK 149981 A DK149981 A DK 149981A DK 164801 B DK164801 B DK 164801B
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DK149981A (da
DK164801C (da
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Heinz Redl
Gert Kriwetz
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Immuno Ag
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

i
DK 164801 B
Opfindelsen angår et apparat til brug ved anbringelse af et vævsklæbestof på basis af menneskelige eller dyriske proteiner til sømløs eller sømunderstøttende forbinding af menneskelige eller dyriske vævs- eller organdele, til sårforsegling, blod-5 stilning eller lignende processer, hvilket vævsklæbestof bliver dannet på stedet ved sammenbringning af opløsninger af proteinet og af blodkoaguleringsfremmende koaguleringsmidler, hvilket apparat har en holdeindretning for et flertal af i konusser udmundende sprøjtelegemer, især standardiserede én-10 gangssprøjtelegemer af plast, hvor konussen for det enkelte sprøjtelegeme gennem et samlehoved er forbundet med en transportkanal for den fra konussen udtrædende komponent af vævsklæbestoffet, hvilken transportkanal er adskilt fra transportkanalerne, som de øvrige konusser er forbundet med.
15
Ved anvendelsen af et vævsklæbestof af den nævnte art bliver en opløsning, der indeholder "Faktor-XIII" og fibrinogen blandet med en opløsning, der indeholder et thrombin og anbragt på det sårsted, der skal klæbes sammen eller beskyttes. Kendte 20 påføringsmåder består i at anbringe den ene opløsning på klæbestedet og den anden opløsning i et lag oven på eller først at blande begge opløsninger i et blandekar eller på en lille plade, trække det op i en sprøjte og så påføre det på det sted, der skal klæbes.
25
Begge metoder har ulemper: Ved den første metode indtræffer der på grund af forskellig viskositet i de to opløsninger en for tidlig størkning på overfladen, før en tilstrækkelig intensiv gennemblanding har fundet sted. Anvendelsen af den an-30 den metode kræver stor behændighed hos det medicinske personale, fordi størkning af klæbemidlet sker allerede kort tid efter sammenbringningen af de to opløsninger. Sammenbringningen af komponenterne, deres blanding, optrækning i en sprøjte og påføring på det sted, der skal klæbes, må ske indenfor få se-35 kunder. Denne metode er derfor begrænset til kun få anvendelsesområder .
2
DK 164801B
En indretning af den i indledningen beskrevne art kendes fra US patentskrift 3.223.083. Sprøjtelegemet bliver omsluttet af en klemmeagtig holdeindretning, og sprøjtelegemets konus er indsat i en Y-formet del. I denne Y-formede del bliver vævs-5 klæbestoffets' to komponenter sammenblandet, hvorved der ved en kortvarig afbrydelse af udsprøjtningen sker en uundgåelig størkning af vævsklæbestoffet i den Y-formede del. Oer må derfor efter en sådan afbrydelse også foretages en udskiftning af den Y-formede del, hvad der er omstændeligt. Formålet med op-10 findelsen er at undgå de nævnte ulemper og vanskeligheder og at anvise et apparat af den i indledningen nævnte art, med hvilket påføringen af vævsklæbestofkomponenterne kan ske samtidigt ved betjening af apparatet med én hånd, hvorved der opnås en tilstrækkelig blanding og undgås en for tidlig størknen 15 af komponenterne, før de når sårstedet.
Dette formål opnås ved hjælp af apparatet ifølge opfindelsen, som er ejendommeligt ved, at transportkanalerne er adskilt fra hinanden helt frem til mundingerne, og at der til stemplerne 20 for alle sprøjtel egernerne findes en fælles betjeningsindret ning. Til apparatet kan anvendes standardiserede, i handelen værende éngangsapparatdele, f.eks. éngangssprøjtelegemer og -stempler såvel som standardiserede kanyler, som kan fås i sterile pakninger i forretninger, hvor man forhandler lægein-25 strumenter.
Fordelagtigt kan der på samlehovedet påsættes en blandingskanyle.
30 Med henblik på at opnå en bedre håndtering af apparatet er den fælles betjeningsindretning for sprøjtestemplerne monteret på en føringsstang, der går gennem holdeindretningen.
Formålstjenligt er mundingerne for transportkanalerne anbragt 35 tæt ved siden af hinanden på endefladen af en påsætningskonus for samlehovedet.
DK 164801 B
3
Fordelagtigt kan mundingerne for transportkanalerne til samle-hovedet ligge i området ved udløbsåbninger for under en vinkel med hinanden fremførte tiIføringskanaler for sterile luftarter.
5
Ved en yderligere fordelagtig udførelsesform er akserne for udløbsåbningerne for tiIføringskanalerne rettet i en spids vinkel i forhold til hinanden, hvor vinkelspidsen ligger i en afstand, fortrinsvis i en afstand på 10-20 cm foran mundinger-10 ne for transportkanalerne.
Opfindelsen bliver i det følgende forklaret nærmere ved hjælp af to udførelsesformer under henvisning til tegningen, hvor 15 fig. 1 viser et billede af en delvist gennemskåret første udførelsesform for apparatet ifølge opfindelsen set fra siden, fig. 2 et snit langs linien 11-11 i fig. 1, 20 fig. 3 et snit langs linien 111-111 i fig. 1, fig. 4 en anden udførelsesform for opfindelsen delvist i snit langs linien IV-IV i fig. 5, og 25 fig. 5 et snit langs linien V-V i fig. 4.
Af de to sprøjtelegemer, der er betegnet med 1 og 2, tjener det ene til optagelse af en thrombin-indeholdende opløsning, 30 og det andet til optagelse af en "Faktor-XIII"- og fibrinogen-indeholdende opløsning. Sprøjtelegemerne 1, 2 er formålstjenligt udformet som standardiserede éngangssprøjtelegemer af plast. De er begge indsat i en holdeindretning 3. Holdeindretningen 3 har to U-formede render 4, 5, som begge i deres ender 35 med det største tværsnit er udformet med overgribende nopper 6, så at sprøjtelegemerne 1, 2, som bliver anbragt i renderne ovenfra, kommer i indgreb og ved hjælp af nopperne 6 bliver
DK 164801 B
4 fastholdt i renderne. Ved den ende af holdeindretningen, der har to ved siderne anbragte fingergreb 7, 8 findes der U-for-mede udvidelser 9, 10 i renderne, som sprøjtelegemernes flangeender 11, 12 er ført ind i, så sprøjtelegemerne 1, 2 også 5 bliver fikseret i retning af deres respektive længdeakser 13 i holdeindretningen 3.
Midt imellem de to U-formede render 4, 5 findes der en udtagning 14 for en føringsstang 15, hvilken udtagning ved den ende 10 af holdeindretningen, hvor fingergrebene 7, 8 sidder, går over i et gennemgående borehul 16 i holdeindretningen. Føringsstangen 15 er fast forbundet med en betjeningsindretning 17, hvori knastopsatse 18, 29 hørende til stemplerne 20, 21 i sprøjtelegemerne 1, 2 er indsat. Knastopsatsene 18, 19 hørende til 15 stemplerne 20, 21 er begge indsat i en U-formet udtagning 22, 23 i betjeningsindretningen 17. Føringsstangen har i sin forreste ende en fortykkelse 24, så at den ikke kan glide ud af hullet 16 i holdeindretningen 3.
20 De to konusser 25, 26 på sprøjtelegemerne er ført ind i ind-stikskonusser 27, 28 i et samlehoved 29 og er via dette samle-hoved forbundet med hinanden. Inden i samlehovedet 29 fører der fra hver indstikskonus 27, 28 en særskilt transportkanal 30, 31 ind i et på samlehovedet anbragt påsætningskonushoved 25 32. Mundingerne 33, 34 hørende til transportkanalerne 30, 31 er anbragt tæt ved siden af hinanden på endefladen 35 af dette påsætningskonushoved. En blandingskanyle 36, som ved sin bageste ende er forsynet med en standardiseret indstikningskonus 37 kan skydes ind over påsætningskonushovedet 32.
30
Ved et tryk med tommelfingeren på betjeningsindretningen 17 træder der samtidigt ud af de to sprøjtelegemer 1, 2 forudbestemte mængder. Som følge af de ringe afstande mellem mundingerne 33, 34 hørende til transportkanalerne 30, 31 kommer op-35 løsningerne straks i berøring med hinanden, hvorved blandingseffekten er optimal. Påføringen med én sprøjtefyldning kan ske såvel intermitterende som også kontinuerligt. Brugte sprøjte-
DK 164801 B
5 legemer 1, 2 og blandingskanylen 36 kan hurtigt udskiftes, og hele apparatet kan i givet fald steriliseres uden problemer. Enhåndsbetjeningen og den automatiske dosering af de to opløsninger i et ønsket blandingsforhold udgør en væsentlig ar-5 bejdslettelse. Bliver der anvendt en blandingskanyle 36, så at blandingen er særlig intensiv, hvorved klæbninger af højeste styrke kan opnås. Bliver påføringen af vævsklæbestoffet afbrudt, så må blandingskanylen 36 aftages og erstattes af en ny. Samlehovedet 29 kan derimod anvendes igen. Det beskrevne 10 apparat muliggør en anvendelse af vævsklæbestoffer på næsten alle områder.
Den i fig. 4 og 5 viste udførelsesform muliggør påsprøjning af vævsklæbestoffet på en overflade, der skal klæbes eller for-15 segles. Ved denne udførelsesform er samlehovedet udformet som et sprøjtehoved 38. Det har med udgangspunkt i indstikningskonusserne 39, 40 to fra hinanden adskilte transportkanaler 41, 42, hvis mundinger 43, 44 er anbragt i en afstand, der svarer til afstanden 45 mellem sprøjtelegemerne 1, 2. Opløsningernes 20 udtrædningsretning 46 fra mundingerne 43, 44 er ca. vinkelret på længderetningen 13 for sprøjtelegemerne 1, 2.
Foruden transportkanalerne 41, 42 har samle- eller sprøjtehovedet 38 en ti 1før ingskanal 47 for en steril luftart, f.eks.
25 trykluft, som inden for samlehovedet deler sig i to grene 48, 49. Udtrædningsåbningerne 50, 51 for disse to ti 1 føringskanaler 48, 49 findes i nærheden af mundingerne 43, 44 hørende til transportkanalerne 41, 42. Akserne 52, 53 for udtrædningsåb- ningerne 50, 51 er rettet ca. vinkelret på udtrædningsretnin-30 gen 46 for opløsningerne, hvortil kommer, at akserne 52, 53 for udtræningsåbningerne er rettet i en spids vinkel 54 i forhold til hinanden, og at vi nkel spidsen 55 ligger i en afstand 56 fra ca. 10-20 cm foran mundingen af transportkanalerne.
35 Ved denne udførelsesform sker doseringen af opløsningerne ligeledes ved hjælp af betjeningsindretningen, som er udformet ligesom ved betjeningsindretningen i den i fig. 1 viste udfø-

Claims (6)

1. Apparat til brug ved anbringelse af et vævsklæbestof på basis af menneskelige eller dyriske proteiner til sømløs eller sømunderstøttende forbinding af menneskelige eller dyriske 25 vævs- eller organdele, til sårforsegling, blodstilning eller lignende processer, hvilket vævsklæbestof bliver dannet på stedet ved sammenbringning af opløsninger af proteinet og af blodkoaguleringsfremmende koaguleringsmidler, hvilket apparat har en holdeindretning (3) for et flertal af i konusser (25, 30 26) udmundende sprøjtelegemer (1, 2), især standardiserede én- gangssprøjtelegemer af plast, hvor konussen (25, 26) for det enkelte sprøjtelegeme (1, 2) gennem et samlehoved (29, 38) er forbundet med en transportkanal (30, 31, 41, 42) for den fra konussen udtrædende komponent af vævsklæbestoffet, hvilken .35 transportkanal (30, 31, 41, 42) er adskilt fra transportkanalerne (31, 30, 42, 41), som de øvrige konusser (26, 25) er forbundet med, kendetegnet ved, at transportkana- 7 DK 164801 B lerne (30, 31, 41, 42) er adskilt fra hinanden helt frem til mundingerne (33, 34, 43, 44), og at der til stemplerne (20, 21. for alle sprøjtelegemerne (1, 2) findes en fmiles betjeningsindretning (17). 5
2. Apparat ifølge krav 1, kendetegnet ved, at en blandingskanyle (36) kan påsættes samlehovedet (29).
3. Apparat ifølge krav 1, kendetegnet ved, at den 10 fælles betjeningsindretning (17) for sprøjtestemplerne er monteret på en fælles føringsstang (15), der går gennem holdeindretningen (3).
4. Apparat ifølge krav l, kendetegnet ved, at mun-15 di ngerne (33, 34) for transportkanalerne (30, 31) er anbragt tæt ved siden af hinanden på endefladen (35) af en påsætningskonus (32) for samlehovedet (29).
5. Apparat ifølge et eller flere af kravene 1-4, kende- 20 tegnet ved, at mundingerne (43, 44) for transportkana lerne (41, 42) til samlehovedet (29, 38) ligger i området ved udløbsåbninger (50, 51) for under en vinkel med hinanden anbragte til førse 1 skanal er (48, 49) for sterile luftarter (f ig. 4 og 5). 25
6. Apparat ifølge krav 5, kendetegnet ved, at ak serne (52, 53) for udløbsåbningerne (50, 51) for tilførselskanalerne (48, 49) er rettet i en’ spids vinkel (54) i forhold til hinanden, og at vinkelspidsen (55) ligger i en afstand 30 (56), fortrinsvis i en afstand på 10-20 cm foran mundingerne (43, 44) af transportkanalerne (41, 42). 35
DK149981A 1980-04-02 1981-04-02 Apparat til brug ved anbringelse af vaevsklaebestof paa basis af menneskelige eller dyriske proteiner DK164801C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0179280A AT366916B (de) 1980-04-02 1980-04-02 Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
AT179280 1980-04-02

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DK149981A DK149981A (da) 1981-10-03
DK164801B true DK164801B (da) 1992-08-24
DK164801C DK164801C (da) 1993-01-11

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DK149981A DK164801C (da) 1980-04-02 1981-04-02 Apparat til brug ved anbringelse af vaevsklaebestof paa basis af menneskelige eller dyriske proteiner

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US (1) US4359049A (da)
EP (1) EP0037393B1 (da)
JP (3) JPS56152641A (da)
AT (1) AT366916B (da)
DE (1) DE3160381D1 (da)
DK (1) DK164801C (da)
ES (1) ES501017A0 (da)

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ES8203227A1 (es) 1982-04-01
EP0037393A1 (de) 1981-10-07
AT366916B (de) 1982-05-25
DK149981A (da) 1981-10-03
JPS56152641A (en) 1981-11-26
JPS6274837U (da) 1987-05-13
DE3160381D1 (en) 1983-07-07
JPS64948U (da) 1989-01-06
JPH0347609Y2 (da) 1991-10-11
EP0037393B1 (de) 1983-06-01
DK164801C (da) 1993-01-11
ES501017A0 (es) 1982-04-01
ATA179280A (de) 1981-10-15
US4359049A (en) 1982-11-16

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