DK164873C - 3-keto-17alfa-mercapto-17beta-(substitueret thio)-androstenderivater med anvendelse som mellemprodukter ved fremstillingen af 17,17-bis(substitueret thio)-3-ketoandrostener samt fremgangsmaade til deres fremstilling - Google Patents

3-keto-17alfa-mercapto-17beta-(substitueret thio)-androstenderivater med anvendelse som mellemprodukter ved fremstillingen af 17,17-bis(substitueret thio)-3-ketoandrostener samt fremgangsmaade til deres fremstilling

Info

Publication number: DK164873C
Authority: DK; Denmark
Prior art keywords: substituted thio; preparation; intermediates; ketostrosters; drostender
Prior art date: 1982-09-09

Application number

DK407983A

Other languages

English (en)

Other versions

DK407983A (da

DK164873B (da

DK407983D0 (da

Inventor

Ravi K Varma

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-09

Filing date

1983-09-08

Publication date

1993-01-11

1983-09-08 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1983-09-08 Publication of DK407983D0 publication Critical patent/DK407983D0/da

1984-03-10 Publication of DK407983A publication Critical patent/DK407983A/da

1992-08-31 Publication of DK164873B publication Critical patent/DK164873B/da

1993-01-11 Application granted granted Critical

1993-01-11 Publication of DK164873C publication Critical patent/DK164873C/da

Links

239000000543 intermediate Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical class C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 title 2
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000001589 carboacyl group Chemical group 0.000 abstract 3
229910052736 halogen Chemical group 0.000 abstract 3
150000002367 halogens Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001443 androstenes Chemical class 0.000 abstract 2
-1 aroyloxyalkyl Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Cosmetics (AREA)

DK407983A 1982-09-09 1983-09-08 3-keto-17alfa-mercapto-17beta-(substitueret thio)-androstenderivater med anvendelse som mellemprodukter ved fremstillingen af 17,17-bis(substitueret thio)-3-ketoandrostener samt fremgangsmaade til deres fremstilling DK164873C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41618182		1982-09-09
US06/416,181 US4435326A (en)	1982-09-09	1982-09-09	Intermediates useful in the preparation of 17,17-bis(substituted thio)androstenes

Publications (4)

Publication Number	Publication Date
DK407983D0 DK407983D0 (da)	1983-09-08
DK407983A DK407983A (da)	1984-03-10
DK164873B DK164873B (da)	1992-08-31
DK164873C true DK164873C (da)	1993-01-11

Family

ID=23648912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK407983A DK164873C (da)	1982-09-09	1983-09-08	3-keto-17alfa-mercapto-17beta-(substitueret thio)-androstenderivater med anvendelse som mellemprodukter ved fremstillingen af 17,17-bis(substitueret thio)-3-ketoandrostener samt fremgangsmaade til deres fremstilling

Country Status (12)

Country	Link
US (1)	US4435326A (da)
EP (1)	EP0105224B1 (da)
JP (1)	JPS5967299A (da)
AT (1)	ATE25089T1 (da)
AU (1)	AU558201B2 (da)
CA (1)	CA1248087A (da)
DE (1)	DE3369326D1 (da)
DK (1)	DK164873C (da)
HU (2)	HU189744B (da)
IE (1)	IE55719B1 (da)
NO (1)	NO159602C (da)
ZA (1)	ZA836358B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4529548A (en) *	1984-05-07	1985-07-16	E. R. Squibb & Sons, Inc.	17β-(substituted thio)androstenes
US4529547A (en) *	1984-06-20	1985-07-16	E.R. Squibb & Sons, Inc.	17-(substituted thio)-17-(substituted dithio)androstenes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2949477A (en) *	1959-03-04	1960-08-16	Searle & Co	1, 3, 17-triacetoxyestra-1, 3, 5(10), 16-tetraene and congeners
US4094840A (en) *	1977-05-12	1978-06-13	E. R. Squibb & Sons, Inc.	17-Alkylthio (and arylthio) androsteno[16α,17α-b]benzodioxin-3-ones
US4091036A (en) *	1977-05-12	1978-05-23	E. R. Squibb & Sons, Inc.	17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 α, 17 α-b]naphthalenes and derivatives
US4133811A (en) *	1978-02-17	1979-01-09	E. R. Squibb & Sons, Inc.	13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes
US4146538A (en) *	1978-02-27	1979-03-27	E. R. Squibb & Sons, Inc.	17-Alkylthio (and arylthio) androsteno[17α,16α-b]benzopyran-3-ones and [16α,17α]naphthopyran-3-ones
US4361559A (en)	1981-08-20	1982-11-30	E. R. Squibb & Sons, Inc.	Antiinflammatory 17,17-bis (substituted thio) androstenes

1982
- 1982-09-09 US US06/416,181 patent/US4435326A/en not_active Expired - Fee Related
1983
- 1983-08-24 CA CA000435269A patent/CA1248087A/en not_active Expired
- 1983-08-25 AU AU18433/83A patent/AU558201B2/en not_active Ceased
- 1983-08-26 ZA ZA836358A patent/ZA836358B/xx unknown
- 1983-09-05 IE IE2080/83A patent/IE55719B1/en not_active IP Right Cessation
- 1983-09-08 JP JP58166447A patent/JPS5967299A/ja active Granted
- 1983-09-08 AT AT83108886T patent/ATE25089T1/de not_active IP Right Cessation
- 1983-09-08 EP EP83108886A patent/EP0105224B1/en not_active Expired
- 1983-09-08 HU HU833143A patent/HU189744B/hu not_active IP Right Cessation
- 1983-09-08 HU HU834616A patent/HU196432B/hu not_active IP Right Cessation
- 1983-09-08 DE DE8383108886T patent/DE3369326D1/de not_active Expired
- 1983-09-08 DK DK407983A patent/DK164873C/da not_active IP Right Cessation
- 1983-09-08 NO NO833208A patent/NO159602C/no unknown

Also Published As

Publication number	Publication date
IE55719B1 (en)	1991-01-02
US4435326A (en)	1984-03-06
EP0105224A2 (en)	1984-04-11
AU1843383A (en)	1984-03-15
AU558201B2 (en)	1987-01-22
EP0105224B1 (en)	1987-01-21
DK407983A (da)	1984-03-10
JPH0439478B2 (da)	1992-06-29
CA1248087A (en)	1989-01-03
HU196432B (en)	1988-11-28
IE832080L (en)	1984-03-09
JPS5967299A (ja)	1984-04-16
HU189744B (en)	1986-07-28
EP0105224A3 (en)	1984-08-01
NO159602B (no)	1988-10-10
ATE25089T1 (de)	1987-02-15
DK164873B (da)	1992-08-31
ZA836358B (en)	1984-04-25
NO159602C (no)	1989-01-18
DK407983D0 (da)	1983-09-08
DE3369326D1 (en)	1987-02-26
NO833208L (no)	1984-03-12

Legal Events

Date	Code	Title	Description
1994-05-24	PBP	Patent lapsed

Publication	Publication Date	Title
DK372982A (da)	1983-02-21	Fremgangsmaade til fremstilling af 17,17-bis(substitueret thio) androstener
FI884087A7 (fi)	1989-03-12	Menetelmä androsta-1,4-dieeni-3,17-dionin metyleenijohdannaisten val mistamiseksi
ATE199015T1 (de)	2001-02-15	Steroid-verbindungen mit einer 17-spiromethylen- lakton- oder lactol-gruppe
DK288287D0 (da)	1987-06-04	Heterocycliske forbindelser samt farmaceutiske praeparater til behandling af allergiske eller inflammatoriske tilstande
DK164873C (da)	1993-01-11	3-keto-17alfa-mercapto-17beta-(substitueret thio)-androstenderivater med anvendelse som mellemprodukter ved fremstillingen af 17,17-bis(substitueret thio)-3-ketoandrostener samt fremgangsmaade til deres fremstilling
AU8988782A (en)	1983-05-05	Pyridazinone derivatives
AU562027B2 (en)	1987-05-28	Androstene-17-dithioketals, and 1,2-and 6,7-dehydro derivatives
NZ337362A (en)	2000-04-28	Heterocyclically substituted piperidyl-amino-indan-1-ol compounds and uses thereof
CA2010982A1 (en)	1990-08-31	Osteogenesis promotion with use of vitamin d derivatives
AU3406684A (en)	1986-09-11	Estrane and androstane derivatives
EP0559706A4 (da)	1994-02-09
AU584225B2 (en)	1989-05-18	Steroidic aromatase inhibitors
DE3564807D1 (en)	1988-10-13	Substituted tetrahydrothiopyran-2,4 diones
BA97185B1 (bs)	1999-08-02	Postupak za dobijanje supstituisanih androsta-1,4-dien-3,17-diona
DE69305659D1 (de)	1996-12-05	17-Phenyl-substituierte Steroide mit cardiotonischer Wirksamkeit