DK165789C - 4-oxo-4h-pyrimidooe2,1,aaaisoquinolinderivater, analogifremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse samt derivaterne til anvendelse som antiallergisk middel - Google Patents

4-oxo-4h-pyrimidooe2,1,aaaisoquinolinderivater, analogifremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse samt derivaterne til anvendelse som antiallergisk middel

Info

Publication number: DK165789C
Authority: DK; Denmark
Prior art keywords: derivatives; aaaisoquinoline; oxo; preparing; analysis
Prior art date: 1983-11-23

Application number

DK536184A

Other languages

English (en)

Other versions

DK165789B (da

DK536184A (da

DK536184D0 (da

Inventor

Ikuo Ueda

Youichi Shiokawa

Takashi Manabe

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-23

Filing date

1984-11-09

Publication date

1993-06-14

1983-11-23 Priority claimed from GB838331228A external-priority patent/GB8331228D0/en

1984-03-06 Priority claimed from GB848405776A external-priority patent/GB8405776D0/en

1984-10-12 Priority claimed from GB848425791A external-priority patent/GB8425791D0/en

1984-11-09 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1984-11-09 Publication of DK536184D0 publication Critical patent/DK536184D0/da

1985-05-24 Publication of DK536184A publication Critical patent/DK536184A/da

1993-01-18 Publication of DK165789B publication Critical patent/DK165789B/da

1993-06-14 Application granted granted Critical

1993-06-14 Publication of DK165789C publication Critical patent/DK165789C/da

Links

238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK536184A 1983-11-23 1984-11-09 4-oxo-4h-pyrimidooe2,1,aaaisoquinolinderivater, analogifremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse samt derivaterne til anvendelse som antiallergisk middel DK165789C (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB838331228A GB8331228D0 (en)	1983-11-23	1983-11-23	Pyrimidoisoquinoline derivatives
GB8331228		1983-11-23
GB8405776		1984-03-06
GB848405776A GB8405776D0 (en)	1984-03-06	1984-03-06	Pyrimidoisoquinoline derivatives
GB8425791		1984-10-12
GB848425791A GB8425791D0 (en)	1984-10-12	1984-10-12	Pyrimidoisoquinoline derivatives

Publications (4)

Publication Number	Publication Date
DK536184D0 DK536184D0 (da)	1984-11-09
DK536184A DK536184A (da)	1985-05-24
DK165789B DK165789B (da)	1993-01-18
DK165789C true DK165789C (da)	1993-06-14

Family

ID=27262222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK536184A DK165789C (da)	1983-11-23	1984-11-09	4-oxo-4h-pyrimidooe2,1,aaaisoquinolinderivater, analogifremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse samt derivaterne til anvendelse som antiallergisk middel

Country Status (17)

Country	Link
US (1)	US4673676A (da)
EP (1)	EP0143001B1 (da)
KR (2)	KR920008168B1 (da)
AR (1)	AR243889A1 (da)
AT (1)	ATE62484T1 (da)
AU (1)	AU582554B2 (da)
CA (1)	CA1232605A (da)
DE (1)	DE3484420D1 (da)
DK (1)	DK165789C (da)
ES (2)	ES8602786A1 (da)
FI (1)	FI77034C (da)
GR (1)	GR81006B (da)
HU (1)	HU202528B (da)
IL (1)	IL73586A (da)
NO (1)	NO162019C (da)
PH (1)	PH22068A (da)
SU (1)	SU1512482A3 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO162019C (no) *	1983-11-23	1989-10-25	Fujisawa Pharmaceutical Co	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4661592A (en) *	1984-06-27	1987-04-28	G. D. Searle & Co.	4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
ES2523169T3 (es)	2008-01-25	2014-11-21	High Point Pharmaceuticals, Llc	Compuestos tricíclicos como moduladores de la síntesis de TNF y como inhibidores de PDE4
CN113861189A (zh)	2020-06-29	2021-12-31	Vtv治疗有限责任公司	喹啉衍生物，其药学上可接受的盐及其使用方法
US12545676B2 (en)	2020-07-28	2026-02-10	Vtv Therapeutics Llc	Crystalline form of hydrochloride salt of quinoline derivative

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3876788A (en) *	1970-08-27	1975-04-08	Burroughs Wellcome Co	Heterocyclic compounds in the treatment of inflammatory of arthritic conditions
US4017625A (en) *	1975-08-01	1977-04-12	Pfizer Inc.	Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor
HU173438B (hu) *	1975-11-27	1979-05-28	Chinoin Gyogyszer Es Vegyeszet	Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
US4127720A (en) *	1977-09-21	1978-11-28	Bristol-Myers Company	Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity
IE51802B1 (en) *	1979-12-03	1987-04-01	Fujisawa Pharmaceutical Co	Quinazoline derivatives,processes for their preparation and pharmaceutical compositions containing them
JPS59172490A (ja) *	1983-03-18	1984-09-29	Fujisawa Pharmaceut Co Ltd	ピリミドイソキノリン誘導体およびその塩類、それらの製造法ならびにそれらを有効成分とする抗アレルギ−剤
JPS59172472A (ja) *	1983-03-18	1984-09-29	Fujisawa Pharmaceut Co Ltd	イソキノリン誘導体およびその塩類、それらの製造法ならびにそれらを有効成分とする抗アレルギ−剤
NO162019C (no) *	1983-11-23	1989-10-25	Fujisawa Pharmaceutical Co	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4661592A (en) *	1984-06-27	1987-04-28	G. D. Searle & Co.	4H-pyrimido[2,1-a]isoquinolin-4-one derivatives

1984
- 1984-11-08 NO NO844466A patent/NO162019C/no unknown
- 1984-11-09 FI FI844406A patent/FI77034C/fi not_active IP Right Cessation
- 1984-11-09 US US06/669,865 patent/US4673676A/en not_active Expired - Fee Related
- 1984-11-09 DK DK536184A patent/DK165789C/da active
- 1984-11-14 AU AU35405/84A patent/AU582554B2/en not_active Ceased
- 1984-11-19 CA CA000468159A patent/CA1232605A/en not_active Expired
- 1984-11-21 GR GR81006A patent/GR81006B/el unknown
- 1984-11-21 IL IL73586A patent/IL73586A/xx unknown
- 1984-11-22 HU HU844338A patent/HU202528B/hu not_active IP Right Cessation
- 1984-11-22 KR KR1019840007323A patent/KR920008168B1/ko not_active Expired
- 1984-11-22 SU SU843818298A patent/SU1512482A3/ru active
- 1984-11-22 AR AR84298701A patent/AR243889A1/es active
- 1984-11-22 AT AT84308109T patent/ATE62484T1/de not_active IP Right Cessation
- 1984-11-22 EP EP84308109A patent/EP0143001B1/en not_active Expired - Lifetime
- 1984-11-22 DE DE8484308109T patent/DE3484420D1/de not_active Expired - Lifetime
- 1984-11-23 PH PH31478A patent/PH22068A/en unknown
- 1984-11-23 ES ES537928A patent/ES8602786A1/es not_active Expired
1985
- 1985-08-16 ES ES546222A patent/ES8604220A1/es not_active Expired
1991
- 1991-09-25 KR KR1019910016712A patent/KR920001673B1/ko not_active Expired

Also Published As

Publication number	Publication date
HUT35674A (en)	1985-07-29
DK165789B (da)	1993-01-18
NO162019C (no)	1989-10-25
AR243889A1 (es)	1993-09-30
DK536184A (da)	1985-05-24
NO844466L (no)	1985-05-24
EP0143001A3 (en)	1986-03-19
PH22068A (en)	1988-05-20
EP0143001A2 (en)	1985-05-29
KR850003538A (ko)	1985-06-20
DE3484420D1 (en)	1991-05-16
CA1232605A (en)	1988-02-09
FI77034B (fi)	1988-09-30
SU1512482A3 (ru)	1989-09-30
FI77034C (fi)	1989-01-10
IL73586A (en)	1988-12-30
ES8604220A1 (es)	1986-01-16
DK536184D0 (da)	1984-11-09
KR920008168B1 (ko)	1992-09-24
EP0143001B1 (en)	1991-04-10
HU202528B (en)	1991-03-28
ES537928A0 (es)	1985-12-01
GR81006B (en)	1985-01-03
AU582554B2 (en)	1989-04-06
AU3540584A (en)	1985-05-30
KR920001673B1 (ko)	1992-02-22
NO162019B (no)	1989-07-17
US4673676A (en)	1987-06-16
ATE62484T1 (de)	1991-04-15
FI844406A0 (fi)	1984-11-09
ES546222A0 (es)	1986-01-16
IL73586A0 (en)	1985-02-28
ES8602786A1 (es)	1985-12-01
FI844406L (fi)	1985-05-24

Similar Documents

Publication	Publication Date	Title
DK163991C (da)	1992-09-21	Dichloranilinderivater, fremgangsmaade til fremstilling af disse, samt farmaceutiske praeparater indeholdende derivaterne
DK160052C (da)	1991-06-10	Chlorsubstituerede disaccharider og fremgangsmaader til fremstilling deraf samt praeparater indeholdende sacchariderne som soedemidler
DK654589A (da)	1990-06-24	Heterocykliske derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende derivaterne
DK181983D0 (da)	1983-04-25	1,8-naphthyridin- og 1,5,8-azanaphthyridin-derivater, fremgangsmade til deres fremstilling samt deres anvendelse
DK219387D0 (da)	1987-04-29	Aminothiazol- og aminooxazolderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK343388D0 (da)	1988-06-22	2,2-dimethylchroman-3-ol-derivater og fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende derivaterne samt disse anvendelse til fremstilling af farmaceutiske midler
DK160492C (da)	1991-08-26	Pyrimidinderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske praeparater indeholdende disse derivater
DK160981C (da)	1991-10-28	Arylsulfonylurinstof-derivater, fremgangsmaade til fremstilling deraf, anvendelse af disse som terapeutisk og antineoplastisk middel samt farmaceutiske midler indeholdende saadanne derivater
DK276189D0 (da)	1989-06-06	Polypeptidforbindelser, fremgangsmaader til fremstilling heraf farmaceutiske midler indeholdende disse
DK160150C (da)	1991-07-01	Benzothiazinderivater, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende samme
DK642588A (da)	1989-05-19	Indanderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK539087A (da)	1988-04-17	4,5-dihydro- og 4,5,6,7-tetrahydro-pyrazolooe1,5-aaapyrimidiner, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK567188A (da)	1989-04-13	2,2-dimethylchromenderivater og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende derivaterne
DK486789D0 (da)	1989-10-03	Benzoxazolinonderivater, fremgangsmaader til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK469189D0 (da)	1989-09-22	Substituerede thienopyraner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK164865C (da)	1993-01-18	Silibininderivater, fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende silibininderivaterne
DK617684D0 (da)	1984-12-20	1,3-dioxolanylderivater, fremgangsmaade til deres fremstilling, deres anvendelse og laegemidler indeholdende disse forbindelser
DK401988A (da)	1989-01-21	11-substituerede 5-aryl-5h,11h-pyrrolo(2,1-c)-(1,4)benzoxazepiner, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK567184D0 (da)	1984-11-29	Pyridonderivater, fremgangsmaader til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK581183A (da)	1984-06-18	2-azabicyclo(2.2.1)heptan-derivater, fremgangsmaader til deres fremstilling, midler indeholdende disse derivater og deres anvendelse, samt 2-azabicyclo(2.2.1)heptan-derivater som mellemprodukter samt fremgangsmaader til deres fremstilling
DK492289A (da)	1990-04-08	3-aryloxymethyl-cephalosporinderivater og fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende derivaterne
DK260884A (da)	1984-11-28	7-oxo-4-thia-1-azabicyclo(3.2.0)hept-2-en-derivater, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler
IL73586A0 (en)	1985-02-28	Pyrimidoisoquinoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
DK379287D0 (da)	1987-07-21	1,3-propandiaminderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK146389A (da)	1989-09-29	(1,3-dioxolan-4-ylmethylthio)phenyl)carbamater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme