DK1661913T3 - Bioaktive peptider udledt fra æggehvideprotein gennem enzymatisk hydrolyse - Google Patents

Bioaktive peptider udledt fra æggehvideprotein gennem enzymatisk hydrolyse

Info

Publication number: DK1661913T3
Authority: DK; Denmark
Prior art keywords: activity; egg white; treatment; bioactive peptides; peptides
Prior art date: 2003-07-31

Application number

DK04766983T

Other languages

English (en)

Inventor

Castro Marta Miguel

Fandi Lopez-Alonso

Sanchez Maria Recio

Gonzales Maria Ramos

De Arti Aleixandre

Original Assignee

Consejo Superior Investigacion

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-31

Filing date

2004-07-23

Publication date

2008-07-07

2004-07-23 Application filed by Consejo Superior Investigacion filed Critical Consejo Superior Investigacion

2008-07-07 Application granted granted Critical

2008-07-07 Publication of DK1661913T3 publication Critical patent/DK1661913T3/da

Links

102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
102000002322 Egg Proteins Human genes 0.000 title abstract 2
108010000912 Egg Proteins Proteins 0.000 title abstract 2
230000000975 bioactive effect Effects 0.000 title abstract 2
230000007071 enzymatic hydrolysis Effects 0.000 title 1
238000006047 enzymatic hydrolysis reaction Methods 0.000 title 1
102100030988 Angiotensin-converting enzyme Human genes 0.000 abstract 3
230000002401 inhibitory effect Effects 0.000 abstract 3
206010020772 Hypertension Diseases 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 2
230000003276 anti-hypertensive effect Effects 0.000 abstract 2
230000003078 antioxidant effect Effects 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
241000700159 Rattus Species 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
235000014103 egg white Nutrition 0.000 abstract 1
210000000969 egg white Anatomy 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
235000013373 food additive Nutrition 0.000 abstract 1
239000002778 food additive Substances 0.000 abstract 1
235000012041 food component Nutrition 0.000 abstract 1
239000005417 food ingredient Substances 0.000 abstract 1
235000013376 functional food Nutrition 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
229940127557 pharmaceutical product Drugs 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/04—Animal proteins
- A23J3/08—Dairy proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/77—Ovalbumin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Biophysics (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Mycology (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK04766983T 2003-07-31 2004-07-23 Bioaktive peptider udledt fra æggehvideprotein gennem enzymatisk hydrolyse DK1661913T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200301829A ES2253036B1 (es)	2003-07-31	2003-07-31	Peptidos bioactivos derivados de proteinas de la clara de huevo mediante hidrolisis enzimatica.
PCT/ES2004/070059 WO2005012355A1 (es)	2003-07-31	2004-07-23	Péptidos bioactivos derivados de proteínas de la clara de huevo mediante hidrólisis enzimática

Publications (1)

Publication Number	Publication Date
DK1661913T3 true DK1661913T3 (da)	2008-07-07

Family

ID=34112522

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04766983T DK1661913T3 (da)	2003-07-31	2004-07-23	Bioaktive peptider udledt fra æggehvideprotein gennem enzymatisk hydrolyse

Country Status (8)

Country	Link
US (1)	US8227207B2 (da)
EP (1)	EP1661913B1 (da)
JP (1)	JP2007523045A (da)
AT (1)	ATE388166T1 (da)
DE (1)	DE602004012289T2 (da)
DK (1)	DK1661913T3 (da)
ES (2)	ES2253036B1 (da)
WO (1)	WO2005012355A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2006273850A (ja) *	2005-03-04	2006-10-12	Pharma Foods International Co Ltd	血中乳酸値上昇抑制組成物及びそれを含有する飲食品
ES2329316B1 (es) *	2005-05-23	2010-10-14	Consejo Superior Investig. Cientificas	Obtencion y propiedades antihipertensivas de peptidos derivados de proteinas de clara de huevo.
JP2008156344A (ja) *	2006-11-27	2008-07-10	Q P Corp	生体内抗酸化材、生体内抗酸化用食品組成物及び生体内抗酸化用医薬品組成物、並びに肝機能障害抑制材、肝機能障害抑制用食品組成物及び肝機能障害抑制用医薬品組成物
CA2732614A1 (en)	2008-08-01	2010-02-04	Natraceutical, S.A.	Obtaining cocoa extracts rich in bioactive peptides with ace and pep enzyme inhibitory activity
US9315563B2 (en) *	2009-03-20	2016-04-19	The Governors Of The University Of Alberta	Peptides that inhibit angiotensin converting enzyme and peptides with antioxidant activity purified from ovotransferrin and methods of producing and using the same
WO2011126054A1 (ja) *	2010-04-07	2011-10-13	国立大学法人京都大学	生理活性ペプチド
EP2548458B1 (en) *	2011-07-22	2013-07-03	HPF Nutraceutics S.r.L.	Lupin-derived compounds having hypotensive activity and process for their production
KR101510178B1 (ko)	2013-05-27	2015-04-10	대한민국	항산화 펩타이드를 포함하는 조성물
WO2015082741A1 (es) *	2013-12-04	2015-06-11	Consejo Superior De Investigaciones Cientificas (Csic)	Uso de productos bioactivos multifuncionales derivados de la hidrólisis enzimática de proteínas de clara de huevo para el tratamiento del síndrome metabólico
WO2016077457A1 (en)	2014-11-11	2016-05-19	Clara Foods Co.	Methods and compositions for egg white protein production
CN104814439B (zh) *	2015-05-27	2017-09-29	吉林大学	一种蛋清小肽降压营养粉及制备方法
KR102056348B1 (ko)	2018-05-28	2019-12-16	주식회사 바이오프로후즈	난백 가수분해물의 제조방법 및 이의 용도
CN109485696B (zh) *	2018-11-06	2020-10-23	渤海大学	一种克服肠道降解的膜肽酶抑制肽
US12096784B2 (en)	2019-07-11	2024-09-24	Clara Foods Co.	Protein compositions and consumable products thereof
FI13395Y1 (fi)	2019-07-11	2023-06-06	Clara Foods Co	Koostumuksia, jotka käsittävät rekombinanttia ovomukoidiproteiinia
US10927360B1 (en)	2019-08-07	2021-02-23	Clara Foods Co.	Compositions comprising digestive enzymes
CN110628856A (zh) *	2019-10-17	2019-12-31	武汉普诺金生物科技股份有限公司	一种降血压小分子肽及其制备方法和应用
CN112616925A (zh) *	2020-12-30	2021-04-09	光明乳业股份有限公司	一种双蛋白发酵乳及其制备方法
EP4046649A1 (en)	2021-02-22	2022-08-24	Bioseutica B.V.	Ovotransferrins for use in the treatment of iron deficiency anaemia
CN115477696A (zh) *	2022-09-27	2022-12-16	杭州佰倍优生物科技有限公司	一种改善乏力症状的白蛋白活性多肽粉及其制备方法
CN116444611B (zh) *	2022-11-30	2024-06-04	内蒙古伊利实业集团股份有限公司	乳源活性肽tdplfkg及其制备方法与应用
CN117264018B (zh) *	2023-09-26	2024-04-09	南京工业大学	一种鸽蛋清中功能肽的制备及其应用
CN118530340B (zh) *	2024-07-25	2024-10-29	青岛农业大学	一种具有抗氧化抗过敏功效的生物活性肽、组合物及应用
CN121622852B (zh) *	2026-02-05	2026-05-29	杭州康源食品科技有限公司	具有调节免疫补气血的蛋清蛋白来源小分子肽及其应用
CN121949464A (zh) *	2026-04-01	2026-05-01	内蒙古乳业技术研究院有限责任公司	具有降血压和抗氧化功效的多肽及其相关产品和应用
CN121949463A (zh) *	2026-04-01	2026-05-01	内蒙古乳业技术研究院有限责任公司	一种具有降血压和抗氧化功效的多肽及其相关产品和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5470970A (en) *	1991-02-28	1995-11-28	Dana-Farber Cancer Institute, Inc.	Maspin, a serpin with tumor suppresing activity
JP3129523B2 (ja) *	1992-05-29	2001-01-31	日本合成化学工業株式会社	新規ペプチド及びその製造方法
GB9310472D0 (en) *	1993-05-20	1993-07-07	Univ Warwick	Phenylalanine-free protein and dna coding thereof
JPH09263597A (ja) *	1996-03-29	1997-10-07	Taiyo Kagaku Co Ltd	新規ペプチド
JP3770659B2 (ja) *	1996-07-23	2006-04-26	日本合成化学工業株式会社	新規ペプチド及びその製造方法
US5935968A (en) *	1997-03-17	1999-08-10	Merck & Co., Inc.	Methods for treating polycystic ovary syndrome
AU5926700A (en) *	1999-07-08	2001-01-30	Stressgen Biotechnologies Corporation	Induction of a th1-like response in vitro
US6514941B1 (en) *	1999-12-10	2003-02-04	Campina Melkunie B.V.	Method of preparing a casein hydrolysate enriched in anti-hypertensive peptides
CA2415688A1 (en)	2000-05-08	2001-11-15	Anand Rao	Enzymatic treatment of whey proteins for the production of antihypertensive peptides, the resulting products and treatment of hypertension in mammals
US7265208B2 (en) *	2001-05-01	2007-09-04	The Regents Of The University Of California	Fusion molecules and treatment of IgE-mediated allergic diseases

2003
- 2003-07-31 ES ES200301829A patent/ES2253036B1/es not_active Expired - Lifetime
2004
- 2004-07-23 WO PCT/ES2004/070059 patent/WO2005012355A1/es not_active Ceased
- 2004-07-23 DK DK04766983T patent/DK1661913T3/da active
- 2004-07-23 ES ES04766983T patent/ES2303090T3/es not_active Expired - Lifetime
- 2004-07-23 AT AT04766983T patent/ATE388166T1/de not_active IP Right Cessation
- 2004-07-23 JP JP2006521598A patent/JP2007523045A/ja active Pending
- 2004-07-23 DE DE602004012289T patent/DE602004012289T2/de not_active Expired - Lifetime
- 2004-07-23 EP EP04766983A patent/EP1661913B1/en not_active Expired - Lifetime
2006
- 2006-01-30 US US11/343,263 patent/US8227207B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1661913B1 (en)	2008-03-05
WO2005012355A1 (es)	2005-02-10
ATE388166T1 (de)	2008-03-15
ES2253036A1 (es)	2006-05-16
WO2005012355B1 (es)	2005-03-24
EP1661913A1 (en)	2006-05-31
DE602004012289T2 (de)	2009-09-03
DE602004012289D1 (de)	2008-04-17
JP2007523045A (ja)	2007-08-16
ES2303090T3 (es)	2008-08-01
US20060280804A1 (en)	2006-12-14
ES2253036B1 (es)	2007-07-16
US8227207B2 (en)	2012-07-24

Publication	Publication Date	Title
DE602004012289D1 (de)	2008-04-17	Bioaktive peptide, die durch enzymatische hydrolyse aus den proteinen von eiweiss gewonnen werden
Adjonu et al.	2013	Screening of whey protein isolate hydrolysates for their dual functionality: Influence of heat pre-treatment and enzyme specificity
Hernández-Ledesma et al.	2007	ACE-inhibitory and radical-scavenging activity of peptides derived from β-lactoglobulin f (19− 25). Interactions with ascorbic acid
Rami et al.	1997	Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity
PH12013501903A1 (en)	2013-11-25	Nutritional compositions including branched chain fatty acids for improving gut barrier function
TR201809592T4 (tr)	2018-07-23	Aktif içerik maddelerinin bileşimleri.
AR053052A1 (es)	2007-04-18	Composiciones que comprenden dos componentes y que son utiles como alimento para mascotas
DK1996028T3 (da)	2011-04-18	Faste enzymformuleringer og fremgangsmåde til deres fremstilling
DE60332358D1 (de)	2010-06-10	Protease-resistente modifizierte interferon alpha polypeptide
MX2009010777A (es)	2010-01-29	Composiciones de carne que comprenden productos de proteina estructurada con color.
MX2010014091A (es)	2011-03-21	Composiciones de hidrolizado de proteinas estables en condiciones acidas.
BR112014016557A2 (pt)	2017-06-13	métodos de tratamento de sintomas comportamentais de distúrbios neurológicos e mentais
MA41067B1 (fr)	2020-08-31	Composition comportant de la chitine et des protéines digestibles
EP2428222A3 (en)	2012-05-09	Vaccine peptide combinations against cat allergy
DE60126829D1 (de)	2007-04-05	Kombination von drei Substanzen zur Vorbeugung und Behandlung von Arthritis
WO2008111562A1 (ja)	2008-09-18	美白剤
MX2020009677A (es)	2020-10-12	Composiciones preparadas de aves de corral y metodos de su uso.
WO2007134118A3 (en)	2009-09-11	Protein based composition and methods of using same
DE602008004345D1 (de)	2011-02-17	Nahrungsmittel enthaltend Dipeptide mit blutdrucksenkenden Eigenschaften.
FR3120188B3 (fr)	2023-09-22	Composition comprenant un extrait deVitis vinifera, de la vitamine C et des probiotiques pour lutter contre le vieillissement de la peau
FR2966016B1 (fr)	2013-10-25	Hydrolysats de proteines animales d'origine marine aux proprietes neuroprotectrices
ATE493966T1 (de)	2011-01-15	Mittel zur förderung der hautkollagenproduktion
WO2005071067A3 (en)	2005-11-03	Non-animal origin stabilizers and processes for producing the same
WO2010065536A3 (en)	2010-09-16	Recombinant bone marrow stromal antigen-2 in the treatment of autoimmune diseases
ATE552271T1 (de)	2012-04-15	Antitumorarzneimittel, medikament, zusammensetzung und anwendung davon