DK167013B1 - 4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer - Google Patents

4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer Download PDF

Info

Publication number: DK167013B1
Authority: DK; Denmark
Prior art keywords: hydrogen; methyl; prop; ynyl; group
Prior art date: 1987-03-25

Application number

DK168488A

Other languages

Danish (da)

English (en)

Other versions

DK168488A (da

DK168488D0 (da

Inventor

Leslie Richard Hughes

Original Assignee

Ici Plc

Nat Res Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-25

Filing date

1988-03-25

Publication date

1993-08-16

1988-03-25 Application filed by Ici Plc, Nat Res Dev filed Critical Ici Plc

1988-03-25 Publication of DK168488D0 publication Critical patent/DK168488D0/da

1988-09-26 Publication of DK168488A publication Critical patent/DK168488A/da

1993-08-16 Application granted granted Critical

1993-08-16 Publication of DK167013B1 publication Critical patent/DK167013B1/da

Links

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125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK168488A 1987-03-25 1988-03-25 4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer DK167013B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878707053A GB8707053D0 (en)	1987-03-25	1987-03-25	Anti-tumour agents
GB8707053		1987-03-25

Publications (3)

Publication Number	Publication Date
DK168488D0 DK168488D0 (da)	1988-03-25
DK168488A DK168488A (da)	1988-09-26
DK167013B1 true DK167013B1 (da)	1993-08-16

Family

ID=10614570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK168488A DK167013B1 (da)	1987-03-25	1988-03-25	4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer

Country Status (17)

Country	Link
US (1)	US4981856A (fr)
EP (1)	EP0284338B1 (fr)
JP (1)	JP2577036B2 (fr)
AT (1)	ATE98956T1 (fr)
AU (1)	AU600105B2 (fr)
CA (1)	CA1301756C (fr)
DE (1)	DE3886435T2 (fr)
DK (1)	DK167013B1 (fr)
ES (1)	ES2061641T3 (fr)
FI (1)	FI881340A7 (fr)
GB (2)	GB8707053D0 (fr)
GR (1)	GR3010208T3 (fr)
IL (1)	IL85696A (fr)
NO (1)	NO881300L (fr)
NZ (1)	NZ224010A (fr)
PT (1)	PT87074B (fr)
ZA (1)	ZA881885B (fr)

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US5145854A (en) *	1991-11-27	1992-09-08	Nair Madhavan G	1-formyl-5,8,10-trideazafolates
GB9205320D0 (en) *	1992-03-11	1992-04-22	Ici Plc	Anti-tumour compounds
GB9205907D0 (en) *	1992-03-18	1992-04-29	Cancer Res Inst Royal	Anti-cancer compounds
US5430148A (en) *	1992-03-31	1995-07-04	Agouron Pharmaceuticals, Inc.	Antiproliferative quinazolines
GB9223352D0 (en) *	1992-11-06	1992-12-23	Ici Plc	Tricyclic compounds
DE4421884A1 (de)	1994-06-23	1996-01-04	Hoechst Ag	Verfahren zur Herstellung von Hydroxycarbonsäureaniliden
DE4427837A1 (de)	1994-08-05	1996-02-08	Hoechst Ag	Verfahren zur Herstellung von O-Acylglykolsäureaniliden
DE19504225A1 (de)	1995-02-09	1996-08-14	Hoechst Ag	Verfahren zur Herstellung von O-Acyloxycarbonsäureaniliden
US5739330A (en) *	1996-02-05	1998-04-14	Hoechst Celanese Corporation	Process for preparing quinazolones
GB9904275D0 (en)	1999-02-24	1999-04-21	Cancer Res Campaign Tech	Anti-cancer compounds
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
US7230000B1 (en) *	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
WO2003043995A1 (fr) *	2001-11-20	2003-05-30	Cytokinetics, Inc.	Procede de racemisation de quinazolinones chirales
EP1463807A4 (fr)	2001-12-19	2006-04-12	Bristol Myers Squibb Co	Pichia pastoris formate deshydrogenase et ses utilisations
JP2005529076A (ja) *	2002-02-15	2005-09-29	サイトキネティクス・インコーポレーテッド	キナゾリノンの合成
RU2004135554A (ru) *	2002-05-09	2006-01-20	Цитокинетикс, Инк. (Us)	Пиримидиноны, композиции на их основе и способы их использования
EP1553931A4 (fr)	2002-05-09	2006-08-30	Cytokinetics Inc	Composes, compositions et procedes
EP1513820A4 (fr)	2002-05-23	2006-09-13	Cytokinetics Inc	Composes, compositions et procedes
CA2489367A1 (fr) *	2002-06-14	2003-12-24	Cytokinetics, Inc.	Composes, compositions et procedes
EP1537089A4 (fr) *	2002-07-23	2008-04-16	Cytokinetics Inc	Composes, compositions et procedes
WO2004018058A2 (fr) *	2002-08-21	2004-03-04	Cytokinetics, Inc.	Composes, compositions et methodes
WO2004034972A2 (fr) *	2002-09-30	2004-04-29	Cytokinetics, Inc.	Composes, compositions, et procedes
GB0317631D0 (en) *	2003-07-28	2003-08-27	Btg Int Ltd	Synthetic method
WO2005041888A2 (fr) *	2003-11-03	2005-05-12	Cytokinetics, Inc.	Composes, compositions et methodes
JP2007510660A (ja) *	2003-11-07	2007-04-26	サイトキネティクス・インコーポレーテッド	化合物、組成物及び方法
EP1692112A4 (fr) *	2003-12-08	2008-09-24	Cytokinetics Inc	Composes, compositions, et methodes associees
KR20100024494A (ko) *	2007-06-22	2010-03-05	아르퀼 인코포레이티드	퀴나졸리논 화합물 및 이의 사용 방법
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
PT3052485T (pt)	2013-10-04	2021-10-22	Infinity Pharmaceuticals Inc	Compostos heterocíclicos e suas utilizações
US9751888B2 (en)	2013-10-04	2017-09-05	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
MX382033B (es)	2014-03-19	2025-03-13	Infinity Pharmaceuticals Inc	Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
WO2016054491A1 (fr)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Composés hétérocycliques et leurs utilisations
WO2017048702A1 (fr)	2015-09-14	2017-03-23	Infinity Pharmaceuticals, Inc.	Formes solides de dérivés d'isoquinolinone, leur procédé de fabrication, compositions les comprenant et méthodes d'utilisation de celles-ci
WO2017161116A1 (fr)	2016-03-17	2017-09-21	Infinity Pharmaceuticals, Inc.	Isotopologues de composés isoquinolinone et quinazolinone et leurs utilisations comme inhibiteurs de la kinase pi3k
WO2017214269A1 (fr)	2016-06-08	2017-12-14	Infinity Pharmaceuticals, Inc.	Composés hétérocycliques et leurs utilisations

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GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents

1987
- 1987-03-25 GB GB878707053A patent/GB8707053D0/en active Pending
1988
- 1988-03-10 IL IL85696A patent/IL85696A/xx not_active IP Right Cessation
- 1988-03-14 GB GB8805982A patent/GB2202847B/en not_active Expired - Lifetime
- 1988-03-16 ZA ZA881885A patent/ZA881885B/xx unknown
- 1988-03-18 AU AU13279/88A patent/AU600105B2/en not_active Ceased
- 1988-03-21 FI FI881340A patent/FI881340A7/fi not_active IP Right Cessation
- 1988-03-22 DE DE88302486T patent/DE3886435T2/de not_active Expired - Fee Related
- 1988-03-22 AT AT88302486T patent/ATE98956T1/de not_active IP Right Cessation
- 1988-03-22 EP EP88302486A patent/EP0284338B1/fr not_active Expired - Lifetime
- 1988-03-22 ES ES88302486T patent/ES2061641T3/es not_active Expired - Lifetime
- 1988-03-24 CA CA000562300A patent/CA1301756C/fr not_active Expired - Lifetime
- 1988-03-24 NO NO881300A patent/NO881300L/no unknown
- 1988-03-24 NZ NZ224010A patent/NZ224010A/en unknown
- 1988-03-24 PT PT87074A patent/PT87074B/pt active IP Right Grant
- 1988-03-25 JP JP63069943A patent/JP2577036B2/ja not_active Expired - Fee Related
- 1988-03-25 DK DK168488A patent/DK167013B1/da not_active IP Right Cessation
1990
- 1990-04-12 US US07/508,528 patent/US4981856A/en not_active Expired - Lifetime
1993
- 1993-12-23 GR GR920402608T patent/GR3010208T3/el unknown

Also Published As

Publication number	Publication date
FI881340A0 (fi)	1988-03-21
DE3886435D1 (de)	1994-02-03
NZ224010A (en)	1990-12-21
ATE98956T1 (de)	1994-01-15
GB2202847B (en)	1990-06-06
DE3886435T2 (de)	1994-04-14
NO881300L (no)	1988-09-26
ES2061641T3 (es)	1994-12-16
JP2577036B2 (ja)	1997-01-29
EP0284338B1 (fr)	1993-12-22
CA1301756C (fr)	1992-05-26
EP0284338A3 (en)	1989-05-17
EP0284338A2 (fr)	1988-09-28
GR3010208T3 (fr)	1994-03-31
IL85696A (en)	1993-05-13
PT87074B (pt)	1992-07-31
GB2202847A (en)	1988-10-05
FI881340A7 (fi)	1988-09-26
DK168488A (da)	1988-09-26
PT87074A (pt)	1988-04-01
GB8707053D0 (en)	1987-04-29
JPS63255270A (ja)	1988-10-21
NO881300D0 (no)	1988-03-24
GB8805982D0 (en)	1988-04-13
AU1327988A (en)	1988-09-29
US4981856A (en)	1991-01-01
AU600105B2 (en)	1990-08-02
DK168488D0 (da)	1988-03-25
ZA881885B (en)	1988-09-26

Legal Events

Date	Code	Title
1993-08-16	B1	Patent granted (law 1993)
1994-04-05	B1	Patent granted (law 1993)
1995-11-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK167013B1 (da)	1993-08-16	4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer
DK166621B1 (da)	1993-06-21	4-oxo-6-aminomethyl-quinazolinderivater, fremgangsmaade til fremstilling heraf, farmaceutisk middel omfattende dem og anvendelse af dem til fremstilling af laegemidler til behandling af tumorer
US5187167A (en)	1993-02-16	Pharmaceutical compositions comprising quinazolin-4-one derivatives
Marsham et al.	1991	Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications
KR100221011B1 (ko)	1999-09-15	항-종양 화합물, 이의 제조 방법 및 이를 함유하는 약학 조성물
US5444061A (en)	1995-08-22	Anti-cancer compounds
EP0318225B1 (fr)	1994-03-16	Dérivés de la 6-arylaminométhylquinoléine et leur utilisation comme agents antitumoraux
US5561133A (en)	1996-10-01	Thymidylate synthase inhibiting quinazolinones
CN1037898A (zh)	1989-12-13	芳族及杂环甲酰胺衍生物抗肿瘤剂的制备
EP0469156B1 (fr)	1996-10-23	Derive de glutathione
GB2217709A (en)	1989-11-01	Anti-tumour 4-oxoquinazolines
US20070105784A1 (en)	2007-05-10	Substituted quinolines for the treatment of cancer