DK168488A - Quinazolinderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse - Google Patents

Quinazolinderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse

Info

Publication number: DK168488A
Authority: DK; Denmark
Prior art keywords: alkyl; hydrogen; alkoxy; alkylthio; procedures
Prior art date: 1987-03-25

Application number

DK168488A

Other languages

English (en)

Other versions

DK167013B1 (da

DK168488D0 (da

Inventor

Leslie Richard Hughes

Original Assignee

Ici Plc

Nat Res Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-25

Filing date

1988-03-25

Publication date

1988-09-26

1988-03-25 Application filed by Ici Plc, Nat Res Dev filed Critical Ici Plc

1988-03-25 Publication of DK168488D0 publication Critical patent/DK168488D0/da

1988-09-26 Publication of DK168488A publication Critical patent/DK168488A/da

1993-08-16 Application granted granted Critical

1993-08-16 Publication of DK167013B1 publication Critical patent/DK167013B1/da

Links

JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
239000008177 pharmaceutical agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000004414 alkyl thio group Chemical group 0.000 abstract 3
125000000547 substituted alkyl group Chemical group 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000004957 naphthylene group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK168488A 1987-03-25 1988-03-25 4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer DK167013B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878707053A GB8707053D0 (en)	1987-03-25	1987-03-25	Anti-tumour agents
GB8707053		1987-03-25

Publications (3)

Publication Number	Publication Date
DK168488D0 DK168488D0 (da)	1988-03-25
DK168488A true DK168488A (da)	1988-09-26
DK167013B1 DK167013B1 (da)	1993-08-16

Family

ID=10614570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK168488A DK167013B1 (da)	1987-03-25	1988-03-25	4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer

Country Status (17)

Country	Link
US (1)	US4981856A (da)
EP (1)	EP0284338B1 (da)
JP (1)	JP2577036B2 (da)
AT (1)	ATE98956T1 (da)
AU (1)	AU600105B2 (da)
CA (1)	CA1301756C (da)
DE (1)	DE3886435T2 (da)
DK (1)	DK167013B1 (da)
ES (1)	ES2061641T3 (da)
FI (1)	FI881340A7 (da)
GB (2)	GB8707053D0 (da)
GR (1)	GR3010208T3 (da)
IL (1)	IL85696A (da)
NO (1)	NO881300L (da)
NZ (1)	NZ224010A (da)
PT (1)	PT87074B (da)
ZA (1)	ZA881885B (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8727737D0 (en) *	1987-11-26	1987-12-31	Ici Plc	Antitumour agents
GB8809978D0 (en) *	1988-04-27	1988-06-02	Ici Plc	Anti-tumour agents
EP0365763A1 (en) *	1988-09-30	1990-05-02	Agouron Pharmaceuticals, Inc.	Antiproliferative cyclic compounds
GB8829296D0 (en) *	1988-12-15	1989-01-25	Ici Plc	Anti-tumour compounds
US5252573A (en) *	1988-12-15	1993-10-12	Imperial Chemical Industries Plc	Anti-tumor agents
US5160727A (en) *	1990-02-13	1992-11-03	Warner-Lambert Company	Tumor cell sensitization method using quinazolinedione derivatives
ZA913730B (en) *	1990-05-30	1992-02-26	Ici Plc	Anti-tumor compounds
GB9013615D0 (en) *	1990-06-19	1990-08-08	Wellcome Found	Pharmaceutical compounds
GB9105771D0 (en) *	1991-03-19	1991-05-01	Cancer Res Inst Royal	Anti-cancer compounds
US5145854A (en) *	1991-11-27	1992-09-08	Nair Madhavan G	1-formyl-5,8,10-trideazafolates
GB9205320D0 (en) *	1992-03-11	1992-04-22	Ici Plc	Anti-tumour compounds
GB9205907D0 (en) *	1992-03-18	1992-04-29	Cancer Res Inst Royal	Anti-cancer compounds
US5430148A (en) *	1992-03-31	1995-07-04	Agouron Pharmaceuticals, Inc.	Antiproliferative quinazolines
GB9223352D0 (en) *	1992-11-06	1992-12-23	Ici Plc	Tricyclic compounds
DE4421884A1 (de)	1994-06-23	1996-01-04	Hoechst Ag	Verfahren zur Herstellung von Hydroxycarbonsäureaniliden
DE4427837A1 (de)	1994-08-05	1996-02-08	Hoechst Ag	Verfahren zur Herstellung von O-Acylglykolsäureaniliden
DE19504225A1 (de)	1995-02-09	1996-08-14	Hoechst Ag	Verfahren zur Herstellung von O-Acyloxycarbonsäureaniliden
US5739330A (en) *	1996-02-05	1998-04-14	Hoechst Celanese Corporation	Process for preparing quinazolones
GB9904275D0 (en)	1999-02-24	1999-04-21	Cancer Res Campaign Tech	Anti-cancer compounds
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
US7230000B1 (en) *	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
WO2003043995A1 (en) *	2001-11-20	2003-05-30	Cytokinetics, Inc.	Process for the racemization of chiral quinazolinones
EP1463807A4 (en)	2001-12-19	2006-04-12	Bristol Myers Squibb Co	FORMATHYDROGENASE FROM PICHIA PASTORIS AND USES THEREOF
JP2005529076A (ja) *	2002-02-15	2005-09-29	サイトキネティクス・インコーポレーテッド	キナゾリノンの合成
RU2004135554A (ru) *	2002-05-09	2006-01-20	Цитокинетикс, Инк. (Us)	Пиримидиноны, композиции на их основе и способы их использования
EP1553931A4 (en)	2002-05-09	2006-08-30	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
EP1513820A4 (en)	2002-05-23	2006-09-13	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
CA2489367A1 (en) *	2002-06-14	2003-12-24	Cytokinetics, Inc.	Compounds, compositions, and methods
EP1537089A4 (en) *	2002-07-23	2008-04-16	Cytokinetics Inc	CONNECTIONS, COMPOSITIONS AND PROCEDURES
WO2004018058A2 (en) *	2002-08-21	2004-03-04	Cytokinetics, Inc.	Compounds, compositions, and methods
WO2004034972A2 (en) *	2002-09-30	2004-04-29	Cytokinetics, Inc.	Compounds, compositions, and methods
GB0317631D0 (en) *	2003-07-28	2003-08-27	Btg Int Ltd	Synthetic method
WO2005041888A2 (en) *	2003-11-03	2005-05-12	Cytokinetics, Inc.	Pyrimidin-4-one compounds, compositions and methods
JP2007510660A (ja) *	2003-11-07	2007-04-26	サイトキネティクス・インコーポレーテッド	化合物、組成物及び方法
EP1692112A4 (en) *	2003-12-08	2008-09-24	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS, AND METHODS
KR20100024494A (ko) *	2007-06-22	2010-03-05	아르퀼 인코포레이티드	퀴나졸리논 화합물 및 이의 사용 방법
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
PT3052485T (pt)	2013-10-04	2021-10-22	Infinity Pharmaceuticals Inc	Compostos heterocíclicos e suas utilizações
US9751888B2 (en)	2013-10-04	2017-09-05	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
MX382033B (es)	2014-03-19	2025-03-13	Infinity Pharmaceuticals Inc	Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
WO2016054491A1 (en)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
WO2017048702A1 (en)	2015-09-14	2017-03-23	Infinity Pharmaceuticals, Inc.	Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017161116A1 (en)	2016-03-17	2017-09-21	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en)	2016-06-08	2017-12-14	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3069468D1 (en) *	1979-12-19	1984-11-22	Nat Res Dev	Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
GB8513754D0 (en) *	1985-05-31	1985-07-03	Jones T R	Anti-cancer quinazoline derivatives
GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents

1987
- 1987-03-25 GB GB878707053A patent/GB8707053D0/en active Pending
1988
- 1988-03-10 IL IL85696A patent/IL85696A/xx not_active IP Right Cessation
- 1988-03-14 GB GB8805982A patent/GB2202847B/en not_active Expired - Lifetime
- 1988-03-16 ZA ZA881885A patent/ZA881885B/xx unknown
- 1988-03-18 AU AU13279/88A patent/AU600105B2/en not_active Ceased
- 1988-03-21 FI FI881340A patent/FI881340A7/fi not_active IP Right Cessation
- 1988-03-22 DE DE88302486T patent/DE3886435T2/de not_active Expired - Fee Related
- 1988-03-22 AT AT88302486T patent/ATE98956T1/de not_active IP Right Cessation
- 1988-03-22 EP EP88302486A patent/EP0284338B1/en not_active Expired - Lifetime
- 1988-03-22 ES ES88302486T patent/ES2061641T3/es not_active Expired - Lifetime
- 1988-03-24 CA CA000562300A patent/CA1301756C/en not_active Expired - Lifetime
- 1988-03-24 NO NO881300A patent/NO881300L/no unknown
- 1988-03-24 NZ NZ224010A patent/NZ224010A/en unknown
- 1988-03-24 PT PT87074A patent/PT87074B/pt active IP Right Grant
- 1988-03-25 JP JP63069943A patent/JP2577036B2/ja not_active Expired - Fee Related
- 1988-03-25 DK DK168488A patent/DK167013B1/da not_active IP Right Cessation
1990
- 1990-04-12 US US07/508,528 patent/US4981856A/en not_active Expired - Lifetime
1993
- 1993-12-23 GR GR920402608T patent/GR3010208T3/el unknown

Also Published As

Publication number	Publication date
FI881340A0 (fi)	1988-03-21
DE3886435D1 (de)	1994-02-03
NZ224010A (en)	1990-12-21
ATE98956T1 (de)	1994-01-15
GB2202847B (en)	1990-06-06
DE3886435T2 (de)	1994-04-14
NO881300L (no)	1988-09-26
ES2061641T3 (es)	1994-12-16
JP2577036B2 (ja)	1997-01-29
DK167013B1 (da)	1993-08-16
EP0284338B1 (en)	1993-12-22
CA1301756C (en)	1992-05-26
EP0284338A3 (en)	1989-05-17
EP0284338A2 (en)	1988-09-28
GR3010208T3 (da)	1994-03-31
IL85696A (en)	1993-05-13
PT87074B (pt)	1992-07-31
GB2202847A (en)	1988-10-05
FI881340A7 (fi)	1988-09-26
PT87074A (pt)	1988-04-01
GB8707053D0 (en)	1987-04-29
JPS63255270A (ja)	1988-10-21
NO881300D0 (no)	1988-03-24
GB8805982D0 (en)	1988-04-13
AU1327988A (en)	1988-09-29
US4981856A (en)	1991-01-01
AU600105B2 (en)	1990-08-02
DK168488D0 (da)	1988-03-25
ZA881885B (en)	1988-09-26

Legal Events

Date	Code	Title
1993-08-16	B1	Patent granted (law 1993)
1994-04-05	B1	Patent granted (law 1993)
1995-11-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK168488D0 (da)	1988-03-25	Quinazolinderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
IE870699L (en)	1987-09-27	Quinazoline derivatives
DK0444659T3 (da)	1996-11-18	Farmaceutisk opløsning indeholdende derivater af FK 506
NO301543B1 (no)	1997-11-10	2-£4-(kinazolinylmetylamino)benzamido\|-4-(tetrazolyl)smörsyrederivater med anti-tumor-aktivitet
DE3588100D1 (de)	1996-05-23	Carbamidsäureester-Derivate, Mittel und Herstellungsverfahren
FI885559A0 (fi)	1988-11-30	Anvaendning av d-cykloserin och dess prodrug som cognition oekande medel.
EP0242690A3 (en)	1989-01-18	5h-1,3,4-thiadiazoloû3,2-a¨pyrimidin-5-one derivatives and agricultural-horticultural fungicide composition containing the same
FI915783A0 (fi)	1991-12-09	N-jodipropargyloxikarbonyl- aminosyraesterar och derivat daerav samt deras anvaendning som antimikroba medel.
ES8402581A1 (es)	1984-02-01	Un procedimiento para preparar derivados de imidazol y triazol.
DK377687D0 (da)	1987-07-20	Triazol-fungicidpraeparater
DK165636C (da)	1993-06-01	1,5-disubstituerede imidazolderivater, fremgangsmaade til fremstilling af saadanne forbindelser, fungicidt praeparat indeholdende saadanne forbindelser samt anvendelse af saadanne forbindelser som fungicider
DK0676399T3 (da)	2000-03-20	Methotrexaderivater
DK164908C (da)	1993-01-25	Phenoxyphthalidderivater, fremgangsmaade til deres fremstilling, samt herbicidt praeparat indeholdende disse
ES8404370A1 (es)	1984-04-16	Procedimiento para preparar fosfatos de oximas aciclicos y heterociclicos con actividad insecticida, acaricida y nematocida.
ATE64375T1 (de)	1991-06-15	N-acyl-aminosaeure-derivate, herstellungsverfahren und verwendung als herbizide.
BR0208440A (pt)	2004-03-30	Derivados de pirimidina-2,4,6-triona, processos para sua produção e agentes farmacêuticos contendo esses compostos