DK1670779T3 - Fremgangsmåde til fremstilling af 3-methylamino-1-(thien-2-yl)-propan-1-ol - Google Patents
Fremgangsmåde til fremstilling af 3-methylamino-1-(thien-2-yl)-propan-1-olInfo
- Publication number
- DK1670779T3 DK1670779T3 DK04765718.4T DK04765718T DK1670779T3 DK 1670779 T3 DK1670779 T3 DK 1670779T3 DK 04765718 T DK04765718 T DK 04765718T DK 1670779 T3 DK1670779 T3 DK 1670779T3
- Authority
- DK
- Denmark
- Prior art keywords
- thien
- propan
- methylamino
- preparation
- enzymes
- Prior art date
Links
- YEJVVFOJMOHFRL-UHFFFAOYSA-N 3-(methylamino)-1-thiophen-2-ylpropan-1-ol Chemical compound CNCCC(O)C1=CC=CS1 YEJVVFOJMOHFRL-UHFFFAOYSA-N 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10345772A DE10345772A1 (de) | 2003-10-01 | 2003-10-01 | Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol |
| PCT/EP2004/010939 WO2005033094A2 (de) | 2003-10-01 | 2004-09-30 | Verfahren zur herstellung von 3-methylamino-1-(thien-2-yl)-propan-1-ol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1670779T3 true DK1670779T3 (da) | 2011-02-28 |
Family
ID=34353261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04765718.4T DK1670779T3 (da) | 2003-10-01 | 2004-09-30 | Fremgangsmåde til fremstilling af 3-methylamino-1-(thien-2-yl)-propan-1-ol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7498448B2 (da) |
| EP (1) | EP1670779B1 (da) |
| JP (2) | JP2007533628A (da) |
| CN (1) | CN1860110B (da) |
| AT (1) | ATE489377T1 (da) |
| DE (2) | DE10345772A1 (da) |
| DK (1) | DK1670779T3 (da) |
| ES (1) | ES2357115T3 (da) |
| PT (1) | PT1670779E (da) |
| SI (1) | SI1670779T1 (da) |
| WO (1) | WO2005033094A2 (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004022686A1 (de) | 2004-05-05 | 2005-11-24 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| DE102005010804A1 (de) * | 2005-03-07 | 2006-09-14 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| DE102005044736A1 (de) * | 2005-09-19 | 2007-03-22 | Basf Ag | Neue Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von optisch aktiven Alkanolen |
| DE102005062661A1 (de) * | 2005-12-23 | 2007-08-16 | Basf Ag | Verfahren zur Herstellung von optisch aktivem (1S)-3-Chlor-(-thien-2-yl)-propan-1-ol |
| DE102005062662A1 (de) * | 2005-12-23 | 2007-06-28 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| EP2044049A2 (en) | 2006-07-03 | 2009-04-08 | Ranbaxy Laboratories Limited | Process for the preparation of enantiomerically pure salts of n-methyl- 3 -( 1-naph-thaleneoxy)- 3 - (-2-thienyl) propanamine |
| WO2008042876A2 (en) | 2006-10-02 | 2008-04-10 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
| CN101627116B (zh) | 2007-02-08 | 2013-07-10 | 科德克希思公司 | 酮还原酶及其用途 |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス, インコーポレイテッド | (r)−3−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| KR101586503B1 (ko) | 2007-09-13 | 2016-01-18 | 코덱시스, 인코포레이티드 | 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드 |
| CN101889081B (zh) | 2007-09-28 | 2014-06-18 | 科德克希思公司 | 酮还原酶多肽及其用途 |
| HUE027683T2 (en) | 2007-10-01 | 2016-10-28 | Codexis Inc | Ketoreductase polypeptides for the production of azetidinone |
| EP2060559A1 (en) * | 2007-11-19 | 2009-05-20 | Cadila Pharmaceuticals Limited | Process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines and their optical stereoisomers |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025238A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| SI2329014T1 (sl) | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
| CN102317450A (zh) | 2008-12-17 | 2012-01-11 | 巴斯夫欧洲公司 | 用于制备度洛西汀(duloxetine)醇之改良生物催化剂 |
| EP2226386A1 (de) | 2009-03-05 | 2010-09-08 | IEP GmbH | Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen |
| WO2011022548A2 (en) | 2009-08-19 | 2011-02-24 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts for ezetimibe synthesis |
| HUE038800T2 (hu) * | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
| CN107746861B (zh) * | 2017-11-20 | 2020-06-23 | 浙江工业大学 | 一种(r)-1-(2-三氟甲基苯基)乙醇的生物制备方法 |
| CN116410946A (zh) * | 2023-01-20 | 2023-07-11 | 浙江工业大学 | 一种羰基还原酶LsCR突变体及其催化合成手性醇的应用 |
| CN117737149B (zh) * | 2024-02-20 | 2024-05-07 | 山东君泰药业有限公司 | 一种酶催化合成高纯度s-玻色因的方法 |
| WO2026083999A1 (ja) * | 2024-10-16 | 2026-04-23 | 株式会社日本触媒 | イソプロパノール生産能を有するコリネバクテリウム属細菌、及び微生物を用いたイソプロパノールの製造方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803173A (en) * | 1971-04-26 | 1974-04-09 | Degussa | 3-(3-(1-(4-hydroxyphenyl)-1-hydroxypropyl-(2)-amino)-propionyl)-thiophene |
| KR880007433A (ko) | 1986-12-22 | 1988-08-27 | 메리 앤 터커 | 3-아릴옥시-3-치환된 프로판아민 |
| IL98108A0 (en) | 1990-05-17 | 1992-06-21 | Lilly Co Eli | Chiral synthesis of 1-aryl-3-aminopropan-1-ols |
| US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| DE19857302C2 (de) * | 1998-12-14 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester |
| JP2003504070A (ja) * | 1999-07-09 | 2003-02-04 | フォルシュングスツェントルム ユーリッヒ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ケトカルボン酸及びそのエステルの還元のための方法 |
| DE19931847A1 (de) * | 1999-07-09 | 2001-01-11 | Basf Ag | Immobilisierte Lipase |
| AU1551701A (en) * | 1999-12-03 | 2001-06-12 | Kaneka Corporation | Novel carbonyl reductase, gene thereof and method of using the same |
| DE10019380A1 (de) | 2000-04-19 | 2001-10-25 | Basf Ag | Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen |
| JP4818507B2 (ja) * | 2000-11-21 | 2011-11-16 | 三菱レイヨン株式会社 | 光学活性3−キヌクリジノールの製造法 |
| JP2002165393A (ja) * | 2000-11-27 | 2002-06-07 | Toshiba Tec Corp | ブラシレスモータ |
| JP4913296B2 (ja) * | 2001-09-21 | 2012-04-11 | 三菱レイヨン株式会社 | 光学活性アルコール及びその製造方法 |
| JP4170221B2 (ja) * | 2001-10-05 | 2008-10-22 | 株式会社カネカ | 光学活性3−ヒドロキシペンタンニトリルの製造方法 |
| JP2003199595A (ja) * | 2001-10-24 | 2003-07-15 | Daicel Chem Ind Ltd | 光学活性マンデル酸誘導体の製造方法 |
| JP2003192681A (ja) * | 2001-12-27 | 2003-07-09 | Mitsubishi Rayon Co Ltd | (s)−3−クロロ−1−(2−チエニル)−1−プロパノール及び(s)−3−n−メチルアミノ−1−(2−チエニル)−1−プロパノールの製造方法 |
| DE10248479A1 (de) * | 2002-10-17 | 2004-05-06 | Consortium für elektrochemische Industrie GmbH | Verfahren zur Herstellung von Thienyl-substituierten sekundären Aminoalkoholen |
| DE10248480A1 (de) * | 2002-10-17 | 2004-05-06 | Consortium für elektrochemische Industrie GmbH | Verfahren zur Herstellung von Thienyl-substituierten sekundären Aminoalkoholen |
-
2003
- 2003-10-01 DE DE10345772A patent/DE10345772A1/de not_active Withdrawn
-
2004
- 2004-09-30 ES ES04765718T patent/ES2357115T3/es not_active Expired - Lifetime
- 2004-09-30 DE DE502004011932T patent/DE502004011932D1/de not_active Expired - Lifetime
- 2004-09-30 CN CN2004800281086A patent/CN1860110B/zh not_active Expired - Fee Related
- 2004-09-30 PT PT04765718T patent/PT1670779E/pt unknown
- 2004-09-30 DK DK04765718.4T patent/DK1670779T3/da active
- 2004-09-30 JP JP2006530058A patent/JP2007533628A/ja active Pending
- 2004-09-30 WO PCT/EP2004/010939 patent/WO2005033094A2/de not_active Ceased
- 2004-09-30 EP EP04765718A patent/EP1670779B1/de not_active Expired - Lifetime
- 2004-09-30 SI SI200431560T patent/SI1670779T1/sl unknown
- 2004-09-30 AT AT04765718T patent/ATE489377T1/de active
- 2004-09-30 US US10/573,130 patent/US7498448B2/en not_active Expired - Fee Related
-
2011
- 2011-01-14 JP JP2011005361A patent/JP2011142908A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1670779A2 (de) | 2006-06-21 |
| JP2011142908A (ja) | 2011-07-28 |
| WO2005033094A2 (de) | 2005-04-14 |
| PT1670779E (pt) | 2010-12-16 |
| SI1670779T1 (sl) | 2011-01-31 |
| CN1860110B (zh) | 2012-03-21 |
| JP2007533628A (ja) | 2007-11-22 |
| DE10345772A1 (de) | 2005-04-21 |
| ATE489377T1 (de) | 2010-12-15 |
| WO2005033094A3 (de) | 2005-11-24 |
| CN1860110A (zh) | 2006-11-08 |
| US20070083055A1 (en) | 2007-04-12 |
| US7498448B2 (en) | 2009-03-03 |
| ES2357115T3 (es) | 2011-04-18 |
| DE502004011932D1 (de) | 2011-01-05 |
| EP1670779B1 (de) | 2010-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE502004011932D1 (de) | Verfahren zur herstellung von 3-methylamino-1-(thien-2-yl)-propan-1-ol | |
| MX2021004898A (es) | Enzima de crispr/cas12f y sistema novedosos. | |
| ATE530643T1 (de) | Säureaktive fungale protease | |
| DK1208205T3 (da) | Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH | |
| DK1266011T3 (da) | Svampetranskriptionsaktivator, der er anvendelig i fremgangsmåder til fremstilling af polypeptider | |
| WO2005069762A8 (en) | Bacillus licheniformis chromosome | |
| EA201170715A1 (ru) | Вектор, содержащий множественные гомологичные нуклеотидные последовательности | |
| WO2002086144A3 (en) | Compositions and methods for recombinational cloning of nucleic acid molecules | |
| DK1675956T3 (da) | Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression | |
| AU2003258187A8 (en) | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives | |
| DK1242601T3 (da) | Trichoderma reesei-xylanase | |
| DK1157100T3 (da) | Oxaloacetathydrolase-defekte svampeværtsceller | |
| ATE532861T1 (de) | Expressionsvektor | |
| WO2003064622A3 (en) | Aggrecanase molecules | |
| DE502005007057D1 (de) | Verfahren zur herstellung von (s)-butan-2-ol | |
| DK1756273T3 (da) | Signalpeptid til frembringelse af et polypeptid | |
| DK1226236T3 (da) | Polypeptider, der har glucanotransferase-aktivitet, og nucleinsyrer, som koder disse | |
| EA201100583A1 (ru) | СПОСОБ ПОЛУЧЕНИЯ ε-КАПРОЛАКТАМА ИЗ N-АЦИЛ-6-АМИНОКАПРОНОВОЙ КИСЛОТЫ | |
| WO2004085651A3 (en) | Pantolactone hydrolase | |
| ATE414905T1 (de) | Diabetesmodell | |
| WO2002033093A3 (en) | Aggrecanase molecules | |
| WO2003064597A3 (en) | Aggrecanase molecules | |
| EA200702009A1 (ru) | Усовершенствованный способ экспрессирующего клонирования в клетке-хозяине | |
| WO2003004607A3 (en) | Aggrecanase molecules | |
| WO2002077009A3 (en) | Polypeptides having gamma-glutamyl transpeptidase activity and nucleic acids encoding same |