DK167158B1 - Dna-sekvens, der koder for et protein, der er immunologisk reaktivt mod antistoffer for lav, et rekombinantplasmid indeholdende dna-sekvensen, bakteriecelle med rekombinantplasmidet, fremgangsmaade til fremstilling af proteiner som er immunologisk reaktive med antistoffer for lav, samt proteinet og anvendelser af proteinet - Google Patents

Dna-sekvens, der koder for et protein, der er immunologisk reaktivt mod antistoffer for lav, et rekombinantplasmid indeholdende dna-sekvensen, bakteriecelle med rekombinantplasmidet, fremgangsmaade til fremstilling af proteiner som er immunologisk reaktive med antistoffer for lav, samt proteinet og anvendelser af proteinet Download PDF

Info

Publication number: DK167158B1
Authority: DK; Denmark
Prior art keywords: protein; lav; antibodies; env; penv
Prior art date: 1985-04-08

Application number

DK157186A

Other languages

Danish (da)

English (en)

Other versions

DK157186A (da

DK157186D0 (da

Inventor

Susan Mitsue Watanabe

Wesley Cosand

Susan Mcardle

Bruce Mcfarland Travis

Original Assignee

Genetic Systems Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-08

Filing date

1986-04-07

Publication date

1993-09-06

1985-11-07 Priority claimed from US06/783,299 external-priority patent/US4784941A/en

1986-04-07 Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp

1986-04-07 Publication of DK157186D0 publication Critical patent/DK157186D0/da

1986-10-09 Publication of DK157186A publication Critical patent/DK157186A/da

1993-09-06 Application granted granted Critical

1993-09-06 Publication of DK167158B1 publication Critical patent/DK167158B1/da

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)

DK157186A 1985-04-08 1986-04-07 Dna-sekvens, der koder for et protein, der er immunologisk reaktivt mod antistoffer for lav, et rekombinantplasmid indeholdende dna-sekvensen, bakteriecelle med rekombinantplasmidet, fremgangsmaade til fremstilling af proteiner som er immunologisk reaktive med antistoffer for lav, samt proteinet og anvendelser af proteinet DK167158B1 (da)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US72123785A	1985-04-08	1985-04-08
US72123785		1985-04-08
US72805285A	1985-04-29	1985-04-29
US72805285		1985-04-29
US75376985A	1985-07-10	1985-07-10
US75376985		1985-07-10
US06/783,299 US4784941A (en)	1985-04-08	1985-11-07	Expression and diagnostic use of pENV-3 encoded peptides which are immunologically reactive with antibodies to LAV
US78329985		1985-11-07

Publications (3)

Publication Number	Publication Date
DK157186D0 DK157186D0 (da)	1986-04-07
DK157186A DK157186A (da)	1986-10-09
DK167158B1 true DK167158B1 (da)	1993-09-06

Family

ID=27505552

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK157186A DK167158B1 (da)	1985-04-08	1986-04-07	Dna-sekvens, der koder for et protein, der er immunologisk reaktivt mod antistoffer for lav, et rekombinantplasmid indeholdende dna-sekvensen, bakteriecelle med rekombinantplasmidet, fremgangsmaade til fremstilling af proteiner som er immunologisk reaktive med antistoffer for lav, samt proteinet og anvendelser af proteinet

Country Status (11)

Country	Link
EP (1)	EP0201716B1 (de)
JP (1)	JP2679973B2 (de)
AT (1)	ATE109830T1 (de)
AU (1)	AU571128B2 (de)
DE (1)	DE3650019T2 (de)
DK (1)	DK167158B1 (de)
ES (1)	ES8706208A1 (de)
FI (1)	FI861485A7 (de)
GR (1)	GR860914B (de)
IE (1)	IE64785B1 (de)
NO (1)	NO301176B1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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US4774175A (en) *	1985-03-01	1988-09-27	Centocor, Inc.	Immunochemical methods for the detection of antibody against HTLV-III
FI861626A7 (fi) *	1985-04-19	1986-10-20	Hoffmann La Roche	Foervaervat immunbristsyndrom (aids) -relaterat viralt rekombinant hoeljeprotein samt ett testfoerfarande foer aids.
US5773210A (en) *	1985-04-19	1998-06-30	The United States Of America As Represented By The Department Of Health And Human Services	Acquired immune deficiency syndrome (AIDS) viral envelope protein and method of testing for AIDS
JP2702911B2 (ja) *	1985-09-11	1998-01-26	ユナイテツド・バイオメデイカル・インコ−ポレ−テツド	合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法
US4734362A (en) *	1986-02-03	1988-03-29	Cambridge Bioscience Corporation	Process for purifying recombinant proteins, and products thereof
US4772547A (en) *	1986-02-03	1988-09-20	Hoffmann-La Roche Inc.	HTLV-III envelope peptides
US4879212A (en) *	1986-04-02	1989-11-07	United Biomedical Inc.	Peptide composition and method for the detection of antibodies to HTLV-III
DE3789633T2 (de) *	1986-05-27	1994-08-04	Hoffmann La Roche	HTLV-III(LAV)Decke-Peptide.
US5017688A (en) *	1986-06-12	1991-05-21	Biogen, Inc.	Peptides involved in the pathogenesis of HIV infection
US4943627A (en) *	1986-06-12	1990-07-24	Biogen, Inc.	Peptides involved in the pathogenesis of HIV infection
DK169582B1 (da) *	1986-06-23	1994-12-12	Squibb Bristol Myers Co	Humant monoklonalt antistof, der er i stand til at reagere med en epitop på LAV/HTLV-III kappeglycoproteinet gp41, cellelinier, som producerer sådant antistof, farmaceutisk præparat indeholdende antistoffet samt fremgangsmåde til bestemmelse af nærværelsen af LAV/HTLV-III i en biologisk prøve og fremgangsmåde til separering af specifikke antigendeterminanter af LAV/HTLV-III under anvendelse af ant
EP0255190A3 (de) *	1986-08-01	1990-08-29	Repligen Corporation	Rekombinante Polypeptide und ihre Verwendungen sowie Test für den AIDS-Virus
NZ221440A (en) *	1986-08-20	1991-11-26	Genetic Systems Corp	Composition containing monoclonal antibodies/peptides useful in treating and diagnosing hiv infections
NO881151L (no) *	1987-03-27	1988-09-28	Syntello Ab	Syntetisk hiv-1-antigen.
SE8701628D0 (sv) *	1987-04-16	1987-04-16	Erling Norrby	Medel for analys mm
US4921787A (en) *	1987-05-01	1990-05-01	Cambridge Bioscience Corporation	Detection of antibodies to human immunodeficiency virus by agglutination of antigen coated latex
US5447837A (en) *	1987-08-05	1995-09-05	Calypte, Inc.	Multi-immunoassay diagnostic system for antigens or antibodies or both
JP2549305B2 (ja) *	1987-08-05	1996-10-30	カリプト・インコーポレイテツド	独立多重式免疫測定法診断システム
DE3727137A1 (de) *	1987-08-14	1989-02-23	Behringwerke Ag	Herstellung von antigenen des human immunodeficiency virus typ 1 sowie deren verwendung als diagnostisches mittel und therapeutikum
DE4405810A1 (de)	1994-02-23	1995-08-24	Behringwerke Ag	Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung

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US3817837A (en)	1971-05-14	1974-06-18	Syva Corp	Enzyme amplification assay
US3766162A (en)	1971-08-24	1973-10-16	Hoffmann La Roche	Barbituric acid antigens and antibodies specific therefor
US3996345A (en)	1974-08-12	1976-12-07	Syva Company	Fluorescence quenching with immunological pairs in immunoassays
US4233402A (en)	1978-04-05	1980-11-11	Syva Company	Reagents and method employing channeling
IL76082A (en) *	1984-08-22	1991-07-18	Us Health	Molecular clones of the genome of htlv-iii and a process for the preparation thereof
US9328391B1 (en) *	1984-08-22	2016-05-03	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Cloning and expression of HIV-1 DNA
CA1341423C (en) *	1984-10-31	2003-03-04	Paul A. Luciw	Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
AU600658B2 (en) *	1984-12-24	1990-08-23	Genentech Inc.	Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
FR2580177B2 (fr) *	1985-04-15	1989-06-02	Pasteur Institut	Antigenes apparentes a la glycoproteine d'enveloppe du virus du sida, notamment precurseurs de cette glycoproteine, procedes d'obtention de ces antigenes et moyens mis en oeuvre dans ces procedes, applications de ces antigenes a la preparation de compositions immunogenes ou pour le diagnostic du sida ou des affections qui lui sont apparentees
FI861626A7 (fi) *	1985-04-19	1986-10-20	Hoffmann La Roche	Foervaervat immunbristsyndrom (aids) -relaterat viralt rekombinant hoeljeprotein samt ett testfoerfarande foer aids.
JP2702911B2 (ja) *	1985-09-11	1998-01-26	ユナイテツド・バイオメデイカル・インコ−ポレ−テツド	合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法

1986
- 1986-04-04 IE IE89386A patent/IE64785B1/xx not_active IP Right Cessation
- 1986-04-07 FI FI861485A patent/FI861485A7/fi not_active Application Discontinuation
- 1986-04-07 ES ES553757A patent/ES8706208A1/es not_active Expired
- 1986-04-07 EP EP86104741A patent/EP0201716B1/de not_active Expired - Lifetime
- 1986-04-07 AT AT86104741T patent/ATE109830T1/de not_active IP Right Cessation
- 1986-04-07 GR GR860914A patent/GR860914B/el unknown
- 1986-04-07 DE DE3650019T patent/DE3650019T2/de not_active Expired - Fee Related
- 1986-04-07 DK DK157186A patent/DK167158B1/da not_active IP Right Cessation
- 1986-04-08 JP JP61080946A patent/JP2679973B2/ja not_active Expired - Lifetime
- 1986-04-08 NO NO861355A patent/NO301176B1/no unknown
- 1986-04-08 AU AU55727/86A patent/AU571128B2/en not_active Ceased

Also Published As

Publication number	Publication date
NO861355L (no)	1986-10-09
DK157186A (da)	1986-10-09
IE860893L (en)	1986-10-08
IE64785B1 (en)	1995-09-06
ES8706208A1 (es)	1987-06-01
ES553757A0 (es)	1987-06-01
ATE109830T1 (de)	1994-08-15
GR860914B (en)	1986-07-25
DE3650019T2 (de)	1995-03-09
DK157186D0 (da)	1986-04-07
EP0201716B1 (de)	1994-08-10
AU571128B2 (en)	1988-03-31
FI861485A7 (fi)	1986-10-09
NO301176B1 (no)	1997-09-22
FI861485A0 (fi)	1986-04-07
EP0201716A2 (de)	1986-11-20
AU5572786A (en)	1986-10-16
JPS62239992A (ja)	1987-10-20
DE3650019D1 (de)	1994-09-15
EP0201716A3 (en)	1987-03-04
JP2679973B2 (ja)	1997-11-19

Legal Events

Date	Code	Title
1993-09-06	B1	Patent granted (law 1993)
1996-11-18	PBP	Patent lapsed
1999-11-29	PBP	Patent lapsed

Publication	Publication Date	Title
US4784941A (en)	1988-11-15	Expression and diagnostic use of pENV-3 encoded peptides which are immunologically reactive with antibodies to LAV
EP0201716B1 (de)	1994-08-10	Expression von Virusproteinen mit immunologischer Aktivität
Whetstone et al.	1990	Humoral immune response to the bovine immunodeficiency-like virus in experimentally and naturally infected cattle
CA1341409C (en)	2002-12-17	Cloning and expression of htlv-iii dna
DK171119B1 (da)	1996-06-17	AIDS-viruskappeprotein, ekspressionsvektor bærende viruskappeproteinet, transformanter transformeret med ekspressionsvektoren, fremgangsmåde til fremstilling af viruskappeproteinet, fremgangsmåde til detektion af AIDS-antistoffer, fremgangsmåde til bestemmelse af AIDS-virus, vaccine mod AIDS, antistoffer mod viruskappeproteinet samt anvendelse af dette til fremstilling af en vaccine og til testnin
JP3073752B2 (ja)	2000-08-07	Ｈｉｖエンベロープタンパク質およびそれを用いたｈｉｖ抗原に対する抗体の検出方法
EP0258404B1 (de)	1992-05-20	Verfahren zum nachweis eines antikörpers gegen htlv-iii
AU594333B2 (en)	1990-03-08	Expression and diagnostic use of gag encoded peptides which are immunologically reactive with antibodies to lav
Steimer et al.	1986	Recombinant polypeptide from the endonuclease region of the acquired immune deficiency syndrome retrovirus polymerase (pol) gene detects serum antibodies in most infected individuals
Hadlock et al.	1997	Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46
US5175098A (en)	1992-12-29	Expression and diagnostic use of gag encoded peptides which are immunologically reactive with antibodies to HIV
JPS6226300A (ja)	1987-02-04	Ｈｔｌｖ−３ｄｎａのクロ−ニングおよび発現
US5175097A (en)	1992-12-29	Expression and diagnostic use of GAG-1 encoded peptides which are immunologically reactive with antibodies to HIV
Bhardwaj et al.	2006	Recombinant HIV-1 p24 protein: cloning, expression, purification and use in the development of ELISA kits
US5328835A (en)	1994-07-12	Expression of immunologically reactive HIV envelope proteins
EP0345792A2 (de)	1989-12-13	HTLV-1/HIV-1-Fusionsproteine
DK168892B1 (da)	1994-07-04	DNA-sekvens, der koder for proteiner, som er immunologisk reaktive med antistoffer mod LAV/HTLV-III, rekombinant plasmid indeholdende DNA'et, Bakteriecelle transformeret med plasmidet, fremgangsmåde til fremstilling af proteinet og anvendelse af proteinet ved analyser.
KR910000748B1 (ko)	1991-02-06	사람 면역결핍증 바이러스의 gag-암호화된 단백질
EP0494317A1 (de)	1992-07-15	SIV cpz-ant Retrovirus und seine Anwendungen
EP0235923B1 (de)	1991-01-09	SOR-Genprodukt von lymphotropem Virus-III menschlicher T-Zellen
KR100264341B1 (ko)	2000-08-16	후천성면역결핍바이러스-1o형 특이항원 및 그의 제조방법
Sohn et al.	1994	Overexpression and simple purification of human immunodeficiency virus-1 gag epitope derived from a recombinant antigen in E. coli and its use in ELISA