DK1678185T3 - 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose - Google Patents

2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose

Info

Publication number
DK1678185T3
DK1678185T3 DK04793412T DK04793412T DK1678185T3 DK 1678185 T3 DK1678185 T3 DK 1678185T3 DK 04793412 T DK04793412 T DK 04793412T DK 04793412 T DK04793412 T DK 04793412T DK 1678185 T3 DK1678185 T3 DK 1678185T3
Authority
DK
Denmark
Prior art keywords
nitroimidazo
tuberculosis
dihydro
treatment
oxazole compounds
Prior art date
Application number
DK04793412T
Other languages
English (en)
Inventor
Hidetsugu Tsubouchi
Hirofumi Sasaki
Motohiro Itotani
Yoshikazu Haraguchi
Shin Miyamura
Makoto Matsumoto
Hiroyuki Hashizume
Tatsuo Grand Kawauch Tomishige
Masanori Kawasaki
Kinue Ohguro
Takumi Sumida
Takeshi Hasegawa
Kazuho Tanaka
Isao Takemura
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of DK1678185T3 publication Critical patent/DK1678185T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK04793412T 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose DK1678185T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003373206 2003-10-31
JP2004111720 2004-04-06
PCT/JP2004/016492 WO2005042542A1 (en) 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis

Publications (1)

Publication Number Publication Date
DK1678185T3 true DK1678185T3 (da) 2008-12-08

Family

ID=34554779

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04793412T DK1678185T3 (da) 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose

Country Status (19)

Country Link
US (1) US8163753B2 (da)
EP (1) EP1678185B1 (da)
KR (1) KR100851802B1 (da)
AR (1) AR046777A1 (da)
AT (1) ATE410430T1 (da)
AU (1) AU2004285811B2 (da)
BR (1) BRPI0414909A (da)
CA (1) CA2539335A1 (da)
CY (1) CY1108481T1 (da)
DE (1) DE602004017037D1 (da)
DK (1) DK1678185T3 (da)
ES (1) ES2314460T3 (da)
MY (1) MY146646A (da)
PL (1) PL1678185T3 (da)
PT (1) PT1678185E (da)
RU (1) RU2365593C2 (da)
SI (1) SI1678185T1 (da)
TW (1) TWI335331B (da)
WO (1) WO2005042542A1 (da)

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SI1678185T1 (sl) * 2003-10-31 2009-02-28 Otsuka Pharma Co Ltd Spojine 2,3-dihidro-6-nitroimidazo (2,1-b) oksazol za zdravljenje tuberkuloze
ES2336130T3 (es) 2004-10-18 2010-04-08 Eli Lilly And Company Derivados 1-(hetero)aril-3-amino-pirrolidina para uso como antagonistas del receptor de mglur3.
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US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
PL1906926T3 (pl) * 2005-07-28 2011-04-29 Otsuka Pharma Co Ltd Kompozycja farmaceutyczna zawierająca pochodne 2,3-dihydro-6-nitroimidazo[2,1-B]oksazolu
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
TW201233389A (en) 2005-10-05 2012-08-16 Otsuka Pharma Co Ltd Antituberculous therapeutic drugs and kit containing the same
JP5105818B2 (ja) * 2005-10-05 2012-12-26 大塚製薬株式会社 医薬組成物
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
JP2009521464A (ja) * 2005-12-23 2009-06-04 ノバルティス アクチエンゲゼルシャフト ニトロイミダゾール化合物
EP2027121A1 (en) * 2006-05-22 2009-02-25 Merck Frosst Canada Ltd. Cyclic amine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US7678791B2 (en) 2006-07-12 2010-03-16 Cumbre Ip Ventures, L.P. Nitroheteroaryl-containing rifamycin derivatives
AR070301A1 (es) * 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
CN101965353B (zh) * 2008-03-26 2014-12-17 丹诺医药(苏州）有限公司 共价连接到取代苯基噁唑烷酮的双环硝基咪唑类
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
NZ598165A (en) * 2009-07-31 2013-05-31 Global Alliance For Tb Drug Dev Nitroimidazooxazine and nitroimidazooxazole analogues and their uses
US9051333B2 (en) 2011-04-15 2015-06-09 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
KR20130083592A (ko) * 2012-01-13 2013-07-23 현대약품 주식회사 치환된 피페리딘 유도체 및 이의 제조방법
KR101650716B1 (ko) * 2012-11-22 2016-08-24 한국화학연구원 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
IN2013DE02954A (da) * 2013-10-04 2015-04-10 Council Scient Ind Res
US11279714B2 (en) * 2014-06-20 2022-03-22 Institut Pasteur Korea Anti-infective compounds
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
TWI687409B (zh) 2014-08-28 2020-03-11 日商大塚製藥股份有限公司 稠合雜環化合物
MX383020B (es) * 2014-10-01 2025-03-13 Henkel Ag & Co Kgaa Aceleradores de curado para composiciones curables anaerobicas.
JP6467042B2 (ja) * 2014-10-21 2019-02-06 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 抗マイコバクテリア剤としての置換１，２，３−トリアゾール−１−イル−メチル−２，３−ジヒドロ−２−メチル−６−ニトロイミダゾ［２，１−ｂ］オキサゾールとその調製方法
EP3252059A4 (en) * 2015-01-29 2018-07-11 Medshine Discovery Inc. Anti-pulmonary tuberculosis nitroimidazole derivative
US10851079B2 (en) 2016-02-26 2020-12-01 Otsuka Pharmaceutical Co., Ltd. Piperidine derivative
WO2018112842A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
CN112236141A (zh) 2018-06-11 2021-01-15 大塚制药株式会社 包含德拉马尼的组合物
EP3669873A1 (en) 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use ine the traeatment of inflammation diseases
CN112300192B (zh) * 2019-08-02 2023-08-11 南京长澳医药科技有限公司 硝基咪唑类化合物及其制备方法和用途

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TW200838855A (en) * 2002-10-15 2008-10-01 Otsuka Pharma Co Ltd Method for preparing 1-substituted-4-nitroimidazole compound
SI1678185T1 (sl) * 2003-10-31 2009-02-28 Otsuka Pharma Co Ltd Spojine 2,3-dihidro-6-nitroimidazo (2,1-b) oksazol za zdravljenje tuberkuloze
PL1906926T3 (pl) * 2005-07-28 2011-04-29 Otsuka Pharma Co Ltd Kompozycja farmaceutyczna zawierająca pochodne 2,3-dihydro-6-nitroimidazo[2,1-B]oksazolu

Also Published As

Publication number Publication date
US20080119478A1 (en) 2008-05-22
EP1678185B1 (en) 2008-10-08
EP1678185A1 (en) 2006-07-12
AU2004285811A1 (en) 2005-05-12
BRPI0414909A (pt) 2006-11-07
HK1097258A1 (zh) 2007-06-22
CA2539335A1 (en) 2005-05-12
ES2314460T3 (es) 2009-03-16
AU2004285811B2 (en) 2008-06-12
PL1678185T3 (pl) 2009-04-30
DE602004017037D1 (de) 2008-11-20
AR046777A1 (es) 2005-12-21
RU2365593C2 (ru) 2009-08-27
PT1678185E (pt) 2009-01-13
KR20060085644A (ko) 2006-07-27
SI1678185T1 (sl) 2009-02-28
KR100851802B1 (ko) 2008-08-13
RU2006118794A (ru) 2007-12-10
TWI335331B (en) 2011-01-01
CY1108481T1 (el) 2014-04-09
ATE410430T1 (de) 2008-10-15
US8163753B2 (en) 2012-04-24
MY146646A (en) 2012-09-14
WO2005042542A1 (en) 2005-05-12
TW200528460A (en) 2005-09-01

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