BRPI0414909A - composto, agente antituberculoso, e, método para produzir um composto - Google Patents

composto, agente antituberculoso, e, método para produzir um composto

Info

Publication number
BRPI0414909A
BRPI0414909A BRPI0414909-2A BRPI0414909A BRPI0414909A BR PI0414909 A BRPI0414909 A BR PI0414909A BR PI0414909 A BRPI0414909 A BR PI0414909A BR PI0414909 A BRPI0414909 A BR PI0414909A
Authority
BR
Brazil
Prior art keywords
compound
group
formula
agent
producing
Prior art date
Application number
BRPI0414909-2A
Other languages
English (en)
Inventor
Hidetsugu Tsubouchi
Hirofumi Sasaki
Motohiro Itotani
Yoshikazu Haraguchi
Shin Miyamura
Makoto Matsumoto
Hiroyuki Hashizume
Tatsuo Tomishige
Masanori Kawasaki
Kinue Ohguro
Takumi Sumida
Takeshi Hasegawa
Kazuho Tanaka
Isao Takemura
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BRPI0414909A publication Critical patent/BRPI0414909A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTO, AGENTE ANTITUBERCULOSO, E, MéTODO PARA PRODUZIR UM COMPOSTO". A presente invenção proporciona um composto de 2,3-diidro-6-nitroimidazo¢2,1-b!oxazol representado pela fórmula geral a seguir: (1) na fórmula (1) acima, R¬ 1¬ representa um átomo de hidrogênio ou grupo alquila C1-C6, n representa um número inteiro de 0 a 6, R¬ 1¬ e - (CH~ 2~)~ n~R¬ 2¬ podem formar um anel espiro representado pela fórmula (30) abaixo, em conjunto com o átomo de carbono adjacente (na fórmula abaixo, RRR representa um grupo piperidila que pode apresentar substituintes no anel piridila), (30) e R¬ 2¬ representa um grupo benzotiazolilóxi, grupo quinolilóxi, grupo piridilóxi ou análogos. O presente composto apresenta uma excelente ação bactericida contra Mycobacterium tuberculosis, Mycobacterium tuberculosis resistente a múltiplas drogas, e bactérias atípicas resistentes a ácido.
BRPI0414909-2A 2003-10-31 2004-10-29 composto, agente antituberculoso, e, método para produzir um composto BRPI0414909A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003373206 2003-10-31
JP2004111720 2004-04-06
PCT/JP2004/016492 WO2005042542A1 (en) 2003-10-31 2004-10-29 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis

Publications (1)

Publication Number Publication Date
BRPI0414909A true BRPI0414909A (pt) 2006-11-07

Family

ID=34554779

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414909-2A BRPI0414909A (pt) 2003-10-31 2004-10-29 composto, agente antituberculoso, e, método para produzir um composto

Country Status (19)

Country Link
US (1) US8163753B2 (pt)
EP (1) EP1678185B1 (pt)
KR (1) KR100851802B1 (pt)
AR (1) AR046777A1 (pt)
AT (1) ATE410430T1 (pt)
AU (1) AU2004285811B2 (pt)
BR (1) BRPI0414909A (pt)
CA (1) CA2539335A1 (pt)
CY (1) CY1108481T1 (pt)
DE (1) DE602004017037D1 (pt)
DK (1) DK1678185T3 (pt)
ES (1) ES2314460T3 (pt)
MY (1) MY146646A (pt)
PL (1) PL1678185T3 (pt)
PT (1) PT1678185E (pt)
RU (1) RU2365593C2 (pt)
SI (1) SI1678185T1 (pt)
TW (1) TWI335331B (pt)
WO (1) WO2005042542A1 (pt)

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WO2005042542A1 (en) * 2003-10-31 2005-05-12 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis
WO2006044454A1 (en) * 2004-10-18 2006-04-27 Eli Lilly And Company 1-(hetero)aryl-3-amino-pyrollidine derivatives for use as mglur3 receptor antagonists
WO2006125181A2 (en) * 2005-05-19 2006-11-23 Xenon Pharmaceuticals Inc. Piperidine derivatives and their use as stearoyl-coa desaturase modulators
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
UA95251C2 (ru) * 2005-07-28 2011-07-25 Оцука Фармасьютикал Ко., Лтд. ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
TW201233389A (en) 2005-10-05 2012-08-16 Otsuka Pharma Co Ltd Antituberculous therapeutic drugs and kit containing the same
JP5105818B2 (ja) * 2005-10-05 2012-12-26 大塚製薬株式会社 医薬組成物
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
RU2008129726A (ru) * 2005-12-23 2010-01-27 Новартис АГ (CH) Нитроимидазольные производные
WO2007134457A1 (en) * 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Cyclic amine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2008008480A2 (en) 2006-07-12 2008-01-17 Cumbre Pharmaceuticals Inc. Nitroheteroaryl-containing rifamycin derivatives
AR070301A1 (es) * 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
CN101965353B (zh) * 2008-03-26 2014-12-17 丹诺医药(苏州）有限公司 共价连接到取代苯基噁唑烷酮的双环硝基咪唑类
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
EP2459570B1 (en) * 2009-07-31 2014-12-24 Global Alliance For Tb Drug Development Nitroimidazooxazine analogues and their uses
EP2697232B1 (en) 2011-04-15 2016-05-18 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo[2,1-b][1,3]oxazine bactericides
KR20130083592A (ko) * 2012-01-13 2013-07-23 현대약품 주식회사 치환된 피페리딘 유도체 및 이의 제조방법
KR101650716B1 (ko) * 2012-11-22 2016-08-24 한국화학연구원 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
ES2707362T3 (es) 2013-10-04 2019-04-03 Council Scient Ind Res 6-nitro-2,3-dihidroimidazo [2,1-b] oxazoles y un procedimiento de preparación de los mismos
JP2017518339A (ja) * 2014-06-20 2017-07-06 インスティチュート パスツール コリア 抗感染化合物
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
AR101704A1 (es) 2014-08-28 2017-01-04 Otsuka Pharma Co Ltd Compuestos heterocíclicos fusionados
MX383020B (es) * 2014-10-01 2025-03-13 Henkel Ag & Co Kgaa Aceleradores de curado para composiciones curables anaerobicas.
US9822126B1 (en) 2014-10-21 2017-11-21 Council Of Scientific & Industrial Research Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof
JP6542900B2 (ja) 2015-01-29 2019-07-10 メッドシャイン ディスカバリー インコーポレイテッド 抗肺結核症のニトロイミダゾール誘導体
WO2017146246A1 (ja) 2016-02-26 2017-08-31 大塚製薬株式会社 ピペリジン誘導体
WO2018112842A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
GEP20257802B (en) 2018-06-11 2025-09-25 Otsuka Pharma Co Ltd Delamanid-containing composition
EP3669873A1 (en) 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use ine the traeatment of inflammation diseases
CN112300192B (zh) * 2019-08-02 2023-08-11 南京长澳医药科技有限公司 硝基咪唑类化合物及其制备方法和用途

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AR041605A1 (es) * 2002-10-15 2005-05-26 Otsuka Pharma Co Ltd Compuesto 1- sustituido-4-nitroimidazol y metodo para preparar el mismo
WO2005042542A1 (en) * 2003-10-31 2005-05-12 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis
UA95251C2 (ru) * 2005-07-28 2011-07-25 Оцука Фармасьютикал Ко., Лтд. ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА

Also Published As

Publication number Publication date
US20080119478A1 (en) 2008-05-22
DK1678185T3 (da) 2008-12-08
PL1678185T3 (pl) 2009-04-30
TWI335331B (en) 2011-01-01
KR100851802B1 (ko) 2008-08-13
US8163753B2 (en) 2012-04-24
RU2006118794A (ru) 2007-12-10
CA2539335A1 (en) 2005-05-12
HK1097258A1 (zh) 2007-06-22
ES2314460T3 (es) 2009-03-16
AU2004285811B2 (en) 2008-06-12
RU2365593C2 (ru) 2009-08-27
PT1678185E (pt) 2009-01-13
KR20060085644A (ko) 2006-07-27
SI1678185T1 (sl) 2009-02-28
DE602004017037D1 (de) 2008-11-20
AR046777A1 (es) 2005-12-21
TW200528460A (en) 2005-09-01
EP1678185B1 (en) 2008-10-08
WO2005042542A1 (en) 2005-05-12
MY146646A (en) 2012-09-14
AU2004285811A1 (en) 2005-05-12
ATE410430T1 (de) 2008-10-15
EP1678185A1 (en) 2006-07-12
CY1108481T1 (el) 2014-04-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2278 DE 02/09/2014.