DK1679072T5 - Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril - Google Patents
Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindoprilInfo
- Publication number
- DK1679072T5 DK1679072T5 DK05113099T DK05113099T DK1679072T5 DK 1679072 T5 DK1679072 T5 DK 1679072T5 DK 05113099 T DK05113099 T DK 05113099T DK 05113099 T DK05113099 T DK 05113099T DK 1679072 T5 DK1679072 T5 DK 1679072T5
- Authority
- DK
- Denmark
- Prior art keywords
- perindopril
- synthesis
- alanyl
- octahydro
- indole
- Prior art date
Links
- 229960002582 perindopril Drugs 0.000 title abstract 10
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 8
- 230000015572 biosynthetic process Effects 0.000 title 2
- 238000003786 synthesis reaction Methods 0.000 title 2
- 238000000034 method Methods 0.000 title 1
- -1 perindopril phthalic acid salt Chemical class 0.000 abstract 2
- OCQAXYHNMWVLRH-UHFFFAOYSA-N 2,3-dibenzoyl-2,3-dihydroxybutanedioic acid Chemical compound C=1C=CC=CC=1C(=O)C(O)(C(O)=O)C(O)(C(=O)O)C(=O)C1=CC=CC=C1 OCQAXYHNMWVLRH-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN17MU2005 | 2005-01-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1679072T3 DK1679072T3 (da) | 2009-02-09 |
| DK1679072T5 true DK1679072T5 (da) | 2009-04-20 |
Family
ID=36269938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05113099T DK1679072T5 (da) | 2005-01-06 | 2005-12-30 | Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1679072B9 (da) |
| AT (1) | ATE409036T1 (da) |
| DE (1) | DE602005009918D1 (da) |
| DK (1) | DK1679072T5 (da) |
| ES (1) | ES2314583T4 (da) |
| PL (1) | PL1679072T3 (da) |
| PT (1) | PT1679072E (da) |
| SI (1) | SI1679072T1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1679072T5 (da) | 2005-01-06 | 2009-04-20 | Ipca Lab Ltd | Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril |
| US20150252001A1 (en) | 2012-10-10 | 2015-09-10 | Piramal Enterprises Limited | Process for preparation of perindopril intermediate |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503155A2 (fr) | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| DE3177130D1 (de) * | 1980-08-30 | 1990-01-11 | Hoechst Ag | Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung. |
| LU88621I2 (fr) * | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
| FR2620709B1 (fr) | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| IT1292426B1 (it) * | 1997-06-27 | 1999-02-08 | Nicox Sa | Sali nitrati di ace-inibitori |
| FR2807431B1 (fr) | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| ATE365714T1 (de) | 2002-01-30 | 2007-07-15 | Servier Lab | Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese |
| FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
| WO2004099138A2 (en) | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
| SI1362864T1 (sl) | 2003-06-30 | 2007-08-31 | Servier Lab | Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli |
| SI1367061T1 (sl) | 2003-06-30 | 2006-04-30 | Servier Lab | Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli |
| ES2250853T3 (es) | 2003-08-29 | 2006-04-16 | Les Laboratoires Servier | Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables. |
| EP1380591B1 (fr) | 2003-08-29 | 2005-11-16 | Les Laboratoires Servier | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
| DE60308102T2 (de) | 2003-08-29 | 2007-06-21 | Les Laboratoires Servier | Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen |
| SI1420029T1 (sl) * | 2003-12-10 | 2008-08-31 | Servier Lab | Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli |
| DK1679072T5 (da) | 2005-01-06 | 2009-04-20 | Ipca Lab Ltd | Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril |
-
2005
- 2005-12-30 DK DK05113099T patent/DK1679072T5/da active
- 2005-12-30 SI SI200530509T patent/SI1679072T1/sl unknown
- 2005-12-30 PL PL05113099T patent/PL1679072T3/pl unknown
- 2005-12-30 ES ES05113099T patent/ES2314583T4/es not_active Expired - Lifetime
- 2005-12-30 EP EP05113099A patent/EP1679072B9/en not_active Expired - Lifetime
- 2005-12-30 EP EP08104990A patent/EP1987828A1/en not_active Withdrawn
- 2005-12-30 DE DE602005009918T patent/DE602005009918D1/de not_active Expired - Lifetime
- 2005-12-30 PT PT05113099T patent/PT1679072E/pt unknown
- 2005-12-30 AT AT05113099T patent/ATE409036T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1679072E (pt) | 2008-12-22 |
| EP1679072B1 (en) | 2008-09-24 |
| EP1987828A1 (en) | 2008-11-05 |
| ES2314583T4 (es) | 2009-05-18 |
| SI1679072T1 (sl) | 2009-02-28 |
| PL1679072T3 (pl) | 2009-03-31 |
| EP1679072B9 (en) | 2009-09-02 |
| EP1679072A1 (en) | 2006-07-12 |
| DK1679072T3 (da) | 2009-02-09 |
| DE602005009918D1 (de) | 2008-11-06 |
| ES2314583T3 (es) | 2009-03-16 |
| ATE409036T1 (de) | 2008-10-15 |
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