DK1776339T3 - 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-on-derivater og relaterede forbindelser til behandling af lidelser i centralnervesystemet - Google Patents
3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-on-derivater og relaterede forbindelser til behandling af lidelser i centralnervesystemetInfo
- Publication number
- DK1776339T3 DK1776339T3 DK05779909T DK05779909T DK1776339T3 DK 1776339 T3 DK1776339 T3 DK 1776339T3 DK 05779909 T DK05779909 T DK 05779909T DK 05779909 T DK05779909 T DK 05779909T DK 1776339 T3 DK1776339 T3 DK 1776339T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- halogen
- carbon atom
- hydrogen
- derivatives
- Prior art date
Links
- -1 (4-phenyl) -piperazin-1-yl Chemical group 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 2
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000005095 gastrointestinal system Anatomy 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Polyurethanes Or Polyureas (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0400957A HU0400957D0 (en) | 2004-05-11 | 2004-05-11 | Piperazinbe derivatives of dialkyl oxindoles |
| HU0500464A HUP0500464A3 (en) | 2005-05-05 | 2005-05-05 | Piperazine derivatives of dialkyl-oxindoles |
| PCT/HU2005/000052 WO2005109987A2 (en) | 2004-05-11 | 2005-05-11 | 3-(((4-phenyl)-piperazine-1-yl)-alkyl)-3-alkyl-1, 3-dihydro-2h-indol-2-one derivatives and related compounds for the treatment of central nervous system disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1776339T3 true DK1776339T3 (da) | 2009-11-02 |
Family
ID=89986001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05779909T DK1776339T3 (da) | 2004-05-11 | 2005-05-11 | 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-on-derivater og relaterede forbindelser til behandling af lidelser i centralnervesystemet |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7786129B2 (da) |
| EP (1) | EP1776339B1 (da) |
| JP (1) | JP2007537229A (da) |
| KR (1) | KR20070011594A (da) |
| AT (1) | ATE435204T1 (da) |
| AU (1) | AU2005244389B2 (da) |
| BG (1) | BG109771A (da) |
| CA (1) | CA2565514A1 (da) |
| CZ (1) | CZ2006777A3 (da) |
| DE (1) | DE602005015223D1 (da) |
| DK (1) | DK1776339T3 (da) |
| EA (1) | EA014236B1 (da) |
| ES (1) | ES2329388T3 (da) |
| HR (2) | HRP20090504T1 (da) |
| IL (1) | IL179029A (da) |
| MX (1) | MXPA06013069A (da) |
| NO (1) | NO20065659L (da) |
| NZ (1) | NZ551547A (da) |
| PL (1) | PL1776339T3 (da) |
| PT (1) | PT1776339E (da) |
| RS (1) | RS20060623A (da) |
| SI (1) | SI1776339T1 (da) |
| SK (1) | SK51072006A3 (da) |
| WO (1) | WO2005109987A2 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2727585A1 (en) | 2006-05-16 | 2014-05-07 | Takeda Pharmaceutical Company Limited | In-vivo screening method |
| EP2216023A4 (en) | 2007-11-15 | 2013-03-13 | Takeda Pharmaceutical | CONDENSED PYRIDINE DERIVATIVE AND ITS USE |
| HUP0900071A2 (en) * | 2009-02-06 | 2010-10-28 | Egis Gyogyszergyar Nyilvanosan | Optically active 3-[(phenyl-piperazin-1-yl)alkyl]-3-alkyl-oxindole derivatives influencing the central nervous system and pharmaceutical compositions containing them |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
| CN118561738B (zh) * | 2024-05-09 | 2026-03-17 | 南京工业大学 | 一种3-吲哚酮的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2635104B1 (fr) * | 1988-08-03 | 1992-04-30 | Synthelabo | Derives d'indolone, leur preparation et leur application en therapeutique |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| WO1998008816A1 (en) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Oxindole derivatives and psychotropic drugs |
| PL1751106T3 (pl) * | 2004-05-11 | 2009-07-31 | Egis Gyogyszergyar Nyrt | Piperazynowe pochodne alkilooksyindoli |
| ATE382045T1 (de) * | 2004-05-11 | 2008-01-15 | Egis Gyogyszergyar Nyrt | Indol-2-onderivate zur behandlung von erkrankungen des zentralen nervensystems, erkrankungen des magen-darm-trakts und herzkreislauferkankungen |
-
2005
- 2005-05-11 PT PT05779909T patent/PT1776339E/pt unknown
- 2005-05-11 CZ CZ20060777A patent/CZ2006777A3/cs unknown
- 2005-05-11 AT AT05779909T patent/ATE435204T1/de active
- 2005-05-11 DE DE602005015223T patent/DE602005015223D1/de not_active Expired - Lifetime
- 2005-05-11 ES ES05779909T patent/ES2329388T3/es not_active Expired - Lifetime
- 2005-05-11 KR KR1020067026024A patent/KR20070011594A/ko not_active Ceased
- 2005-05-11 PL PL05779909T patent/PL1776339T3/pl unknown
- 2005-05-11 RS RSP-2006/0623A patent/RS20060623A/sr unknown
- 2005-05-11 NZ NZ551547A patent/NZ551547A/en unknown
- 2005-05-11 SI SI200530785T patent/SI1776339T1/sl unknown
- 2005-05-11 CA CA002565514A patent/CA2565514A1/en not_active Abandoned
- 2005-05-11 SK SK5107-2006A patent/SK51072006A3/sk not_active Application Discontinuation
- 2005-05-11 DK DK05779909T patent/DK1776339T3/da active
- 2005-05-11 AU AU2005244389A patent/AU2005244389B2/en not_active Ceased
- 2005-05-11 JP JP2007512537A patent/JP2007537229A/ja not_active Ceased
- 2005-05-11 MX MXPA06013069A patent/MXPA06013069A/es active IP Right Grant
- 2005-05-11 HR HR20090504T patent/HRP20090504T1/hr unknown
- 2005-05-11 WO PCT/HU2005/000052 patent/WO2005109987A2/en not_active Ceased
- 2005-05-11 EP EP05779909A patent/EP1776339B1/en not_active Expired - Lifetime
- 2005-05-11 US US11/596,473 patent/US7786129B2/en not_active Expired - Fee Related
- 2005-05-11 HR HR20060404A patent/HRP20060404A2/xx not_active Application Discontinuation
- 2005-05-11 EA EA200602083A patent/EA014236B1/ru not_active IP Right Cessation
-
2006
- 2006-11-02 IL IL179029A patent/IL179029A/en not_active IP Right Cessation
- 2006-12-06 NO NO20065659A patent/NO20065659L/no not_active Application Discontinuation
- 2006-12-11 BG BG109771A patent/BG109771A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005015223D1 (de) | 2009-08-13 |
| IL179029A0 (en) | 2007-03-08 |
| RS20060623A (sr) | 2008-09-29 |
| SI1776339T1 (sl) | 2009-12-31 |
| BG109771A (bg) | 2008-05-30 |
| WO2005109987A3 (en) | 2006-05-04 |
| WO2005109987A2 (en) | 2005-11-24 |
| US20070232619A1 (en) | 2007-10-04 |
| WO2005109987A9 (en) | 2007-03-29 |
| SK51072006A3 (sk) | 2007-05-03 |
| PL1776339T3 (pl) | 2009-12-31 |
| NZ551547A (en) | 2010-06-25 |
| CA2565514A1 (en) | 2005-11-24 |
| ES2329388T3 (es) | 2009-11-25 |
| KR20070011594A (ko) | 2007-01-24 |
| EP1776339B1 (en) | 2009-07-01 |
| MXPA06013069A (es) | 2007-03-30 |
| AU2005244389B2 (en) | 2011-09-01 |
| ATE435204T1 (de) | 2009-07-15 |
| EA014236B1 (ru) | 2010-10-29 |
| IL179029A (en) | 2011-11-30 |
| HRP20060404A2 (en) | 2007-04-30 |
| HRP20090504T1 (hr) | 2009-10-31 |
| EP1776339A2 (en) | 2007-04-25 |
| PT1776339E (pt) | 2009-09-16 |
| EA200602083A1 (ru) | 2007-06-29 |
| CZ2006777A3 (cs) | 2007-03-14 |
| JP2007537229A (ja) | 2007-12-20 |
| US7786129B2 (en) | 2010-08-31 |
| AU2005244389A1 (en) | 2005-11-24 |
| NO20065659L (no) | 2007-01-29 |
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