DK1682124T3 - Farmaceutiske præparater på grundlag af idazoxansalt elle4r en polymorf deraf - Google Patents

Farmaceutiske præparater på grundlag af idazoxansalt elle4r en polymorf deraf

Info

Publication number: DK1682124T3
Authority: DK; Denmark
Prior art keywords: idazoxan; salt; pharmaceutical composition; neuroleptic; exhibiting
Prior art date: 2003-10-28

Application number

DK04805330T

Other languages

Danish (da)

English (en)

Inventor

Joel Bougaret

Jean-Louis Avan

Roland Segonds

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-28

Filing date

2004-10-28

Publication date

2008-04-28

2004-10-28 Application filed by Pf Medicament filed Critical Pf Medicament

2008-04-28 Application granted granted Critical

2008-04-28 Publication of DK1682124T3 publication Critical patent/DK1682124T3/da

Links

HPMRFMKYPGXPEP-UHFFFAOYSA-N idazoxan Chemical class N1CCN=C1C1OC2=CC=CC=C2OC1 HPMRFMKYPGXPEP-UHFFFAOYSA-N 0.000 title abstract 4
239000000825 pharmaceutical preparation Substances 0.000 title 1
208000028017 Psychotic disease Diseases 0.000 abstract 2
239000005557 antagonist Substances 0.000 abstract 2
230000001747 exhibiting effect Effects 0.000 abstract 2
229950001476 idazoxan Drugs 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000003176 neuroleptic agent Substances 0.000 abstract 2
230000000701 neuroleptic effect Effects 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
102000004980 Dopamine D2 Receptors Human genes 0.000 abstract 1
108090001111 Dopamine D2 Receptors Proteins 0.000 abstract 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
238000002441 X-ray diffraction Methods 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000000648 anti-parkinson Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
239000000939 antiparkinson agent Substances 0.000 abstract 1
239000003693 atypical antipsychotic agent Substances 0.000 abstract 1
229940127236 atypical antipsychotics Drugs 0.000 abstract 1
239000008119 colloidal silica Substances 0.000 abstract 1
238000009109 curative therapy Methods 0.000 abstract 1
238000004455 differential thermal analysis Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000008101 lactose Substances 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
239000008108 microcrystalline cellulose Substances 0.000 abstract 1
229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
238000001757 thermogravimetry curve Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Inorganic Chemistry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK04805330T 2003-10-28 2004-10-28 Farmaceutiske præparater på grundlag af idazoxansalt elle4r en polymorf deraf DK1682124T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0312626A FR2861299B1 (fr)	2003-10-28	2003-10-28	Compositions pharmaceutiques a base de derives d'idasoxan sous formes polymorphes
PCT/FR2004/002773 WO2005041956A1 (fr)	2003-10-28	2004-10-28	Compositions pharmaceutiques a base de sel d’idazoxan ou l’un de ses polymorphes

Publications (1)

Publication Number	Publication Date
DK1682124T3 true DK1682124T3 (da)	2008-04-28

Family

ID=34400871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04805330T DK1682124T3 (da)	2003-10-28	2004-10-28	Farmaceutiske præparater på grundlag af idazoxansalt elle4r en polymorf deraf

Country Status (18)

Country	Link
US (2)	US7338970B2 (de)
EP (1)	EP1682124B1 (de)
JP (1)	JP5160090B2 (de)
CN (2)	CN102349873B (de)
AT (1)	ATE381331T1 (de)
AU (1)	AU2004285316B2 (de)
BR (1)	BRPI0416006B1 (de)
CA (1)	CA2542752A1 (de)
CY (1)	CY1107304T1 (de)
DE (1)	DE602004010837T2 (de)
DK (1)	DK1682124T3 (de)
ES (1)	ES2297525T3 (de)
FR (1)	FR2861299B1 (de)
HR (1)	HRP20080108T3 (de)
MX (1)	MXPA06004717A (de)
PL (1)	PL1682124T3 (de)
PT (1)	PT1682124E (de)
WO (1)	WO2005041956A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8476307B2 (en) *	2003-10-28	2013-07-02	Pierre Fabre Medicament	Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
US8088824B2 (en) *	2007-08-15	2012-01-03	Reata Pharmaceuticals Inc.	Forms of CDDO methyl ester
UA102128C2 (en) *	2008-12-05	2013-06-10	Х. Луннбек А/С	Nalmefene hydrochloride dihydrate
US12702790B2 (en)	2019-06-13	2026-08-11	Hollister Incorporated	Reusable urinary catheter kits
LT3952973T (lt)	2019-06-13	2023-07-10	Hollister Incorporated	Daugkartinio naudojimo šlapimo kateterio produktai
WO2020263859A1 (en)	2019-06-25	2020-12-30	Hollister Incorporated	Reusable urinary catheter products
EP4479365A4 (de) *	2022-02-16	2026-03-11	Terran Biosciences Inc	Deuteriertes idazoxan und verfahren zur verwendung davon
CN117338772B (zh) *	2023-11-22	2024-04-09	徐州医科大学	一种药物组合物及其在制备用于预防和/或治疗重性抑郁障碍的药物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH16249A (en) *	1980-02-04	1983-08-16	Reckitt & Colmann Prod Ltd	Imidazoline derivatives,its pharmaceutical composition and method of use
US4541893A (en) *	1984-05-15	1985-09-17	Advanced Micro Devices, Inc.	Process for fabricating pedestal interconnections between conductive layers in an integrated circuit
FR2698789B1 (fr)	1992-12-07	1995-03-03	Pf Medicament	Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution.
US5492907A (en) *	1992-12-09	1996-02-20	The United States Of America As Represented By The Department Of Health & Human Services	Antipsychotic composition and method of treatment
IT1264517B1 (it) *	1993-05-31	1996-09-24	Ekita Investments Nv	Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati
US5574059A (en) *	1995-10-27	1996-11-12	Cornell Research Foundation, Inc.	Treating disorders mediated by vascular smooth muscle cell proliferation
FR2746314B1 (fr)	1996-03-25	1998-06-12	Pf Medicament	Produit contenant du milnacipran et de l'idazoxan comme preparation pharmaceutique combinee
US6232215B1 (en) *	1996-09-18	2001-05-15	United Microelectronics Corp.	Method for forming increased density for interconnection metallization
FR2774811B1 (fr) *	1998-02-10	2003-05-09	Sgs Thomson Microelectronics	Procede de formation de lignes conductrices sur des circuits integres
FR2801786B1 (fr) *	1999-12-01	2002-03-01	Fabre Pierre Cosmetique	Nouvelles compositions topiques a base d'idazoxan et de cafeine ou de ses derives solubles et leur utilisation comme amincissant et/ou dans le traitement de la cellulite

2003
- 2003-10-28 FR FR0312626A patent/FR2861299B1/fr not_active Expired - Fee Related
- 2003-11-28 US US10/722,451 patent/US7338970B2/en not_active Expired - Fee Related
2004
- 2004-10-28 ES ES04805330T patent/ES2297525T3/es not_active Expired - Lifetime
- 2004-10-28 CA CA002542752A patent/CA2542752A1/fr not_active Abandoned
- 2004-10-28 DK DK04805330T patent/DK1682124T3/da active
- 2004-10-28 DE DE602004010837T patent/DE602004010837T2/de not_active Expired - Lifetime
- 2004-10-28 PT PT04805330T patent/PT1682124E/pt unknown
- 2004-10-28 MX MXPA06004717A patent/MXPA06004717A/es active IP Right Grant
- 2004-10-28 PL PL04805330T patent/PL1682124T3/pl unknown
- 2004-10-28 EP EP04805330A patent/EP1682124B1/de not_active Expired - Lifetime
- 2004-10-28 AU AU2004285316A patent/AU2004285316B2/en not_active Ceased
- 2004-10-28 WO PCT/FR2004/002773 patent/WO2005041956A1/fr not_active Ceased
- 2004-10-28 CN CN2011101941032A patent/CN102349873B/zh not_active Expired - Fee Related
- 2004-10-28 HR HR20080108T patent/HRP20080108T3/xx unknown
- 2004-10-28 JP JP2006537357A patent/JP5160090B2/ja not_active Expired - Fee Related
- 2004-10-28 AT AT04805330T patent/ATE381331T1/de active
- 2004-10-28 BR BRPI0416006A patent/BRPI0416006B1/pt not_active IP Right Cessation
- 2004-10-28 CN CN2004800315006A patent/CN1870993B/zh not_active Expired - Fee Related
2008
- 2008-01-17 US US12/015,788 patent/US8124640B2/en not_active Expired - Fee Related
- 2008-03-13 CY CY20081100286T patent/CY1107304T1/el unknown

Also Published As

Publication number	Publication date
PL1682124T3 (pl)	2008-05-30
MXPA06004717A (es)	2006-07-05
US7338970B2 (en)	2008-03-04
CA2542752A1 (fr)	2005-05-12
PT1682124E (pt)	2008-03-05
DE602004010837D1 (de)	2008-01-31
EP1682124A1 (de)	2006-07-26
US8124640B2 (en)	2012-02-28
CY1107304T1 (el)	2012-11-21
FR2861299A1 (fr)	2005-04-29
US20080113022A1 (en)	2008-05-15
FR2861299B1 (fr)	2006-01-27
US20050090537A1 (en)	2005-04-28
CN102349873A (zh)	2012-02-15
CN1870993B (zh)	2012-04-04
CN1870993A (zh)	2006-11-29
EP1682124B1 (de)	2007-12-19
CN102349873B (zh)	2013-09-25
JP2007509911A (ja)	2007-04-19
DE602004010837T2 (de)	2008-12-11
ES2297525T3 (es)	2008-05-01
AU2004285316A1 (en)	2005-05-12
JP5160090B2 (ja)	2013-03-13
HK1094769A1 (en)	2007-04-13
ATE381331T1 (de)	2008-01-15
AU2004285316B2 (en)	2010-08-19
WO2005041956A1 (fr)	2005-05-12
BRPI0416006B1 (pt)	2019-02-05
BRPI0416006A (pt)	2007-01-02
HRP20080108T3 (hr)	2008-04-30

Publication	Publication Date	Title
CY1107304T1 (el)	2012-11-21	Φαρμακευτικες συνθεσεις με βαση ιδαζοξανη ή μια απο τις πολυμορφικες μορφες της
FI2498756T4 (fi)	2023-03-22	Neratinibimaleaatin tablettiformulaatiot
NO20075641L (no)	2007-11-20	Kroman og kromenderivater og ders anvendelse
JP2002520273A5 (de)	2006-08-31
US20080107756A1 (en)	2008-05-08	Lithium combinations, and uses related thereto
DE60315674D1 (de)	2007-09-27	Neue imidazopyridine und ihre verwendung
HUP0102511A2 (hu)	2001-11-28	Kombinált gyógykezelés bipoláris betegségek kezelésére
UA102517C2 (ru)	2013-07-25	Замещенные производные морфолина и тиоморфолина, фармацевтическая композиция на их основе и их применение для производства лекарственного средства для лечения расстройства или заболевания центральной нервной системы
MX2008013836A (es)	2008-11-10	Derivados de 2-piridona para el tratamiento de enfermedades o condiciones en las cuales es benefica la inhibicion de la actividad de elastasa de neutrofilos.
RS49828B (sr)	2008-08-07	Farmaceutski sastavi
CA2507002A1 (en)	2004-07-01	Solid drug for oral use
SE0104341D0 (sv)	2001-12-20	New use
NO20051263L (no)	2005-05-12	Ny anvendelse av benzotiazolderivater
CN101198322A (zh)	2008-06-11	用于治疗或预防抑郁症的新治疗组合
JP2007516193A5 (de)	2007-08-16
WO1999061027A1 (en)	1999-12-02	Combination therapy for treatment of refractory depression
KR20160101012A (ko)	2016-08-24	신규 조성물
CN116209657A (zh)	2023-06-02	用于精神障碍或增强的2-氨基茚满化合物
CA2488138A1 (en)	2003-12-24	Treatment for depression and anxiety by the combination of a pde iv inhibitor and an antidepressant or an anxiolytic agent
US20160346249A1 (en)	2016-12-01	Use of amitifadine, (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in methods and compositions with enhanced efficacy and reduced metabolic side effects and toxicity for treatment of depression and other central nervous system disorders and conditions affected by monoamine neurotransmitters
GEP20074225B (en)	2007-10-25	Use of carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders
EP1784173A4 (de)	2009-07-01	Pharmazeutische zusammensetzung zur prävention und behandlung von metabolischen knochenerkrankungen mit alpha-arylmethoxyacrylat-derivaten
DE60215525D1 (de)	2006-11-30	Kombination aus quetiapin und zolmitriptan
TW200513462A (en)	2005-04-16	Stable polymorph of bifeprunox mesilate (7-[4-([1,1'-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
Bailey	2003	Aripiprazole: The Newest Antipsychotic Agent for Treatment of Schizophrenia