DK169276B1 - Vaccine indeholdende et immunogent virusprotein - Google Patents

Vaccine indeholdende et immunogent virusprotein Download PDF

Info

Publication number: DK169276B1
Authority: DK; Denmark
Prior art keywords: inactivated; protein; picornavirus; poliovirus; vaccine
Prior art date: 1986-08-27

Application number

DK446287A

Other languages

Danish (da)

English (en)

Other versions

DK446287A (da

DK446287D0 (da

Inventor

Antonius Ludovicus Van Wezel

Antonius Gerardus Hazendonk

Eduard Coen Beuvery

Original Assignee

Nederlanden Staat

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-27

Filing date

1987-08-26

Publication date

1994-10-03

1987-08-26 Application filed by Nederlanden Staat filed Critical Nederlanden Staat

1987-08-26 Publication of DK446287D0 publication Critical patent/DK446287D0/da

1988-02-28 Publication of DK446287A publication Critical patent/DK446287A/da

1994-10-03 Application granted granted Critical

1994-10-03 Publication of DK169276B1 publication Critical patent/DK169276B1/da

Links

229960005486 vaccine Drugs 0.000 title claims abstract description 32
230000002163 immunogen Effects 0.000 title claims description 12
108010067390 Viral Proteins Proteins 0.000 title claims description 4
102100023321 Ceruloplasmin Human genes 0.000 claims abstract description 47
108090000623 proteins and genes Proteins 0.000 claims abstract description 46
102000004169 proteins and genes Human genes 0.000 claims abstract description 45
108090000565 Capsid Proteins Proteins 0.000 claims abstract description 42
241000991587 Enterovirus C Species 0.000 claims abstract description 25
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 25
241000709664 Picornaviridae Species 0.000 claims abstract description 17
230000001681 protective effect Effects 0.000 claims abstract description 10
230000001939 inductive effect Effects 0.000 claims abstract description 5
238000004519 manufacturing process Methods 0.000 claims abstract description 4
241000709661 Enterovirus Species 0.000 claims description 19
230000015572 biosynthetic process Effects 0.000 claims description 10
239000000203 mixture Substances 0.000 claims description 9
230000000694 effects Effects 0.000 claims description 7
108050000278 Picornavirus capsid Proteins 0.000 claims description 6
241000709701 Human poliovirus 1 Species 0.000 claims description 5
241000709687 Coxsackievirus Species 0.000 claims description 3
241001466953 Echovirus Species 0.000 claims description 3
241000709721 Hepatovirus A Species 0.000 claims description 3
241000709704 Human poliovirus 2 Species 0.000 claims description 3
241000709727 Human poliovirus 3 Species 0.000 claims description 3
230000037452 priming Effects 0.000 claims description 3
230000004044 response Effects 0.000 claims description 3
230000036039 immunity Effects 0.000 claims description 2
102000004196 processed proteins & peptides Human genes 0.000 abstract description 13
230000003053 immunization Effects 0.000 abstract description 10
239000002671 adjuvant Substances 0.000 abstract description 6
125000003275 alpha amino acid group Chemical group 0.000 abstract description 3
241000700605 Viruses Species 0.000 description 23
239000000427 antigen Substances 0.000 description 13
102000036639 antigens Human genes 0.000 description 13
108091007433 antigens Proteins 0.000 description 13
230000003472 neutralizing effect Effects 0.000 description 13
238000002347 injection Methods 0.000 description 11
239000007924 injection Substances 0.000 description 11
238000002649 immunization Methods 0.000 description 9
230000000638 stimulation Effects 0.000 description 9
230000002708 enhancing effect Effects 0.000 description 8
229940029583 inactivated polio vaccine Drugs 0.000 description 8
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 8
239000000725 suspension Substances 0.000 description 7
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
230000000890 antigenic effect Effects 0.000 description 6
210000003719 b-lymphocyte Anatomy 0.000 description 6
210000002443 helper t lymphocyte Anatomy 0.000 description 6
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 6
238000000034 method Methods 0.000 description 5
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 4
230000000240 adjuvant effect Effects 0.000 description 4
235000019253 formic acid Nutrition 0.000 description 4
208000005252 hepatitis A Diseases 0.000 description 4
238000006386 neutralization reaction Methods 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
238000002255 vaccination Methods 0.000 description 4
241000710198 Foot-and-mouth disease virus Species 0.000 description 3
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
210000000234 capsid Anatomy 0.000 description 3
239000004202 carbamide Substances 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
101710132601 Capsid protein Proteins 0.000 description 2
101800000593 Capsid protein 2 Proteins 0.000 description 2
101710197658 Capsid protein VP1 Proteins 0.000 description 2
102000009016 Cholera Toxin Human genes 0.000 description 2
108010049048 Cholera Toxin Proteins 0.000 description 2
241000710188 Encephalomyocarditis virus Species 0.000 description 2
102000002067 Protein Subunits Human genes 0.000 description 2
108010001267 Protein Subunits Proteins 0.000 description 2
101710118046 RNA-directed RNA polymerase Proteins 0.000 description 2
241000700159 Rattus Species 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
101710108545 Viral protein 1 Proteins 0.000 description 2
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239000000872 buffer Substances 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
230000003993 interaction Effects 0.000 description 2
238000002955 isolation Methods 0.000 description 2
238000003199 nucleic acid amplification method Methods 0.000 description 2
239000008188 pellet Substances 0.000 description 2
229960001539 poliomyelitis vaccine Drugs 0.000 description 2
239000011148 porous material Substances 0.000 description 2
239000000523 sample Substances 0.000 description 2
241000500386 Boone cardiovirus Species 0.000 description 1
101800000592 Capsid protein 3 Proteins 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
241000709675 Coxsackievirus B3 Species 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
241000274177 Juniperus sabina Species 0.000 description 1
239000012741 Laemmli sample buffer Substances 0.000 description 1
241000710185 Mengo virus Species 0.000 description 1
239000000020 Nitrocellulose Substances 0.000 description 1
208000000474 Poliomyelitis Diseases 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
101710166307 Protein lines Proteins 0.000 description 1
241000700157 Rattus norvegicus Species 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
241000914334 Sahlbergella singularis Species 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000008901 benefit Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
230000036755 cellular response Effects 0.000 description 1
238000005352 clarification Methods 0.000 description 1
230000009260 cross reactivity Effects 0.000 description 1
230000004069 differentiation Effects 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
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230000000984 immunochemical effect Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
210000002751 lymph Anatomy 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
210000004180 plasmocyte Anatomy 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
230000002516 postimmunization Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
229940023143 protein vaccine Drugs 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
241000894007 species Species 0.000 description 1
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
229940124856 vaccine component Drugs 0.000 description 1
210000002845 virion Anatomy 0.000 description 1
230000003612 virological effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Virology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

DK446287A 1986-08-27 1987-08-26 Vaccine indeholdende et immunogent virusprotein DK169276B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US90073986		1986-08-27
US06/900,739 US4946676A (en)	1986-08-27	1986-08-27	Vaccine comprising an immunogenic protein and, as an adjuvant, a substantially non-immunogenic, sequentially homologous peptide

Publications (3)

Publication Number	Publication Date
DK446287D0 DK446287D0 (da)	1987-08-26
DK446287A DK446287A (da)	1988-02-28
DK169276B1 true DK169276B1 (da)	1994-10-03

Family

ID=25413018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK446287A DK169276B1 (da)	1986-08-27	1987-08-26	Vaccine indeholdende et immunogent virusprotein

Country Status (10)

Country	Link
US (1)	US4946676A (de)
EP (1)	EP0257721B1 (de)
JP (1)	JPS63132844A (de)
AT (1)	ATE71534T1 (de)
CA (1)	CA1292690C (de)
DE (1)	DE3776034D1 (de)
DK (1)	DK169276B1 (de)
ES (1)	ES2032812T3 (de)
GR (1)	GR3003754T3 (de)
NO (1)	NO873593L (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6797270B1 (en) *	1989-03-16	2004-09-28	Center For Blood Research, Inc.	Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy
CA2105629A1 (en) *	1992-09-14	1994-03-15	Robert S. Becker	Potentiation of immunogenic response
CA2454882A1 (en) *	2001-06-21	2003-01-03	Uab Research Foundation	Chimeric capsid proteins and uses thereof
US20040002058A1 (en) *	2001-06-21	2004-01-01	Uab Research Foundation	Chimeric capsid proteins and uses thereof
US20090142364A1 (en) *	2007-08-30	2009-06-04	Fedor Alexandrovich Brovko	Method for finding novel peptide immunostimulatory adjuvants, compositions and methods of use
WO2016205389A1 (en)	2015-06-15	2016-12-22	Emory University	Multivalent enterovirus vaccine compositions and uses related thereto
CA3055900A1 (en) *	2016-03-20	2017-09-28	The Trustees Of The University Of Pennsylvania	Codon optimization and ribosome profiling for increasing transgene expression in chloroplasts of higher plants

1986
- 1986-08-27 US US06/900,739 patent/US4946676A/en not_active Expired - Lifetime
1987
- 1987-08-26 NO NO873593A patent/NO873593L/no unknown
- 1987-08-26 DK DK446287A patent/DK169276B1/da active
- 1987-08-27 ES ES198787201620T patent/ES2032812T3/es not_active Expired - Lifetime
- 1987-08-27 AT AT87201620T patent/ATE71534T1/de not_active IP Right Cessation
- 1987-08-27 CA CA000545494A patent/CA1292690C/en not_active Expired - Lifetime
- 1987-08-27 EP EP87201620A patent/EP0257721B1/de not_active Expired - Lifetime
- 1987-08-27 DE DE8787201620T patent/DE3776034D1/de not_active Expired - Lifetime
- 1987-08-27 JP JP62214131A patent/JPS63132844A/ja active Pending
1992
- 1992-02-11 GR GR920400176T patent/GR3003754T3/el unknown

Also Published As

Publication number	Publication date
EP0257721A2 (de)	1988-03-02
EP0257721A3 (en)	1988-06-08
NO873593L (no)	1988-02-29
ATE71534T1 (de)	1992-02-15
CA1292690C (en)	1991-12-03
JPS63132844A (ja)	1988-06-04
GR3003754T3 (de)	1993-03-16
DK446287A (da)	1988-02-28
DE3776034D1 (de)	1992-02-27
NO873593D0 (no)	1987-08-26
US4946676A (en)	1990-08-07
ES2032812T3 (es)	1993-03-01
DK446287D0 (da)	1987-08-26
EP0257721B1 (de)	1992-01-15

Legal Events

Date	Code	Title	Description
1987-08-26	A0	Application filed

Publication	Publication Date	Title
Wang et al.	2002	Effective synthetic peptide vaccine for foot-and-mouth disease in swine
Beard et al.	1999	Development of DNA vaccines for foot-and-mouth disease, evaluation of vaccines encoding replicating and non-replicating nucleic acids in swine
Yang et al.	2007	Induction of protective immunity in swine by recombinant bamboo mosaic virus expressing foot-and-mouth disease virus epitopes
Kalnciema et al.	2012	Potato virus Y-like particles as a new carrier for the presentation of foreign protein stretches
CN1134174A (zh)	1996-10-23	改构的植物病毒作为异源肽的载体
Reimann et al.	1991	Mapping of a neutralizing antigenic site of Coxsackievirus B4 by construction of an antigen chimera
CN103442730B (zh)	2016-08-17	组合七价疫苗
NO313917B1 (no)	2002-12-23	Antigen-presenterende kapsid med fusert MS2-kappeprotein
EP0090581A2 (de)	1983-10-05	Kleine, für Maul- und Klauenseuche spezifische Peptide
Beachy et al.	2006	Use of plant viruses for delivery of vaccine epitopes
Lei et al.	2019	Artificially designed hepatitis B virus core particles composed of multiple epitopes of type A and O foot‐and‐mouth disease virus as a bivalent vaccine candidate
AU2025205386A1 (en)	2025-07-31	Feline calicivirus vaccine
WO1996005293A1 (en)	1996-02-22	Molecular presenting system
Francis	1990	Peptide vaccines for viral diseases
EP0257721B1 (de)	1992-01-15	Vakzine
BRPI0717145A2 (pt)	2013-11-12	Processo para produzir uma vacina combinada, e, vacina
CN101322844B (zh)	2011-10-05	无病毒非结构蛋白的口蹄疫疫苗及其制备方法
CA1271717A (en)	1990-07-17	Polypeptides useful in vaccination against enteroviruses
Jameson et al.	1985	Natural variants of the Sabin type 1 vaccine strain of poliovirus and correlation with a poliovirus neutralization site
WO1984002847A1 (en)	1984-08-02	Methods and materials for development of parvovirus vaccine
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CN109096393A (zh)	2018-12-28	猫瘟热治疗性抗体的制备方法
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Kusov et al.	2007	Immunogenicity of a chimeric hepatitis A virus (HAV) carrying the HIV gp41 epitope 2F5
US11229699B2 (en)	2022-01-25	Feline calicivirus vaccine