DK169384A - Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner - Google Patents

Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner Download PDF

Info

Publication number
DK169384A
DK169384A DK169384A DK169384A DK169384A DK 169384 A DK169384 A DK 169384A DK 169384 A DK169384 A DK 169384A DK 169384 A DK169384 A DK 169384A DK 169384 A DK169384 A DK 169384A
Authority
DK
Denmark
Prior art keywords
trans
preparing
azetidinones
disubstituted
disubstituted azetidinones
Prior art date
Application number
DK169384A
Other languages
English (en)
Other versions
DK165686C (da
DK169384D0 (da
DK165686B (da
Inventor
Ivan Ernest
Jaroslav Kalvoda
Wolfgang Froestl
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK169384D0 publication Critical patent/DK169384D0/da
Publication of DK169384A publication Critical patent/DK169384A/da
Publication of DK165686B publication Critical patent/DK165686B/da
Application granted granted Critical
Publication of DK165686C publication Critical patent/DK165686C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK169384A 1983-03-28 1984-03-27 Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner DK165686C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH167883 1983-03-28
CH167883 1983-03-28

Publications (4)

Publication Number Publication Date
DK169384D0 DK169384D0 (da) 1984-03-27
DK169384A true DK169384A (da) 1984-09-29
DK165686B DK165686B (da) 1993-01-04
DK165686C DK165686C (da) 1993-05-24

Family

ID=4216038

Family Applications (1)

Application Number Title Priority Date Filing Date
DK169384A DK165686C (da) 1983-03-28 1984-03-27 Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner

Country Status (6)

Country Link
US (1) US4614614A (da)
EP (1) EP0126709B1 (da)
JP (1) JPS59181254A (da)
DE (1) DE3484362D1 (da)
DK (1) DK165686C (da)
IE (1) IE57095B1 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
EP0171064B1 (en) * 1984-08-06 1995-07-12 Fujisawa Pharmaceutical Co., Ltd. Azetidinone derivative and processes for production thereof
DE3567644D1 (de) * 1984-10-18 1989-02-23 Hoffmann La Roche Sterical uniform 2-azetidinones
JPS61267553A (ja) * 1984-11-29 1986-11-27 Sankyo Co Ltd アゼチジノン誘導体およびその製法
US4882429A (en) * 1986-03-03 1989-11-21 Schering Corporation Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine
US5008404A (en) * 1988-08-01 1991-04-16 Schering Corporation Preparation of azetidinones via novel protected intermediates
US4740595A (en) * 1986-03-13 1988-04-26 Schering Corporation Preparation of azetidinones via N-protected oxirancecarboxamide intermediates
US4963670A (en) * 1986-03-13 1990-10-16 Schering Corporation Preparation of azetidinones via novel protected intermediates
US4827006A (en) * 1986-03-13 1989-05-02 Schering Corporation Preparation of azetidinones via novel protected intermediates
DE3615520A1 (de) * 1986-05-07 1987-11-12 Bayer Ag Verfahren zur herstellung von 2,3-epoxyamiden
FR2609032B1 (fr) * 1986-12-30 1990-01-05 Centre Nat Rech Scient Epoxydes fonctionnels enantiomeriquement purs, leur procede de preparation et leur application comme synthons chiraux
US5274188A (en) * 1987-05-04 1993-12-28 Ciba-Geigy Corporation Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones
JPH0623150B2 (ja) * 1988-11-15 1994-03-30 高砂香料工業株式会社 光学活性３−ヒドロキシブタン酸類の製造方法
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US5075439A (en) * 1990-08-17 1991-12-24 Pfizer Inc. Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
DK1355644T3 (da) * 2001-01-26 2006-10-23 Schering Corp Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi
IL156585A0 (en) * 2001-01-26 2004-01-04 Schering Corp Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
US20020183305A1 (en) * 2001-01-26 2002-12-05 Schering Corporation Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
PL364178A1 (en) * 2001-01-26 2004-12-13 Schering Corporation Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
HU230253B1 (hu) * 2001-01-26 2015-11-30 Merck Sharp & Dohme Corp Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
AU2002241956A1 (en) * 2001-01-26 2002-08-06 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
JP2004532868A (ja) * 2001-05-25 2004-10-28 シェーリング　コーポレイション アルツハイマー病の処置におけるアゼチジノン置換誘導体の使用
AU2002335770B2 (en) * 2001-09-21 2005-08-18 Merck Sharp & Dohme Corp. Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
JP2005504091A (ja) * 2001-09-21 2005-02-10 シェーリング　コーポレイション ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
CA2517571C (en) * 2003-03-07 2011-07-05 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja) 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
JP2006519869A (ja) * 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
DE10339168A1 (de) * 2003-08-21 2005-04-28 Kabelschlepp Gmbh Kettenlasche für eine Energieführungskette sowie Energieführungskette
EP1680189A2 (en) * 2003-11-05 2006-07-19 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55111463A (en) * 1979-02-21 1980-08-28 Sankyo Co Ltd Beta-lactam compound and its preparation
DE3069597D1 (en) * 1979-08-01 1984-12-13 Ciba Geigy Ag 3-substituted bicyclic azetidinone derivatives, process for their preparation, and intermediates as well as their preparation
JPS56142259A (en) * 1980-03-11 1981-11-06 Sankyo Co Ltd Beta-lactam compound and its preparation
EP0041768B1 (en) * 1980-04-24 1987-11-11 Beecham Group Plc Beta-lactam compounds, their preparation and use
ATA396081A (de) * 1980-09-15 1983-10-15 Richter Gedeon Vegyeszet Verfahren zur herstellung von eine c-acetylgruppe enthaltenden neuen heterocyclischen verbindungen
JPS57163362A (en) * 1981-03-30 1982-10-07 Sankyo Co Ltd Azetidinone derivative and its preparation

Also Published As

Publication number Publication date
DE3484362D1 (de) 1991-05-08
IE840744L (en) 1984-09-28
DK165686C (da) 1993-05-24
DK169384D0 (da) 1984-03-27
EP0126709A1 (de) 1984-11-28
JPH0557979B2 (da) 1993-08-25
JPS59181254A (ja) 1984-10-15
US4614614A (en) 1986-09-30
IE57095B1 (en) 1992-04-22
EP0126709B1 (de) 1991-04-03
DK165686B (da) 1993-01-04

Similar Documents

Publication Publication Date Title
DK169384A (da) Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner
KR880009550A (ko) 4-치환된-2-아제티디논 화합물의 제조방법
DK301986D0 (da) Fremgangsmaade til fremstilling af 1-hydroxyvitamin-d-forbindelser
DK164864C (da) Fremgangsmaade til fremstilling af 2-oxo-1,3-dioxolaner
DK140886A (da) Fremgangsmaade til fremstilling af cis,endo-octahydrocyclo-penta(b)pyrrol-2-carboxylater
DK143491D0 (da) Fremgangsmaade til fremstilling af 3-oen-phenylacetylaminopiperidinaa-2,6-dion
DK8685D0 (da) Fremgangsmaade til fremstilling af 1alfa,25-hydroxylerede vitamin d2-og beslaegtede forbindelser
DK210083D0 (da) Fremgangsmade til fremstilling af 6a,10a-trans-hexahydrodibenzopyranoner
DK120884D0 (da) Fremgangsmaade til fremstilling af heptakis-(2,6-di-0-methyl)-beta-cyclodekstrin
DK379985A (da) Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin
DK583A (da) Fremgangsmaade til fremstilling af 2-oxo-1-(aminocarbonylaminosulfonylaminocarbonyl)azetidiner
DK154207C (da) Fremgangsmaade til fremstilling af 1,8-dihydroxy-10-acyl-9-anthroner
DK23784D0 (da) Fremgangsmade til fremstilling af beta-lactam
DK281384D0 (da) Fremgangsmaade til fremstilling af 2-alkyl-1,4-butandioler
DK19784D0 (da) Fremgangsmade til fremstilling af 2-substituerede 5-nitroso-4,6-diamino-pyrimidiner
DK189088D0 (da) Fremgangsmaade til fremstilling af alfa-(1-metylaetyl)-3,4-dimetoxybenzenacetonitril
DK97682A (da) Fremgangsmaade til fremstilling af 1-(1,3-benzodioxol-5-yl)-2-pyrrolidinon
DK457983D0 (da) Fremgangsmade til fremstilling af beta-lactam
DK146500C (da) Listeskaeremaskine, navnlig til skaering af rammelister i gering
DK446583A (da) Fremgangsmaade til fremstilling af isoquinolin-5,8-quinoner
DK156061C (da) Fremgangsmaade til fremstilling af 2-alkyl-4-amino-5-aminomethylpyrimidin
DK311783D0 (da) Skaereapparat, isaer til skaering af kabelaffald
DK358386A (da) Fremgangsmaade til fremstilling af alkyl-2-carboalkoxy-3,4-dialkoxybenzencarbamater
DK534084A (da) Fremgangsmaade til fremstilling af substituerede 2-imino-3,4,6,7-tetrahydro-4h-purimido(6,1-a)isoquinolin-4-oner
DK200784A (da) Fremgangsmaade til fremstilling af 2,3-dihydro-2,2-dimethyl-7-benzofuranol

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
B1 Patent granted (law 1993)
PBP Patent lapsed