DK169478A - Fremgangsmaade til fremstilling af thymosin alfa1 og en analog - Google Patents

Fremgangsmaade til fremstilling af thymosin alfa1 og en analog

Info

Publication number: DK169478A
Authority: DK; Denmark
Prior art keywords: alfa1; thymosin; analog; procedure; preparation
Prior art date: 1977-04-22

Application number

DK169478A

Other languages

English (en)

Other versions

DK147918C (da

DK147918B (da

Inventor

S S Wang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-22

Filing date

1978-04-18

Publication date

1978-10-23

1978-01-23 Priority claimed from US05/871,563 external-priority patent/US4116951A/en

1978-04-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1978-10-23 Publication of DK169478A publication Critical patent/DK169478A/da

1985-01-07 Publication of DK147918B publication Critical patent/DK147918B/da

1985-08-19 Application granted granted Critical

1985-08-19 Publication of DK147918C publication Critical patent/DK147918C/da

Links

102000007501 Thymosin Human genes 0.000 title 1
108010046075 Thymosin Proteins 0.000 title 1
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK169478A 1977-04-22 1978-04-18 Analogifremgangsmaade til fremstilling af thymosin alfa1 (18 - 28) eller farmaceutisk acceptable salte deraf DK147918C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US78989877A	1977-04-22	1977-04-22
US78989877		1977-04-22
US87156378		1978-01-23
US05/871,563 US4116951A (en)	1977-04-22	1978-01-23	[Asn2 ]-thymosin α1 and analogs thereof

Publications (3)

Publication Number	Publication Date
DK169478A true DK169478A (da)	1978-10-23
DK147918B DK147918B (da)	1985-01-07
DK147918C DK147918C (da)	1985-08-19

Family

ID=27120967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK169478A DK147918C (da)	1977-04-22	1978-04-18	Analogifremgangsmaade til fremstilling af thymosin alfa1 (18 - 28) eller farmaceutisk acceptable salte deraf

Country Status (18)

Country	Link
JP (1)	JPS53137914A (da)
AT (1)	AT364470B (da)
CA (1)	CA1113088A (da)
CH (3)	CH641152A5 (da)
DE (1)	DE2817082A1 (da)
DK (1)	DK147918C (da)
ES (1)	ES469016A1 (da)
FI (1)	FI781241A7 (da)
FR (2)	FR2401134A1 (da)
GB (1)	GB1590668A (da)
GR (1)	GR71886B (da)
HU (1)	HU180783B (da)
IT (1)	IT1113134B (da)
LU (1)	LU79488A1 (da)
NL (1)	NL7804364A (da)
NO (2)	NO781404L (da)
PT (1)	PT67937B (da)
SE (1)	SE447262B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4116951A (en) *	1977-04-22	1978-09-26	Hoffmann-La Roche Inc.	[Asn2 ]-thymosin α1 and analogs thereof
DE2919592A1 (de) *	1979-05-15	1981-01-15	Max Planck Gesellschaft	Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
EP0033384B1 (de) *	1980-01-18	1984-02-15	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunstimulierender Wirkung, und Thymosin-alpha-1-Fragmente
US4339427A (en) *	1980-04-14	1982-07-13	Hoffmann-La Roche Inc.	Radioimmunoassay of thymosinα
EP0056594B1 (de) *	1981-01-14	1984-09-12	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunregulierender Wirkung und Thymosin-alpha-1-Fragmente
CN1058500C (zh) *	1993-02-03	2000-11-15	施塞克龙药品公司	胸腺素α－1衍生物
US6262230B1 (en) *	1994-01-28	2001-07-17	Sciclone Pharmaceuticals Inc.	Analogs of thymosin α1

1978
- 1978-04-17 CH CH408878A patent/CH641152A5/de not_active IP Right Cessation
- 1978-04-18 DK DK169478A patent/DK147918C/da not_active IP Right Cessation
- 1978-04-19 DE DE19782817082 patent/DE2817082A1/de not_active Ceased
- 1978-04-20 FR FR7811686A patent/FR2401134A1/fr active Granted
- 1978-04-20 GR GR56036A patent/GR71886B/el unknown
- 1978-04-21 GB GB1574/78A patent/GB1590668A/en not_active Expired
- 1978-04-21 HU HU78HO2067A patent/HU180783B/hu unknown
- 1978-04-21 SE SE7804612A patent/SE447262B/sv not_active IP Right Cessation
- 1978-04-21 ES ES469016A patent/ES469016A1/es not_active Expired
- 1978-04-21 JP JP4673978A patent/JPS53137914A/ja active Pending
- 1978-04-21 IT IT22629/78A patent/IT1113134B/it active
- 1978-04-21 FI FI781241A patent/FI781241A7/fi not_active Application Discontinuation
- 1978-04-21 PT PT67937A patent/PT67937B/pt unknown
- 1978-04-21 LU LU79488A patent/LU79488A1/de unknown
- 1978-04-21 CA CA301,643A patent/CA1113088A/en not_active Expired
- 1978-04-21 NO NO781404A patent/NO781404L/no unknown
- 1978-04-21 AT AT0286178A patent/AT364470B/de not_active IP Right Cessation
- 1978-04-24 NL NL7804364A patent/NL7804364A/xx not_active Application Discontinuation
- 1978-12-15 FR FR7835404A patent/FR2405926A1/fr active Granted
1982
- 1982-05-13 NO NO821608A patent/NO148924C/no unknown
- 1982-11-05 CH CH644982A patent/CH640218A5/de not_active IP Right Cessation
- 1982-11-05 CH CH645082A patent/CH641153A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK147918C (da)	1985-08-19
DK147918B (da)	1985-01-07
JPS53137914A (en)	1978-12-01
SE447262B (sv)	1986-11-03
NO781404L (no)	1978-10-24
PT67937B (en)	1980-04-07
NO821608L (no)	1978-10-24
CH640218A5 (en)	1983-12-30
FR2405926B1 (da)	1983-09-09
DE2817082A1 (de)	1978-11-02
NO148924B (no)	1983-10-03
IT1113134B (it)	1986-01-20
ATA286178A (de)	1981-03-15
HU180783B (en)	1983-04-29
NL7804364A (nl)	1978-10-24
CH641153A5 (en)	1984-02-15
PT67937A (en)	1978-05-01
FR2405926A1 (fr)	1979-05-11
NO148924C (no)	1984-01-11
FR2401134A1 (fr)	1979-03-23
ES469016A1 (es)	1980-01-01
AT364470B (de)	1981-10-27
GB1590668A (en)	1981-06-03
CA1113088A (en)	1981-11-24
IT7822629A0 (it)	1978-04-21
LU79488A1 (de)	1979-05-25
GR71886B (da)	1983-08-04
CH641152A5 (en)	1984-02-15
FR2401134B1 (da)	1983-09-30
SE7804612L (sv)	1978-12-20
FI781241A7 (fi)	1978-10-23

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Legal Events

Date	Code	Title
1989-12-11	PBP	Patent lapsed
1994-11-07	B1	Patent granted (law 1993)
1997-05-20	PBP	Patent lapsed